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List of works by Pilar Santisteban

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Association between BRAF V600E mutation and mortality in patients with papillary thyroid cancer

scientific article published on April 2013
Association between BRAF V600E mutation and recurrence of papillary thyroid cancer.

scientific article
The oncogene BRAFV600E is associated with a high risk of recurrence and less differentiated papillary thyroid carcinoma due to the impairment of Na+/I− targeting to the membrane

scientific article published on 01 March 2006
The BRAFV600E oncogene induces transforming growth factor beta secretion leading to sodium iodide symporter repression and increased malignancy in thyroid cancer

scientific article
A perspective view of sodium iodide symporter research and its clinical implications

scientific article
The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors

scientific article published on 4 September 2009
mRNA circularization by METTL3-eIF3h enhances translation and promotes oncogenesis

scientific article published in Nature
Differential Clinicopathological Risk and Prognosis of Major Papillary Thyroid Cancer Variants.

scientific article
The small GTP-binding protein, Rhes, regulates signal transduction from G protein-coupled receptors

scientific article (publication date: 15 January 2004)
The forkhead factor FoxE1 binds to the thyroperoxidase promoter during thyroid cell differentiation and modifies compacted chromatin structure

scientific article published in October 2007
TSH-activated signaling pathways in thyroid tumorigenesis

scientific article published on December 2003
Transcriptional repressor DREAM interacts with thyroid transcription factor-1 and regulates thyroglobulin gene expression

scientific article published on 4 June 2004
TSH signalling and cancer

scientific article
New insights in thyroid follicular cell biology and its impact in thyroid cancer therapy

scientific article published on December 2007
DNA methylation signatures identify biologically distinct thyroid cancer subtypes.

scientific article published on 10 May 2013
Role of the wnt pathway in thyroid cancer

scientific article published on 29 February 2012
The functional interaction between the paired domain transcription factor Pax8 and Smad3 is involved in transforming growth factor-beta repression of the sodium/iodide symporter gene

scientific article published on 17 November 2003
Thyroid transcription factors in development, differentiation and disease

scientific article
PI3K is involved in the IGF-I inhibition of TSH-induced sodium/iodide symporter gene expression

scientific article published on February 2002
Thyroid-specific gene expression in the multi-step process of thyroid carcinogenesis

scientific article published in April 1999
Insulin and insulin-like growth factor I regulate a thyroid-specific nuclear protein that binds to the thyroglobulin promoter

scientific article published on August 1992
Transcriptional Control of the Forkhead Thyroid Transcription Factor TTF-2 by Thyrotropin, Insulin, and Insulin-like Growth Factor I

scientific article published in Journal of Biological Chemistry
Activation of the GLP-1 Receptor by Liraglutide Increases ACE2 Expression, Reversing Right Ventricle Hypertrophy, and Improving the Production of SP-A and SP-B in the Lungs of Type 1 Diabetes Rats

scientific article published on 21 July 2015
The miR-146b-3p/PAX8/NIS Regulatory Circuit Modulates the Differentiation Phenotype and Function of Thyroid Cells during Carcinogenesis

scientific article published on 17 August 2015
Gbetagamma dimers released in response to thyrotropin activate phosphoinositide 3-kinase and regulate gene expression in thyroid cells

scientific article published on 17 January 2008
Thyroid development and effect on the nervous system

scientific article
New insights into FoxE1 functions: identification of direct FoxE1 targets in thyroid cells

scientific article
Genome-wide analysis of Pax8 binding provides new insights into thyroid functions

scientific article
The Interaction between the Forkhead Thyroid Transcription Factor TTF-2 and the Constitutive Factor CTF/NF-1 Is Required for Efficient Hormonal Regulation of the Thyroperoxidase Gene Transcription

scientific article published in Journal of Biological Chemistry
Functional Study of a Novel Single Deletion in theTITF1/NKX2.1Homeobox Gene That Produces Congenital Hypothyroidism and Benign Chorea But Not Pulmonary Distress

article
Thyroid cancer GWAS identifies 10q26.12 and 6q14.1 as novel susceptibility loci and reveals genetic heterogeneity among populations

scientific article published on 22 April 2015
Key signaling pathways in thyroid cancer

scientific article published in November 2017
MicroRNA deep-sequencing reveals master regulators of follicular and papillary thyroid tumors.

scientific article published on 27 February 2015
Wnt-independent role of β-catenin in thyroid cell proliferation and differentiation

scientific article
Identification of a cis-regulatory element and a thyroid-specific nuclear factor mediating the hormonal regulation of rat thyroid peroxidase promoter activity

scientific article published on October 1993
MicroRNA-146b promotes PI3K/AKT pathway hyperactivation and thyroid cancer progression by targeting PTEN.

scientific article published on 22 January 2018
Somatostatin interferes with thyrotropin-induced G1-S transition mediated by cAMP-dependent protein kinase and phosphatidylinositol 3-kinase. Involvement of RhoA and cyclin E x cyclin-dependent kinase 2 complexes

scientific article
Dynamic expression of Groucho-related genes Grg1 and Grg3 in foregut endoderm and antagonism of differentiation

scientific article
Regulation of thyroid oxidative state by thioredoxin reductase has a crucial role in thyroid responses to iodide excess

scientific article
Function of the homeo and paired domain proteins TTF-1 and Pax-8 in thyroid cell proliferation

scientific article
FOXO1 Controls Thyroid Cell Proliferation in Response to TSH and IGF-I and Is Involved in Thyroid Tumorigenesis

scientific article published on November 16, 2012
Insulin-induced Early Growth Response Gene (Egr-1) Mediates a Short Term Repression of Rat Malic Enzyme Gene Transcription

scientific article published in Journal of Biological Chemistry
Association Study of 69 Genes in the Ret Pathway Identifies Low-penetrance Loci in Sporadic Medullary Thyroid Carcinoma

article
Patient Age-Associated Mortality Risk Is Differentiated by BRAF V600E Status in Papillary Thyroid Cancer.

scientific article published on 14 December 2017
ENDOCRINE TUMOURS: Advances in the molecular pathogenesis of thyroid cancer: lessons from the cancer genome

scientific article
Lung hypoplasia caused by nitrofen is mediated by down-regulation of thyroid transcription factor TTF-1

scientific article
β-catenin signaling is required for RAS-driven thyroid cancer through PI3K activation.

scientific article published on 30 June 2016
The Prognostic Value of Tumor Multifocality in Clinical Outcomes of Papillary Thyroid Cancer

scientific article published on 05 June 2017
BRAF V600E Mutation-Assisted Risk Stratification of Solitary Intrathyroidal Papillary Thyroid Cancer for Precision Treatment

scientific article published on 18 November 2017
NIS mediates iodide uptake in the female reproductive tract and is a poor prognostic factor in ovarian cancer

scientific article published on 7 April 2014

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