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List of works by Nilesh Samani

52 Genetic Loci Influencing Myocardial Mass

scientific article

A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure

scientific article

A common variant in low-density lipoprotein receptor-related protein 6 gene (LRP6) is associated with LDL-cholesterol

scientific article

A comprehensive 1,000 Genomes-based genome-wide association meta-analysis of coronary artery disease

scientific article

A functional genomics approach reveals novel quantitative trait loci associated with platelet signaling pathways.

scientific article published on 8 May 2009

A genome-wide association study for coronary artery disease identifies a novel susceptibility locus in the major histocompatibility complex

scientific article published on 7 February 2012

A genome-wide association study identifies LIPA as a susceptibility gene for coronary artery disease

scientific article

A genome-wide association study reveals variants in ARL15 that influence adiponectin levels

scientific article

A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium

scientific article

A genomewide linkage study of 1,933 families affected by premature coronary artery disease: The British Heart Foundation (BHF) Family Heart Study

scientific article

A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease

scientific article published on June 2016

A genomic exploration identifies mechanisms that may explain adverse cardiovascular effects of COX-2 inhibitors

scientific article published on 31 August 2017

A miR-327-FGF10-FGFR2-mediated autocrine signaling mechanism controls white fat browning.

scientific article published on 12 December 2017

A multi-ancestry genome-wide study incorporating gene-smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure

scientific article published on 10 April 2019

A network analysis to identify pathophysiological pathways distinguishing ischaemic from non-ischaemic heart failure

scientific article published on 03 April 2020

A novel surface electrocardiogram-based marker of ventricular arrhythmia risk in patients with ischemic cardiomyopathy

scientific article

A novel variant on chromosome 7q22.3 associated with mean platelet volume, counts, and function

scientific article published on 12 February 2009

A polymorphism of the cholesteryl ester transfer protein gene predicts cardiovascular events in non-smokers in the West of Scotland Coronary Prevention Study ⬇️

scientific article published on October 1, 2003

A regulatory SNP of the BICD1 gene contributes to telomere length variation in humans

article

A sequence variant associated with sortilin-1 (SORT1) on 1p13.3 is independently associated with abdominal aortic aneurysm

scientific article published on 27 March 2013

A systems BIOlogy Study to TAilored Treatment in Chronic Heart Failure: rationale, design, and baseline characteristics of BIOSTAT-CHF.

scientific article

A systems biology framework identifies molecular underpinnings of coronary heart disease

scientific article published on 28 March 2013

A trans-acting locus regulates an anti-viral expression network and type 1 diabetes risk

scientific article published on 8 September 2010

A variant in LDLR is associated with abdominal aortic aneurysm

scientific journal article

A £30m international research award

scientific article published on 01 October 2018

ANGPTL3 Deficiency and Protection Against Coronary Artery Disease

scientific article published on 29 March 2017

Abdominal aortic aneurysm is associated with a variant in low-density lipoprotein receptor-related protein 1

scientific article

Adiposity as a cause of cardiovascular disease: a Mendelian randomization study

scientific article

Adult height and risk of 50 diseases: a combined epidemiological and genetic analysis

scientific article published on 25 October 2018

Age- and sex-specific causal effects of adiposity on cardiovascular risk factors

scientific article published on 23 February 2015

Allelic variant of NOS1AP effects on cardiac alternans of repolarization during exercise testing

scientific article

An evaluation of inflammatory gene polymorphisms in sibships discordant for premature coronary artery disease: the GRACE-IMMUNE study

scientific article

Anaemia is associated with shorter leucocyte telomere length in patients with chronic heart failure

scientific article published in April 2010

Analysis of gene-gene interactions among common variants in candidate cardiovascular genes in coronary artery disease

scientific article

Analysis of predicted loss-of-function variants in UK Biobank identifies variants protective for disease

scientific article published on 24 April 2018

Analysis of the Role of the SA Gene in Blood Pressure Regulation by Gene Targeting ⬇️

scientific article published on April 21, 2003

Analysis with the exome array identifies multiple new independent variants in lipid loci

scientific article published on 27 July 2016

Apolipoprotein(a) genetic sequence variants associated with systemic atherosclerosis and coronary atherosclerotic burden but not with venous thromboembolism

scientific article published in August 2012

Arachidonate 5-lipoxygenase (5-LO) promoter genotype and risk of myocardial infarction: a case-control study

scientific article published on 7 January 2008

Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases: A Mendelian Randomization Study ⬇️

scientific article published on 23 February 2017

Association analyses based on false discovery rate implicate new loci for coronary artery disease ⬇️

scientific article published on 17 July 2017

Association analysis of IL-12B and IL-23R polymorphisms in myocardial infarction

scientific article published on 28 September 2007

Association between C reactive protein and coronary heart disease: mendelian randomisation analysis based on individual participant data

scientific article (publication date: 15 February 2011)

Association between left ventricular mass and telomere length in a population study.

scientific article published on 26 July 2010

Association between lipid profile and circulating concentrations of estrogens in young men.

scientific article published on 17 June 2008

Association between the chromosome 9p21 locus and angiographic coronary artery disease burden: a collaborative meta-analysis

scientific article published on 23 January 2013

Association of Chromosome 9p21 With Subsequent Coronary Heart Disease Events

scientific article published on 21 March 2019

Association of Factor V Leiden with Subsequent Atherothrombotic Events: A GENIUS-CHD Study of Individual Participant Data

scientific article published on 13 July 2020

Association of Rare and Common Variation in the Lipoprotein Lipase Gene With Coronary Artery Disease

scientific article

Association of WNK1 gene polymorphisms and haplotypes with ambulatory blood pressure in the general population

scientific article

Association of adiponectin and leptin with relative telomere length in seven independent cohorts including 11,448 participants

scientific article

Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants

scientific article

Association with outcomes and response to treatment of trimethylamine N-oxide in heart failure (from BIOSTAT-CHF)

scientific article published on 29 October 2018

Bayesian refinement of association signals for 14 loci in 3 common diseases

scientific article published on 28 October 2012

Beyond “misunderstanding”: Written information and decisions about taking part in a genetic epidemiology study

scientific article (publication date: December 2007)

Bio-adrenomedullin as a marker of congestion in patients with new-onset and worsening heart failure

scientific article published on 06 March 2019

Biochemical Screening for Nonadherence Is Associated With Blood Pressure Reduction and Improvement in Adherence.

scientific article published on 28 August 2017

Biological, clinical and population relevance of 95 loci for blood lipids

scientific article

Biomarker-Guided Versus Guideline-Based Treatment of Patients With Heart Failure: Results From BIOSTAT-CHF.

scientific article

Blood pressure loci identified with a gene-centric array

scientific article

Can low risk cardiac patients be 'fast tracked' to Phase IV community exercise schemes for cardiac rehabilitation? A randomised controlled trial

scientific article published on 18 July 2009

Cardiac Expression of ms1/STARS, a Novel Gene Involved in Cardiac Development and Disease, Is Regulated by GATA4 ⬇️

scientific article published on March 19, 2012

Causal Assessment of Serum Urate Levels in Cardiometabolic Diseases Through a Mendelian Randomization Study

scientific article

Chromosome 2p Shows Significant Linkage to Antihypertensive Response in the British Genetics of Hypertension Study

article

Cigarette smoking reduces DNA methylation levels at multiple genomic loci but the effect is partially reversible upon cessation

scientific article

Circadian clock genes cause activation of the human PAI-1 gene promoter with 4G/5G allelic preference

scientific article published on 14 July 2006

Circulating brain-derived neurotrophic factor concentrations and the risk of cardiovascular disease in the community

scientific article

Circulating leukocyte and carotid atherosclerotic plaque telomere length: interrelation, association with plaque characteristics, and restenosis after endarterectomy

scientific article

Circulating microRNAs and hypertension--from new insights into blood pressure regulation to biomarkers of cardiovascular risk

scientific article published on 28 January 2016

Circulating plasma concentrations of angiotensin-converting enzyme 2 in men and women with heart failure and effects of renin-angiotensin-aldosterone inhibitors

scientific article published on 10 May 2020

Clinical correlates and outcome associated with changes in 6-minute walking distance in patients with heart failure: findings from the BIOSTAT-CHF study

scientific article published on 01 January 2019

Coding Variation in ANGPTL4, LPL, and SVEP1 and the Risk of Coronary Disease

scientific article published on 2 March 2016

Common and Rare Coding Genetic Variation Underlying the Electrocardiographic PR Interval

Common and Rare Genetic Variation in CCR2, CCR5, or CX3CR1 and Risk of Atherosclerotic Coronary Heart Disease and Glucometabolic Traits

scientific article published on 24 March 2016

Common genetic loci influencing plasma homocysteine concentrations and their effect on risk of coronary artery disease

scientific article

Common genetic variants associated with telomere length confer risk for neuroblastoma and other childhood cancers ⬇️

scientific article published on April 2016

Common genetic variation near the phospholamban gene is associated with cardiac repolarisation: meta-analysis of three genome-wide association studies

scientific article

Common variants associated with plasma triglycerides and risk for coronary artery disease

scientific article

Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways ⬇️

scientific article

Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction

scientific article

Common variants in genes underlying monogenic hypertension and hypotension and blood pressure in the general population

scientific article

Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes

scientific article

Common variants near MC4R are associated with fat mass, weight and risk of obesity

scientific article

Common variants near TERC are associated with mean telomere length

scientific article published on 7 February 2010

Comparative analysis of genome-wide association studies signals for lipids, diabetes, and coronary heart disease: Cardiovascular Biomarker Genetics Collaboration

scientific article published on 30 July 2011

Comparative in silico analysis identifies bona fide MyoD binding sites within the Myocyte stress 1 gene promoter

scientific article

Comparing biomarker profiles of patients with heart failure: atrial fibrillation vs. sinus rhythm and reduced vs. preserved ejection fraction

scientific article published on 01 November 2018

Comparison of exercise testing and CMR measured myocardial perfusion reserve for predicting outcome in asymptomatic aortic stenosis: the PRognostic Importance of MIcrovascular Dysfunction in Aortic Stenosis (PRIMID AS) Study ⬇️

scientific article published on 13 February 2017

Comprehensive exploration of the effects of miRNA SNPs on monocyte gene expression

scientific article

Concentric vs. eccentric remodelling in heart failure with reduced ejection fraction: clinical characteristics, pathophysiology and response to treatment

scientific article published on 11 November 2019

Concept, design and implementation of a cardiovascular gene-centric 50 k SNP array for large-scale genomic association studies

scientific article

Coronary Artery Disease-Associated LIPA Coding Variant rs1051338 Reduces Lysosomal Acid Lipase Levels and Activity in Lysosomes.

scientific article

Coronary angiography in worsening heart failure: determinants, findings and prognostic implications

scientific article published on 10 August 2017

Coronary artery disease-related genetic variant on chromosome 10q11 is associated with carotid intima-media thickness and atherosclerosis

scientific article published on 16 September 2010

Correction to: The influence of atrial fibrillation on the levels of NT-proBNP versus GDF-15 in patients with heart failure

scientific article published on 03 November 2020

Correction: Comprehensive Exploration of the Effects of miRNA SNPs on Monocyte Gene Expression.

scientific article published on 5 October 2012

Correction: Genome-Wide Association Scan Meta-Analysis Identifies Three Loci Influencing Adiposity and Fat Distribution.

scientific article published on 27 July 2009

Corrigendum: Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk

scientific article published in September 2017

Corrigendum: Whole-genome sequencing identifies rare genotypes in COMP and CHADL associated with high risk of hip osteoarthritis.

scientific article published in July 2017

Cumulative effects of common genetic variants on risk of sudden cardiac death

scientific article published on June 2015

Cystatin C and Cardiovascular Disease: A Mendelian Randomization Study

scientific article

DCAF4, a novel gene associated with leucocyte telomere length

scientific article

DNA Sequence Variation in Encoding the Activin-Receptor Like Kinase 7 Influences Body Fat Distribution and Protects Against Type 2 Diabetes

DNA methylation and body-mass index: a genome-wide analysis

scientific article

Daily remote ischaemic conditioning following acute myocardial infarction: a randomised controlled trial.

scientific article published on 10 May 2018

Defining the role of common variation in the genomic and biological architecture of adult human height

scientific article

Dense genotyping of candidate gene loci identifies variants associated with high-density lipoprotein cholesterol

scientific article published on 8 February 2011

Design of the Coronary ARtery DIsease Genome-Wide Replication And Meta-Analysis (CARDIoGRAM) Study: A Genome-wide association meta-analysis involving more than 22 000 cases and 60 000 controls

scientific article

Determinants and Functional Significance of Myocardial Perfusion Reserve in Severe Aortic Stenosis

scientific article published on 01 February 2012

Development and validation of multivariable models to predict mortality and hospitalization in patients with heart failure

scientific article published on March 2017

Dimorphism in the P2Y1 ADP receptor gene is associated with increased platelet activation response to ADP.

scientific article published on 28 October 2004

Directional dominance on stature and cognition in diverse human populations

scientific article published in July 2015

Discovery and Fine-Mapping of Glycaemic and Obesity-Related Trait Loci Using High-Density Imputation

scientific article

Discovery and refinement of loci associated with lipid levels

scientific article

Discovery of novel heart rate-associated loci using the Exome Chip

scientific article

Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals

scientific article published on 23 November 2020

Dissecting the roles of microRNAs in coronary heart disease via integrative genomic analyses

scientific article

Distinct loci in the CHRNA5/CHRNA3/CHRNB4 gene cluster are associated with onset of regular smoking

scientific article

Diurnal variation in excitation-contraction coupling is lost in the adult spontaneously hypertensive rat heart

scientific article published on June 2013

Dysfunctional nitric oxide signalling increases risk of myocardial infarction

scientific article published on 10 November 2013

ERRATUM: Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height

article by Matthew B. Lanktree et al published June 2012 in American Journal of Human Genetics

Effect of Bile Acid Sequestrants on the Risk of Cardiovascular Events: A Mendelian Randomization Analysis

scientific article published on 04 June 2015

Effects of Calcium, Magnesium, and Potassium Concentrations on Ventricular Repolarization in Unselected Individuals

scientific article published on 01 June 2019

Effects of size at birth, childhood growth patterns and growth hormone treatment on leukocyte telomere length.

scientific article

Effects of the coronary artery disease associated LPA and 9p21 loci on risk of aortic valve stenosis

scientific article published on 17 November 2018

Elucidating mechanisms of genetic cross-disease associations at the PROCR vascular disease locus

scientific article published on 09 March 2022

Endocrine vasculatures are preferable targets of an antitumor ineffective low dose of anti-VEGF therapy

scientific article published on 28 March 2016

Endothelial PDGF-CC regulates angiogenesis-dependent thermogenesis in beige fat

scientific article published on 05 August 2016

Enhanced linkage of a locus on chromosome 2 to premature coronary artery disease in the absence of hypercholesterolemia

scientific article published on 6 December 2006

Erratum: Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution

scientific article published in November 2011

Evidence for reduced susceptibility to cardiac bradycardias in South Asians compared with Caucasians

scientific article published on 20 February 2018

Exome sequencing and directed clinical phenotyping diagnose cholesterol ester storage disease presenting as autosomal recessive hypercholesterolemia

scientific article published on 26 September 2013

Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction

scientific article

Exome-chip meta-analysis identifies novel loci associated with cardiac conduction, including ADAMTS6

Exome-wide association study of plasma lipids in >300,000 individuals

scientific article published on 30 October 2017

ExomeChip-Wide Analysis of 95 626 Individuals Identifies 10 Novel Loci Associated With QT and JT Intervals

Expression quantitative trait Loci acting across multiple tissues are enriched in inherited risk for coronary artery disease

scientific article

FGF21 signalling pathway and metabolic traits - genetic association analysis

scientific article

Fibroblast growth factor 23 is related to profiles indicating volume overload, poor therapy optimization and prognosis in patients with new-onset and worsening heart failure

scientific article

Fifteen new risk loci for coronary artery disease highlight arterial-wall-specific mechanisms

scientific article published on 22 May 2017

Four genetic loci influencing electrocardiographic indices of left ventricular hypertrophy

scientific article published on 30 September 2011

Galactosylation of IgA1 Is Associated with Common Variation in C1GALT1.

scientific article published on 16 February 2017

Gender and effects of a common genetic variant in the NOS1 regulator NOS1AP on cardiac repolarization in 3761 individuals from two independent populations

Gender differences in left ventricular geometry and determinants of myocardial perfusion reserve in patients with severe aortic stenosis

Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip

scientific article

Gene-centric meta-analyses for central adiposity traits in up to 57 412 individuals of European descent confirm known loci and reveal several novel associations

scientific article published on 17 December 2013

Gene-centric meta-analysis in 87,736 individuals of European ancestry identifies multiple blood-pressure-related loci

scientific article published on 20 February 2014

Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci

scientific article published on 05 May 2020

Genetic Association of Lipids and Lipid Drug Targets With Abdominal Aortic Aneurysm: A Meta-analysis

scientific article published on 29 November 2017

Genetic Insights Into Bicuspid Aortic Valve Disease

scientific article published on July 2017

Genetic Loci associated with C-reactive protein levels and risk of coronary heart disease

scientific article

Genetic Susceptibility Loci for Cardiovascular Disease and Their Impact on Atherosclerotic Plaques

Genetic Variation Associated with Longer Telomere Length Increases Risk of Chronic Lymphocytic Leukemia

scientific article published on 13 May 2016

Genetic analysis for a shared biological basis between migraine and coronary artery disease

scientific article published on June 2015

Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

scientific article published on 17 September 2018

Genetic analysis of over one million people identifies 535 novel loci for blood pressure

Genetic architecture of ambulatory blood pressure in the general population: insights from cardiovascular gene-centric array

scientific article

Genetic association analysis of inositol polyphosphate phosphatase-like 1 (INPPL1, SHIP2) variants with essential hypertension

scientific article published on 8 June 2007

Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization

scientific article

Genetic associations for activated partial thromboplastin time and prothrombin time, their gene expression profiles, and risk of coronary artery disease

scientific article

Genetic associations with lipoprotein subfractions provide information on their biological nature

scientific article

Genetic determinants of diastolic and pulse pressure map to different loci in Lyon hypertensive rats

article by Christopher Dubay et al published April 1993 in Nature Genetics

Genetic evidence of assortative mating in humans

article

Genetic invalidation of Lp-PLA2 as a therapeutic target: Large-scale study of five functional Lp-PLA2-lowering alleles

scientific article

Genetic loci influencing kidney function and chronic kidney disease

scientific article

Genetic markers enhance coronary risk prediction in men: the MORGAM prospective cohorts

scientific article

Genetic predisposition to higher blood pressure increases coronary artery disease risk

scientific article published on 11 March 2013

Genetic regulation of serum phytosterol levels and risk of coronary artery disease

scientific article

Genetic risk and atrial fibrillation in patients with heart failure

scientific article published on 09 January 2020

Genetic studies of body mass index yield new insights for obesity biology

scientific article

Genetic variants associated with celiac disease and the risk for coronary artery disease

scientific article published on 18 April 2015

Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk

scientific article published on 6 October 2011

Genetic variants influencing circulating lipid levels and risk of coronary artery disease

scientific article published on 23 September 2010

Genetic variants primarily associated with type 2 diabetes are related to coronary artery disease risk

scientific article

Genetic variation at chromosome 1p13.3 affects sortilin mRNA expression, cellular LDL-uptake and serum LDL levels which translates to the risk of coronary artery disease

scientific article published on 8 July 2009

Genetically determined height and coronary artery disease

scientific article

Genetics of myocardial infarction: a progress report

scientific article published on 10 March 2010

Genome-wide Association Analysis in Humans Links Nucleotide Metabolism to Leukocyte Telomere Length

scientific article published on 27 February 2020

Genome-wide association analyses identify 18 new loci associated with serum urate concentrations

scientific article published in February 2013

Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure

scientific article published on 09 January 2020

Genome-wide association and functional studies identify 46 novel loci for alcohol consumption and suggest common genetic mechanisms with neuropsychiatric disorders

Genome-wide association meta-analysis of 30,000 samples identifies seven novel loci for quantitative ECG traits

scientific article published on 24 January 2019

Genome-wide association meta-analysis of PR interval identifies 47 novel loci associated with atrial and atrioventricular electrical activity

Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age.

scientific article

Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants

scientific article

Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution

scientific article published in June 2009

Genome-wide association study identifies 74 loci associated with educational attainment

scientific article published on 11 May 2016

Genome-wide association study identifies genes for biomarkers of cardiovascular disease: serum urate and dyslipidemia

scientific article

Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure

scientific article

Genome-wide association study identifies variants in casein kinase II (CSNK2A2) to be associated with leukocyte telomere length in a Punjabi Sikh diabetic cohort

scientific article

Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease

scientific article

Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls

scientific article

Genome-wide association study of blood pressure extremes identifies variant near UMOD associated with hypertension

scientific article

Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region

scientific article

Genome-wide haplotype analysis of cis expression quantitative trait loci in monocytes

scientific article

Genome-wide haplotype association study identifies the SLC22A3-LPAL2-LPA gene cluster as a risk locus for coronary artery disease

scientific article published on 8 February 2009

Genome-wide mapping of human loci for essential hypertension

scientific article

Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture

scientific journal article

Genome-wide meta-analysis of common variant differences between men and women

scientific article published on 27 July 2012

Genome-wide scan identifies CDH13 as a novel susceptibility locus contributing to blood pressure determination in two European populations

scientific article published on 20 March 2009

Genomewide association analysis of coronary artery disease

scientific article

Genomewide association study using a high-density single nucleotide polymorphism array and case-control design identifies a novel essential hypertension susceptibility locus in the promoter region of endothelial NO synthase

scientific article published on 19 December 2011

Genomic Risk Prediction of Coronary Artery Disease in 480,000 Adults: Implications for Primary Prevention

scientific article published on 01 October 2018

Genomic correlates of glatiramer acetate adverse cardiovascular effects lead to a novel locus mediating coronary risk

scientific article

Genomic prediction of coronary heart disease

scientific article published on 21 September 2016

Genotypes and haplotypes predisposing to myocardial infarction: a multilocus case-control study

scientific article published on March 2004

Geographical differences in heart failure characteristics and treatment across Europe: results from the BIOSTAT-CHF study

scientific article published on 29 January 2020

Geographical location affects the levels and association of trimethylamine N-oxide with heart failure mortality in BIOSTAT-CHF: a post-hoc analysis

scientific article published on 28 July 2019

Haplotypes of the WNK1 gene associate with blood pressure variation in a severely hypertensive population from the British Genetics of Hypertension study

article

Heart failure treatment up-titration and outcome and age: an analysis of BIOSTAT-CHF

scientific article published on 25 March 2020

Hepatic metabolism and transporter gene variants enhance response to rosuvastatin in patients with acute myocardial infarction: the GEOSTAT-1 Study

scientific article

High rates of non-adherence to antihypertensive treatment revealed by high-performance liquid chromatography-tandem mass spectrometry (HP LC-MS/MS) urine analysis

scientific article

Higher doses of loop diuretics limit uptitration of angiotensin-converting enzyme inhibitors in patients with heart failure and reduced ejection fraction

scientific article published on 30 January 2020

Homocysteine and Coronary Heart Disease: Meta-analysis of MTHFR Case-Control Studies, Avoiding Publication Bias ⬇️

scientific article (publication date: February 2012)

Human Validation of Genes Associated With a Murine Atherosclerotic Phenotype

scientific article

Human metabolic individuality in biomedical and pharmaceutical research

scientific article (publication date: 31 August 2011)

Hundreds of variants clustered in genomic loci and biological pathways affect human height

scientific article

Hypothesis-based analysis of gene-gene interactions and risk of myocardial infarction

scientific article

Identification of ADAMTS7 as a novel locus for coronary atherosclerosis and association of ABO with myocardial infarction in the presence of coronary atherosclerosis: two genome-wide association studies

scientific article

Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders

scientific article published on 14 April 2013

Identification of seven loci affecting mean telomere length and their association with disease

scientific article published on April 2013

Identification of the BCAR1-CFDP1-TMEM170A locus as a determinant of carotid intima-media thickness and coronary artery disease risk

scientific article

Identifying Novel Gene Variants in Coronary Artery Disease and Shared Genes With Several Cardiovascular Risk Factors

scientific article

Identifying Pathophysiological Mechanisms in Heart Failure With Reduced Versus Preserved Ejection Fraction

article by Jasper Tromp et al published September 2018 in Journal of the American College of Cardiology

Identifying optimal doses of heart failure medications in men compared with women: a prospective, observational, cohort study

scientific article published on 22 August 2019

Improving clinical trials for cardiovascular diseases: a position paper from the Cardiovascular Round Table of the European Society of Cardiology

scientific article published on 15 June 2015

Increased genetic vulnerability to smoking at CHRNA5 in early-onset smokers

scientific article

Influence of a Coronary Artery Disease-Associated Genetic Variant on FURIN Expression and Effect of Furin on Macrophage Behavior.

scientific article published in August 2018

Inheritance of coronary artery disease in men: an analysis of the role of the Y chromosome

scientific article published on 9 February 2012

Integrating genome-wide genetic variations and monocyte expression data reveals trans-regulated gene modules in humans

scientific article

Integration of genetics into a systems model of electrocardiographic traits using HumanCVD BeadChip

scientific article published on 8 November 2012

Integrative genomics reveals novel molecular pathways and gene networks for coronary artery disease.

scientific article

Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility

scientific article

Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies

scientific article published on 14 March 2012

Into the great wide open: 10 years of genome-wide association studies

scientific article published on 01 July 2018

Inverse associations between androgens and renal function: the Young Men Cardiovascular Association (YMCA) study

scientific article

Is Acute heart failure a distinctive disorder? An analysis from BIOSTAT-CHF

scientific article published on 19 December 2020

Is Southern blotting necessary to measure telomere length reproducibly? Authors' Response to: Commentary: The reliability of telomere length measurements

scientific article published on 24 September 2015

Ischemic preconditioning of the whole heart confers protection on subsequently isolated ventricular myocytes

scientific article

JCAD Gene at the 10p11 Coronary Artery Disease Locus Regulates Hippo Signaling in Endothelial Cells.

scientific article

KLB is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preference

scientific article

Kidney specificity of rat chromosome 1 blood pressure quantitative trait locus region

scientific article

LGALS2 functional variant rs7291467 is not associated with susceptibility to myocardial infarction in Caucasians

scientific article

Lack of association between the Trp719Arg polymorphism in kinesin-like protein-6 and coronary artery disease in 19 case-control studies

scientific article

Lack of association of genetic variants in the LRP8 gene with familial and sporadic myocardial infarction

article

Large-Scale Analysis of Determinants, Stability, and Heritability of High-Density Lipoprotein Cholesterol Efflux Capacity

scientific article published on 31 August 2017

Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease

scientific article

Large-scale association analysis identifies new risk loci for coronary artery disease

scientific article published on 02 December 2012

Large-scale candidate gene analysis of HDL particle features

scientific article (publication date: 21 January 2011)

Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci

scientific article

Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci

scientific article

Left atrial radiofrequency ablation during mitral valve surgery for continuous atrial fibrillation: a randomized controlled trial

scientific article

Leukocyte Telomere Length in Young Adults Born Preterm: Support for Accelerated Biological Ageing

scientific article published on 30 November 2015

Leukocyte telomere length and marital status among middle-aged adults

scientific article

Leukocyte telomere length associates with prospective mortality independent of immune-related parameters and known genetic markers

scientific article

Leukotriene B4production in healthy subjects carrying variants of the arachidonate 5-lipoxygenase-activating protein gene associated with a risk of myocardial infarction

article

Lifelong reduction of LDL-cholesterol related to a common variant in the LDL-receptor gene decreases the risk of coronary artery disease--a Mendelian Randomisation study

scientific article published in 2008

Linkage analysis using co-phenotypes in the BRIGHT study reveals novel potential susceptibility loci for hypertension

scientific article

Loci influencing blood pressure identified using a cardiovascular gene-centric array

scientific article published on 8 January 2013

Loci influencing blood pressure identified using a cardiovascular gene-centric array.

scientific article

Long-range DNA looping and gene expression analyses identify DEXI as an autoimmune disease candidate gene

scientific article published on 11 October 2011

Longer genotypically-estimated leukocyte telomere length is associated with increased adult glioma risk

scientific article published on 4 December 2015

Loss of Cardioprotective Effects at the ADAMTS7 Locus as a Result of Gene-Smoking Interactions

scientific article published on May 2017

Loss-of-function mutations in APOC3, triglycerides, and coronary disease

scientific article published on 18 June 2014

Low Birth Weight in MZ Twins Discordant for Birth Weight is Associated with Shorter Telomere Length and lower IQ, but not Anxiety/Depression in Later Life

scientific article

Male-specific region of the Y chromosome and cardiovascular risk: phylogenetic analysis and gene expression studies

scientific article

Mapping of a major locus that determines telomere length in humans

scientific article

Mendelian randomization of blood lipids for coronary heart disease

scientific article

Mendelian randomization studies in coronary artery disease

scientific article

Meta-Analysis of Genome-Wide Association Studies for Abdominal Aortic Aneurysm Identifies Four New Disease-Specific Risk Loci ⬇️

scientific article

Meta-analysis and imputation refines the association of 15q25 with smoking quantity

scientific article

Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution

scientific article

Meta-analysis identifies common and rare variants influencing blood pressure and overlapping with metabolic trait loci

scientific article published on 12 September 2016

Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations

scientific article published in June 2009

Meta-analysis of 65,734 individuals identifies TSPAN15 and SLC44A2 as two susceptibility loci for venous thromboembolism

scientific article

Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height

scientific article

Meta-analysis of telomere length in 19,713 subjects reveals high heritability, stronger maternal inheritance and a paternal age effect

scientific article published on 16 January 2013

Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci

scientific article published on 07 January 2019

Metabolomics reveals a link between homocysteine and lipid metabolism and leukocyte telomere length: the ENGAGE consortium

scientific article published on 12 August 2019

MicroRNAs in cardiovascular disease: an introduction for clinicians

scientific article

Mineralocorticoid receptor antagonist pattern of use in heart failure with reduced ejection fraction: findings from BIOSTAT-CHF.

scientific article published on 5 June 2017

Molecular insights into genome-wide association studies of chronic kidney disease-defining traits

scientific article published in Nature Communications

Multi-Ancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions

Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction

scientific article published on 21 May 2020

Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids

article

Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity

scientific article published in Nature Communications

Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease

scientific article (publication date: 17 September 2013)

Myocyte stress 1 plays an important role in cellular hypertrophy and protection against apoptosis

scientific article

Network analysis of coronary artery disease risk genes elucidates disease mechanisms and druggable targets

scientific article published on 21 February 2018

New Blood Pressure-Associated Loci Identified in Meta-Analyses of 475 000 Individuals

scientific article published in October 2017

New gene functions in megakaryopoiesis and platelet formation

scientific article published on 30 November 2011

New genetic loci link adipose and insulin biology to body fat distribution

scientific article

New susceptibility locus for coronary artery disease on chromosome 3q22.3.

scientific article published on 08 February 2009

No Association of Coronary Artery Disease with X-Chromosomal Variants in Comprehensive International Meta-Analysis ⬇️

scientific article published on 12 October 2016

Non-cardiac comorbidities in heart failure with reduced, mid-range and preserved ejection fraction

scientific article published on 07 July 2018

Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney

scientific article

Novel genetic approach to investigate the role of plasma secretory phospholipase A2 (sPLA2)-V isoenzyme in coronary heart disease: modified Mendelian randomization analysis using PLA2G5 expression levels

scientific article

Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries.

scientific article published on 18 June 2018

Novel loci associated with increased risk of sudden cardiac death in the context of coronary artery disease

scientific article

Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals

scientific article

PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity

scientific article published in Nature Communications

PROTEIN-CODING VARIANTS IMPLICATE NOVEL GENES RELATED TO LIPID HOMEOSTASIS CONTRIBUTING TO BODY FAT DISTRIBUTION

article

PSeudoautosomal region 1 and predisposition to coronary artery disease

scientific article published on 12 August 2017

Pathway Analysis Shows Association between FGFBP1 and Hypertension ⬇️

scientific article published on March 24, 2011

Phenotypic Characterization of Genetically Lowered Human Lipoprotein(a) Levels

scientific article published on December 2016

Phenotypic Consequences of a Genetic Predisposition to Enhanced Nitric Oxide Signaling

scientific article published on 5 October 2017

Physiological Interaction Between α-Adducin and WNK1-NEDD4L Pathways on Sodium-Related Blood Pressure Regulation

Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study

scientific article (publication date: 11 August 2012)

Plasma matrix metalloproteinase-9 and left ventricular remodelling after acute myocardial infarction in man: a prospective cohort study

scientific article

Plasma proteomic approach in patients with heart failure: insights into pathogenesis of disease progression and potential novel treatment targets

scientific article published on 06 November 2019

Plasma tissue inhibitor of metalloproteinase-1 and matrix metalloproteinase-9: novel indicators of left ventricular remodelling and prognosis after acute myocardial infarction

scientific article

Platelet-Related Variants Identified by Exomechip Meta-analysis in 157,293 Individuals

scientific article

Polymorphic variation in the 11beta-hydroxylase gene associates with reduced 11-hydroxylase efficiency

scientific article published on 30 October 2006

Polymorphisms in catechol-O-methyltransferase modify treatment effects of aspirin on risk of cardiovascular disease

scientific article

Polymorphisms in the WNK1 gene are associated with blood pressure variation and urinary potassium excretion

scientific article

Possible association between telomere length and renal dysfunction in patients with chronic heart failure.

scientific article

Posttraumatic stress disorder and not depression is associated with shorter leukocyte telomere length: findings from 3,000 participants in the population-based KORA F4 study

scientific article

Potassium and the use of renin-angiotensin-aldosterone system inhibitors in heart failure with reduced ejection fraction: data from BIOSTAT-CHF.

scientific article

Powerful identification of cis-regulatory SNPs in human primary monocytes using allele-specific gene expression

scientific article

Prediction of Causal Candidate Genes in Coronary Artery Disease Loci

scientific article

Premature coronary artery disease shows no evidence of linkage to loci encoding for tissue inhibitors of matrix metalloproteinases

scientific article published on 19 September 2003

Proenkephalin, an Opioid System Surrogate, as a Novel Comprehensive Renal Marker in Heart Failure

scientific article published on 01 May 2019

Prognostic significance of changes in heart rate following uptitration of beta-blockers in patients with sub-optimally treated heart failure with reduced ejection fraction in sinus rhythm versus atrial fibrillation

scientific article published on 04 January 2019

Prospective evaluation of two novel ECG-based restitution biomarkers for prediction of sudden cardiac death risk in ischaemic cardiomyopathy

scientific article published on 04 August 2014

Protein-Truncating Variants at the Cholesteryl Ester Transfer Protein Gene and Risk for Coronary Heart Disease

scientific article published on 15 May 2017

Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

scientific article published on 22 December 2017

Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution

article

Proteomic diversity of high-density lipoprotein explains its association with clinical outcome in patients with heart failure

scientific article published on 18 December 2017

Publisher Correction: Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

scholarly article published in Nature Genetics

Publisher Correction: Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

erratum

Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

scientific article published on 16 March 2018

Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

scientific article

Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

scientific article published on 01 July 2019

QALYs in cost-effectiveness analysis: an overview for cardiologists

scientific article published on 22 September 2015

RANTES/CCL5 and risk for coronary events: results from the MONICA/KORA Augsburg case-cohort, Athero-Express and CARDIoGRAM studies

scientific article

Rare and low-frequency coding variants alter human adult height

scientific article (publication date: February 2017)

Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease

scientific journal article

Rationale and design of the PRognostic Importance of MIcrovascular Dysfunction in asymptomatic patients with Aortic Stenosis (PRIMID-AS): a multicentre observational study with blinded investigations

scientific article published on 18 December 2013

Relation of microvascular dysfunction to exercise capacity and symptoms in patients with severe aortic stenosis

scientific article

Relations between lipoprotein(a) concentrations, LPA genetic variants, and the risk of mortality in patients with established coronary heart disease: a molecular and genetic association study

scientific article published on 26 May 2017

Renal Mechanisms of Association between Fibroblast Growth Factor 1 and Blood Pressure

scientific article

Renal dysfunction is associated with shorter telomere length in heart failure

scientific article published on 15 July 2009

Repeated replication and a prospective meta-analysis of the association between chromosome 9p21.3 and coronary artery disease

scientific article published on 24 March 2008

Reproducibility of Telomere Length Assessment--An International Collaborative Study

scientific article published on 24 September 2015

Reproducibility of telomere length assessment: Authors' Response to Damjan Krstajic and Ljubomir Buturovic

scientific article published on 24 September 2015

Reproducibility of telomere length assessment: an international collaborative study

scientific article published on 19 September 2014

Response to the letter by Esteves et al

scientific article published on 25 April 2018

Rheumatoid Arthritis and Coronary Artery Disease: Genetic Analyses Do Not Support a Causal Relation

scientific article published on 15 October 2016

Runs of Homozygosity: Association with Coronary Artery Disease and Gene Expression in Monocytes and Macrophages

scientific article

SLC2A9 is a high-capacity urate transporter in humans

scientific article

STARS Is Essential to Maintain Cardiac Development and Function In Vivo via a SRF Pathway ⬇️

scientific article published on July 18, 2012

Secretory phospholipase A(2)-IIA and cardiovascular disease: a mendelian randomization study

scientific article published on 31 July 2013

Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior

scientific article

Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits

scientific article

Signatures of miR-181a on renal transcriptome and blood pressure

scientific article

Six new loci associated with body mass index highlight a neuronal influence on body weight regulation

scientific article

Sorting Out Cholesterol and Coronary Artery Disease ⬇️

scientific article published on December 16, 2010

Subsequent Event Risk in Individuals With Established Coronary Heart Disease

scientific article published on 21 March 2019

Switching harmful visceral fat to beneficial energy combustion improves metabolic dysfunctions

scientific article

Systematic Evaluation of Pleiotropy Identifies 6 Further Loci Associated With Coronary Artery Disease ⬇️

scientific article published on February 2017

Systematic Review of Studies That Have Evaluated Screening Tests in Relatives of Patients Affected by Nonsyndromic Thoracic Aortic Disease

scientific article published on 01 August 2018

Systems Genetics Analysis of Genome-Wide Association Study Reveals Novel Associations Between Key Biological Processes and Coronary Artery Disease

scientific article published on 14 May 2015

Targeting 160 candidate genes for blood pressure regulation with a genome-wide genotyping array

scientific article

Telomere Length in Newborns is Related to Maternal Stress During Pregnancy.

scientific article published on 11 April 2017

Telomere biology in heart failure

scientific article published on 24 September 2008

Telomere length and outcome in heart failure

scientific article published in January 2010

Telomere length and psychological well-being in patients with chronic heart failure

scientific article

Telomere length in circulating leukocytes is associated with lung function and disease.

scientific article published on 5 December 2013

Telomere length, risk of coronary heart disease, and statin treatment in the West of Scotland Primary Prevention Study: a nested case-control study

scientific article published on January 2007

The 9p21 locus does not affect risk of coronary artery disease through induction of type 1 interferons

scientific article published on 7 August 2013

The John Swales Lecture: a new initiative to honour the founding editor of the Journal of Hypertension

scientific article published in November 2012

The PCSK9-LDL Receptor Axis and Outcomes in Heart Failure: BIOSTAT-CHF Subanalysis

scientific article

The PDGF-BB-SOX7 axis-modulated IL-33 in pericytes and stromal cells promotes metastasis through tumour-associated macrophages

scientific article published on 6 May 2016

The Prevalence and Significance of the Early Repolarization Pattern in Sudden Arrhythmic Death Syndrome Families

scientific article published on 01 June 2016

The clinical significance of interleukin-6 in heart failure: results from the BIOSTAT-CHF study

scientific article published on 14 May 2019

The effect of preoperative atrial fibrillation on survival following mitral valve repair for degenerative mitral regurgitation

scientific article published on 5 February 2007

The epithelial sodium channel γ-subunit gene and blood pressure: family based association, renal gene expression, and physiological analyses

scientific article published on 17 October 2011

The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke

article

The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals

scientific article published on 12 September 2016

The impact of low-frequency and rare variants on lipid levels

scientific article published on 11 May 2015

The impact of newly identified loci on coronary heart disease, stroke and total mortality in the MORGAM prospective cohorts

scientific article published on April 2009

The impact of power output during percutaneous catheter radiofrequency ablation for atrial fibrillation on efficacy and safety outcomes: a systematic review

scientific article published on 25 July 2013

The influence of atrial fibrillation on the levels of NT-proBNP versus GDF-15 in patients with heart failure

scientific article published on 01 July 2019

The metabochip, a custom genotyping array for genetic studies of metabolic, cardiovascular, and anthropometric traits

scientific article

The narrow-sense and common single nucleotide polymorphism heritability of early repolarization

The novel genetic variant predisposing to coronary artery disease in the region of the PSRC1 and CELSR2 genes on chromosome 1 associates with serum cholesterol

scientific article published on 23 July 2008

The personal genome--the future of personalised medicine?

scientific article

The relationship between plasma angiopoietin-like protein 4 levels, angiopoietin-like protein 4 genotype, and coronary heart disease risk

scientific article published on 9 September 2010

The role of adiposity in cardiometabolic traits: a Mendelian randomization analysis

scientific article (publication date: 2013)

The role of cathepsin D in the pathophysiology of heart failure and its potentially beneficial properties: a translational approach

scientific article published on 03 December 2019

The transcriptional landscape of age in human peripheral blood

scientific article

The value of spot urinary creatinine as a marker of muscle wasting in patients with new-onset or worsening heart failure

scientific article published on 20 March 2021

Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation

scientific article

Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension

scientific article published on 12 September 2016

Transcription profiling in human platelets reveals LRRFIP1 as a novel protein regulating platelet function

scientific article

Triglyceride-mediated pathways and coronary disease: collaborative analysis of 101 studies

scientific article

Two-dimensional genome-scan identifies novel epistatic loci for essential hypertension

article

Urotensin-II system in genetic control of blood pressure and renal function

scientific article

Using matrix assisted laser desorption ionisation mass spectrometry (MALDI-MS) profiling in order to predict clinical outcomes of patients with heart failure

scholarly article by Thong Huy Cao published in January 2018

Variant ASGR1 Associated with a Reduced Risk of Coronary Artery Disease

scientific article

Variants near TERT and TERC influencing telomere length are associated with high-grade glioma risk

scientific article

Waist-to-hip ratio and mortality in heart failure

article by Koen W. Streng et al published September 2018 in European Journal of Heart Failure

Whole genome survey of copy number variation in the spontaneously hypertensive rat: relationship to quantitative trait loci, gene expression, and blood pressure

scientific article published on 15 March 2010

Whole-genome sequencing identifies rare genotypes in COMP and CHADL associated with high risk of hip osteoarthritis

scientific article published on 20 March 2017

ms1, a novel stress-responsive, muscle-specific gene that is up-regulated in the early stages of pressure overload-induced left ventricular hypertrophy

scientific article

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