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List of works by Marja Jäättelä

A Method to Monitor Lysosomal Membrane Permeabilization by Immunocytochemistry.

scientific article published on October 2015

A comprehensive glossary of autophagy-related molecules and processes (2nd edition)

scientific article

A comprehensive siRNA screen for kinases that suppress macroautophagy in optimal growth conditions.

scientific article

A novel specific role for I kappa B kinase complex-associated protein in cytosolic stress signaling.

scientific article

A sub-set of immediate early mRNAs induced by tumor necrosis factor-alpha during cellular cytotoxic and non-cytotoxic responses.

scientific article published on October 1993

A20 zinc finger protein inhibits TNF and IL-1 signaling

scientific article published on 01 February 1996

A20 zinc finger protein inhibits TNF-induced apoptosis and stress response early in the signaling cascades and independently of binding to TRAF2 or 14-3-3 proteins.

scientific article published on March 2001

Acquired antiestrogen resistance in MCF-7 human breast cancer sublines is not accomplished by altered expression of receptors in the ErbB-family

scientific article

Activation of invasion by oncogenic reprogramming of cholesterol metabolism via increased NPC1 expression and macropinocytosis

scientific article published in 2023

Activation of phospholipase A2 by Hsp70 in vitro

scientific article published on 13 June 2011

Age-related Macular Degeneration

scientific article published in Journal of Biological Chemistry

Annexin A7 is required for ESCRT III-mediated plasma membrane repair

scientific article published on 30 April 2019

Antihistamine use and risk of ovarian cancer: A population-based case-control study

scientific article published on 23 November 2018

Apoptosis induced by vitamin D compounds in breast cancer cells is inhibited by Bcl-2 but does not involve known caspases or p53

scientific article published on 01 October 1999

Apoptosome-independent activation of the lysosomal cell death pathway by caspase-9.

scientific article

Autophagy as a basis for the health-promoting effects of vitamin D

article

Autophagy role(s) in response to oncogenes and DNA replication stress

scientific article published on 14 August 2019

Autophagy, Inflammation, and Metabolism (AIM) Center of Biomedical Research Excellence: supporting the next generation of autophagy researchers and fostering international collaborations

scientific article published on 01 January 2018

Autophagy: an emerging target for cancer therapy.

scientific article published on 17 March 2008

BAMLET activates a lysosomal cell death program in cancer cells.

scientific article

BIBX1382BS, but not AG1478 or PD153035, inhibits the ErbB kinases at different concentrations in intact cells.

scientific article

Bcl-x and Bcl-2 inhibit TNF and Fas-induced apoptosis and activation of phospholipase A2 in breast carcinoma cells.

scientific article

Burning up TNF toxicity for cancer therapy

article

CIP2A oncoprotein controls cell growth and autophagy through mTORC1 activation

scientific article published on March 2014

Calcium and calpain as key mediators of apoptosis-like death induced by vitamin D compounds in breast cancer cells

scientific article

Cancer-associated lysosomal changes: friends or foes?

scientific article published on 09 July 2012

Caspase-independent cell death in T lymphocytes

scientific article

Cathepsin B acts as a dominant execution protease in tumor cell apoptosis induced by tumor necrosis factor

scientific article

Cathepsin B mediates tumor necrosis factor-induced arachidonic acid release in tumor cells

scientific article published on 15 August 2002

Cationic amphiphilic drugs induce elevation in lysoglycerophospholipid levels and cell death in leukemia cells

scientific article published on 26 August 2020

Cell Death Induced by Cationic Amphiphilic Drugs Depends on Lysosomal Ca2+ Release and Cyclic AMP

scientific article published on 08 July 2019

Cell death induced by down-regulation of heat shock protein 70 in lung cancer cell lines is p53-independent and does not require DNA cleavage ⬇️

scientific article published on September 1, 2003

Chemosensitization by a non-apoptogenic heat shock protein 70-binding apoptosis-inducing factor mutant.

scientific article published in December 2003

Combating apoptosis and multidrug resistant cancers by targeting lysosomes.

scientific article published on 02 July 2010

Connecting Hsp70, sphingolipid metabolism and lysosomal stability

scientific article published on 15 June 2010

Connecting endoplasmic reticulum stress to autophagy by unfolded protein response and calcium.

scientific article published on 6 July 2007

Continuous interferon-? or tumor necrosis factor-? exposure of enterocytes attenuates cell death responses

article

Cytosolic FoxO1: alive and killing

article

DNA-dependent protein kinase regulates lysosomal AMP-dependent protein kinase activation and autophagy

scientific article published on 26 January 2020

Demonstration of tumor necrosis factor in human amniotic fluids and supernatants of placental and decidual tissues

scientific article published on 01 January 1988

Depletion of kinesin 5B affects lysosomal distribution and stability and induces peri-nuclear accumulation of autophagosomes in cancer cells

scientific article (publication date: 2009)

Depletion of the AP-1 repressor JDP2 induces cell death similar to apoptosis

scientific article

Diarylurea compounds inhibit caspase activation by preventing the formation of the active 700-kilodalton apoptosome complex

scientific article published on November 2003

Dihydroceramide accumulation mediates cytotoxic autophagy of cancer cells via autolysosome destabilization

scientific article published on 16 September 2016

Dual function of membrane-bound heat shock protein 70 (Hsp70), Bag-4, and Hsp40: protection against radiation-induced effects and target structure for natural killer cells.

scientific article

Effective tumor cell death by sigma-2 receptor ligand siramesine involves lysosomal leakage and oxidative stress.

scientific article published on October 2005

Emerging role of heat shock proteins in biology and medicine

scientific article

Eradication of glioblastoma, and breast and colon carcinoma xenografts by Hsp70 depletion.

scientific article published in December 2002

ErbB2-associated changes in the lysosomal proteome.

scientific article published on 14 June 2011

ErbB2-driven breast cancer cell invasion depends on a complex signaling network activating myeloid zinc finger-1-dependent cathepsin B expression.

scientific article

Excess sphingomyelin disturbs ATG9A trafficking and autophagosome closure

scientific article

Four deaths and a funeral: from caspases to alternative mechanisms.

scientific article

Guidelines for the use and interpretation of assays for monitoring autophagy

scientific article

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

scientific article

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

scientific article

Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes.

scientific article published on 17 April 2009

HSP27 and HSP70 increase the survival of WEHI-S cells exposed to hyperthermia

scientific article published on 01 January 1996

HSP70 overexpression mediates the escape of a doxorubicin-induced G2 cell cycle arrest.

scientific article

Heat shock protects WEHI-164 target cells from the cytolysis by tumor necrosis factors alpha and beta

scientific article

Heat shock protein 70 inhibits shrinkage-induced programmed cell death via mechanisms independent of effects on cell volume-regulatory membrane transport proteins.

scientific article published on 31 August 2004

Heat shock protein 70 is required for the survival of cancer cells.

scientific article

Heat shock protein 70 promotes cancer cell viability by safeguarding lysosomal integrity.

scientific article

Heat shock protein 70 promotes cell survival by inhibiting lysosomal membrane permeabilization

scientific article published on August 2004

Heat shock protein-based therapy as a potential candidate for treating the sphingolipidoses.

scientific article

Heat shock proteins as cellular lifeguards

scientific article

Heat-shock protein 70 antagonizes apoptosis-inducing factor

scientific article (publication date: September 2001)

Hepatoma-derived growth factor-related protein 2 promotes DNA repair by homologous recombination

scientific article published on 31 December 2015

High-Affinity Small Molecule−Phospholipid Complex Formation: Binding of Siramesine to Phosphatidic Acid

scientific article published on 04 September 2008

Hsp70 exerts its anti-apoptotic function downstream of caspase-3-like proteases.

scientific article

Hsp70 interactions with membrane lipids regulate cellular functions in health and disease

scientific article published on 30 January 2019

Hsp70 stabilizes lysosomes and reverts Niemann-Pick disease-associated lysosomal pathology.

scientific article

Hsp70-2 is required for tumor cell growth and survival

scientific article published on 11 July 2005

Hsp70-RAP46 interaction in downregulation of DNA binding by glucocorticoid receptor

scientific article

Human heat shock protein 70 (Hsp70) as a peripheral membrane protein

scientific article published on 28 January 2014

IKAP localizes to membrane ruffles with filamin A and regulates actin cytoskeleton organization and cell migration

scientific article published on 26 February 2008

Identification of a c-Jun N-terminal kinase-2-dependent signal amplification cascade that regulates c-Myc levels in ras transformation.

scientific article

Identification of autophagosome-associated proteins and regulators by quantitative proteomic analysis and genetic screens.

scientific article

Identification of cytoskeleton-associated proteins essential for lysosomal stability and survival of human cancer cells

scientific article

Identification of novel autophagy regulators by a luciferase-based assay for the kinetics of autophagic flux

scientific article

Identification of small molecule inhibitors of phosphatidylinositol 3-kinase and autophagy.

scientific article

Induction of TNF-sensitive cellular phenotype by c-Myc involves p53 and impaired NF-kappaB activation

scientific article published in December 1997

Inhibitors of cysteine cathepsin and calpain do not prevent ultraviolet-B-induced apoptosis in human keratinocytes and HeLa cells

scientific article

Integrating proteomic and functional genomic technologies in discovery-driven translational breast cancer research

scientific article

JNK2 mediates TNF-induced cell death in mouse embryonic fibroblasts via regulation of both caspase and cathepsin protease pathways

scientific article published in March 2004

KIAA1524/CIP2A promotes cancer growth by coordinating the activities of MTORC1 and MYC.

scientific article published on 15 May 2014

Lack of neuroprotection by heat shock protein 70 overexpression in a mouse model of global cerebral ischemia.

scientific article published on 25 October 2003

Lens Epithelium-Derived Growth Factor Is an Hsp70-2 Regulated Guardian of Lysosomal Stability in Human Cancer

scientific article published on 01 March 2007

Let-7 microRNA controls invasion-promoting lysosomal changes via the oncogenic transcription factor myeloid zinc finger-1.

scientific article published on 3 February 2018

Lysosomal cell death at a glance.

scientific article published on May 2013

Lysosomal involvement in cell death and cancer.

scientific article published on 02 October 2008

Lysosome as a Central Hub for Rewiring PH Homeostasis in Tumors

scientific article published on 27 August 2020

Lysosomes and mitochondria in the commitment to apoptosis: a potential role for cathepsin D and AIF.

scientific article published in February 2004

Lysosomes in cancer-living on the edge (of the cell).

scientific article published on 24 February 2016

Major heat shock protein hsp70 protects tumor cells from tumor necrosis factor cytotoxicity ⬇️

scientific article published on October 1, 1992

Methods for Probing Lysosomal Membrane Permeabilization.

scientific article published on 2 November 2015

Methods for the quantification of lysosomal membrane permeabilization: a hallmark of lysosomal cell death

scientific article published on 14 January 2015

Molecular definitions of autophagy and related processes.

scientific article published on 08 June 2017

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

scientific article

Multiple cell death pathways as regulators of tumour initiation and progression.

scientific article published on April 2004

Natural resistance of human beta cells toward nitric oxide is mediated by heat shock protein 70.

scientific article

Over-expression of hsp70 confers tumorigenicity to mouse fibrosarcoma cells

scientific article published on 01 March 1995

Overexpression of heat shock protein 70 in R6/2 Huntington's disease mice has only modest effects on disease progression

scientific article

Peripheral blood monocytes from patients with reactive arthritis show normal production of tumour necrosis factor-alpha

scientific article published on 01 March 1991

Phagocyte function in familial hypercholesterolaemia: peripheral blood monocytes exposed to lipopolysaccharide show increased tumour necrosis factor production.

scientific article

Production of TNF by monocytes of patients with early rheumatoid arthritis is increased.

scientific article

Production of tumour necrosis factor and interleukin 1 by monocytes of patients with previous Yersinia arthritis.

scientific article published on June 1988

Programmed cell death: many ways for cells to die decently.

scientific article

Proton pump inhibitor use and cancer mortality.

scientific article published on 15 April 2018

Pterostilbene-induced tumor cytotoxicity: a lysosomal membrane permeabilization-dependent mechanism

scientific article

Quantification of Lysosomal Membrane Permeabilization by Cytosolic Cathepsin and β-N-Acetyl-Glucosaminidase Activity Measurements

scientific article published on 2 November 2015

ROS-induced DNA damage and PARP-1 are required for optimal induction of starvation-induced autophagy ⬇️

scientific article published on April 24, 2012

Ragulator-a multifaceted regulator of lysosomal signaling and trafficking

scientific article

Regulation of ACTH-induced steroidogenesis in human fetal adrenals by rTNF-α

scientific article published on 01 January 1990

Release of transcriptional repression via ErbB2-induced, SUMO-directed phosphorylation of myeloid zinc finger-1 serine 27 activates lysosome redistribution and invasion

scientific article published on 08 January 2019

Renilla Luciferase-LC3 Based Reporter Assay for Measuring Autophagic Flux

scientific article published on 12 November 2016

Repurposing Cationic Amphiphilic Antihistamines for Cancer Treatment

scientific article

S100A11 is required for efficient plasma membrane repair and survival of invasive cancer cells

scientific article

STAT3 associates with vacuolar H-ATPase and regulates cytosolic and lysosomal pH

scientific article published on 20 August 2018

Screening and identification of small molecule inhibitors of ErbB2-induced invasion.

scientific article published on 12 July 2014

Selective autophagy maintains centrosome integrity and accurate mitosis by turnover of centriolar satellites

scientific article published on 13 September 2019

Selective depletion of heat shock protein 70 (Hsp70) activates a tumor-specific death program that is independent of caspases and bypasses Bcl-2.

scientific article

Selective depletion of inducible HSP70 enhances immunogenicity of rat colon cancer cells ⬇️

scientific article published on November 8, 2001

Sensitive detection of lysosomal membrane permeabilization by lysosomal galectin puncta assay.

scientific article

Sensitization to TNF-induced apoptosis by 1,25-dihydroxy vitamin D3 involves up-regulation of the TNF receptor 1 and cathepsin B

scientific article published on 01 July 2001

Sensitization to the lysosomal cell death pathway by oncogene-induced down-regulation of lysosome-associated membrane proteins 1 and 2.

scientific article published on August 2008

Sensitization to the lysosomal cell death pathway upon immortalization and transformation

scientific article published on August 2004

Setting up an efficient and reliable screening method for novel c-Jun N-terminal kinase substrates.

scientific article published on 12 March 2000

Spatially and temporally defined lysosomal leakage facilitates mitotic chromosome segregation

scientific article published on 13 January 2020

Sunitinib and SU11652 inhibit acid sphingomyelinase, destabilize lysosomes, and inhibit multidrug resistance

scientific article

TAK1 activates AMPK-dependent cytoprotective autophagy in TRAIL-treated epithelial cells.

scientific article published on 05 February 2009

TAK1 activates AMPK-dependent cytoprotective autophagy in TRAIL-treated epithelial cells.

scientific article published in May 2009

TNF-induced mitochondrial changes and activation of apoptotic proteases are inhibited by A20.

scientific article published in July 1998

Targeting ions-induced autophagy in cancer

scientific article published on 10 November 2014

The Mutational Landscape of the Oncogenic MZF1 SCAN Domain in Cancer.

scientific article

The ability of BHRF1 to inhibit apoptosis is dependent on stimulus and cell type.

scientific article published in October 1997

The heat shock protein 70 family: Highly homologous proteins with overlapping and distinct functions.

scientific article published on 25 May 2007

The ubiquitin-conjugating enzyme UBE2QL1 coordinates lysophagy in response to endolysosomal damage

scientific article published on 21 August 2019

Transformation-associated changes in sphingolipid metabolism sensitize cells to lysosomal cell death induced by inhibitors of acid sphingomyelinase

scientific article published on September 2013

Triggering caspase-independent cell death to combat cancer.

scientific article

Triggering of apoptosis by cathepsins

scientific article published on 01 April 2001

Truncated ErbB2 receptor enhances ErbB1 signaling and induces reversible, ERK-independent loss of epithelial morphology

scientific article published on 01 October 2001

Tumor necrosis factor as a potent inhibitor of adrenocorticotropin-induced cortisol production and steroidogenic P450 enzyme gene expression in cultured human fetal adrenal cells.

scientific article

Tumor necrosis factor-alpha and interferon-gamma inhibit insulin-like growth factor II gene expression in human fetal adrenal cell cultures.

scientific article

Vascular endothelial growth factor C promotes tumor lymphangiogenesis and intralymphatic tumor growth

scientific article published on 01 March 2001

Vincristine induces dramatic lysosomal changes and sensitizes cancer cells to lysosome-destabilizing siramesine.

scientific article

Visualizing Lysosomal Membrane Permeabilization by Fluorescent Dextran Release.

scientific article published on October 2015

Vitamin D analog EB1089 triggers dramatic lysosomal changes and Beclin 1-mediated autophagic cell death.

scientific article

[Heat shock protein 70: an important survival factor for cancer cells]

scientific article published on 01 September 2004

[Mechanisms of apoptotic cell death]

scientific article published on 01 January 1997

c-Jun NH2-terminal kinase 2 is required for Ras transformation independently of activator protein 1.

scientific article published on January 2007

microRNA-101 is a potent inhibitor of autophagy

scientific article published on 13 September 2011

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