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List of works by Tobias Moser

A critical role for the cholesterol-associated proteolipids PLP and M6B in myelination of the central nervous system

scientific article published on 16 January 2013

A dual‐AAV approach restores fast exocytosis and partially rescues auditory function in deaf otoferlin knock‐out mice

scientific article published on 01 January 2019

A missense mutation in a highly conserved alternate exon of dynamin-1 causes epilepsy in fitful mice ⬇️

scientific article (publication date: August 2010)

A mutation in CABP2, expressed in cochlear hair cells, causes autosomal-recessive hearing impairment

scientific article

A mutation in PNPT1, encoding mitochondrial-RNA-import protein PNPase, causes hereditary hearing loss

scientific article

A new probe for super-resolution imaging of membranes elucidates trafficking pathways

scientific article

A sensory cell diversifies its output by varying Ca<sup>2+</sup> influx-release coupling among active zones

scientific article published on 21 December 2020

A synthetic prestin reveals protein domains and molecular operation of outer hair cell piezoelectricity.

scientific article published on 24 June 2011

AP180 promotes release site clearance and clathrin-dependent vesicle reformation in mouse cochlear inner hair cells

scientific article published on 22 January 2020

ATP Hydrolysis Is Critically Required for Function of CaV1.3 Channels in Cochlear Inner Hair Cells via Fueling Ca2+ Clearance

scientific article published on 01 May 2014

Analyzing efficacy, stability, and safety of AAV-mediated optogenetic hearing restoration in mice

scientific article published on 05 May 2022

Auditory neuropathy--neural and synaptic mechanisms

scientific article published on 19 February 2016

Axial Tubule Junctions Activate Atrial Ca Release Across Species

scientific article published on 08 October 2018

Bassoon and the synaptic ribbon organize Ca²+ channels and vesicles to add release sites and promote refilling

scientific article

Bassoon-disruption slows vesicle replenishment and induces homeostatic plasticity at a CNS synapse.

scientific article published on 17 January 2014

BetaIVSigma1 spectrin stabilizes the nodes of Ranvier and axon initial segments

scientific article

CSPalpha-deficiency causes massive and rapid photoreceptor degeneration

scientific article

Ca Regulates the Kinetics of Synaptic Vesicle Fusion at the Afferent Inner Hair Cell Synapse

scientific article published on 17 October 2018

Ca2+-binding protein 2 inhibits Ca2+-channel inactivation in mouse inner hair cells

scientific article published on 9 February 2017

Ca2+-binding proteins tune Ca2+-feedback to Cav1.3 channels in mouse auditory hair cells

scientific article published on 18 October 2007

Calcium Dependence of Exocytosis and Endocytosis at the Cochlear Inner Hair Cell Afferent Synapse

scientific article published on 01 March 2001

Calcium regulates exocytosis at the level of single vesicles

scientific article

Complexin-I is required for high-fidelity transmission at the endbulb of Held auditory synapse.

scientific article published in June 2009

Concurrent maturation of inner hair cell synaptic Ca2+ influx and auditory nerve spontaneous activity around hearing onset in mice.

scientific article published in June 2013

Conditional deletion of pejvakin in adult outer hair cells causes progressive hearing loss in mice

scientific article

Connexin32 can restore hearing in connexin26 deficient mice

scientific article published on 2 August 2011

Considering optogenetic stimulation for cochlear implants.

scientific article

Cytomatrix proteins CAST and ELKS regulate retinal photoreceptor development and maintenance

article

Cytosolic Ca2+ acts by two separate pathways to modulate the supply of release-competent vesicles in chromaffin cells

scientific article published on June 1998

DNA Diagnostics of Hereditary Hearing Loss: A Targeted Resequencing Approach Combined with a Mutation Classification System

scientific article published on 6 May 2016

Deletion of the presynaptic scaffold CAST reduces active zone size in rod photoreceptors and impairs visual processing.

scientific article

Detection and differentiation of sensorineural hearing loss in mice using auditory steady-state responses and transient auditory brainstem responses

scientific article published on 10 August 2007

Developmental refinement of hair cell synapses tightens the coupling of Ca2+ influx to exocytosis

scientific article

Diagnosis and therapy of auditory synaptopathy/neuropathy

scientific article published in November 2006

Disruption of Otoferlin Alters the Mode of Exocytosis at the Mouse Inner Hair Cell Ribbon Synapse

scientific article published on 01 January 2018

Disruption of adaptor protein 2μ (AP-2μ) in cochlear hair cells impairs vesicle reloading of synaptic release sites and hearing

scientific article

Disruption of the presynaptic cytomatrix protein bassoon degrades ribbon anchorage, multiquantal release, and sound encoding at the hair cell afferent synapse.

scientific article published in March 2013

Does a single session of theta-burst transcranial magnetic stimulation of inferior temporal cortex affect tinnitus perception?

scientific article

EF-hand protein Ca2+ buffers regulate Ca2+ influx and exocytosis in sensory hair cells

scientific article

Endophilin-A regulates presynaptic Ca2+ influx and synaptic vesicle recycling in auditory hair cells

scientific article published on 07 February 2019

Ephrin-A5/EphA4 signalling controls specific afferent targeting to cochlear hair cells

scientific article

Estimation of mean exocytic vesicle capacitance in mouse adrenal chromaffin cells

scientific article

Exocytosis at the hair cell ribbon synapse apparently operates without neuronal SNARE proteins

scientific article

Expression pattern and functional characterization of connexin29 in transgenic mice

scientific article published in April 2006

Eyes without a ribbon

scientific article published on 22 March 2016

Few CaV1.3 channels regulate the exocytosis of a synaptic vesicle at the hair cell ribbon synapse.

scientific article published in December 2005

Flexible auditory training, psychophysics, and enrichment of common marmosets with an automated, touchscreen-based system

scientific article published in 2022

Functional properties of synaptic transmission in primary sense organs

scientific article

GaN-based micro-LED arrays on flexible substrates for optical cochlear implants

article published in 2014

Gene therapy for deafness: How close are we?

scientific article published on July 2015

Glyoxal as an alternative fixative to formaldehyde in immunostaining and super-resolution microscopy

scientific article published on 16 November 2017

Hair cell ribbon synapses

scientific article

Hair cell synaptic ribbons are essential for synchronous auditory signalling

scientific article published in April 2005

Hair cells use active zones with different voltage dependence of Ca2+ influx to decompose sounds into complementary neural codes.

scientific article

Harmonin enhances voltage-dependent facilitation of Cav1.3 channels and synchronous exocytosis in mouse inner hair cells

scientific article published on 22 April 2013

Harmonin inhibits presynaptic Cav1.3 Ca²⁺ channels in mouse inner hair cells

scientific article published on 07 August 2011

Hearing requires otoferlin-dependent efficient replenishment of synaptic vesicles in hair cells

scientific journal article

High frequency neural spiking and auditory signaling by ultrafast red-shifted optogenetics.

scientific article

High-fidelity CRISPR/Cas9- based gene-specific hydroxymethylation rescues gene expression and attenuates renal fibrosis

scientific article published in Nature Communications

Impairment of SLC17A8 encoding vesicular glutamate transporter-3, VGLUT3, underlies nonsyndromic deafness DFNA25 and inner hair cell dysfunction in null mice.

scientific article

Individual synaptic vesicles mediate stimulated exocytosis from cochlear inner hair cells

article published in the Proceedings of the National Academy of Sciences of the United States of America

Intracellular calcium dependence of large dense-core vesicle exocytosis in the absence of synaptotagmin I

scientific article

Intrinsic planar polarity mechanisms influence the position-dependent regulation of synapse properties in inner hair cells

scientific article published on 11 April 2019

Is there an unmet medical need for improved hearing restoration?

scientific article published in 2022

Kinetics of exocytosis and endocytosis at the cochlear inner hair cell afferent synapse of the mouse

scientific article

Low‐conductance intercellular coupling between mouse chromaffin cells in situ ⬇️

scientific article published on January 1, 1998

Macromolecular and electrical coupling between inner hair cells in the rodent cochlea

scientific article published on 25 June 2020

Mapping developmental maturation of inner hair cell ribbon synapses in the apical mouse cochlea

scientific article published on 13 March 2019

Maturation of ribbon synapses in hair cells is driven by thyroid hormone

scientific article

Measurements of membrane patch capacitance using a software-based lock-in system

scientific article published on 6 January 2007

Mechanisms Underlying Phasic and Sustained Secretion in Chromaffin Cells from Mouse Adrenal Slices

scientific article published on 01 July 1999

Mechanisms contributing to synaptic Ca2+ signals and their heterogeneity in hair cells

scientific article

Mechanisms underlying the temporal precision of sound coding at the inner hair cell ribbon synapse

scientific article published on 10 August 2006

Mice with altered KCNQ4 K+ channels implicate sensory outer hair cells in human progressive deafness

scientific article

Modes and regulation of endocytic membrane retrieval in mouse auditory hair cells

scientific article

Molekulares Verstehen des Hörens – Was ändert sich für den Patienten?

scientific article published on 22 March 2018

Multichannel optogenetic stimulation of the auditory pathway using microfabricated LED cochlear implants in rodents

scientific article published on 01 July 2020

Multiscale photonic imaging of the native and implanted cochlea

scientific article published in 2021

Munc18-1 promotes large dense-core vesicle docking

scientific journal article

Near physiological spectral selectivity of cochlear optogenetics

scientific article published on 29 April 2019

Neural circuit development in the mammalian cochlea

scientific article published on April 2012

Neuroligin 2 controls the maturation of GABAergic synapses and information processing in the retina

scientific article published on June 2009

Neuroligin-4 is localized to glycinergic postsynapses and regulates inhibition in the retina

scientific article

New insights into cochlear sound encoding

scientific article

On the Fabrication and Characterization of Polymer-Based Waveguide Probes for Use in Future Optical Cochlear Implants

scientific article published in 2022

Onset coding is degraded in auditory nerve fibers from mutant mice lacking synaptic ribbons

scientific article

Optogenetic stimulation of cochlear neurons activates the auditory pathway and restores auditory-driven behavior in deaf adult gerbils

Optogenetic stimulation of the auditory nerve

scientific article

Optogenetic stimulation of the auditory pathway for research and future prosthetics

scientific article

Optogenetic stimulation of the auditory pathway.

scientific article

Optogenetics and electron tomography for structure-function analysis of cochlear ribbon synapses

scientific article published in 2022

Otoferlin, defective in a human deafness form, is essential for exocytosis at the auditory ribbon synapse

scientific article

Otoferlin: a multi-C2 domain protein essential for hearing

scientific article published on 07 September 2012

Phase contrast tomography of the mouse cochlea at microfocus x-ray sources

Piccolo Promotes Vesicle Replenishment at a Fast Central Auditory Synapse

scientific article published on 25 October 2017

Pou4f1 Defines a Subgroup of Type I Spiral Ganglion Neurons and Is Necessary for Normal Inner Hair Cell Presynaptic Ca2+ Signaling

scientific article published on 13 May 2019

Probing the functional equivalence of otoferlin and synaptotagmin 1 in exocytosis

scientific article

Probing the mechanism of exocytosis at the hair cell ribbon synapse.

scientific article published in November 2007

Propagation-based phase-contrast x-ray tomography of cochlea using a compact synchrotron source.

scientific article

Quantitative optical nanophysiology of Ca2+ signaling at inner hair cell active zones.

scientific article published on 18 January 2018

RIM-Binding Protein 2 Organizes Ca<sup>2+</sup> Channel Topography and Regulates Release Probability and Vesicle Replenishment at a Fast Central Synapse

scientific article published on 05 August 2021

RIM-Binding Protein 2 Promotes a Large Number of CaV1.3 Ca2+-Channels and Contributes to Fast Synaptic Vesicle Replenishment at Hair Cell Active Zones

scientific article published on 2 November 2017

Rab Interacting Molecules 2 and 3 Directly Interact with the Pore-Forming CaV1.3 Ca2+ Channel Subunit and Promote Its Membrane Expression.

scientific article

Rab3-interacting molecules 2α and 2β promote the abundance of voltage-gated CaV1.3 Ca2+ channels at hair cell active zones

scientific article

Rapid exocytosis in single chromaffin cells recorded from mouse adrenal slices

scientific article published on 01 April 1997

Relating structure and function of inner hair cell ribbon synapses

scientific article

Review of hair cell synapse defects in sensorineural hearing impairment

scientific article published on August 2013

Sensory Processing at Ribbon Synapses in the Retina and the Cochlea

scientific article published on 02 August 2019

Spike encoding of neurotransmitter release timing by spiral ganglion neurons of the cochlea

scientific article published in April 2012

Structure and function of cochlear afferent innervation

scientific article published on October 2010

Super-resolution optical microscopy of the organ of Corti. Investigations on the fine structure of the inner hair cell afferent synapse by the 4Pi and STED techniques

scientific article

Swelling-induced catecholamine secretion recorded from single chromaffin cells

scientific article published on 01 December 1995

Synaptic encoding and processing of auditory information in physiology and disease

scientific article

Synaptic organization in cochlear inner hair cells deficient for the CaV1.3 (alpha1D) subunit of L-type Ca2+ channels

scientific article published on 10 July 2006

The CAPOS mutation in ATP1A3 alters Na/K-ATPase function and results in auditory neuropathy which has implications for management

scientific article published on 5 January 2018

The Ca2+ channel subunit beta2 regulates Ca2+ channel abundance and function in inner hair cells and is required for hearing

scientific article

The Cl--channel TMEM16A is involved in the generation of cochlear Ca2+ waves and promotes the refinement of auditory brainstem networks in mice

scientific article published in 2022

The afferent synapse of cochlear hair cells

scientific article

The connexin26 S17F mouse mutant represents a model for the human hereditary keratitis-ichthyosis-deafness syndrome

scientific article published on 6 October 2010

The crystal structure of the C₂A domain of otoferlin reveals an unconventional top loop region

scientific article

The mammalian rod synaptic ribbon is essential for Cav channel facilitation and ultrafast synaptic vesicle fusion

scientific article published in 2021

The mechanosensory structure of the hair cell requires clarin-1, a protein encoded by Usher syndrome III causative gene

scientific article

The presynaptic function of mouse cochlear inner hair cells during development of hearing.

scientific article

The synaptic ribbon is critical for sound encoding at high rates and with temporal precision

scientific article published on 12 January 2018

Toward the Optical Cochlear Implant

scientific article published on 01 August 2019

Towards optogenetic approaches for hearing restoration

scientific article published on 04 February 2020

Towards the optical cochlear implant: optogenetic approaches for hearing restoration

scientific article published on 30 March 2020

Tryptophan-rich basic protein (WRB) mediates insertion of the tail-anchored protein otoferlin and is required for hair cell exocytosis and hearing

scientific article published on 25 July 2016

Tuning of synapse number, structure and function in the cochlea

scientific article published on 8 March 2009

Ultrafast optogenetic stimulation of the auditory pathway by targeting-optimized Chronos

scientific article published on 05 November 2018

Unconventional molecular regulation of synaptic vesicle replenishment in cochlear inner hair cells

scientific journal article

Uniquantal release through a dynamic fusion pore is a candidate mechanism of hair cell exocytosis

scientific article

Update on physiology and pathophysiology of the inner ear: pathomechanisms of sensorineural hearing loss

scientific article published in January 2008

Viral rhodopsins 1 are an unique family of light-gated cation channels

scientific article published on 11 November 2020

alpha-Neurexins are required for efficient transmitter release and synaptic homeostasis at the mouse neuromuscular junction

scientific article published on 10 January 2006

β-Secretase BACE1 Is Required for Normal Cochlear Function

scientific article published on 16 September 2019

μLED-based optical cochlear implants for spectrally selective activation of the auditory nerve

scientific article published on 29 June 2020

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