List of works - Michel Lazdunski

A phospholipid sensor controls mechanogating of the K+ channel TREK-1.

scientific article

A proton-gated cation channel involved in acid-sensing

scientific article

A structural homologue of colipase in black mamba venom revealed by NMR floating disulphide bridge analysis ⬇️

scientific article published on January 1, 1998

A tarantula peptide against pain via ASIC1a channels and opioid mechanisms

scientific article

ARF6-dependent interaction of the TWIK1 K+ channel with EFA6, a GDP/GTP exchange factor for ARF6

scientific article

An intracellular proton sensor commands lipid- and mechano-gating of the K(+) channel TREK-1.

scientific article

Calcicludine, a venom peptide of the Kunitz-type protease inhibitor family, is a potent blocker of high-threshold Ca2+ channels with a high affinity for L-type channels in cerebellar granule neurons

scientific article

Calciseptine, a peptide isolated from black mamba venom, is a specific blocker of the L-type calcium channel ⬇️

scientific article

Cloning and cDNA sequence analysis of Lys(49) and Asp(49) basic phospholipase A(2) myotoxin isoforms from Bothrops asper

scientific article

Cloning and expression of human TRAAK, a polyunsaturated fatty acids-activated and mechano-sensitive K(+) channel

scientific article

Cloning and recombinant expression of a structurally novel human secreted phospholipase A2

scientific article

Cloning and recombinant expression of human group IIF-secreted phospholipase A(2)

scientific article

Cloning of a new mouse two-P domain channel subunit and a human homologue with a unique pore structure

scientific article

Cloning provides evidence for a family of inward rectifier and G-protein coupled K+ channels in the brain

scientific article (publication date: 10 October 1994)

Cloning, expression, pharmacology and regulation of a delayed rectifier K+ channel in mouse heart ⬇️

scientific article (publication date: October 1991)

Constitution and properties of axonal membranes of crustacean nerves ⬇️

scientific article published on December 16, 1975

Deletion of the acid-sensing ion channel ASIC3 prevents gastritis-induced acid hyperresponsiveness of the stomach-brainstem axis

scientific article

Diamine oxidase is the amiloride-binding protein and is inhibited by amiloride analogues

scientific article

Dimerization of TWIK-1 K+ channel subunits via a disulfide bridge

scientific article

Effects of phrixotoxins on the Kv4 family of potassium channels and implications for the role of Ito1 in cardiac electrogenesis

scientific article

Expression cloning of an epithelial amiloride-sensitive Na+ channel. A new channel type with homologies to Caenorhabditis elegans degenerins

scientific article

Four novel tarantula toxins as selective modulators of voltage-gated sodium channel subtypes

scientific article

Genetic analysis of the beta subunit of the epithelial Na+ channel in essential hypertension

scientific article

Human TREK2, a 2P domain mechano-sensitive K+ channel with multiple regulations by polyunsaturated fatty acids, lysophospholipids, and Gs, Gi, and Gq protein-coupled receptors

scientific article

Identification, functional expression and chromosomal localisation of a sustained human proton-gated cation channel

scientific article

Inhalational anesthetics activate two-pore-domain background K+ channels

scientific article (publication date: May 1999)

International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels

scientific article

International Union of Pharmacology. LIV. Nomenclature and Molecular Relationships of Inwardly Rectifying Potassium Channels ⬇️

scientific article

K(V)LQT1 and lsK (minK) proteins associate to form the I(Ks) cardiac potassium current

scientific article

KCNE2 confers background current characteristics to the cardiac KCNQ1 potassium channel

scientific article

Kv2.1/Kv9.3, a novel ATP-dependent delayed-rectifier K+ channel in oxygen-sensitive pulmonary artery myocytes ⬇️

scientific article published on November 17, 1997

Localization of a potassium channel gene (KCNE1) to 21q22.1-q22.2 by in situ hybridization and somatic cell hybridization

scientific article

Localization of structural elements of bee venom phospholipase A2 involved in N-type receptor binding and neurotoxicity

scientific article

M-type KCNQ2-KCNQ3 potassium channels are modulated by the KCNE2 subunit

scientific article (publication date: September 2000)

Mapping of Human Potassium Channel Genes TREK-1 (KCNK2) and TASK (KCNK3) to Chromosomes 1q41 and 2p23 ⬇️

scientific article published on August 1, 1998

Molecular cloning and functional expression of a novel amiloride-sensitive Na+ channel

scientific article

Neuroleptics of the diphenylbutylpiperidine series are potent calcium channel inhibitors

scientific article

Neuroprotective and neuroproliferative activities of NeuroAid (MLC601, MLC901), a Chinese medicine, in vitro and in vivo

scientific article

Neurotoxicity and other pharmacological activities of the snake venom phospholipase A2 OS2: the N-terminal region is more important than enzymatic activity

scientific article

Nonsteroid anti-inflammatory drugs inhibit both the activity and the inflammation-induced expression of acid-sensing ion channels in nociceptors

scientific article (publication date: 15 October 2001)

Novel Mammalian Group XII Secreted Phospholipase A2Lacking Enzymatic Activity, ⬇️

scientific article published on October 7, 2003

Novel human secreted phospholipase A(2) with homology to the group III bee venom enzyme

scientific article

Novel tarantula toxins for subtypes of voltage-dependent potassium channels in the Kv2 and Kv4 subfamilies

scientific article

PP2A-Bgamma subunit and KCNQ2 K+ channels in bipolar disorder

scientific article

Polyunsaturated fatty acids are cerebral vasodilators via the TREK-1 potassium channel

scientific article

Polyunsaturated fatty acids are potent neuroprotectors

scientific article

Proinflammatory mediators, stimulators of sensory neuron excitability via the expression of acid-sensing ion channels.

scientific article

Properties of KvLQT1 K+ channel mutations in Romano-Ward and Jervell and Lange-Nielsen inherited cardiac arrhythmias ⬇️

scientific article published on September 1, 1997

Properties of structure and interaction of the receptor for omega-conotoxin, a polypeptide active on Ca2+ channels

scientific article (publication date: 15 February 1988)

Purification and pharmacological characterization of peptide toxins from the black mamba (Dendroaspis polylepis) venom

scientific article (publication date: 1990)

Purification and subunit structure of a putative K+-channel protein identified by its binding properties for dendrotoxin I

scientific article

Receptors for a growing family of secreted phospholipases A2.

scientific article

Recombinant production and solution structure of PcTx1, the specific peptide inhibitor of ASIC1a proton-gated cation channels

scientific article

Riluzole improves functional recovery after ischemia in the rat retina

scientific article

Scyllatoxin, a blocker of Ca(2+)-activated K+ channels: structure-function relationships and brain localization of the binding sites

scientific article

Secreted phospholipases A(2), a new class of HIV inhibitors that block virus entry into host cells

scientific article

Solution structure of Phrixotoxin 1, a specific peptide inhibitor of Kv4 potassium channels from the venom of the theraphosid spider Phrixotrichus auratus

scientific article

Structure-function relations and site of action of apamin, a neurotoxic polypeptide of bee venom with an action on the central nervous system ⬇️

scientific article (publication date: 3 June 1975)

TASK, a human background K+ channel to sense external pH variations near physiological pH ⬇️

scientific article published on September 1, 1997

TWIK-1, a ubiquitous human weakly inward rectifying K+ channel with a novel structure

scientific article

The KCNQ2 potassium channel: splice variants, functional and developmental expression. Brain localization and comparison with KCNQ3

scientific article

The acid-sensitive ionic channel subunit ASIC and the mammalian degenerin MDEG form a heteromultimeric H+-gated Na+ channel with novel properties

scientific article

The bee venom peptide tertiapin underlines the role of I(KACh) in acetylcholine-induced atrioventricular blocks

scientific article

The endocannabinoid anandamide is a direct and selective blocker of the background K(+) channel TASK-1.

scientific article

The human 180-kDa receptor for secretory phospholipases A2. Molecular cloning, identification of a secreted soluble form, expression, and chromosomal localization

scientific article

The human inward rectifying K+ channel Kir 2.2 (KCNJ12) gene: gene structure, assignment to chromosome 17p11.1, and identification of a simple tandem repeat polymorphism

scientific article

The lung amiloride-sensitive Na+ channel: biophysical properties, pharmacology, ontogenesis, and molecular cloning

scientific article

The mechano-activated K+ channels TRAAK and TREK-1 control both warm and cold perception

scientific article

The multivalent PDZ domain-containing protein CIPP is a partner of acid-sensing ion channel 3 in sensory neurons

scientific article (publication date: 10 May 2002)

The neuroprotective agent riluzole activates the two P domain K(+) channels TREK-1 and TRAAK

scientific article

Two phospholipase A2 inhibitors from the plasma of Cerrophidion (Bothrops) godmani which selectively inhibit two different group-II phospholipase A2 myotoxins from its own venom: isolation, molecular cloning and biological properties.

scientific article published on March 2000

List of works by Michel Lazdunski

A phospholipid sensor controls mechanogating of the K+ channel TREK-1.

A proton-gated cation channel involved in acid-sensing

A structural homologue of colipase in black mamba venom revealed by NMR floating disulphide bridge analysis ⬇️

A tarantula peptide against pain via ASIC1a channels and opioid mechanisms

ARF6-dependent interaction of the TWIK1 K+ channel with EFA6, a GDP/GTP exchange factor for ARF6

An intracellular proton sensor commands lipid- and mechano-gating of the K(+) channel TREK-1.

Calcicludine, a venom peptide of the Kunitz-type protease inhibitor family, is a potent blocker of high-threshold Ca2+ channels with a high affinity for L-type channels in cerebellar granule neurons

Calciseptine, a peptide isolated from black mamba venom, is a specific blocker of the L-type calcium channel ⬇️

Cloning and cDNA sequence analysis of Lys(49) and Asp(49) basic phospholipase A(2) myotoxin isoforms from Bothrops asper

Cloning and expression of human TRAAK, a polyunsaturated fatty acids-activated and mechano-sensitive K(+) channel

Cloning and recombinant expression of a structurally novel human secreted phospholipase A2

Cloning and recombinant expression of human group IIF-secreted phospholipase A(2)

Cloning of a new mouse two-P domain channel subunit and a human homologue with a unique pore structure

Cloning provides evidence for a family of inward rectifier and G-protein coupled K+ channels in the brain

Cloning, expression, pharmacology and regulation of a delayed rectifier K+ channel in mouse heart ⬇️

Constitution and properties of axonal membranes of crustacean nerves ⬇️

Deletion of the acid-sensing ion channel ASIC3 prevents gastritis-induced acid hyperresponsiveness of the stomach-brainstem axis

Diamine oxidase is the amiloride-binding protein and is inhibited by amiloride analogues

Dimerization of TWIK-1 K+ channel subunits via a disulfide bridge

Effects of phrixotoxins on the Kv4 family of potassium channels and implications for the role of Ito1 in cardiac electrogenesis

Expression cloning of an epithelial amiloride-sensitive Na+ channel. A new channel type with homologies to Caenorhabditis elegans degenerins

Four novel tarantula toxins as selective modulators of voltage-gated sodium channel subtypes

Genetic analysis of the beta subunit of the epithelial Na+ channel in essential hypertension

Human TREK2, a 2P domain mechano-sensitive K+ channel with multiple regulations by polyunsaturated fatty acids, lysophospholipids, and Gs, Gi, and Gq protein-coupled receptors

Identification, functional expression and chromosomal localisation of a sustained human proton-gated cation channel

Inhalational anesthetics activate two-pore-domain background K+ channels

International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels

International Union of Pharmacology. LIV. Nomenclature and Molecular Relationships of Inwardly Rectifying Potassium Channels ⬇️

K(V)LQT1 and lsK (minK) proteins associate to form the I(Ks) cardiac potassium current

KCNE2 confers background current characteristics to the cardiac KCNQ1 potassium channel

Kv2.1/Kv9.3, a novel ATP-dependent delayed-rectifier K+ channel in oxygen-sensitive pulmonary artery myocytes ⬇️

Localization of a potassium channel gene (KCNE1) to 21q22.1-q22.2 by in situ hybridization and somatic cell hybridization

Localization of structural elements of bee venom phospholipase A2 involved in N-type receptor binding and neurotoxicity

M-type KCNQ2-KCNQ3 potassium channels are modulated by the KCNE2 subunit

Mapping of Human Potassium Channel Genes TREK-1 (KCNK2) and TASK (KCNK3) to Chromosomes 1q41 and 2p23 ⬇️

Molecular cloning and functional expression of a novel amiloride-sensitive Na+ channel

Neuroleptics of the diphenylbutylpiperidine series are potent calcium channel inhibitors

Neuroprotective and neuroproliferative activities of NeuroAid (MLC601, MLC901), a Chinese medicine, in vitro and in vivo

Neurotoxicity and other pharmacological activities of the snake venom phospholipase A2 OS2: the N-terminal region is more important than enzymatic activity

Nonsteroid anti-inflammatory drugs inhibit both the activity and the inflammation-induced expression of acid-sensing ion channels in nociceptors

Novel Mammalian Group XII Secreted Phospholipase A2Lacking Enzymatic Activity, ⬇️

Novel human secreted phospholipase A(2) with homology to the group III bee venom enzyme

Novel tarantula toxins for subtypes of voltage-dependent potassium channels in the Kv2 and Kv4 subfamilies

PP2A-Bgamma subunit and KCNQ2 K+ channels in bipolar disorder

Polyunsaturated fatty acids are cerebral vasodilators via the TREK-1 potassium channel

Polyunsaturated fatty acids are potent neuroprotectors

Proinflammatory mediators, stimulators of sensory neuron excitability via the expression of acid-sensing ion channels.

Properties of KvLQT1 K+ channel mutations in Romano-Ward and Jervell and Lange-Nielsen inherited cardiac arrhythmias ⬇️

Properties of structure and interaction of the receptor for omega-conotoxin, a polypeptide active on Ca2+ channels

Purification and pharmacological characterization of peptide toxins from the black mamba (Dendroaspis polylepis) venom

Purification and subunit structure of a putative K+-channel protein identified by its binding properties for dendrotoxin I

Receptors for a growing family of secreted phospholipases A2.

Recombinant production and solution structure of PcTx1, the specific peptide inhibitor of ASIC1a proton-gated cation channels

Riluzole improves functional recovery after ischemia in the rat retina

Scyllatoxin, a blocker of Ca(2+)-activated K+ channels: structure-function relationships and brain localization of the binding sites

Secreted phospholipases A(2), a new class of HIV inhibitors that block virus entry into host cells

Solution structure of Phrixotoxin 1, a specific peptide inhibitor of Kv4 potassium channels from the venom of the theraphosid spider Phrixotrichus auratus

Structure-function relations and site of action of apamin, a neurotoxic polypeptide of bee venom with an action on the central nervous system ⬇️

TASK, a human background K+ channel to sense external pH variations near physiological pH ⬇️

TWIK-1, a ubiquitous human weakly inward rectifying K+ channel with a novel structure

The KCNQ2 potassium channel: splice variants, functional and developmental expression. Brain localization and comparison with KCNQ3

The acid-sensitive ionic channel subunit ASIC and the mammalian degenerin MDEG form a heteromultimeric H+-gated Na+ channel with novel properties

The bee venom peptide tertiapin underlines the role of I(KACh) in acetylcholine-induced atrioventricular blocks

The endocannabinoid anandamide is a direct and selective blocker of the background K(+) channel TASK-1.

The human 180-kDa receptor for secretory phospholipases A2. Molecular cloning, identification of a secreted soluble form, expression, and chromosomal localization

The human inward rectifying K+ channel Kir 2.2 (KCNJ12) gene: gene structure, assignment to chromosome 17p11.1, and identification of a simple tandem repeat polymorphism

The lung amiloride-sensitive Na+ channel: biophysical properties, pharmacology, ontogenesis, and molecular cloning

The mechano-activated K+ channels TRAAK and TREK-1 control both warm and cold perception

The multivalent PDZ domain-containing protein CIPP is a partner of acid-sensing ion channel 3 in sensory neurons

The neuroprotective agent riluzole activates the two P domain K(+) channels TREK-1 and TRAAK

Two phospholipase A2 inhibitors from the plasma of Cerrophidion (Bothrops) godmani which selectively inhibit two different group-II phospholipase A2 myotoxins from its own venom: isolation, molecular cloning and biological properties.