List of works - Michael Sheetz

A force-dependent switch reverses type IV pilus retraction ⬇️

scholarly article

A new component in synaptic plasticity: upregulation of kinesin in the neurons of the gill-withdrawal reflex.

scientific article

Actin polymerization-dependent activation of Cas-L promotes immunological synapse stability

scientific article

Activation of a signaling cascade by cytoskeleton stretch

scientific article

An in vivo covalent TMP-tag based on proximity-induced reactivity

scientific article published on July 2009

Analysis of the local organization and dynamics of cellular actin networks

scientific article

Cell crawling mediates collective cell migration to close undamaged epithelial gaps

scientific article

Cell response to substrate rigidity is regulated by active and passive cytoskeletal stress

scientific article published on 22 May 2020

Cells test substrate rigidity by local contractions on submicrometer pillars.

scientific article

Clustering of alpha(5)beta(1) integrins determines adhesion strength whereas alpha(v)beta(3) and talin enable mechanotransduction

scientific article

Conversion of PtdIns(4,5)P(2) into PtdIns(5)P by the S.flexneri effector IpgD reorganizes host cell morphology

scientific article

Cooperative Vinculin Binding to Talin Mapped by Time-Resolved Super Resolution Microscopy.

scientific article

Cooperative retraction of bundled type IV pili enables nanonewton force generation

scientific article (publication date: 15 April 2008)

Correction

scientific article published in July 2010

Cyclic stretching of soft substrates induces spreading and growth

scientific article

Cytoskeletal coherence requires myosin-IIA contractility

scientific article

DNA transport into Bacillus subtilis requires proton motive force to generate large molecular forces

scientific article

Direct evidence for coherent low velocity axonal transport of mitochondria

scientific article

Early events in cell spreading as a model for quantitative analysis of biomechanical events

scientific article

Force Sensing by Mechanical Extension of the Src Family Kinase Substrate p130Cas

scientific article (publication date: December 2006)

Force generated by actomyosin contraction builds bridges between adhesive contacts

scientific article

Force-dependent polymorphism in type IV pili reveals hidden epitopes.

scientific article

Immediate-early signaling induced by E-cadherin engagement and adhesion

scientific article

Integrin-beta3 clusters recruit clathrin-mediated endocytic machinery in the absence of traction force

scientific article

Integrin-dependent force transmission to the extracellular matrix by α-actinin triggers adhesion maturation

scientific article

Integrin-matrix clusters form podosome-like adhesions in the absence of traction forces

scientific journal article

Lamellipodial actin mechanically links myosin activity with adhesion-site formation

scientific article

Local force and geometry sensing regulate cell functions

scientific article (publication date: April 2006)

Mechanical confinement triggers glioma linear migration dependent on formin FHOD3.

scientific article

Mechanisms controlling cell size and shape during isotropic cell spreading

scientific article

Mechanosensing Controlled Directly by Tyrosine Kinases.

scientific article

Mechanotransduction in vivo by repeated talin stretch-relaxation events depends upon vinculin

scientific article

Membrane cholesterol, lateral mobility, and the phosphatidylinositol 4,5-bisphosphate-dependent organization of cell actin ⬇️

scientific article published on November 11, 2003

Methotrexate conjugates: a molecular in vivo protein tag.

scientific article published on March 2004

Micro-stepping Extended Focus reduces photobleaching and preserves structured illumination super-resolution features

scientific article published on 07 April 2020

Modularity and functional plasticity of scaffold proteins as p(l)acemakers in cell signaling

scientific article

Molecular Occupancy of Nanodot Arrays

scientific article

Myosin 1E localizes to actin polymerization sites in lamellipodia, affecting actin dynamics and adhesion formation

scientific article published on 15 December 2013

N-WASP-directed actin polymerization activates Cas phosphorylation and lamellipodium spreading.

scientific article

Netrin-1 attracts axons through FAK-dependent mechanotransduction

scientific article

Nonmuscle myosin IIA-dependent force inhibits cell spreading and drives F-actin flow

scientific article

Plasma membrane area increases with spread area by exocytosis of a GPI-anchored protein compartment.

scientific article

Quantification of cell edge velocities and traction forces reveals distinct motility modules during cell spreading

scientific article

Rapid recruitment of p53 to DNA damage sites directs DNA repair choice and integrity

scientific article published on 02 March 2022

Second-Generation Covalent TMP-Tag for Live Cell Imaging ⬇️

scientific article published on August 9, 2012

Signaling network triggers and membrane physical properties control the actin cytoskeleton-driven isotropic phase of cell spreading

scientific article

Single pilus motor forces exceed 100 pN.

scientific article

Stopping transformed cancer cell growth by rigidity sensing

scientific article published on 28 October 2019

Stretching single talin rod molecules activates vinculin binding

scientific article

Structural effects of PrP polymorphisms on intra- and interspecies prion transmission.

scientific article

T Lymphocyte Myosin IIA is Required for Maturation of the Immunological Synapse

scientific article

Talin Dependent Mechanosensitivity of Cell Focal Adhesions

scientific article

Talin depletion reveals independence of initial cell spreading from integrin activation and traction

scientific article

Temporary increase in plasma membrane tension coordinates the activation of exocytosis and contraction during cell spreading.

scientific article

Transformation proteins and DNA uptake localize to the cell poles in Bacillus subtilis

scientific article published on July 2005

Tropomyosin controls sarcomere-like contractions for rigidity sensing and suppressing growth on soft matrices

scientific article

Two-piconewton slip bond between fibronectin and the cytoskeleton depends on talin

scientific journal article

List of works by Michael Sheetz

A force-dependent switch reverses type IV pilus retraction ⬇️

A new component in synaptic plasticity: upregulation of kinesin in the neurons of the gill-withdrawal reflex.

Actin polymerization-dependent activation of Cas-L promotes immunological synapse stability

Activation of a signaling cascade by cytoskeleton stretch

An in vivo covalent TMP-tag based on proximity-induced reactivity

Analysis of the local organization and dynamics of cellular actin networks

Cell crawling mediates collective cell migration to close undamaged epithelial gaps

Cell response to substrate rigidity is regulated by active and passive cytoskeletal stress

Cells test substrate rigidity by local contractions on submicrometer pillars.

Clustering of alpha(5)beta(1) integrins determines adhesion strength whereas alpha(v)beta(3) and talin enable mechanotransduction

Conversion of PtdIns(4,5)P(2) into PtdIns(5)P by the S.flexneri effector IpgD reorganizes host cell morphology

Cooperative Vinculin Binding to Talin Mapped by Time-Resolved Super Resolution Microscopy.

Cooperative retraction of bundled type IV pili enables nanonewton force generation

Correction

Cyclic stretching of soft substrates induces spreading and growth

Cytoskeletal coherence requires myosin-IIA contractility

DNA transport into Bacillus subtilis requires proton motive force to generate large molecular forces

Direct evidence for coherent low velocity axonal transport of mitochondria

Early events in cell spreading as a model for quantitative analysis of biomechanical events

Force Sensing by Mechanical Extension of the Src Family Kinase Substrate p130Cas

Force generated by actomyosin contraction builds bridges between adhesive contacts

Force-dependent polymorphism in type IV pili reveals hidden epitopes.

Immediate-early signaling induced by E-cadherin engagement and adhesion

Integrin-beta3 clusters recruit clathrin-mediated endocytic machinery in the absence of traction force

Integrin-dependent force transmission to the extracellular matrix by α-actinin triggers adhesion maturation

Integrin-matrix clusters form podosome-like adhesions in the absence of traction forces

Lamellipodial actin mechanically links myosin activity with adhesion-site formation

Local force and geometry sensing regulate cell functions

Mechanical confinement triggers glioma linear migration dependent on formin FHOD3.

Mechanisms controlling cell size and shape during isotropic cell spreading

Mechanosensing Controlled Directly by Tyrosine Kinases.

Mechanotransduction in vivo by repeated talin stretch-relaxation events depends upon vinculin

Membrane cholesterol, lateral mobility, and the phosphatidylinositol 4,5-bisphosphate-dependent organization of cell actin ⬇️

Methotrexate conjugates: a molecular in vivo protein tag.

Micro-stepping Extended Focus reduces photobleaching and preserves structured illumination super-resolution features

Modularity and functional plasticity of scaffold proteins as p(l)acemakers in cell signaling

Molecular Occupancy of Nanodot Arrays

Myosin 1E localizes to actin polymerization sites in lamellipodia, affecting actin dynamics and adhesion formation

N-WASP-directed actin polymerization activates Cas phosphorylation and lamellipodium spreading.

Netrin-1 attracts axons through FAK-dependent mechanotransduction

Nonmuscle myosin IIA-dependent force inhibits cell spreading and drives F-actin flow

Plasma membrane area increases with spread area by exocytosis of a GPI-anchored protein compartment.

Quantification of cell edge velocities and traction forces reveals distinct motility modules during cell spreading

Rapid recruitment of p53 to DNA damage sites directs DNA repair choice and integrity

Second-Generation Covalent TMP-Tag for Live Cell Imaging ⬇️

Signaling network triggers and membrane physical properties control the actin cytoskeleton-driven isotropic phase of cell spreading

Single pilus motor forces exceed 100 pN.

Stopping transformed cancer cell growth by rigidity sensing

Stretching single talin rod molecules activates vinculin binding

Structural effects of PrP polymorphisms on intra- and interspecies prion transmission.

T Lymphocyte Myosin IIA is Required for Maturation of the Immunological Synapse

Talin Dependent Mechanosensitivity of Cell Focal Adhesions

Talin depletion reveals independence of initial cell spreading from integrin activation and traction

Temporary increase in plasma membrane tension coordinates the activation of exocytosis and contraction during cell spreading.

Transformation proteins and DNA uptake localize to the cell poles in Bacillus subtilis

Tropomyosin controls sarcomere-like contractions for rigidity sensing and suppressing growth on soft matrices

Two-piconewton slip bond between fibronectin and the cytoskeleton depends on talin