List of works by Michael Houghton

5′ end-dependent translation initiation of hepatitis C viral RNA and the presence of putative positive and negative translational control elements within the 5′ untranslated region ⬇️

scientific article published on December 1, 1992

A Comprehensive Computational Analysis for the Binding Modes of Hepatitis C Virus NS5A Inhibitors: The Question of Symmetry.

scientific article

A Fibrosis-Independent Hepatic Transcriptomic Signature Identifies Novel Drivers of Disease Progression in Primary Sclerosing Cholangitis

scientific article published on 03 August 2020

A Recombinant Hepatitis C Virus Genotype 1a E1/E2 Envelope Glycoprotein Vaccine Elicits Antibodies That Differentially Neutralize Closely Related 2a Strains through Interactions of the N-Terminal Hypervariable Region 1 of E2 with Scavenger Receptor

scientific article published on 29 October 2019

A Refined Model of the HCV NS5A protein bound to daclatasvir explains drug-resistant mutations and activity against divergent genotypes.

scientific article published on 14 April 2014

A cDNA fragment of hepatitis C virus isolated from an implicated donor of post-transfusion non-A, non-B hepatitis in Japan

scientific article

A central hydrophobic E1 region controls the pH range of hepatitis C virus membrane fusion and susceptibility to fusion inhibitors

scientific article published on 13 February 2019

A computational approach for predicting off-target toxicity of antiviral ribonucleoside analogues to mitochondrial RNA polymerase.

scientific article

A computational model for overcoming drug resistance using selective dual-inhibitors for aurora kinase A and its T217D variant

scientific article published on 5 November 2013

A hepatitis C virus (HCV) vaccine comprising envelope glycoproteins gpE1/gpE2 derived from a single isolate elicits broad cross-genotype neutralizing antibodies in humans

scientific article

A human ether-á-go-go-related (hERG) ion channel atomistic model generated by long supercomputer molecular dynamics simulations and its use in predicting drug cardiotoxicity.

scientific article published on 13 August 2014

A novel method for detection of IFN-lambda 3 binding to cells for quantifying IFN-lambda receptor expression

scientific article published on 5 March 2017

A proposed system for the nomenclature of hepatitis C viral genotypes

article by Peter Simmonds et al published May 1994 in Hepatology

A quantitative test to estimate neutralizing antibodies to the hepatitis C virus: cytofluorimetric assessment of envelope glycoprotein 2 binding to target cells

scientific article (publication date: 5 March 1996)

A single antigenomic open reading frame of the hepatitis delta virus encodes the epitope(s) of both hepatitis delta antigen polypeptides p24 delta and p27 delta

scientific article

A unique, predominant hepatitis C virus variant found in an infant born to a mother with multiple variants

scientific article

A196 IDENTIFICATION OF AN IMMUNOSUPPRESSIVE DOMAIN IN HUMAN BETARETROVIRUS

Activation of naïve B lymphocytes via CD81, a pathogenetic mechanism for hepatitis C virus-associated B lymphocyte disorders

scientific article

Activation of the grp78 and grp94 promoters by hepatitis C virus E2 envelope protein

scientific article published on May 1999

An ELISA Based Binding and Competition Method to Rapidly Determine Ligand-receptor Interactions

scientific article

An inactivated hepatitis C virus vaccine on the horizon?

scientific article published on 25 June 2013

Analysis of a successful immune response against hepatitis C virus

scientific article (publication date: April 1999)

Analysis of genomic variability of hepatitis C virus

scientific article published on January 1991

Anti-hepatitis C antibodies and non-A, non-B post-transfusion hepatitis in The Netherlands

scientific article

Antibody response to core, envelope and nonstructural hepatitis C virus antigens: comparison of immunocompetent and immunosuppressed patients

scientific article published in September 1993

Arylacetamide deacetylase: a novel host factor with important roles in the lipolysis of cellular triacylglycerol stores, VLDL assembly and HCV production

scientific article published on 28 March 2013

Association of cytotoxic T lymphocyte (CTL) escape mutations with persistent hepatitis C virus (HCV) infection

scientific article published on 01 January 1995

Association of hepatitis C virus envelope proteins with exosomes

scientific article published on October 2004

Association of multispecific CD4(+) response to hepatitis C and severity of recurrence after liver transplantation

scientific article published in October 1999

Binding of hepatitis C virus to CD81

scientific article

Blood screening for non-A, non-B hepatitis by hepatitis C virus antibody assay

scientific article published in May 1990

CD4 T lymphocyte proliferative responses to hepatitis C virus (HCV) antigens in patients coinfected with HCV and human immunodeficiency virus who responded to anti-HCV treatment

scientific article published on 17 July 2002

Cationic microparticles are a potent delivery system for a HCV DNA vaccine

scientific article published in December 2004

Characterization of an Immunodominant Antigenic Site on GB Virus C Glycoprotein E2 That Is Involved in Cell Binding

scientific article (publication date: December 2006)

Characterization of antibodies induced by vaccination with hepatitis C virus envelope glycoproteins.

scientific article

Characterization of hepatitis C virus core-specific immune responses primed in rhesus macaques by a nonclassical ISCOM vaccine

scientific article published in March 2001

Characterization of hepatitis C virus envelope glycoprotein complexes expressed by recombinant vaccinia viruses

scientific article

Characterization of liver T-cell receptor gammadelta T cells obtained from individuals chronically infected with hepatitis C virus (HCV): evidence for these T cells playing a role in the liver pathology associated with HCV infections

scientific article published on May 2001

Characterization of the terminal regions of hepatitis C viral RNA: identification of conserved sequences in the 5' untranslated region and poly(A) tails at the 3' end

scholarly article

Chlorcyclizine Inhibits Viral Fusion of Hepatitis C Virus Entry by Directly Targeting HCV Envelope Glycoprotein 1

scientific article published on 30 April 2020

Clinical Medical Research Award. Hepatitis C virus and eliminating post-transfusion hepatitis

scientific article published in October 2000

Coinhibitory Receptor Expression and Immune Checkpoint Blockade: Maintaining a Balance in CD8+ T Cell Responses to Chronic Viral Infections and Cancer.

scientific article published on 29 September 2017

Comparison of secretion of a hepatitis C virus glycoprotein in Saccharomyces cerevisiae and Kluyveromyces lactis

scientific article published in April 1999

Compartmentalization of T lymphocytes to the site of disease: intrahepatic CD4+ T cells specific for the protein NS4 of hepatitis C virus in patients with chronic hepatitis C

scientific article

Complex processing and protein:protein interactions in the E2:NS2 region of HCV.

scientific article published on October 1994

Comprehensive in vitro characterization of PD-L1 small molecule inhibitors

scientific article published on 27 August 2019

Computational Prediction of the Heterodimeric and Higher-Order Structure of gpE1/gpE2 Envelope Glycoproteins Encoded by Hepatitis C Virus

scientific article

Critical challenges and emerging opportunities in hepatitis C virus research in an era of potent antiviral therapy: Considerations for scientists and funding agencies.

scientific article published on 22 February 2018

Cytotoxic T lymphocyte response to hepatitis C virus-derived peptides containing the HLA A2.1 binding motif

scientific article

Detailed computational study of the active site of the hepatitis C viral RNA polymerase to aid novel drug design.

scientific article published on 24 October 2013

Detection of antibody against antigen expressed by molecularly cloned hepatitis C virus cDNA: application to diagnosis and blood screening for posttransfusion hepatitis

scientific article published on February 1990

Detection of antibody to hepatitis C virus in prospectively followed transfusion recipients with acute and chronic non-A, non-B hepatitis

scientific article (publication date: 30 November 1989)

Detection of hepatitis C viral sequences in non-A, non-B hepatitis.

scientific article published in January 1990

Different clinical behaviors of acute hepatitis C virus infection are associated with different vigor of the anti-viral cell-mediated immune response

scientific article (publication date: August 1996)

Differential cytotoxic T-lymphocyte responsiveness to the hepatitis B and C viruses in chronically infected patients

scientific article

Differential expression of interferon-lambda receptor 1 splice variants determines the magnitude of the antiviral response induced by interferon-lambda 3 in human immune cells

scientific article published on 30 April 2020

Differential serum levels of eosinophilic eotaxins in primary sclerosing cholangitis, primary biliary cirrhosis, and autoimmune hepatitis.

scientific article published on 29 October 2013

Disappearance of hepatitis C virus RNA in plasma during interferon alpha-2B treatment in hemophilia patients

scientific article published on January 1, 1992

Discovery of the hepatitis C virus

scientific article

Early antihepatitis C virus response with second-generation C200/C22 ELISA

scientific article published on January 1, 1992

Early events in hepatitis C virus infection of chimpanzees.

scientific article

Effect of Different Adjuvants on the Longevity and Strength of Humoral and Cellular Immune Responses to the HCV Envelope Glycoproteins

scientific article published on 03 December 2019

Effect of Immunosuppression on T-Helper 2 and B-Cell Responses to Influenza Vaccination

scientific article published on 14 January 2015

Effects of interferon treatment on the antiviral T-cell response in hepatitis C virus genotype 1b- and genotype 2c-infected patients

scientific article published on September 1997

Elevated serum alanine aminotransferase levels in blood donors: the contribution of hepatitis C virus

scientific article published in December 1991

Enhanced activation of memory, but not naïve, B cells in chronic hepatitis C virus-infected patients with cryoglobulinemia and advanced liver fibrosis

scientific article

Enhanced sensitivity of a second generation ELISA for antibody to hepatitis C virus

scientific article published on January 1, 1992

Epidemiology of hepatitis C virus. A preliminary study in volunteer blood donors

scientific article published in January 1990

Erratum: Structure, sequence and expression of the hepatitis delta (δ) viral genome

scientific article published in Nature

Evaluation of hepatitis C virus glycoprotein E2 for vaccine design: an endoplasmic reticulum-retained recombinant protein is superior to secreted recombinant protein and DNA-based vaccine candidates

scientific article

Expression of human CD81 in transgenic mice does not confer susceptibility to hepatitis C virus infection

scientific article published in December 2002

Expression, identification and subcellular localization of the proteins encoded by the hepatitis C viral genome

scientific article (publication date: June 1993)

Fabrication of flexible self-standing all-cellulose nanofibrous composite membranes for virus removal.

scientific article published on 04 February 2016

Folding and dimerization of hepatitis C virus E1 and E2 glycoproteins in stably transfected CHO cells

scientific article published on February 2005

Folding of hepatitis C virus E1 glycoprotein in a cell-free system.

scientific article

Functional and immunogenic characterization of diverse HCV glycoprotein E2 variants

scientific article published on 13 November 2018

Generation of an MHC class II-restricted T cell epitope by extracellular processing of hepatitis delta antigen

scientific article published on June 1998

Glycogen synthase kinase 3β inhibitors prevent hepatitis C virus release/assembly through perturbation of lipid metabolism

scientific article

Group specific sequences and conserved secondary structures at the 3' end of HCV genome and its implication for viral replication ⬇️

scientific article published on July 11, 1992

HCV E1E2-MF59 vaccine in chronic hepatitis C patients treated with PEG-IFNα2a and Ribavirin: a randomized controlled trial

scientific article published on 27 August 2013

HCV testing in low-risk population

scientific article published in September 1990

HLA class I-restricted cytotoxic T lymphocytes specific for hepatitis C virus. Identification of multiple epitopes and characterization of patterns of cytokine release ⬇️

scientific article published on November 1, 1995

Hepatitis C Virus: 30 Years after Its Discovery

scientific article published on 02 December 2019

Hepatitis C antibody and chronic liver disease in haemophilia

scientific article

Hepatitis C antibody in patients with chronic liver disease and hepatocellular carcinoma

scientific article published on August 1991

Hepatitis C vaccines

Hepatitis C viral cDNA clones isolated from a healthy carrier donor implicated in post-transfusion non-A, non-B hepatitis

scientific article published on July 1990

Hepatitis C virus (HCV)-specific cytotoxic T lymphocytes recognize epitopes in the core and envelope proteins of HCV ⬇️

scientific article published on December 1, 1993

Hepatitis C virus antibodies in acute icteric and chronic non-A, non-B hepatitis ⬇️

scientific article published on October 1, 1991

Hepatitis C virus antibodies in southern African blacks with hepatocellular carcinoma ⬇️

scientific article published on April 14, 1990

Hepatitis C virus antigen in hepatocytes: immunomorphologic detection and identification

scientific article published on August 1, 1992

Hepatitis C virus core and E2 protein expression in transgenic mice

scientific article published on March 1997

Hepatitis C virus envelope glycoprotein E1 originates in the endoplasmic reticulum and requires cytoplasmic processing for presentation by class I MHC molecules

scientific article published on January 1999

Hepatitis C virus envelope glycoprotein immunization of rodents elicits cross-reactive neutralizing antibodies

scientific article published on 14 September 2007

Hepatitis C virus heteroduplex tracking assay : application to genotype determination, quasispecies analysis, and molecular evolution studies.

scientific article published in January 1999

Hepatitis C virus heteroduplex tracking assay for genotype determination reveals diverging genotype 2 isolates in Italian hemodialysis patients

scientific article

Hepatitis C virus markers in patients with long-term biochemical and histological remission of chronic hepatitis.

scientific article published in April 1994

Hepatitis C virus polyprotein vaccine formulations capable of inducing broad antibody and cellular immune responses

scientific article published in August 2006

Hepatitis C virus-specific CD4+ T cell response after liver transplantation occurs early, is multispecific, compartmentalizes to the liver, and does not correlate with recurrent disease

scientific article published on 14 March 2001

Hepatitis C virus-specific CTL responses in the liver of chimpanzees with acute and chronic hepatitis C.

scientific article published on October 1993

Hepatitis C virus-specific cytolytic T lymphocyte and T helper cell responses in seronegative persons

scientific article published in October 1997

Hepatitis C virus: structure, protein products and processing of the polyprotein precursor.

scientific article published in January 1994

Hepatitis C virus: the major causative agent of viral non-A, non-B hepatitis

scientific article published on April 1990

Hepatitis C-associated hepatocellular carcinoma

scientific article published on 01 September 1990

Hepatitis C: the next 25years

scientific article published on 17 July 2014

Hepatitis delta (delta) cDNA clones: undetectable hybridization to nucleic acids from infectious non-A, non-B hepatitis materials and hepatitis B DNA.

scientific article published in March 1987

High prevalence of G1 and G2 TT-virus infection in subjects with high and low blood exposure risk: identification of G4 isolates in Italy.

scientific article published in December 1999

High titers of antibodies inhibiting the binding of envelope to human cells correlate with natural resolution of chronic hepatitis C.

scientific article published on October 1998

Human CD4+ T-cell response to hepatitis delta virus: identification of multiple epitopes and characterization of T-helper cytokine profiles.

scientific article

Human serum leads to differentiation of human hepatoma cells, restoration of very-low-density lipoprotein secretion, and a 1000-fold increase in HCV Japanese fulminant hepatitis type 1 titers.

scientific article published on 17 October 2013

IL-28B is a key regulator of B- and T-cell vaccine responses against influenza

scientific article

Identification of the major, parenteral non-A, non-B hepatitis agent (hepatitis C virus) using a recombinant cDNA approach

scientific article published on August 1, 1992

Immune responses to plasmid DNA encoding the hepatitis C virus core protein ⬇️

scientific article published on September 1, 1995

Immunization of human volunteers with hepatitis C virus envelope glycoproteins elicits antibodies that cross-neutralize heterologous virus strains

scientific article published on 25 July 2011

Immunization of woodchucks with adjuvanted sHDAg (p24): immune response and outcome following challenge

article

Immunodominant CD4+ T-cell epitope within nonstructural protein 3 in acute hepatitis C virus infection

scientific article published in August 1997

Immunomodulatory Function of Interleukin 28B during primary infection with cytomegalovirus.

scientific article published on 11 March 2014

Induction in vitro of a primary human antiviral cytotoxic T cell response

scientific article published in February 1995

Induction of broad CD4+ and CD8+ T-cell responses and cross-neutralizing antibodies against hepatitis C virus by vaccination with Th1-adjuvanted polypeptides followed by defective alphaviral particles expressing envelope glycoproteins gpE1 and [...]

scientific article (publication date: August 2008)

Intrafamilial transmission of hepatitis C virus

scientific article published on 01 October 1989

Intrahepatic cytotoxic T lymphocytes specific for hepatitis C virus in persons with chronic hepatitis

scientific article published on November 1992

Intrahepatic genetic inoculation of hepatitis C virus RNA confers cross-protective immunity

scientific article

Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome

scientific article (publication date: 21 April 1989)

Lack of antibodies to the envelope glycoproteins of hepatitis C virus in immunoglobulin preparations from screened donors

scientific article published in January 1996

Liver-derived CTL in hepatitis C virus infection: breadth and specificity of responses in a cohort of persons with chronic infection.

scientific article published on February 1998

Liver-derived hepatitis C virus (HCV)-specific CD4(+) T cells recognize multiple HCV epitopes and produce interferon gamma

scientific article published in September 2000

Long term treatment of chronic hepatitis C with interferon alfa-2b: disappearance of HCV-RNA in a pilot study of eight haemophilia patients

scientific article

Memory CD8+ T cells are required for protection from persistent hepatitis C virus infection

scientific article (publication date: 16 June 2003)

Modeling the human Nav1.5 sodium channel: structural and mechanistic insights of ion permeation and drug blockade.

scientific article

Molecular biology of the hepatitis C viruses: implications for diagnosis, development and control of viral disease

scientific article (publication date: August 1991)

Native Folding of a Recombinant gpE1/gpE2 Heterodimer Vaccine Antigen from a Precursor Protein Fused with Fc IgG.

scientific article published on 19 October 2016

No evidence for XMRV nucleic acids, infectious virus or anti-XMRV antibodies in Canadian patients with chronic fatigue syndrome

scientific article

Nucleotide sequence of core and envelope genes of the hepatitis C virus genome derived directly from human healthy carriers

scientific article published in August 1990

Peptide immunogen mimicry of putative E1 glycoprotein-specific epitopes in hepatitis C virus

scientific article

Persistence of HCV despite antibodies to both putative envelope glycoproteins ⬇️

scientific article published on October 9, 1993

Persistent hepatitis C virus infection in a chimpanzee is associated with emergence of a cytotoxic T lymphocyte escape variant

scientific article

Perspectives for a vaccine against hepatitis C virus

scientific article

Prevalence of antibodies to hepatitis C virus among patients with cryptogenic chronic hepatitis and cirrhosis ⬇️

scientific article published on February 1, 1992

Prevalence of antibodies to hepatitis C virus in Italian patients with hepatocellular carcinoma

scientific article published in October 1989

Prevention of hepatitis C virus infection using a broad cross-neutralizing monoclonal antibody (AR4A) and epigallocatechin gallate

scientific article published on 21 September 2015

Priming of CD4+ and CD8+ T cell responses using a HCV core ISCOMATRIX vaccine: a phase I study in healthy volunteers

scientific article published on 15 March 2009

Priming of hepatitis C virus-specific cytotoxic T lymphocytes in mice following portal vein injection of a liver-specific plasmid DNA.

scientific article

Progress towards a hepatitis C virus vaccine

scientific article

Prospects for a hepatitis C virus vaccine

scientific article

Prospects for a vaccine against the hepatitis C virus

scientific article

Prospects for prophylactic and therapeutic hepatitis C virus vaccines

scientific article published on 01 January 1995

Prospects for prophylactic and therapeutic vaccines against the hepatitis C viruses

scientific article published on January 2011

Protective immune response to hepatitis C virus in chimpanzees rechallenged following clearance of primary infection

scientific article published in June 2001

Quantification of the number of cytotoxic T cells specific for an immunodominant HCV-specific CTL epitope primed by DNA immunization

scientific article

Quantitative analysis of the peripheral blood cytotoxic T lymphocyte response in patients with chronic hepatitis C virus infection

scientific article published on September 1996

Rabbit-derived anti-HD antibodies for HDAg immunoblotting

scientific article published in January 1991

Rabbit-derived anti-HD antibodies for HDAg immunoblotting

scientific article published on 01 January 1993

Recombinant hepatitis C virus envelope glycoprotein vaccine elicits antibodies targeting multiple epitopes on the envelope glycoproteins associated with broad cross-neutralization

scientific article

Recombinant human monoclonal antibodies against different conformational epitopes of the E2 envelope glycoprotein of hepatitis C virus that inhibit its interaction with CD81.

scientific article

Reductions in circulating levels of IL-16, IL-7 and VEGF-A in myalgic encephalomyelitis/chronic fatigue syndrome

scientific article

Role of Hepatitis C Virus in Non-B Chronic Liver Disease ⬇️

scientific article published on August 1, 1991

Role of the E2 Hypervariable Region (HVR1) in the Immunogenicity of a Recombinant Hepatitis C Virus Vaccine.

scientific article

Safety and immunogenicity of HCV E1E2 vaccine adjuvanted with MF59 administered to healthy adults.

scientific article

Serum antibodies against the hepatitis C virus E2 protein mediate antibody-dependent cellular cytotoxicity (ADCC).

scientific article published on 21 January 2005

Small Interfering RNA-Mediated Inhibition of Hepatitis C Virus Replication in the Human Hepatoma Cell Line Huh-7

scientific article (publication date: 2003)

Storage conditions of blood samples and primer selection affect the yield of cDNA polymerase chain reaction products of hepatitis C virus

scientific article

Strategies and prospects for vaccination against the hepatitis C viruses

scientific article

Structure and Function of the Hepatitis C Virus Envelope Glycoproteins E1 and E2: Antiviral and Vaccine Targets

scientific article published on 16 August 2016

Structure, sequence and expression of the hepatitis delta (delta) viral genome

scientific article

Structure-function analysis of hepatitis C virus envelope-CD81 binding

scientific article

Superior immunogenicity of HCV envelope glycoproteins when adjuvanted with cyclic-di-AMP, a STING activator or archaeosomes

scientific article

Synthesis and characterization of a native, oligomeric form of recombinant severe acute respiratory syndrome coronavirus spike glycoprotein

scientific article

Targeting the Achilles heel of the hepatitis B virus: a review of current treatments against covalently closed circular DNA.

scientific article

The 3rd Canadian Symposium on Hepatitis C Virus: expanding care in the interferon-free era.

scientific article published on October 2014

The Second Canadian Symposium on hepatitis C virus: a call to action

scientific article published on November 2013

The effects of using recombinant vaccinia viruses expressing either large or small HDAg to protect woodchuck hepadnavirus carriers from HDV superinfection

scientific article published on 01 January 1993

The hepatitis C virus encodes a serine protease involved in processing of the putative nonstructural proteins from the viral polyprotein precursor

scientific article published in April 1993

The impact of the interferon-lambda family on the innate and adaptive immune response to viral infections

scientific article published on 16 July 2014

The long and winding road leading to the identification of the hepatitis C virus

scientific article

The outcome of hepatitis C virus infection is predicted by escape mutations in epitopes targeted by cytotoxic T lymphocytes

scientific article (publication date: December 2001)

The putative nucleocapsid and envelope protein genes of hepatitis C virus determined by comparison of the nucleotide sequences of two isolates derived from an experimentally infected chimpanzee and healthy human carriers

scientific article published on December 1990

The role of chronic viral hepatitis in hepatocellular carcinoma in the United States

scientific article published on March 1, 1991

The role of hepatitis C virus-specific cytotoxic T lymphocytes in chronic hepatitis C.

scientific article published on February 1997

The viroid-like structure of the hepatitis delta (delta) genome: synthesis of a viral antigen in recombinant bacteria

scientific article published on 01 January 1987

Towards a vaccine for the prevention of hepatitis delta virus superinfection in HBV carriers.

scientific article published in January 1993

Transfection of a differentiated human hepatoma cell line (Huh7) with in vitro-transcribed hepatitis C virus (HCV) RNA and establishment of a long-term culture persistently infected with HCV

scientific article

Use of a signature nucleotide sequence of hepatitis C virus for detection of viral RNA in human serum and plasma

scientific article

Vaccine adjuvants--understanding molecular mechanisms to improve vaccines.

scientific article published on 20 May 2014

Vaccine-induced cross-genotype reactive neutralizing antibodies against hepatitis C virus

scientific article

Variable Patterns of Programmed Death-1 Expression on Fully Functional Memory T Cells after Spontaneous Resolution of Hepatitis C Virus Infection

scientific article

Variable and hypervariable domains are found in the regions of HCV corresponding to the flavivirus envelope and NS1 proteins and the pestivirus envelope glycoproteins ⬇️

scientific article (publication date: February 1991)

Vertical transmission of hepatitis C virus ⬇️

scientific article published on July 6, 1991

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