List of works by Carl H. June

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part one

scientific article (publication date: November 2016)

4-1BB and CD28 signaling plays a synergistic role in redirecting umbilical cord blood T cells against B-cell malignancies

scientific article

4-1BB costimulation promotes CAR T cell survival through noncanonical NF-κB signaling

scientific article published on 31 March 2020

4-1BB costimulation promotes human T cell adhesion to fibronectin

scientific article published on February 1999

4-1BB is superior to CD28 costimulation for generating CD8+ cytotoxic lymphocytes for adoptive immunotherapy

scientific article published on October 2007

4-1BB-mediated expansion affords superior detection of in vivo primed effector memory CD8+ T cells from melanoma sentinel lymph nodes

scientific article published on 13 August 2010

A 44 kilodalton cell surface homodimer regulates interleukin 2 production by activated human T lymphocytes

scientific article published on 01 May 1986

A Chimeric Switch-Receptor Targeting PD1 Augments the Efficacy of Second-Generation CAR T Cells in Advanced Solid Tumors

scientific article published on March 2016

A Cure for HIV Infection: "Not in My Lifetime" or "Just Around the Corner"?

scientific article

A cell-based artificial antigen-presenting cell coated with anti-CD3 and CD28 antibodies enables rapid expansion and long-term growth of CD4 T lymphocytes

scientific article published on December 2002

A cellular antidote to specifically deplete anti-CD19 chimeric antigen receptor-positive cells

scientific article published on 01 February 2020

A human memory T cell subset with stem cell-like properties

scientific article

A novel system for simultaneous in vivo tracking and biological assessment of leukemia cells and ex vivo generated leukemia-reactive cytotoxic T cells

scientific article published in June 2004

A phase 1 trial of donor lymphocyte infusions expanded and activated ex vivo via CD3/CD28 costimulation.

scientific article published on 3 November 2005

A phase I clinical trial of single-dose intrapleural IFN-beta gene transfer for malignant pleural mesothelioma and metastatic pleural effusions: high rate of antitumor immune responses

scientific article published on August 2007

A phase I trial of repeated intrapleural adenoviral-mediated interferon-beta gene transfer for mesothelioma and metastatic pleural effusions

scientific article

A phase II randomized study of HIV-specific T-cell gene therapy in subjects with undetectable plasma viremia on combination antiretroviral therapy

scientific article published in June 2002

A rational mouse model to detect on-target off-tumor CAR T cell toxicity

scientific article published on 16 June 2020

A single dose of peripherally infused EGFRvIII-directed CAR T cells mediates antigen loss and induces adaptive resistance in patients with recurrent glioblastoma.

scientific article published in July 2017

A translational bridge to cancer immunotherapy: exploiting costimulation and target antigens for active and passive T cell immunotherapy

scientific article

A trial of intrapleural adenoviral-mediated Interferon-α2b gene transfer for malignant pleural mesothelioma

scientific article

A versatile system for rapid multiplex genome-edited CAR T cell generation

scientific article

AU RNA-binding factors differ in their binding specificities and affinities

scientific article

Absence of Replication-Competent Lentivirus in the Clinic: Analysis of Infused T Cell Products

scientific article published on 12 September 2017

Absorbable microparticulate cation exchanger for immunotherapeutic delivery

scientific article published on May 2004

Abstract B05: A biologic screen to evaluate potential toxicity of chimeric antigen receptor modified T cells against primary normal human tissues

scientific article published in October 2015

Abstract CT105: Safety and feasibility of chimeric antigen receptor modified T cells directed against mesothelin (CART-meso) in patients with mesothelin expressing cancers

scientific article published in August 2015

Abstracts of the 29th Annual Scientific Meeting of the Society for Immunotherapy of Cancer (SITC)

Activation of human B lymphocytes by nanogram concentrations of anti-IgM-dextran conjugates

scientific article published on 01 August 1990

Activation of tyrosine phosphorylation in human T cells via the CD2 pathway. Regulation by the CD45 tyrosine phosphatase

scientific article

Activity of Mesothelin-specific Chimeric Antigen Receptor T cells Against Pancreatic Carcinoma Metastases in a Phase 1 Trial.

scientific article published on 19 March 2018

Acute graft-versus-host reaction can be aborted by blockade of costimulatory molecules

scientific article published on August 15, 1995

Addition of deoxynucleosides enhances human immunodeficiency virus type 1 integration and 2LTR formation in resting CD4+ T cells

scientific article published on 10 October 2007

Adoptive T cell therapy for cancer in the clinic

scientific article

Adoptive T cell transfer for cancer immunotherapy in the era of synthetic biology

scientific article published on July 2013

Adoptive cellular therapy

scientific article published on 01 January 2011

Adoptive cellular therapy: a race to the finish line.

scientific article published on March 2015

Adoptive immunotherapy for cancer or viruses

scientific article published on 09 January 2014

Adoptive immunotherapy with engineered T cells expressing and HLA-A2 restricted affinity-enhanced TCR for LAGE-1 and NY-ESO-1 in patients with multiple myeloma following auto-SCT.

scientific article published on 7 November 2013

Adoptive immunotherapy: good habits instilled at youth have long-term benefits.

scientific article published on January 2008

Adoptive immunotherapy: new ways to skin the cat?

scientific article

Adoptive transfer of autologous T cells improves T-cell repertoire diversity and long-term B-cell function in pediatric patients with neuroblastoma.

scientific article published on 23 October 2012

Adoptive transfer of costimulated CD4+ T cells induces expansion of peripheral T cells and decreased CCR5 expression in HIV infection.

scientific article published in January 2002

Adoptive transfer of costimulated T cells induces lymphocytosis in patients with relapsed/refractory non-Hodgkin lymphoma following CD34+-selected hematopoietic cell transplantation

scientific article published on 22 May 2003

Adoptive transfer of simian immunodeficiency virus (SIV) naïve autologous CD4(+) cells to macaques chronically infected with SIV is sufficient to induce long-term nonprogressor status

scientific article published in January 2002

Affinity-Tuned ErbB2 or EGFR Chimeric Antigen Receptor T Cells Exhibit an Increased Therapeutic Index against Tumors in Mice

scientific article

An HIV-1-infected T cell clone defective in IL-2 production and Ca2+ mobilization after CD3 stimulation.

scientific article published on November 1991

An inducible cytoplasmic factor (AU-B) binds selectively to AUUUA multimers in the 3' untranslated region of lymphokine mRNA

scientific article

Analysis of antigen receptor signaling in B cells from mice with a retrovirus-induced acquired immunodeficiency syndrome

scientific article published on 01 January 1995

Analysis of lentiviral vector integration in HIV+ study subjects receiving autologous infusions of gene modified CD4+ T cells

scientific article

Analysis of lymphocyte activation and metabolism by flow cytometry

scientific article published on April 1, 1992

Anti-CD19 CAR T cells with high-dose melphalan and autologous stem cell transplantation for refractory multiple myeloma

scientific article published on 21 February 2019

Anti-CD19 CAR T cells with high-dose melphalan and autologous stem cell transplantation for refractory multiple myeloma.

scientific article published on 19 April 2018

Anti-CD3/anti-CD28 bead stimulation overcomes CD3 unresponsiveness in patients with head and neck squamous cell carcinoma

scientific article published on 01 April 2000

Anti-CD3/anti-CD28 monoclonal antibody-coated suture enhances the immune response of patients with head and neck squamous cell carcinoma

scientific article published on 01 November 1999

Anti-Ig-mediated proliferation of human B cells in the absence of protein kinase C

scientific article published on 01 May 1988

Antibody and B7/BB1-mediated ligation of the CD28 receptor induces tyrosine phosphorylation in human T cells

scientific article published on April 1, 1992

Antibody binding to CD5 (Tp67) and Tp44 T cell surface molecules: effects on cyclic nucleotides, cytoplasmic free calcium, and cAMP-mediated suppression

scientific article published in November 1986

Antibody-modified T cells: CARs take the front seat for hematologic malignancies

scientific article published on 27 February 2014

Antigen-independent activation enhances the efficacy of 4-1BB-costimulated CD22 CAR T cells

scientific article published on 22 April 2021

Antigen-independent regulation of cytoplasmic calcium in B cells with a 12-kDa B-cell growth factor and anti-CD19.

scientific article

Antiviral effect and ex vivo CD4+ T cell proliferation in HIV-positive patients as a result of CD28 costimulation

scientific article published in June 1996

Antiviral effects of autologous CD4 T cells genetically modified with a conditionally replicating lentiviral vector expressing long antisense to HIV

scientific article published on 20 December 2012

Association between cyclosporin neurotoxicity and hypomagnesaemia

scientific article published on November 17, 1984

Augmentation of Antitumor Immunity by Human and Mouse CAR T Cells Secreting IL-18.

scientific article published in September 2017

Author Correction: Targeting cardiac fibrosis with engineered T cells

scientific article published on 01 December 2019

Autologous CD4 T Lymphocytes Modified with a Tat-Dependent, Virus-Specific Endoribonuclease Gene in HIV-Infected Individuals

scientific article published on 10 November 2020

Autologous lysate-pulsed dendritic cell vaccination followed by adoptive transfer of vaccine-primed ex vivo co-stimulated T cells in recurrent ovarian cancer.

scientific article published on January 2013

B cell maturation antigen-specific CAR T cells are clinically active in multiple myeloma

scientific article published on 21 March 2019

B lymphocyte immunoglobulin receptor desensitization is downstream of tyrosine kinase activation.

scientific article published in June 1994

B7-mediated costimulation can either provoke or prevent clinical manifestations of experimental allergic encephalomyelitis

scientific article published on January 1995

Bi-specific TCR-anti CD3 redirected T-cell targeting of NY-ESO-1- and LAGE-1-positive tumors

scientific article published on 22 December 2012

Bimodal effect of phorbol ester on B cell activation. Implication for the role of protein kinase C

scientific article published on 01 March 1991

Biochemical analysis of the immune B cell defect in xid mice

scientific article published on 01 December 1991

Bispecific and split CAR T cells targeting CD13 and TIM3 eradicate acute myeloid leukemia

scientific article published on 01 March 2020

Blockade of CD28 during in vitro activation of encephalitogenic T cells or after disease onset ameliorates experimental autoimmune encephalomyelitis

scientific article published on 01 August 1999

Blocking HIV's attack

scientific article published on 01 March 2012

Boosting engineered T cells

scientific article published on 01 July 2019

Both CD28 ligands CD80 (B7-1) and CD86 (B7-2) activate phosphatidylinositol 3-kinase, and wortmannin reveals heterogeneity in the regulation of T cell IL-2 secretion.

scientific article published in June 1995

CAR T cell immunotherapy for human cancer.

scientific article published in March 2018

CAR T cell viability release testing and clinical outcomes: is there a lower limit?

scientific article published on 01 November 2019

CAR T-Cell Therapies in Glioblastoma: A First Look

scientific article published on 20 November 2017

CAR T-cell therapy for glioblastoma: recent clinical advances and future challenges

article

CAR T-cell therapy is effective for CD19-dim B-lymphoblastic leukemia but is impacted by prior blinatumomab therapy

scientific article published on 01 November 2019

CAR T-cells for T-cell malignancies: challenges in distinguishing between therapeutic, normal, and neoplastic T-cells

scientific article published on 12 October 2018

CARTs on the road for myeloma

scientific article published on 11 June 2014

CARs on track in the clinic

scientific article

CD19-targeted chimeric antigen receptor T-cell therapy for CNS relapsed or refractory acute lymphocytic leukaemia: a post-hoc analysis of pooled data from five clinical trials

scientific article

CD19-targeting CAR T cell immunotherapy outcomes correlate with genomic modification by vector integration

scientific article published on 01 February 2020

CD28 activation pathway regulates the production of multiple T-cell-derived lymphokines/cytokines

scientific article

CD28 activation promotes Th2 subset differentiation by human CD4+ cells

scientific article published on 01 February 1995

CD28 and inducible costimulatory protein Src homology 2 binding domains show distinct regulation of phosphatidylinositol 3-kinase, Bcl-xL, and IL-2 expression in primary human CD4 T lymphocytes

scientific article published on 01 July 2003

CD28 and staphylococcal enterotoxins synergize to induce MHC-independent T-cell proliferation

scientific article published on November 1, 1992

CD28 co-receptor signal transduction in T-cell activation

scientific article published on May 1997

CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-XL.

scientific article

CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-xL. Immunity. 1995. 3: 87-98

scientific article published on October 1, 2010

CD28 costimulation is essential for human T regulatory expansion and function

scientific article published on August 2008

CD28 dependence of T cell differentiation to IL-4 production varies with the particular type 2 immune response

scientific article

CD28 is an inducible T cell surface antigen that transduces a proliferative signal in CD3+ mature thymocytes

scientific article published on 01 March 1990

CD28 ligands CD80 (B7-1) and CD86 (B7-2) induce long-term autocrine growth of CD4+ T cells and induce similar patterns of cytokine secretion in vitro

scientific article published on 01 June 1995

CD28 ligation in T-cell activation: evidence for two signal transduction pathways

scientific article published on April 1990

CD28-deficient mice generate an impaired Th2 response to Schistosoma mansoni infection

article

CD33-specific chimeric antigen receptor T cells exhibit potent preclinical activity against human acute myeloid leukemia

scientific article

CD40 ligand (CD154) triggers a short-term CD4(+) T cell activation response that results in secretion of immunomodulatory cytokines and apoptosis

scientific article

CD40 ligand/CD40 stimulation regulates the production of IFN-gamma from human peripheral blood mononuclear cells in an IL-12- and/or CD28-dependent manner

scientific article published on 01 February 1998

CD45 tyrosine phosphatase activity and membrane anchoring are required for T-cell antigen receptor signaling

scientific article published on December 1994

CD5 antibodies increase intracellular ionized calcium concentration in T cells.

scientific article

CRISPR-engineered T cells in patients with refractory cancer

scientific article published on 07 February 2020

CTLA-4 blockade enhances clinical disease and cytokine production during experimental allergic encephalomyelitis

article

CTLA-4 ligation delivers a unique signal to resting human CD4 T cells that inhibits interleukin-2 secretion but allows Bcl-X(L) induction

scientific article published on 01 January 1998

Calcium-independent calcineurin regulation.

scientific article

Can't Get Any Help? New Approaches for Adoptive Immunotherapy of Cancer

scientific article published on 01 September 2001

Can't get any help? New approaches for adoptive immunotherapy of cancer

scientific article published on 01 September 2001

Cancer Killers.

scientific article

Cancer immunotherapy comes of age and looks for maturity

scientific article published on 03 July 2020

Cardiovascular toxicity and titin cross-reactivity of affinity-enhanced T cells in myeloma and melanoma.

scientific article published on 14 June 2013

Cellular and growth-factor requirements for the replication of human herpesvirus 6 in primary lymphocyte cultures

scientific article published on January 1990

Cellular kinetics of CTL019 in relapsed/refractory B-cell acute lymphoblastic leukemia and chronic lymphocytic leukemia

scientific article

Changing the mindset in life sciences toward translation: a consensus

scientific article published on November 2014

Checkpoint Blockade Reverses Anergy in IL-13Rα2 Humanized scFv-Based CAR T Cells to Treat Murine and Canine Gliomas

scientific article published on 28 August 2018

Chemokine receptor 5 knockout strategies

scientific article

Chimeric Antigen Receptor T Cell Therapies: A Review of Cellular Kinetic-Pharmacodynamic Modeling Approaches

scientific article published on 01 October 2020

Chimeric Antigen Receptor T Cells against CD19 for Multiple Myeloma

scientific article

Chimeric Antigen Receptor T Cells in Myeloma

scientific article published on 01 January 2016

Chimeric Antigen Receptor T Cells in Refractory B-Cell Lymphomas

scientific article published on 10 December 2017

Chimeric Antigen Receptor T cells for B Cell Neoplasms: Choose the Right CAR for You.

scientific article

Chimeric Antigen Receptor Therapy

scientific article published on 01 July 2018

Chimeric Antigen Receptor Therapy for B-cell Malignancies

scientific article published on June 2011

Chimeric Antigen Receptor- and TCR-Modified T Cells Enter Main Street and Wall Street

scientific article

Chimeric antigen receptor (CAR) T therapies for the treatment of hematologic malignancies: clinical perspective and significance

article by Michael M Boyiadzis et al published 4 December 2018 in Journal for Immunotherapy of Cancer

Chimeric antigen receptor T Cells with dissociated signaling domains exhibit focused antitumor activity with reduced potential for toxicity in vivo

scientific article published on July 2013

Chimeric antigen receptor T cells for sustained remissions in leukemia

scientific article (publication date: 16 October 2014)

Chimeric antigen receptor T cells persist and induce sustained remissions in relapsed refractory chronic lymphocytic leukemia

scientific article published on September 2015

Chimeric antigen receptor therapy for cancer

scientific article

Chimeric antigen receptor--modified T cells: clinical translation in stem cell transplantation and beyond

scientific article published on 17 October 2012

Chimeric antigen receptor-modified T cells for acute lymphoid leukemia

scientific article (publication date: 18 April 2013)

Chimeric antigen receptor-modified T cells in chronic lymphoid leukemia

scientific article

Chimeric receptors containing CD137 signal transduction domains mediate enhanced survival of T cells and increased antileukemic efficacy in vivo

scientific article published on 21 April 2009

Chronic lymphocytic leukemia cells impair mitochondrial fitness in CD8+ T cells and impede CAR T-cell efficacy

scientific article published on 10 May 2019

Circulating and tissue-bound immune complex formation in murine malaria

scientific article published on June 1, 1979

Clinical Pharmacology of Tisagenlecleucel in B-cell Acute Lymphoblastic Leukemia

scientific article published on 06 September 2018

Clinical application of expanded CD4+25+ cells

scientific article

Clinical perspectives for regulatory T cells in transplantation tolerance

scientific article published on 05 August 2011

Combination immunotherapy after ASCT for multiple myeloma using MAGE-A3/Poly-ICLC immunizations followed by adoptive transfer of vaccine-primed and costimulated autologous T cells

scientific article

Combination immunotherapy using adoptive T-cell transfer and tumor antigen vaccination on the basis of hTERT and survivin after ASCT for myeloma.

scientific article

Complex effects of phenylarsine oxide in T cells. Induction of tyrosine phosphorylation and calcium mobilization independent of CD45 expression

scientific article published on November 5, 1993

Considerations for the clinical application of chimeric antigen receptor T cells: observations from a recombinant DNA Advisory Committee Symposium held June 15, 2010

scientific article

Constitutive and regulated expression of telomerase reverse transcriptase (hTERT) in human lymphocytes

scientific article

Control of HIV-1 immune escape by CD8 T cells expressing enhanced T-cell receptor

scientific article published on 9 November 2008

Control of large, established tumor xenografts with genetically retargeted human T cells containing CD28 and CD137 domains.

scholarly article

Cord blood CD4(+)CD25(+)-derived T regulatory cell lines express FoxP3 protein and manifest potent suppressor function

scientific article published on 16 September 2004

Correlation of hypomagnesemia with the onset of cyclosporine-associated hypertension in marrow transplant patients.

scientific article published on January 1986

Corrigendum: Is autoimmunity the Achilles' heel of cancer immunotherapy?

scientific article published on 01 August 2017

Costimulated tumor-infiltrating lymphocytes are a feasible and safe alternative donor cell therapy for relapse after allogeneic stem cell transplantation

scientific article published on 30 January 2012

Costimulation light: activation of CD4+ T cells with CD80 or CD86 rather than anti-CD28 leads to a Th2 cytokine profile.

scientific article published in December 2000

Costimulation of T cell receptor/CD3-mediated activation of resting human CD4+ T cells by leukocyte function-associated antigen-1 ligand intercellular cell adhesion molecule-1 involves prolonged inositol phospholipid hydrolysis and sustained increas

scientific article published on December 15, 1992

Costimulatory approaches to adoptive immunotherapy.

scientific article published in November 1998

Critical requirement for the membrane-proximal cytosolic tyrosine residue for CD28-mediated costimulation in vivo

scientific article

Cross-linkage of Ly-6A/E induces Ca2+ translocation in the absence of phosphatidylinositol turnover and mediates proliferation of normal murine B lymphocytes

scientific article published on 01 August 1991

Crosslinking of surface antigens causes mobilization of intracellular ionized calcium in T lymphocytes

scientific article

Cutting edge: Foxp3-mediated induction of pim 2 allows human T regulatory cells to preferentially expand in rapamycin

scientific article published on May 2008

Cutting edge: Regulatory T cells from lung cancer patients directly inhibit autologous T cell proliferation

scientific article published on 01 May 2002

Cytokine Release Syndrome After Chimeric Antigen Receptor T Cell Therapy for Acute Lymphoblastic Leukemia.

scientific article

Cytokine Storm

scientific article published on 01 December 2020

Cytokine release syndrome associated with chimeric-antigen receptor T-cell therapy: clinicopathological insights

scientific article published on 26 October 2017

Cytokine release syndrome in severe COVID-19

scientific article published on 17 April 2020

Decade-long safety and function of retroviral-modified chimeric antigen receptor T cells

scientific article

Decreased dependence of myelin basic protein-reactive T cells on CD28-mediated costimulation in multiple sclerosis patients. A marker of activated/memory T cells

scientific article published on February 1998

Defective signal transduction by the CD2 molecule in immature T-cell receptor/CD3- thymocytes

scientific article published on September 15, 1992

Defining the critical hurdles in cancer immunotherapy

scientific article published on 14 December 2011

Delivery technologies for cancer immunotherapy

scientific article published on 01 March 2019

Dendritic cell-activated CD44hiCD8+ T cells are defective in mediating acute graft-versus-host disease but retain graft-versus-leukemia activity.

scientific article published on 5 February 2004

Depletion of endogenous tumor-associated regulatory T cells improves the efficacy of adoptive cytotoxic T-cell immunotherapy in murine acute myeloid leukemia

scientific article published on September 2009

Detection of antigen specific T lymphocytes by determination of intracellular calcium concentration using flow cytometry

scientific article published on 01 April 1992

Determinants of response and resistance to CD19 chimeric antigen receptor (CAR) T cell therapy of chronic lymphocytic leukemia.

scientific article published on 30 April 2018

Development of an animal model for autotransfusion therapy: in vitro characterization and analysis of anti-CD3/CD28 expanded cells

scientific article published on 01 November 1998

Development of novel substrates for tumor immunotherapy

scientific article published in August 2003

Diagnostic biomarkers to differentiate sepsis from cytokine release syndrome in critically ill children

scientific article published on 01 October 2020

Different patterns of inositol polyphosphate production are seen in B lymphocytes after cross-linking of sIg by anti-Ig antibody or by a multivalent anti-Ig antibody dextran conjugate

scientific article published on 01 September 1989

Differential regulation of HIV-1 fusion cofactor expression by CD28 costimulation of CD4+ T cells

scientific article

Differential sensitivity of human leukocyte subpopulations to ultraviolet light

scientific article published on 01 February 1989

Disease-modifying therapeutic concepts for HIV in the era of highly active antiretroviral therapy

scientific article

Disruption of TET2 promotes the therapeutic efficacy of CD19-targeted T cells

scientific article published in Nature

Disseminated Fusarium moniliforme infection after allogeneic marrow transplantation

scientific article

Distinct Signaling of Coreceptors Regulates Specific Metabolism Pathways and Impacts Memory Development in CAR T Cells

scientific article published in February 2016

Distinct Signaling of Coreceptors Regulates Specific Metabolism Pathways and Impacts Memory Development in CAR T Cells

scientific article published on 15 March 2016

Distinct effects of IL-18 on the engraftment and function of human effector CD8 T cells and regulatory T cells

scientific article

Distinct patterns of transmembrane calcium flux and intracellular calcium mobilization after differentiation antigen cluster 2 (E rosette receptor) or 3 (T3) stimulation of human lymphocytes.

scientific article published on April 1986

Distinct roles for B7-1 (CD-80) and B7-2 (CD-86) in the initiation of experimental allergic encephalomyelitis

scientific article published on November 1, 1995

Distinct signal transduction in mouse CD4+ and CD8+ splenic T cells after CD28 receptor ligation.

scientific article published on February 1995

Distinguishing Truncated and Normal MUC1 Glycoform Targeting from Tn-MUC1-Specific CAR T Cells: Specificity Is the Key to Safety

scientific article published in November 2016

Dominant-Negative TGF-β Receptor Enhances PSMA-Targeted Human CAR T Cell Proliferation And Augments Prostate Cancer Eradication

scientific article published on 08 May 2018

Driving cars to the clinic for solid tumors

scientific article published on 07 June 2018

Driving gene-engineered T cell immunotherapy of cancer

scientific article published on 27 December 2016

Drugging the Undruggable Ras - Immunotherapy to the Rescue?

scientific article published in December 2016

Dual CD19 and CD123 targeting prevents antigen-loss relapses after CD19-directed immunotherapies

scientific article

Dual Targeting of Mesothelin and CD19 with Chimeric Antigen Receptor-Modified T Cells in Patients with Metastatic Pancreatic Cancer

scientific article published on 21 July 2020

Early positron emission tomography/computed tomography as a predictor of response after CTL019 chimeric antigen receptor -T-cell therapy in B-cell non-Hodgkin lymphomas

scientific article published on 29 October 2018

Effects of CD28 costimulation on long-term proliferation of CD4+ T cells in the absence of exogenous feeder cells.

scientific article

Efficient clinical scale gene modification via zinc finger nuclease-targeted disruption of the HIV co-receptor CCR5

scientific article

Efficient lentiviral vector-mediated control of HIV-1 replication in CD4 lymphocytes from diverse HIV+ infected patients grouped according to CD4 count and viral load

scientific article

Efficient priming of protein antigen-specific human CD4(+) T cells by monocyte-derived dendritic cells

scientific article published on 01 November 2000

Emerging Cellular Therapies for Cancer

scientific article published on 10 December 2018

Emerging Use of CRISPR Technology - Chasing the Elusive HIV Cure

scientific article published on 11 September 2019

Engineered CAR T Cells Targeting the Cancer-Associated Tn-Glycoform of the Membrane Mucin MUC1 Control Adenocarcinoma

scientific article published on June 2016

Engineered T cells for cancer therapy.

scientific article

Engineered T cells: the promise and challenges of cancer immunotherapy.

scientific article published on August 2016

Engineered artificial antigen presenting cells facilitate direct and efficient expansion of tumor infiltrating lymphocytes

scientific article

Engineering HIV-resistant human CD4+ T cells with CXCR4-specific zinc-finger nucleases

scientific article

Engineering T cells for cancer: our synthetic future

scientific article published on January 2014

Engineering artificial antigen-presenting cells to express a diverse array of co-stimulatory molecules.

scientific article published on 20 March 2007

Engineering lymphocyte subsets: tools, trials and tribulations

scientific article

Enhanced T cell engraftment after retroviral delivery of an antiviral gene in HIV-infected individuals

scientific article published on February 1998

Enhanced cytotoxicity against solid tumors by bispecific antibody-armed CD19 CAR T cells: a proof-of-concept study

scientific article published on 24 May 2020

Enhanced effector responses in activated CD8+ T cells deficient in diacylglycerol kinases

scientific article published on 10 April 2013

Enhanced function of redirected human T cells expressing linker for activation of T cells that is resistant to ubiquitylation

scientific article published on 6 November 2012

Enhanced responsiveness of human memory T cells to CD2 and CD3 receptor-mediated activation

scientific article published on May 1989

Enhanced transmembrane signalling activity of monoclonal antibody heteroconjugates suggests molecular interactions between receptors on the T cell surface

scientific article published on 01 February 1989

Enhancing CAR T cell persistence through ICOS and 4-1BB costimulation.

scientific article published on 11 January 2018

Enhancing Chimeric Antigen Receptor T Cell Anti-tumor Function through Advanced Media Design

scientific article published on 09 July 2020

Enhancing T cell persistence of CAR-redirected T cells in solid tumors

scientific article published on 6 November 2014

Establishment of HIV-1 resistance in CD4+ T cells by genome editing using zinc-finger nucleases

scientific article (publication date: July 2008)

Evaluating the skin in patients undergoing chimeric antigen receptor modified T-cell therapy

scientific article published in November 2016

Evidence for distinct intracellular signaling pathways in CD34+ progenitor to dendritic cell differentiation from a human cell line model

scientific article published on March 1999

Evidence for the involvement of three distinct signals in the induction of IL-2 gene expression in human T lymphocytes.

scientific article

Ex vivo expansion of polyclonal and antigen-specific cytotoxic T lymphocytes by artificial APCs expressing ligands for the T-cell receptor, CD28 and 4-1BB.

scientific article published on February 2002

Ex vivo induction and expansion of antigen-specific cytotoxic T cells by HLA-Ig–coated artificial antigen-presenting cells

scientific article published on 21 April 2003

Ex vivo replicative potential of adult human peripheral blood CD4+ T cells

scientific article published on 01 June 1997

Examination of the inhibitory and stimulatory effects of IFN-alpha, -beta, and -gamma on human B-cell proliferation induced by various B-cell mitogens

scientific article

Expanding the Therapeutic Window for CAR T Cell Therapy in Solid Tumors: The Knowns and Unknowns of CAR T Cell Biology

article by Keisuke Watanabe et al published 26 October 2018 in Frontiers in Immunology

Expression of a functional CCR2 receptor enhances tumor localization and tumor eradication by retargeted human T cells expressing a mesothelin-specific chimeric antibody receptor

scientific article published on 24 May 2011

Expression of miR-17-92 enhances anti-tumor activity of T-cells transduced with the anti-EGFRvIII chimeric antigen receptor in mice bearing human GBM xenografts

scientific article

Expression of the human epidermal growth factor receptor in a murine T-cell hybridoma. A transmembrane protein tyrosine kinase can synergize with the T-cell antigen receptor

scientific article published on 01 March 1992

Extensive replicative capacity of human central memory T cells

scientific article published in June 2004

Fibroblast activation protein expression by stromal cells and tumor-associated macrophages in human breast cancer.

scientific article

Flow cytometric measurement of cellular ionized calcium concentration

scientific article published on January 1988

Flow cytometric measurement of intracellular ionized calcium in single cells with indo-1 and fluo-3.

scientific article published on January 1990

Flow cytometry in the evaluation of immune status in cancer and HIV infection

scientific article

GLYCAN-DIRECTED CAR-T CELLS.

scientific article published on 23 January 2018

Gene editing of CCR5 in autologous CD4 T cells of persons infected with HIV

scientific article (publication date: 6 March 2014)

Gene transfer in humans using a conditionally replicating lentiviral vector

scientific article

Gene-based immunotherapy for human immunodeficiency virus infection and acquired immunodeficiency syndrome

scientific article published on June 2006

Generating and Expanding Autologous Chimeric Antigen Receptor T Cells from Patients with Acute Myeloid Leukemia

scientific article published in January 2017

Generation and large-scale expansion of human inducible regulatory T cells that suppress graft-versus-host disease

scientific article published on 12 May 2011

Genetic engineering of T cells for adoptive immunotherapy

scientific article

Genetic therapies against HIV.

scientific article published on December 2007

Genome-Editing Technologies in Adoptive T Cell Immunotherapy for Cancer

scientific article published on 16 October 2017

Glucocorticoids suppress calcium mobilization and phospholipid hydrolysis in anti-Ig antibody-stimulated B cells.

scientific article

Going viral: chimeric antigen receptor T-cell therapy for hematological malignancies

scientific article

Growth factors can enhance lymphocyte survival without committing the cell to undergo cell division

scientific article

Gut microbiome correlates of response and toxicity following anti-CD19 CAR T cell therapy

scientific article published in 2022

Gut microbiota modulates adoptive cell therapy via CD8α dendritic cells and IL-12.

scientific article published on 22 February 2018

HIV-1-infected T cells show a selective signaling defect after perturbation of CD3/antigen receptor

scientific article published in July 1988

HLA tetramer-based artificial antigen-presenting cells for stimulation of CD4+ T cells

article

Harnessing CAR T Cell Insights to Develop Treatments for Hyperinflammatory Responses in COVID-19 patients

scientific article published on 17 April 2020

Heterogeneity among T cells in intracellular free calcium responses after mitogen stimulation with PHA or anti-CD3. Simultaneous use of indo-1 and immunofluorescence with flow cytometry

scientific article published on 01 August 1986

High-Dose Sirolimus and Immune-Selective Pentostatin plus Cyclophosphamide Conditioning Yields Stable Mixed Chimerism and Insufficient Graft-versus-Tumor Responses

scientific article

Human CD26high T cells elicit tumor immunity against multiple malignancies via enhanced migration and persistence.

scientific article published on 6 December 2017

Human CD8+ T cells do not require the polarization of lipid rafts for activation and proliferation

scientific article

Human Genome Editing in the Clinic: New Challenges in Regulatory Benefit-Risk Assessment.

scientific article published in October 2017

Human T regulatory cell therapy: take a billion or so and call me in the morning

scientific article

Human chimeric antigen receptor macrophages for cancer immunotherapy

scientific article published on 23 March 2020

Human naive and memory T lymphocytes differ in telomeric length and replicative potential

scientific article

ICOS costimulation requires IL-2 and can be prevented by CTLA-4 engagement

scientific article published on 01 April 2001

ICOS-based chimeric antigen receptors program bipolar TH17/TH1 cells

scientific article

IL-21 promotes the expansion of CD27+ CD28+ tumor infiltrating lymphocytes with high cytotoxic potential and low collateral expansion of regulatory T cells.

scientific article published on 12 February 2013

IL-5 induces a Pgp-1 (CD44) bright B cell subpopulation that is highly enriched in proliferative and Ig secretory activity and binds to hyaluronate

scientific article published on 01 December 1990

IMCT-15PILOT STUDY OF T CELLS REDIRECTED TO EGFRvIII WITH A CHIMERIC ANTIGEN RECEPTOR IN PATIENTS WITH EGFRvIII+ GLIOBLASTOMA.

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Ibrutinib enhances chimeric antigen receptor T-cell engraftment and efficacy in leukemia

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Ibrutinib treatment improves T cell number and function in CLL patients

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Identification of Predictive Biomarkers for Cytokine Release Syndrome after Chimeric Antigen Receptor T-cell Therapy for Acute Lymphoblastic Leukemia

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Identification of a Titin-derived HLA-A1-presented peptide as a cross-reactive target for engineered MAGE A3-directed T cells

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Identification of chimeric antigen receptors that mediate constitutive or inducible proliferation of T cells

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IgE secretion by Epstein-Barr virus-infected purified human B lymphocytes is stimulated by interleukin 4 and suppressed by interferon gamma

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Immunodynamics: a cancer immunotherapy trials network review of immune monitoring in immuno-oncology clinical trials

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Immunopathological aspects of Plasmodium berghei infection in five strains of mice. I. Immune complexes and other serological features during the infection

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Immunopathological aspects of Plasmodium berghei infection in five strains of mice. II. Immunopathology of cerebral and other tissue lesions during the infection

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Immunotherapy for Brain Tumors.

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Immunotherapy for Breast Cancer: Current and Future Strategies.

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Immunotherapy for Glioblastoma: Adoptive T-cell Strategies

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Immunotherapy opportunities in ovarian cancer.

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Impaired Death Receptor Signaling in Leukemia Causes Antigen-Independent Resistance by Inducing CAR T-cell Dysfunction

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Impaired induction of the apoptosis-protective protein Bcl-xL in activated PBMC from asymptomatic HIV-infected individuals

scientific article published in May 1997

Improved anti-leukemia activities of adoptively transferred T cells expressing bispecific T-cell engager in mice

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Improved detection of immune complexes in human and mouse serum using a microassay adaptation of the C1Q binding test

scientific article published on January 1, 1979

Improving CART-Cell Therapy of Solid Tumors with Oncolytic Virus-Driven Production of a Bispecific T-cell Engager

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In Vitro Induction of Human Regulatory T Cells Using Conditions of Low Tryptophan Plus Kynurenines

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In vitro-expanded human CD4(+)CD25(+) T-regulatory cells can markedly inhibit allogeneic dendritic cell-stimulated MLR cultures

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In vivo calcium elevations in thymocytes with T cell receptors that are specific for self ligands

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In vivo persistence, tumor localization, and antitumor activity of CAR-engineered T cells is enhanced by costimulatory signaling through CD137 (4-1BB)

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Increased immunogenicity of surviving tumor cells enables cooperation between liposomal doxorubicin and IL-18.

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Increases in T cell telomere length in HIV infection after antiretroviral combination therapy for HIV-1 infection implicate distinct population dynamics in CD4+ and CD8+ T cells

scientific article published on 01 July 1999

Increases in tyrosine phosphorylation are detectable before phospholipase C activation after T cell receptor stimulation

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Induction of calcium flux and enhancement of cytolytic activity in natural killer cells by cross-linking of the sheep erythrocyte binding protein (CD2) and the Fc-receptor (CD16).

scientific article published in September 1987

Induction of resistance to chimeric antigen receptor T cell therapy by transduction of a single leukemic B cell

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Inflammatory cytokines IFN-gamma plus TNF-alpha induce regulated expression of CD80 (B7-1) but not CD86 (B7-2) on murine fibroblasts

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Infusion of CD3/CD28 costimulated umbilical cord blood T cells at the time of single umbilical cord blood transplantation may enhance engraftment

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Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: safety profile and detection kinetics

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Inhibition of T cell receptor expression and function in immature CD4+CD8+ cells by CD4

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Inhibition of tyrosine phosphorylation prevents T-cell receptor-mediated signal transduction

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Intact antigen receptor-mediated calcium signals in patients with early stage HIV-1 infection

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Interferon beta adenoviral gene therapy in a patient with ovarian cancer.

scientific article published in November 2006

Intracellular ionized calcium

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Intracellular survival pathways against glutamate receptor agonist excitotoxicity in cultured neurons. Intracellular calcium responses

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Intrinsic resistance to T cell infection with HIV type 1 induced by CD28 costimulation

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Introduction to functional cell assays.

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Introduction to the reports from the National Cancer Institute First International Workshop on the Biology, Prevention, and Treatment of Relapse after Allogeneic Hematopoietic Stem Cell Transplantation.

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Ionizable Lipid Nanoparticle-Mediated mRNA Delivery for Human CAR T Cell Engineering

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Is autoimmunity the Achilles' heel of cancer immunotherapy?

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Isolation of a new herpesvirus from human CD4+ T cells

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Kinase inhibitor ibrutinib to prevent cytokine-release syndrome after anti-CD19 chimeric antigen receptor T cells for B-cell neoplasms.

scientific article published on 28 September 2016

L-Selectin(hi) but not the L-selectin(lo) CD4+25+ T-regulatory cells are potent inhibitors of GVHD and BM graft rejection

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Lack of coreceptor allows survival of chronically stimulated double-negative alpha/beta T cells: implications for autoimmunity

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Large-scale production of CD4+ T cells from HIV-1-infected donors after CD3/CD28 costimulation

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Ligand-stimulated signaling events in immature CD4+CD8+ thymocytes expressing competent T-cell receptor complexes

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Lipopolysaccharide-induced protein tyrosine phosphorylation in human macrophages is mediated by CD14

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Long-Term Outcomes From a Randomized Dose Optimization Study of Chimeric Antigen Receptor Modified T Cells in Relapsed Chronic Lymphocytic Leukemia

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Making Better Chimeric Antigen Receptors for Adoptive T-cell Therapy

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Massive ex vivo expansion of human natural regulatory T cells (T(regs)) with minimal loss of in vivo functional activity

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Measurement of CD69 induction in the assessment of immune function in asymptomatic HIV-infected individuals

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Measurement of intracellular calcium ions by flow cytometry

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Measurement of intracellular ions by flow cytometry

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Measurement of intracellular ions by flow cytometry

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Measuring IL-6 and sIL-6R in serum from patients treated with tocilizumab and/or siltuximab following CAR T cell therapy

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Meeting report: The 13th Annual Meeting of the Translational Research Cancer Centers Consortium (TrC3); Immune Suppression and the Tumor Microenvironment, Columbus, Ohio; March 1-2, 2010.

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Mesothelin expression is associated with poor outcomes in breast cancer

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Mesothelin, a novel immunotherapy target for triple negative breast cancer

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Mesothelin-specific chimeric antigen receptor mRNA-engineered T cells induce anti-tumor activity in solid malignancies.

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Mitogen-induced genes are subject to multiple pathways of regulation in the initial stages of T-cell activation

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Mitogenic stimulation of T cells reveals differing contributions for B7-1 (CD80) and B7-2 (CD86) costimulation

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Modulation of TCR-induced transcriptional profiles by ligation of CD28, ICOS, and CTLA-4 receptors

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Modulation of susceptibility to HIV-1 infection by the cytotoxic T lymphocyte antigen 4 costimulatory molecule.

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Molecular remission of CML after autotransplantation followed by adoptive transfer of costimulated autologous T cells

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Monoclonal TCR-redirected tumor cell killing.

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Monoclonal antibody-defined functional epitopes on the adhesion-promoting glycoprotein complex (CDw18) of human neutrophils

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Monosomy 1p36 uncovers a role for OX40 in survival of activated CD4+ T cells.

scientific article published on 03 June 2008

Monovalent ligands of complement receptor 2 inhibit whereas polyvalent ligands enhance anti-Ig-induced human B cell intracytoplasmic free calcium concentration

scientific article published on 01 March 1990

Multifactorial T-cell hypofunction that is reversible can limit the efficacy of chimeric antigen receptor-transduced human T cells in solid tumors

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Multiparametric magnetic resonance imaging in the assessment of anti-EGFRvIII chimeric antigen receptor T cell therapy in patients with recurrent glioblastoma

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Multiple Injections of Electroporated Autologous T Cells Expressing a Chimeric Antigen Receptor Mediate Regression of Human Disseminated Tumor

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Multiple cancer-specific antigens are targeted by a chimeric antigen receptor on a single cancer cell

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Multiple cancer-specific antigens are targeted by a chimeric antigen receptor on a single cancer cell

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Multiple mechanisms regulate c-myc gene expression during normal T cell activation.

scientific article published on September 1988

Multiplex Genome Editing to Generate Universal CAR T Cells Resistant to PD1 Inhibition

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NCI first International Workshop on the biology, prevention, and treatment of relapse after allogeneic hematopoietic stem cell transplantation: report from the committee on the biological considerations of hematological relapse following allogeneic

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NY-ESO-1-specific TCR-engineered T cells mediate sustained antigen-specific antitumor effects in myeloma.

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National Cancer Institute's First International Workshop on the Biology, Prevention, and Treatment of Relapse after Allogeneic Hematopoietic Stem Cell Transplantation: summary and recommendations from the organizing committee

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Nature of tumor control by permanently and transiently modified GD2 chimeric antigen receptor T cells in xenograft models of neuroblastoma

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Naïve and memory CD4 T cells differ in their susceptibilities to human immunodeficiency virus type 1 infection following CD28 costimulation: implicatip6s for transmission and pathogenesis.

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No T-cell tyrosine protein kinase signalling or calcium mobilization after CD4 association with HIV-1 or HIV-1 gp120

scientific article published on December 6, 1990

Noninvasive bioluminescent imaging of primary patient acute lymphoblastic leukemia: a strategy for preclinical modeling.

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Nonviral RNA chimeric antigen receptor-modified T cells in patients with Hodgkin lymphoma

scientific article published on 20 June 2018

Novel T cells with improved in vivo anti-tumor activity generated by RNA electroporation

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Novel cell and gene therapies for HIV.

scientific article published on October 2012

Novel role of phosphatidylinositol 3-kinase in CD28-mediated costimulation

scientific article published on 11 December 2000

Nucleic acid vaccine-induced immune responses require CD28 costimulation and are regulated by CTLA4

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Oncolytic Adenoviral Delivery of an EGFR-Targeting T-cell Engager Improves Antitumor Efficacy

scientific article published on 31 January 2017

Opposing Functions of Interferon Coordinate Adaptive and Innate Immune Responses to Cancer Immune Checkpoint Blockade

scientific article published on 01 August 2019

Opposing effects of CTLA4-Ig and anti-CD80 (B7-1) plus anti-CD86 (B7-2) on experimental allergic encephalomyelitis

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Optimization of cGMP purification and expansion of umbilical cord blood-derived T-regulatory cells in support of first-in-human clinical trials

scientific article published on 22 November 2016

Optimization of the PiggyBac transposon system for the sustained genetic modification of human T lymphocytes

scientific article published on October 2009

Optimized depletion of chimeric antigen receptor T cells in murine xenograft models of human acute myeloid leukemia

scientific article published on 28 February 2017

Optimizing Chimeric Antigen Receptor T-Cell Therapy for Adults With Acute Lymphoblastic Leukemia

scientific article published on 09 December 2019

Ovarian cancer chemokines may not be a significant barrier during whole tumor antigen dendritic-cell vaccine and adoptive T-cell immunotherapy

scientific article published on 19 October 2015

Overcoming the Immunosuppressive Tumor Microenvironment of Hodgkin Lymphoma Using Chimeric Antigen Receptor T Cells.

scientific article published on 2 June 2017

PD-1 blockade modulates chimeric antigen receptor (CAR)-modified T cells: refueling the CAR.

scientific article published on 28 December 2016

PI 3-kinase: a pivotal pathway in T-cell activation?

scientific article published on April 1996

Pancreatic cancer therapy with combined mesothelin-redirected chimeric antigen receptor T cells and cytokine-armed oncolytic adenoviruses.

scientific article published on 5 April 2018

Patient monitoring and follow-up in lentiviral clinical trials

scientific article published in February 2013

Persistence of long-lived plasma cells and humoral immunity in individuals responding to CD19-directed CAR T-cell therapy

scientific article published on 10 May 2016

Persistent calcium elevation correlates with the induction of surface immunoglobulin-mediated B cell DNA synthesis

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Personalized cancer vaccine effectively mobilizes antitumor T cell immunity in ovarian cancer.

scientific article published in April 2018

Perspective: assembly line immunotherapy

scientific article published in June 2013

Phase 2 clinical trial of rapamycin-resistant donor CD4+ Th2/Th1 (T-Rapa) cells after low-intensity allogeneic hematopoietic cell transplantation

scientific article published on 20 February 2013

Phase I Study of Lentiviral-Transduced Chimeric Antigen Receptor-Modified T Cells Recognizing Mesothelin in Advanced Solid Cancers

scientific article published on 30 July 2019

Phase I clinical trial of costimulated, IL-4 polarized donor CD4+ T cells as augmentation of allogeneic hematopoietic cell transplantation

scientific article published on 01 November 2006

Phase I trial of adoptive cell transfer with mixed-profile type-I/type-II allogeneic T cells for metastatic breast cancer

scientific article published on 26 September 2011

Phase I/II randomized trial of dendritic cell vaccination with or without cyclophosphamide for consolidation therapy of advanced ovarian cancer in first or second remission

scientific article published on 22 October 2011

Phase II study of intraperitoneal recombinant interleukin-12 (rhIL-12) in patients with peritoneal carcinomatosis (residual disease < 1 cm) associated with ovarian cancer or primary peritoneal carcinoma

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Phorbol esters induce differentiation of human CD34+ hemopoietic progenitors to dendritic cells: evidence for protein kinase C-mediated signaling

scientific article published on 01 April 1998

Phosphatidylinositol 3-Kinase p110δ Isoform Regulates CD8+ T Cell Responses during Acute Viral and Intracellular Bacterial Infections

scientific article published on 6 January 2016

Pilot study of prophylactic ex vivo costimulated donor leukocyte infusion after reduced-intensity conditioned allogeneic stem cell transplantation

scientific article published on 28 April 2013

Possible Compartmental Cytokine Release Syndrome in a Patient With Recurrent Ovarian Cancer After Treatment With Mesothelin-targeted CAR-T Cells

scientific article published on 23 February 2017

Post-transplant adoptive T-cell immunotherapy

scientific article published on September 2008

Potent and Broad Inhibition of HIV-1 by a Peptide from the gp41 Heptad Repeat-2 Domain Conjugated to the CXCR4 Amino Terminus

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Potential clinical applications of signal transduction measurements in marrow transplantation and HIV-1 infection

scientific article published on 01 March 1993

Potential roles of the B7 and CD28 receptor families in autoimmunity and immune evasion

scientific article published on May 1995

Preclinical targeting of human acute myeloid leukemia and myeloablation using chimeric antigen receptor-modified T cells

scientific article published on 04 March 2014

Predicting Dangerous Rides in CAR T Cells: Bridging the Gap between Mice and Humans

scientific article published on 19 May 2018

Predicting cytokine storms: it's about density

scientific article published on 01 December 2011

Preparation of clinical-grade recombinant canarypox-human immunodeficiency virus vaccine-loaded human dendritic cells

scientific article published on 7 October 2002

Primary human CD4+ T cells contain heterogeneous I kappa B kinase complexes: role in activation of the IL-2 promoter.

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Primary porcine endothelial cells express membrane-bound B7-2 (CD86) and a soluble factor that co-stimulate cyclosporin A-resistant and CD28-dependent human T cell proliferation

scientific article published on 01 July 1996

Principles of adoptive T cell cancer therapy

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Proceedings from the Second Haploidentical Stem Cell Transplantation Symposium-Haplo2014, San Francisco, California, December 4, 2014.

scientific article published on 12 January 2016

Productive infection of neonatal CD8+ T lymphocytes by HIV-1.

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Profound hypomagnesemia and renal magnesium wasting associated with the use of cyclosporine for marrow transplantation

scientific article published on 01 June 1985

Program death-1 signaling and regulatory T cells collaborate to resist the function of adoptively transferred cytotoxic T lymphocytes in advanced acute myeloid leukemia.

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Programming the next generation of dendritic cells

scientific article published on May 2007

Prolonged survival and tissue trafficking following adoptive transfer of CD4zeta gene-modified autologous CD4(+) and CD8(+) T cells in human immunodeficiency virus-infected subjects

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Protection against lethal toxic shock by targeted disruption of the CD28 gene

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Protein kinase C activation in B cells by indolactam inhibits anti-Ig-mediated phosphatidylinositol bisphosphate hydrolysis but not B cell proliferation

scientific article published on January 1990

Putting the brakes on BTLA in T cell-mediated cancer immunotherapy

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Radiation and immunotherapy: a synergistic combination.

scientific article published on July 2013

Rapamycin generates anti-apoptotic human Th1/Tc1 cells via autophagy for induction of xenogeneic GVHD

scientific article published on 16 May 2010

Rapid activation of C-Raf-1 after stimulation of the T-cell receptor or the muscarinic receptor type 1 in resting T cells

scientific article published on 01 October 1993

Rapid immune recovery and graft-versus-host disease-like engraftment syndrome following adoptive transfer of Costimulated autologous T cells.

scientific article

Rational development and characterization of humanized anti-EGFR variant III chimeric antigen receptor T cells for glioblastoma

scientific article published on February 2015

Reciprocal expression of human ETS1 and ETS2 genes during T-cell activation: regulatory role for the protooncogene ETS1

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Reducing Ex Vivo Culture Improves the Antileukemic Activity of Chimeric Antigen Receptor (CAR) T Cells

scientific article published on 20 July 2018

Regimen-specific effects of RNA-modified chimeric antigen receptor T cells in mice with advanced leukemia

scientific article published on August 2013

Regulated expression of telomerase activity in human T lymphocyte development and activation

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Regulation of 4F2 heavy-chain gene expression during normal human T-cell activation can be mediated by multiple distinct molecular mechanisms

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Regulation of TCR signaling by CD45 lacking transmembrane and extracellular domains

scientific article published on 01 April 1993

Regulation of interleukin 3 gene induction in normal human T cells

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Regulation of lymphokine messenger RNA stability by a surface-mediated T cell activation pathway

scientific article published on 01 April 1989

Regulation of telomerase RNA template expression in human T lymphocyte development and activation.

scientific article published in April 1997

Regulatory CD4(+)CD25(+) T cells in tumors from patients with early-stage non-small cell lung cancer and late-stage ovarian cancer.

scientific article published in June 2001

Regulatory T cells and cytokines in malignant pleural effusions secondary to mesothelioma and carcinoma

scientific article published on 01 March 2005

Regulatory T cells and human myeloid dendritic cells promote tolerance via programmed death ligand-1.

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Regulatory considerations for novel gene therapy products: a review of the process leading to the first clinical lentiviral vector

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Relation of clinical culture method to T-cell memory status and efficacy in xenograft models of adoptive immunotherapy

scientific article published on 16 January 2014

Remote Controlled CARs: Towards a Safer Therapy for Leukemia

scientific article published on 23 June 2016

Replication-competent retroviruses in gene-modified T cells used in clinical trials: is it time to revise the testing requirements?

scientific article published on February 2012

Response differences between human CD4(+) and CD8(+) T-cells during CD28 costimulation: implications for immune cell-based therapies and studies related to the expansion of double-positive T-cells during aging

scientific article published on September 2000

Responsiveness of fetal and adult CD4-, CD8- thymocytes to T cell activation

scientific article published on 01 April 1989

Restoration of immunity in lymphopenic individuals with cancer by vaccination and adoptive T-cell transfer.

scientific article published on 16 October 2005

Rethinking the Regulatory Infrastructure for Human Gene Transfer Clinical Trials

scientific article published on August 2016

Retroviral and Lentiviral Safety Analysis of Gene-Modified T Cell Products and Infused HIV and Oncology Patients

scientific article published on 20 October 2017

Role of B7:CD28/CTLA-4 in the induction of chronic relapsing experimental allergic encephalomyelitis

scientific article published on 01 February 1995

Role of CD2 cross-linking in cytoplasmic calcium responses and T cell activation

scientific article published in October 1988

Role of the CD28 receptor in T-cell activation

scientific article published on June 1990

SAP: natural inhibitor or grand SLAM of T cell activation?

scientific article published on 01 August 2001

SHP-1 and SHP-2 associate with immunoreceptor tyrosine-based switch motif of programmed death 1 upon primary human T cell stimulation, but only receptor ligation prevents T cell activation

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Safety and Efficacy of Intratumoral Injections of Chimeric Antigen Receptor (CAR) T Cells in Metastatic Breast Cancer

scientific article published on 6 November 2017

Safety, tumor trafficking and immunogenicity of chimeric antigen receptor (CAR)-T cells specific for TAG-72 in colorectal cancer

scientific article published on 21 March 2017

Selective killing of malignant B cells using T cells redirected against malignancy variant receptor

scientific article published on 6 November 2014

Serial Killers and Mass Murderers: Engineered T Cells Are up to the Task

scientific article published on 01 May 2015

Signal transduction by B and T cells early after bone marrow transplantation: B cell calcium flux responses are intact whereas lack of CD4 cells accounts for impaired T cell responses

scientific article published on 01 July 1995

Signal transduction in T cells

scientific article published on June 1, 1991

Signal transduction properties of the T cell activation monoclonal antibody panel: ubiquitous increase in cellular substrate tyrosine phosphorylation in the absence of detectable calcium mobilization

scientific article published on 01 October 1996

Signal transduction through CD4 receptors: stimulatory vs. inhibitory activity is regulated by CD4 proximity to the CD3/T cell receptor

scientific article published on 01 April 1988

Simultaneous zinc-finger nuclease editing of the HIV coreceptors ccr5 and cxcr4 protects CD4+ T cells from HIV-1 infection.

scientific article published on 25 October 2013

Single residue in CD28-costimulated CAR T cells limits long-term persistence and antitumor durability

scientific article published on 18 February 2020

Single-Cell Analyses Identify Brain Mural Cells Expressing CD19 as Potential Off-Tumor Targets for CAR-T Immunotherapies

scientific article published on 11 September 2020

Single-cell antigen-specific landscape of CAR T infusion product identifies determinants of CD19-positive relapse in patients with ALL

scientific article published on 08 June 2022

Sleeping Beauty transposon-mediated engineering of human primary T cells for therapy of CD19+ lymphoid malignancies

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Stable gene transfer and expression in human primary T cells by the Sleeping Beauty transposon system

scientific article published on 27 September 2005

Stimulation of CD5 enhances signal transduction by the T cell antigen receptor

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Stimulation of T cells through the CD3/T-cell receptor complex: role of cytoplasmic calcium, protein kinase C translocation, and phosphorylation of pp60c-src in the activation pathway

scientific article published on February 1987

Stimulation of the antigen receptor complex leads to transcriptional activation of the c-myc gene in normal human T cells

scientific article published on 01 January 1988

Studying Immunoreceptor Signaling in Human T Cells Using Electroporation of In Vitro Transcribed mRNA.

scientific article published in January 2017

Suppression of HIV-1 infection in primary CD4 T cells transduced with a self-inactivating lentiviral vector encoding a membrane expressed gp41-derived fusion inhibitor

scientific article published on April 2005

Suppressor function of umbilical cord blood-derived CD4+CD25+ T-regulatory cells exposed to graft-versus-host disease drugs

scientific article published on 01 July 2006

Surface immunoglobulin-mediated B-cell activation in the absence of detectable elevations in intracellular ionized calcium: a model for T-cell-independent B-cell activation

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T cell engineering as therapy for cancer and HIV: our synthetic future

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T cells coactivated with immobilized anti-CD3 and anti-CD28 as potential immunotherapy for cancer

scientific article published on 01 July 1999

T cells expressing chimeric antigen receptors can cause anaphylaxis in humans.

scientific article published on July 2013

T cells targeting NY-ESO-1 demonstrate efficacy against disseminated neuroblastoma

scientific article published on 12 August 2015

T cells with chimeric antigen receptors have potent antitumor effects and can establish memory in patients with advanced leukemia

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T-cell activation is required for efficient replication of human herpesvirus 6.

scientific article published on September 1990

T-cell immunotherapy: looking forward

scientific article published on September 2014

T-cell phenotypes associated with effective CAR T-cell therapy in postinduction vs relapsed multiple myeloma

scientific article published on 01 October 2019

T-cell proliferation involving the CD28 pathway is associated with cyclosporine-resistant interleukin 2 gene expression

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T-cell reconstitution and expansion after hematopoietic stem cell transplantation: 'T' it up!

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T-cell therapy at the threshold

scientific article published on 10 July 2012

T-cell-targeted immunotherapy

scientific article published on 01 March 1992

TRANCE- and CD40 ligand-matured dendritic cells reveal MHC class I-restricted T cells specific for autologous tumor in late-stage ovarian cancer patients.

scientific article published on April 2003

Tales of tails: regulation of telomere length and telomerase activity during lymphocyte development, differentiation, activation, and aging

scientific article published on December 1997

Targeting HER-2/neu in early breast cancer development using dendritic cells with staged interleukin-12 burst secretion.

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Targeting cardiac fibrosis with engineered T cells

scientific article published on 11 September 2019

Targeting fibroblast activation protein in tumor stroma with chimeric antigen receptor T cells can inhibit tumor growth and augment host immunity without severe toxicity

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Tat-functionalized near-infrared emissive polymersomes for dendritic cell labeling

scientific article published on January 2007

Telomere length, telomerase activity, and replicative potential in HIV infection: analysis of CD4+ and CD8+ T cells from HIV-discordant monozygotic twins

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The 4F2 heavy chain gene: a molecular model of inducible gene expression in human T cells

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The Addition of the BTK Inhibitor Ibrutinib to Anti-CD19 Chimeric Antigen Receptor T Cells (CART19) Improves Responses against Mantle Cell Lymphoma.

scientific article published on 27 January 2016

The B7 and CD28 receptor families

scientific article published on July 1, 1994

The CD28 and CTLA-4 receptor family

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The CD28 family: a T-cell rheostat for therapeutic control of T-cell activation.

scientific article published on 7 September 2004

The CD28 signaling pathway regulates glucose metabolism

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The CD45 tyrosine phosphatase regulates phosphotyrosine homeostasis and its loss reveals a novel pattern of late T cell receptor-induced Ca2+ oscillations

scientific article published on September 1, 1992

The CPT1a inhibitor, etomoxir induces severe oxidative stress at commonly used concentrations.

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The IgV domain of human B7-2 (CD86) is sufficient to co-stimulate T lymphocytes and induce cytokine secretion

The NFAT-1 DNA binding complex in activated T cells contains Fra-1 and JunB.

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The Ovarian Cancer Chemokine Landscape Is Conducive to Homing of Vaccine-Primed and CD3/CD28-Costimulated T Cells Prepared for Adoptive Therapy.

scientific article published on 23 February 2015

The PDL1-PD1 axis converts human TH1 cells into regulatory T cells

scientific article published on November 2011

The Principles of Engineering Immune Cells to Treat Cancer

scientific article published on February 2017

The Safety of Bridging Radiation with Anti-BCMA CAR T-Cell Therapy for Multiple Myeloma

scientific article published on 15 September 2021

The cytological features of CAR(T) cells

scientific article published on 9 September 2016

The genomic organization of the CD28 gene. Implications for the regulation of CD28 mRNA expression and heterogeneity

scientific article published on July 1990

The inducible costimulator (ICOS) is critical for the development of human T(H)17 cells.

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The promise of T-lymphocyte immunotherapy for the treatment of malignant disease

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The protein tyrosine kinase inhibitor herbimycin A, but not genistein, specifically inhibits signal transduction by the T cell antigen receptor

scientific article published in November 1992

The road to recovery: translating PD-1 biology into clinical benefit

scientific article published on 22 December 2006

The role of co-stimulation in regulation of chemokine receptor expression and HIV-1 infection in primary T lymphocytes

scientific article published in June 1998

Time-dependent cytotoxic drugs selectively cooperate with IL-18 for cancer chemo-immunotherapy.

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Tisagenlecleucel Model-Based Cellular Kinetic Analysis of Chimeric Antigen Receptor-T Cells.

scientific article published on 7 March 2019

Tisagenlecleucel in Children and Young Adults with B-Cell Lymphoblastic Leukemia.

scientific article published in February 2018

Toward synthetic biology with engineered T cells: a long journey just begun

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Toxic shock syndrome toxin-1-induced death is prevented by CTLA4Ig

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Transcription of T cell antigen receptor genes is induced by protein kinase C activation

scientific article published on 01 September 1988

Transdifferentiation of lymphoma into sarcoma associated with profound reprogramming of epigenome

scientific article published on 09 June 2020

Transfer of influenza vaccine-primed costimulated autologous T cells after stem cell transplantation for multiple myeloma leads to reconstitution of influenza immunity: results of a randomized clinical trial.

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Transforming growth factor-beta receptor blockade augments the effectiveness of adoptive T-cell therapy of established solid cancers

scientific article published on June 2008

Treatment of advanced leukemia in mice with mRNA engineered T cells

scientific article published on 23 September 2011

Treatment of leukemia antigen-loss relapses occurring after CD19-targeted immunotherapies by combination of anti-CD123 and anti-CD19 chimeric antigen receptor T cells.

scientific article published on 4 November 2015

Trispecific antibodies offer a third way forward for anticancer immunotherapy

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Tumor Expression of 4-1BB Ligand Sustains Tumor Lytic T Cells

scientific article published on September 1, 2003

Tumor-Promoting Desmoplasia Is Disrupted by Depleting FAP-Expressing Stromal Cells.

scientific article published on 15 May 2015

Tumor-associated macrophages as a source of functional dendritic cells in ovarian cancer patients

scientific article published on 01 March 2002

Two distinct mechanisms of interleukin-2 gene expression in human T lymphocytes

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Tyrosine kinase-regulated and inositol phosphate-independent Ca2+ elevation and mobilization in T cells

scientific article published on 01 April 1992

UV irradiation of lymphocytes triggers an increase in intracellular Ca2+ and prevents lectin-stimulated Ca2+ mobilization: evidence for UV- and nifedipine-sensitive Ca2+ channels

scientific article published on September 1, 1991

Umbilical cord blood regulatory T-cell expansion and functional effects of tumor necrosis factor receptor family members OX40 and 4-1BB expressed on artificial antigen-presenting cells

scientific article published on 21 July 2008

Umbilical cord blood xenografts in immunodeficient mice reveal that T cells enhance hematopoietic engraftment beyond overcoming immune barriers by stimulating stem cell differentiation.

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Umbilical cord blood-derived T regulatory cells to prevent GVHD: kinetics, toxicity profile, and clinical effect

scientific article published on 12 November 2015

Use of cell-based therapies for modification of host immune responses.

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Valency of CD3 binding and internalization of the CD3 cell-surface complex control T cell responses to second signals: distinction between effects on protein kinase C, cytoplasmic free calcium, and proliferation

scientific article published on 01 June 1986

Variations in thymocyte susceptibility to clonal deletion during ontogeny. Implications for neonatal tolerance

scientific article published on July 15, 1991

Very-low-dose streptozotocin induces diabetes in insulin promoter-mB7-1 transgenic mice

scientific article published on 01 July 1995

Voices of biotech

scientific article published on March 2016

Zoom Zoom: racing CARs for multiple myeloma

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cis-acting sequences required for inducible interleukin-2 enhancer function bind a novel Ets-related protein, Elf-1.

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iGUIDE: an improved pipeline for analyzing CRISPR cleavage specificity

miR-146b antagomir-treated human Tregs acquire increased GVHD inhibitory potency

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