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List of works by Darrell Abernethy

A 2012 Workshop: Vaccine and Drug Ontology in the Study of Mechanism and Effect (VDOSME 2012).

scientific article published on 18 December 2012

A Drug Burden Index to Define the Functional Burden of Medications in Older People

scientific article published on 01 April 2007

A pilot randomized clinical trial utilizing the drug burden index to reduce exposure to anticholinergic and sedative medications in older people

scientific article

Abciximab pharmacodynamic model with neural networks used to integrate sources of patient variability

scientific article published on January 2004

Absolute and relative bioavailability of oral acetaminophen preparations.

scientific article

Absorption and disposition of ibuprofen in the elderly

scientific article published on 01 September 1984

Acetaminophen kinetics in the elderly

scientific article published on 01 February 1982

Advice on statistical analysis, and new journal guidance for experimental design and analysis.

scientific article published in February 2015

Age and gender effects on chlordiazepoxide kinetics: relation to antipyrine disposition

scientific article published on 01 January 1989

Age does not alter acetaminophen absorption

scientific article published on 01 April 1982

Age, sex, and nitrazepam kinetics: relation to antipyrine disposition.

scientific article

Alprazolam kinetics in the elderly. Relation to antipyrine disposition

scientific article published on 01 March 1983

Alterations in drug distribution and clearance due to obesity ⬇️

scientific article published on June 1, 1981

An investigation of the cause of accumulation of verapamil during regular dosing in patients

scientific article

Analysis of functional signaling domains from fluorescence imaging and the two-dimensional continuous wavelet transform.

scientific article

Antipyretic analgesic drugs as models for studies of drug disposition in old age

scientific article published on 01 November 1983

Antipyrine kinetics in patients with primary biliary cirrhosis

scientific article published on 01 January 1993

Antipyrine kinetics in the elderly: prediction of age-related changes in benzodiazepine oxidizing capacity

scientific article published on 01 January 1982

Anxiolytic drug therapy in patients with medical disease: clinical importance of pharmacokinetic drug interactions

scientific article published on January 1, 1984

Atherosclerosis-related molecular alteration of the human CaV1.2 calcium channel alpha1C subunit

scientific article

Benzodiazepine drug-drug interactions commonly occurring in clinical practice

scientific article published on 01 January 1984

Benzodiazepine hypnotic metabolism: drug interactions and clinical implications

scientific article published in January 1986

Benzodiazepine hypnotics: kinetic and therapeutic options.

scientific article published in January 1982

Benzodiazepine kinetics: implications for therapeutics and pharmacogeriatrics

scientific article published on January 1983

Caffeine disposition in obesity

scientific article

Caloric restriction and intermittent fasting alter spectral measures of heart rate and blood pressure variability in rats

scientific article

Caloric restriction reduces age-related pseudocapillarization of the hepatic sinusoid

scientific article published on 3 January 2007

Cerebrospinal fluid uptake and peripheral distribution of centrally acting drugs: relation to lipid solubility

scientific article published on 01 June 1985

Cimetidine disposition in obesity

scientific article published on 01 February 1984

Cimetidine impairs clearance of antipyrine and desmethyldiazepam in the elderly

scientific article published on 01 November 1982

Cimetidine impairs nitrazepam clearance

scientific article

Clinical Pharmacokinetics of the Newer Benzodiazepines

scientific article published on May 1, 1983

Clinical importance of the interaction of diazepam and cimetidine

scientific article published in June 1984

Close correlation of acetaminophen clearance with that of conjugated benzodiazepines but not oxidized benzodiazepines

scientific article published on 01 January 1983

Comparative molecular field analysis of the binding of the stereoisomers of fenoterol and fenoterol derivatives to the beta2 adrenergic receptor.

scientific article

Comparison in young and elderly patients of pharmacodynamics and disposition of labetalol in systemic hypertension

scientific article published on 01 September 1987

Determination of Ro 15-1788, a benzodiazepine antagonist, in human plasma by gas-liquid chromatography with nitrogen-phosphorus detection. Application to single-dose pharmacokinetic studies

scientific article published on 01 January 1983

Diazepam Kinetics in Relation to Age and Sex ⬇️

scientific article published on January 1, 1981

Diazepam kinetics in patients with renal insufficiency or hyperthyroidism ⬇️

scientific article published on December 1, 1981

Differential effect of cimetidine on drug oxidation (antipyrine and diazepam) vs. conjugation (acetaminophen and lorazepam): prevention of acetaminophen toxicity by cimetidine

scientific article published in March 1983

Differential effects of isoniazid and oral contraceptive steroids on antipyrine oxidation and acetaminophen conjugation

scientific article published on 01 January 1984

Differential role of the alpha1C subunit tails in regulation of the Cav1.2 channel by membrane potential, beta subunits, and Ca2+ ions

scientific article published on 25 January 2005

Digoxin disposition in obesity: Clinical pharmacokinetic investigation ⬇️

scientific article published on 01 October 1981

Diltiazem and desacetyldiltiazem analysis in human plasma using high-performance liquid chromatography: improved sensitivity without derivation

Diltiazem treatment impairs hepatic drug oxidation: studies of antipyrine

scientific article published on 01 August 1986

Diphenhydramine determination in human plasma by gas-liquid chromatography using nitrogen-phosphorus detection: application to single low-dose pharmacokinetic studies

scientific article published in August 1983

Dose-independent pharmacokinetics of intravenous lidocaine in humans

scientific article published in April 1983

Doxepin-cimetidine interaction: increased doxepin bioavailability during cimetidine treatment

scientific article published on 01 February 1986

Drug Burden Index and Its Association With Hip Fracture Among Older Adults: A National Population-Based Study

scientific article published on 01 June 2019

Drug Burden Index and physical function in older Australian men.

scientific article published on July 2009

Drug Burden Index for International Assessment of the Functional Burden of Medications in Older People

scientific article published on 01 April 2014

Drug Burden and its Association with Falls Among Older Adults in New Zealand: A National Population Cross-Sectional Study

scientific article published on 8 December 2017

Drug burden index and beers criteria: impact on functional outcomes in older people living in self-care retirement villages

scientific article published in February 2012

Drug burden index score and functional decline in older people

scientific article published on December 2009

Drug disposition in obese humans. An update

scientific article

Drug therapy. Current status of benzodiazepines

scientific article published on August 1983

Drug therapy. Current status of benzodiazepines

scientific article

Effect of age, gender, and obesity on midazolam kinetics.

scientific article published in July 1984

Effect of angiotensin-converting enzyme insertion/deletion polymorphism DD genotype on high-frequency heart rate variability in African Americans

scientific article published on December 2003

Effect of food on acetaminophen absorption in young and elderly subjects.

scientific article published in November 1982

Effect of obesity on the pharmacokinetics of drugs in humans

scientific article published on January 2010

Effect of penbutolol on lidocaine kinetics.

scientific article

Effects of desmethyldiazepam on diazepam kinetics: a study of effects of a metabolite on parent drug disposition

scientific article published in June 1981

Effects of endothelial nitric oxide synthase gene polymorphisms on platelet function, nitric oxide release, and interactions with estradiol

scientific article published in July 2002

Effects of the physical work environment on physiological measures of stress.

scientific article

Enantioselective separation and online affinity chromatographic characterization of R,R- and S,S-fenoterol

scientific article

Enhanced glucuronide conjugation of drugs in obesity: studies of lorazepam, oxazepam, and acetaminophen

scientific article published on 01 June 1983

Exendin-4 pharmacodynamics: insights from the hyperglycemic clamp technique

scientific article

Finding the right research question: quality science depends on quality careers

scientific article published on 09 July 2008

HPLC-atmospheric pressure chemical ionization mass spectrometric method for enantioselective determination of R,S-propranolol and R,S-hyoscyamine in human plasma

scientific article

Haloperidol determination in serum and cerebrospinal fluid using gas--liquid chromatography with nitrogen--phosphorus detection: application to pharmacokinetic studies

scientific article published on 01 April 1984

High-performance liquid chromatographic determination of acetaminophen in plasma: single-dose pharmacokinetic studies

scientific article published on 01 November 1981

High-risk prescribing and incidence of frailty among older community-dwelling men.

scientific article published in February 2012

IN VITRO QUANTITATION OF BENZODIAZEPINE LIPOPHILICITY: RELATION TO IN VIVO DISTRIBUTION

scientific article published on 01 October 1983

IUPHAR International geriatric clinical pharmacology curriculum for medical students

scientific article published on 17 January 2019

Ibuprofen disposition in obese individuals

Ibuprofen does not impair antipyrine clearance

scientific article published on 01 November 1983

Identification of plasma membrane macro- and microdomains from wavelet analysis of FRET microscopy

scientific article

Imipramine and desipramine disposition in the elderly

scientific article published on 01 January 1985

Imipramine disposition in users of oral contraceptive steroids

scientific article published on 01 June 1984

Imipramine-cimetidine interaction: impairment of clearance and enhanced absolute bioavailability

scientific article published on 01 June 1984

Impairment of Lidocaine Clearance in Elderly Male Subjects ⬇️

scientific article published on November 1, 1983

Impairment of antipyrine metabolism by low-dose oral contraceptive steroids

scientific article published on 01 January 1981

Impairment of caffeine clearance by chronic use of low-dose oestrogen-containing oral contraceptives

scientific article published in January 1985

Impairment of diazepam metabolism by low-dose estrogen-containing oral-contraceptive steroids

scientific article published in April 1982

Impairment of hepatic drug oxidation by propoxyphene

scientific article published on 01 August 1982

Improved liquid chromatographic analysis of phenytoin and salicylate using radial compression separation

scientific article published on 01 July 1983

In Memoriam: David A. Flockhart, 1952-2015

scientific article published on 26 February 2016

In vitro correlates of benzodiazepine cerebrospinal fluid uptake, pharmacodynamic action and peripheral distribution

scientific article

Increased cimetidine clearance in burn patients

scientific article published on 01 March 1985

Increased metabolic clearance of acetaminophen with oral contraceptive use

scientific article published on 01 September 1982

Influence of age, gender, and obesity on salicylate kinetics following single doses of aspirin

scientific article published on 01 August 1986

Influence of oral contraceptive use and cigarette smoking, alone and together, on antipyrine pharmacokinetics

scientific article published on 01 May 1997

Interaction of Cimetidine with Oxazepam, Lorazepam, and Flurazepam ⬇️

scientific article published on 01 April 1984

Interaction of cimetidine with the triazolobenzodiazepines alprazolam and triazolam

scientific article published on 01 January 1983

Interaction of propoxyphene with diazepam, alprazolam and lorazepam

scientific article

Is Volume of Distribution at Steady State a Meaningful Kinetic Variable? ⬇️

scientific article published on August 1, 1983

Ketoconazole does not impair antipyrine clearance in humans

scientific article published on 01 May 1986

Kinetics of low-dose intravenous antipyrine: use of liquid chromatography

scientific article published on 01 February 1983

Kinetics, brain uptake, and receptor binding characteristics of flurazepam and its metabolites

scientific article

Kullback-Leibler clustering of continuous wavelet transform measures of heart rate variability.

scientific article published in January 2004

Labetalol in the treatment of hypertension in elderly and younger patients

scientific article published on 01 November 1987

Lack of interaction between verapamil and cimetidine

scientific article published in September 1985

Lidocaine determination in human plasma with application to single low-dose pharmacokinetic studies

scientific article published on 01 October 1982

Lidocaine disposition in obesity

scientific article published in April 1984

Linking MedDRA(®)-Coded Clinical Phenotypes to Biological Mechanisms by the Ontology of Adverse Events: A Pilot Study on Tyrosine Kinase Inhibitors.

scientific article published on 22 March 2016

Logic-Based and Cellular Pharmacodynamic Modeling of Bortezomib Responses in U266 Human Myeloma Cells

scientific article

Lorazepam analysis using liquid chromatography: improved sensitivity for single-dose pharmacokinetic studies

scientific article published on 01 July 1986

Lorazepam and oxazepam kinetics in women on low-dose oral contraceptives

scientific article published on 01 May 1983

Mapping the dose-effect relationship of orbofiban from sparse data with an artificial neural network.

scientific article

Measures of drug toxicity in older adults

scientific article published on 01 September 2008

Method for the determination of 5,5-diphenylbarbituric acid and its separation from 1,3-dimethoxymethyl-5,5-diphenylbarbituric acid in plasma by high-performance liquid chromatography ⬇️

scientific article published on June 12, 1998

Methodologic factors influencing plasma binding of alpha-1-acid glycoprotein-bound and albumin-bound drugs

scientific article published in October 1985

Methods for the determination of lorazepam and chlordiazepoxide and metabolites in brain tissue. A comparison with plasma concentrations in the rat

scientific article published on 01 October 1983

Molecular basis of cardiovascular drug metabolism: implications for predicting clinically important drug interactions

scientific article

New short splice variants of the human cardiac Cavbeta2 subunit: redefining the major functional motifs implemented in modulation of the Cav1.2 channel

scientific article

Noninteraction of temazepam and cimetidine

scientific article published on 01 March 1984

Obesity effects on nitrazepam disposition

scientific article

Obesity, sex, and acetaminophen disposition

scientific article published on 01 June 1982

Paracetamol absorption from a feeding jejunostomy

scientific article published in July 1986

Pharmacodynamic profile of short-term readministration of abciximab in healthy subjects

scientific article published on 01 January 2002

Pharmacodynamics of abciximab during angioplasty: comparison to healthy subjects

scientific article published on 01 March 2002

Pharmacoepidemiology in the postmarketing assessment of the safety and efficacy of drugs in older adults

scientific article published on 08 June 2011

Pharmacokinetic aspects of drug therapy in the elderly

scientific article published on 01 January 1986

Pharmacokinetic properties of benzodiazepine hypnotics

scientific article published on April 1, 1983

Pharmacokinetic studies on Ro 15-1788, a benzodiazepine receptor ligand, in the brain of the rat.

scientific article published in January 1984

Pharmacokinetics and dynamics of (+/-)-verapamil in lean and obese Zucker rats

scientific article published on 01 August 1986

Pharmacokinetics and pharmacodynamics of enalapril in patients with congestive heart failure and patients with hypertension

scientific article published on 01 July 1985

Pharmacokinetics of Benzodiazepine Hypnotics ⬇️

scientific article published on January 1, 1983

Pharmacokinetics of alprazolam

scientific article published on 01 August 1983

Pharmacokinetics of benzodiazepine hypnotics

scientific article published on January 1, 1982

Pharmacokinetics of calcium antagonists under development

scientific article published on July 1988

Pharmacokinetics of drugs in obesity

scientific article published on March 1982

Pharmacokinetics, Central Nervous System Uptake, and Lipid Solubility of Propranolol, Acebutolol, and Sotalol ⬇️

scientific article published on January 1, 1984

Pharmacologic properties of acebutolol: relationship of hydrophilicity to central nervous system penetration

scientific article

Pharmacotherapy in Older Adults with Cardiovascular Disease: Report from an American College of Cardiology, American Geriatrics Society, and National Institute on Aging Workshop

scientific article published on 07 December 2018

Phenytoin disposition in obesity. Determination of loading dose

scientific article published on 01 May 1985

Physical and cognitive performance and burden of anticholinergics, sedatives, and ACE inhibitors in older women

scientific article published on 22 August 2007

Physiologic changes in old age: relation to altered drug disposition

scientific article published on 01 November 1982

Physiological pharmacokinetics and pharmacodynamics of (+/-)-verapamil in female rats

scientific article published on 01 May 1987

Plasma levels of trazodone: methodology and applications

scientific article published on 01 January 1984

Plasma protein binding of drugs after severe burn injury

scientific article published in April 1984

Potentially toxic serum lidocaine concentrations following spray anesthesia for bronchoscopy

scientific article published in April 1983

Prolongation of drug half-life due to obesity: studies of desmethyldiazepam (clorazepate).

scientific article published in August 1982

Prolonged accumulation of diazepam in obesity

scientific article published in August 1983

Ranitidine does not impair oxidative or conjugative metabolism: noninteraction with antipyrine, diazepam, and lorazepam

scientific article published in February 1984

Reduced Distribution and Clearance of Acetaminophen in Patients with Congestive Heart Failure ⬇️

scientific article published on 01 July 1983

Reduced clearance of triazolam in old age: relation to antipyrine oxidizing capacity ⬇️

scientific article published on March 1, 1983

Reducing Drugs in Older Adults Is More ⬇️

scientific article published on 01 May 2011

Replication - why we need to publish our findings

scientific article published on 24 July 2015

Responses to intravenous and oral diltiazem in elderly and younger patients with systemic hypertension

scientific article published on 01 May 1987

Revision of instructions to authors for pharmacology research and perspectives: enhancing the quality and transparency of published work

scientific article published in March 2015

Serum haloperidol concentrations and clinical response in acute psychosis

scientific article published on 01 December 1984

Simultaneous Modeling of Abciximab Plasma Concentrations and ex Vivo Pharmacodynamics in Patients Undergoing Coronary Angioplasty ⬇️

scientific article published on October 8, 2003

Simultaneous determination of lidocaine and its deethylated metabolites using gas-liquid chromatography with nitrogen-phosphorus detection

scientific article published on 01 April 1984

Steady state verapamil tissue distribution in the dog: differing tissue accumulation

scientific article published on 01 January 1986

Stereochemistry of an agonist determines coupling preference of beta2-adrenoceptor to different G proteins in cardiomyocytes

scientific article published on 07 October 2008

Structure-functional diversity of human L-type Ca2+ channel: perspectives for new pharmacological targets

scientific article

Thalidomide does not alter the pharmacokinetics of ethinyl estradiol and norethindrone

scientific article published on 01 December 1998

The Influence of Obesity on the Pharmacokinetics of Oral Alprazolam and Triazolam

scientific article published on 01 March 1984

The concept of geriatric clinical pharmacology. Panel I: The ideal training program

scientific article published in December 1987

The effect of propylene glycol on antipyrine clearance in humans

scientific article published on 01 May 1987

The pharmacokinetics of diazepam and desmethyldiazepam in rat brain and plasma

scientific article published on January 1986

The pharmacokinetics of midazolam in chronic renal failure patients

scientific article published in November 1983

Ticlopidine inhibition of phenytoin metabolism mediated by potent inhibition of CYP2C19*

scientific article published on 01 November 1997

Ticlopidine inhibits phenytoin clearance

Treatment of Diazepam Withdrawal Syndrome with Propranolol

scientific article published on March 1, 1981

Triazolam and ethanol interaction: kinetic and dynamic consequences

scientific article published in May 1985

Tricyclic Antidepressant Determination in Human Plasma by Gas-Liquid Chromatography Using Nitrogen-Phosphorous Detection: Application to Single-Dose Pharmacokinetic Studies ⬇️

scientific article published on 01 January 1981

Trimipramine kinetics and absolute bioavailability: use of gas-liquid chromatography with nitrogen-phosphorus detection

scientific article published on 01 March 1984

Use of Biomedical Ontologies for Integration of Biological Knowledge for Learning and Prediction of Adverse Drug Reactions.

scientific article

Use of internet search logs to evaluate potential drug adverse events.

scientific article published in August 2014

Use of wavelet and fast Fourier transforms in pharmacodynamics

scientific article published on December 2006

Verapamil and norverapamil determination in human plasma by gas-liquid chromatography using nitrogen-phosphorus detection: application to single-dose pharmacokinetic studies

scientific article published on January 1984

Verapamil pharmacodynamics and disposition in obese hypertensive patients

scientific article published on 01 February 1988

Verapamil pharmacodynamics and disposition in young and elderly hypertensive patients. Altered electrocardiographic and hypotensive responses

scientific article published on September 1986

Verapamil pharmacokinetics

scientific article

Voltage-gated mobility of the Ca2+ channel cytoplasmic tails and its regulatory role

scientific article published on 06 December 2002

Voltage-gated rearrangements associated with differential beta-subunit modulation of the L-type Ca(2+) channel inactivation

scientific article

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