List of works by Manfred T. Reetz

1-Butanol as a Solvent for Efficient Extraction of Polar Compounds from Aqueous Medium: Theoretical and Practical Aspects

scientific article published on 02 July 2018

A Method for High-Throughput Screening of Enantioselective Catalysts

scientific article published on 01 June 1999

A New Catalyst System for the Heck Reaction of Unreactive Aryl Halides

scientific article published on 01 March 1998

A New Type of Stereoselectivity in Baeyer-Villiger Reactions: Access toE- andZ-Olefins

scientific article published on 7 January 2013

A cell-based adrenaline assay for automated high-throughput activity screening of epoxide hydrolases

scientific article

A genetic selection system for evolving enantioselectivity of enzymes

scientific article

A high-throughput NMR-based ee-assay using chemical shift imaging

scientific article published on 14 May 2004

A light-driven stereoselective biocatalytic oxidation.

scientific article published on January 2007

A machine learning approach for reliable prediction of amino acid interactions and its application in the directed evolution of enantioselective enzymes

scientific article published in Scientific Reports

A new principle in combinatorial asymmetric transition-metal catalysis: mixtures of chiral monodentate P ligands

scientific article

A practical high-throughput screening system for enantioselectivity by using FTIR spectroscopy

A redox-mediated Kemp eliminase

scientific article published on 28 March 2017

A robust protein host for anchoring chelating ligands and organocatalysts

scientific article

A screening system for enantioselective enzymes based on differential cell growth

scientific article

A thermostable variant of P. aeruginosa cold-adapted LipC obtained by rational design and saturation mutagenesis

article published in 2012

Achieving regio- and enantioselectivity of P450-catalyzed oxidative CH activation of small functionalized molecules by structure-guided directed evolution

scientific article published on 18 June 2012

Addressing the numbers problem in directed evolution

scientific article

Alternate-site enzyme promiscuity

scientific article published on 01 January 2007

An Artificial Metalloenzyme: Creation of a Designed Copper Binding Site in a Thermostable Protein

scientific article published on 01 July 2010

An efficient catalyst system for the asymmetric transfer hydrogenation of ketones: remarkably broad substrate scope

scientific article published in February 2006

An overview of high-throughput screening systems for enantioselective enzymatic transformations

Analysis of Enantioselective Biotransformations Using a Few Hundred Cells on an Integrated Microfluidic Chip.

scientific article published on 29 January 2016

Artificial cysteine-lipases with high activity and altered catalytic mechanism created by laboratory evolution

scientific article published on 19 July 2019

Artificial metalloenzymes as catalysts in stereoselective Diels-Alder reactions

scientific article published on 18 June 2012

Assembly of Designed Oligonucleotides: a useful tool in synthetic biology for creating high-quality combinatorial DNA libraries.

scientific article

Assembly of designed oligonucleotides as an efficient method for gene recombination: a new tool in directed evolution

scientific article

Asymmetric hydrogenation of quinolines catalyzed by iridium complexes of BINOL-derived diphosphonites

scholarly article by Manfred T. Reetz & Xiaoguang Li published 2006 in Chemical Communications

BINOL-derived N-phosphino sulfoximines as ligands for asymmetric catalysis

Beating Bias in the Directed Evolution of Proteins: Combining High-Fidelity on-Chip Solid-Phase Gene Synthesis with Efficient Gene Assembly for Combinatorial Library Construction

scientific article published on 24 November 2017

Binding of phage displayed Bacillus subtilis lipase A to a phosphonate suicide inhibitor

scientific article

Binol-derived monodentate phosphites and phosphoramidites with phosphorus stereogenic centers: novel ligands for transition-metal catalysis

scientific article published on 01 January 2005

Biocatalysis in ionic liquids: batchwise and continuous flow processes using supercritical carbon dioxide as the mobile phase

Biocatalysis in ionic liquids: batchwise and continuous flow processes using supercritical carbon dioxide as the mobile phase

Biocatalysis in organic chemistry and biotechnology: past, present, and future

scientific article published on 20 August 2013

Biocatalysis: Chiral cascades

scientific article published on 01 December 2015

Biocatalysts for the pharmaceutical industry created by structure-guided directed evolution of stereoselective enzymes.

scientific article

Biocatalytic route to chiral acyloins: P450-catalyzed regio- and enantioselective α-hydroxylation of ketones

scientific article published on 23 December 2014

Bioorthogonal Enzymatic Activation of Caged Compounds.

scientific article published on 10 September 2015

Biophysical characterization of mutants ofBacillus subtilislipase evolved for thermostability: Factors contributing to increased activity retention

scientific article

Boosting the efficiency of site-saturation mutagenesis for a difficult-to-randomize gene by a two-step PCR strategy.

scientific article

CH-activating oxidative hydroxylation of 1-tetralones and related compounds with high regio- and stereoselectivity

scientific article published on 01 November 2014

Changing the enantioselectivity of enzymes by directed evolution

article published in 2004

Chemical and Biocatalytic Routes to Arbutin †

scientific article published on 11 September 2019

Chemo- and Regioselective Dihydroxylation of Benzene to Hydroquinone Enabled by Engineered Cytochrome P450 Monooxygenase

scientific article published on 04 December 2018

Chiral diphosphites and diphosphoramidites as cheap and efficient ligands in Rh-catalyzed asymmetric olefin hydrogenation

scientific article published on 02 May 2006

Clarifying the Difference between Iterative Saturation Mutagenesis as a Rational Guide in Directed Evolution and OmniChange as a Gene Mutagenesis Technique

article

Combinatorial and Evolution-Based Methods in the Creation of Enantioselective Catalysts

scientific article

Combinatorial evolution of phosphotriesterase toward a robust malathion degrader by hierarchical iteration mutagenesis

scientific article published on 23 May 2016

Combinatorial transition-metal catalysis: mixing monodentate ligands to control enantio-, diastereo-, and regioselectivity

scientific article published on January 2008

Comparing Different Strategies in Directed Evolution of Enzyme Stereoselectivity: Single- versus Double-Code Saturation Mutagenesis

scientific article published on 13 July 2016

Concerning the Role of Supercritical Carbon Dioxide in SN 1 Reactions

Constructing and analyzing the fitness landscape of an experimental evolutionary process

scientific article

Controlling the enantioselectivity of enzymes by directed evolution: practical and theoretical ramifications

scholarly article

Coordination polymers constructed from o-phthalic acid and diamines: Syntheses and crystal structures of the phthalate-imidazole complexes {[Cu(Pht)(Im)2]·1.5H2O}n and [Co(Pht)(Im)2]n and their application in oxidation catalysis

Copper-phthalocyanine conjugates of serum albumins as enantioselective catalysts in Diels-Alder reactions

scientific article published on 01 April 2006

Correction to "Investigating Substrate Scope and Enantioselectivity of a Defluorinase by a Stereochemical Probe".

scientific article

Correction: Simultaneous engineering of an enzyme's entrance tunnel and active site: the case of monoamine oxidase MAO-N

scientific article published on 16 May 2017

Creation of an amino acid network of structurally coupled residues in the directed evolution of a thermostable enzyme

scientific article published on 01 January 2009

Crystal structure of 7,8,9,10-tetra-hydro-benzo[b]naphtho-[2,1-d]furan

scientific article published on January 2016

Cytochrome P450 catalyzed oxidative hydroxylation of achiral organic compounds with simultaneous creation of two chirality centers in a single C-H activation step

scientific article published on 3 March 2014

Deazaflavins as mediators in light-driven cytochrome P450 catalyzed hydroxylations

scientific article published on 14 October 2009

Designer cells for stereocomplementary de novo enzymatic cascade reactions based on laboratory evolution

scientific article published in December 2013

Designing new Baeyer-Villiger monooxygenases using restricted CASTing

article

Directed Evolution of Artificial Metalloenzymes: A Universal Means to Tune the Selectivity of Transition Metal Catalysts?

scientific article published on 28 January 2019

Directed Evolution of Proteins Based on Mutational Scanning.

scientific article published in January 2018

Directed Evolution of an Enantioselective Enzyme through Combinatorial Multiple-Cassette Mutagenesis

article by Manfred T. Reetz et al published 1 October 2001 in Angewandte Chemie

Directed Evolution of an EnantioselectiveBacillus subtilisLipase

Directed Evolution to Increase Pseudomonas sp. 42A2 LipC Thermostability

Directed evolution and axial chirality: optimization of the enantioselectivity of Pseudomonas aeruginosa lipase towards the kinetic resolution of a racemic allene

scientific article published on 01 May 2007

Directed evolution as a method to create enantioselective cyclohexanone monooxygenases for catalysis in Baeyer-Villiger reactions.

scientific article published in August 2004

Directed evolution by using iterative saturation mutagenesis based on multiresidue sites

scientific article

Directed evolution of Bacillus subtilis lipase A by use of enantiomeric phosphonate inhibitors: crystal structures and phage display selection

scientific article

Directed evolution of an enantioselective epoxide hydrolase: uncovering the source of enantioselectivity at each evolutionary stage

scientific article

Directed evolution of an enantioselective lipase

Directed evolution of cyclohexanone monooxygenases: enantioselective biocatalysts for the oxidation of prochiral thioethers

Directed evolution of enantioselective enzymes: an unconventional approach to asymmetric catalysis in organic chemistry

scientific article published in August 2009

Directed evolution of enantioselective enzymes: iterative cycles of CASTing for probing protein-sequence space

Directed evolution of hybrid enzymes: Evolving enantioselectivity of an achiral Rh-complex anchored to a protein

scientific article

Directed evolution of phenylacetone monooxygenase as an active catalyst for the Baeyer-Villiger conversion of cyclohexanone to caprolactone

scientific article published on 30 April 2015

Directed evolution of stereoselective enzymes based on genetic selection as opposed to screening systems.

scientific article published on 29 April 2014

Economical analysis of saturation mutagenesis experiments

scientific article published on 20 July 2015

Editorial

Einfache Darstellung von Lithiumdiisopropylamid in molarem Maßstab

Enantioselective Rh-catalyzed hydrogenation of vinyl carboxylates with monodentate phosphite ligands

scientific article published on 01 August 2003

Enantioselective catalysis and analysis on a chip.

scientific article published in April 2006

Enhancing the efficiency of directed evolution in focused enzyme libraries by the adaptive substituent reordering algorithm.

scientific article

Enhancing the enantioselectivity of an epoxide hydrolase by directed evolution

scientific article published on 01 January 2004

Enhancing the thermal robustness of an enzyme by directed evolution: least favorable starting points and inferior mutants can map superior evolutionary pathways

scientific article

Enzyme promiscuity: using a P450 enzyme as a carbene transfer catalyst.

scientific article published on 16 April 2013

Expanding the range of substrate acceptance of enzymes: combinatorial active-site saturation test

scientific article published on 01 July 2005

Expanding the substrate scope of enzymes: combining mutations obtained by CASTing

scientific article

Expanding the toolbox of organic chemists: directed evolution of P450 monooxygenases as catalysts in regio- and stereoselective oxidative hydroxylation

article

Exploiting Designed Oxidase-Peroxygenase Mutual Benefit System for Asymmetric Cascade Reactions

scientific article published on 01 April 2019

Exploring productive sequence space in directed evolution using binary patterning versus conventional mutagenesis strategies

Exploring substrate scope and stereoselectivity of P450 peroxygenase OleTJE in olefin-forming oxidative decarboxylation

scientific article published on 01 June 2016

Extreme synergistic mutational effects in the directed evolution of a baeyer-villiger monooxygenase as catalyst for asymmetric sulfoxidation

article

Focused rational iterative site-specific mutagenesis (FRISM)

scientific article published on 11 May 2020

Front Cover: Beating Bias in the Directed Evolution of Proteins: Combining High-Fidelity on-Chip Solid-Phase Gene Synthesis with Efficient Gene Assembly for Combinatorial Library Construction (ChemBioChem 3/2018)

article

Greatly reduced amino acid alphabets in directed evolution: making the right choice for saturation mutagenesis at homologous enzyme positions

article published in 2008

Gruppentransfer-Polymerisation von Acrylsäureestern mit Alkylthio- oder Arylthiosilanen als Initiatoren

scientific article published in December 1986

Helical triskelion monophosphites as ligands in asymmetric catalysis

scientific article

High-throughput selection system for assessing the activity of epoxide hydrolases

scientific article

Highly Enantioselective Rh-Catalyzed Hydrogenation Reactions Based on Chiral Monophosphite Ligands

scientific article published on 01 November 2000

Hinge-Type Dimerization of Proteins by a Tetracysteine Peptide of High Pairing Specificity

scientific article published on 14 June 2018

Improved PCR method for the creation of saturation mutagenesis libraries in directed evolution: application to difficult-to-amplify templates

scientific article

Increasing the activity and enantioselectivity of lipases by sol-gel immobilization: further advancements of practical interest

scientific article published on June 2014

Increasing the stability of an enzyme toward hostile organic solvents by directed evolution based on iterative saturation mutagenesis using the B-FIT method

article

Induced allostery in the directed evolution of an enantioselective Baeyer-Villiger monooxygenase

scientific article

Induced axial chirality in biocatalytic asymmetric ketone reduction

scientific article published on 07 November 2012

Inducing high activity of a thermophilic enzyme at ambient temperatures by directed evolution

scientific article published on 10 August 2017

Investigating Substrate Scope and Enantioselectivity of a Defluorinase by a Stereochemical Probe.

scientific article published on 25 July 2017

Iterative saturation mutagenesis (ISM) for rapid directed evolution of functional enzymes

scientific article

Iterative saturation mutagenesis accelerates laboratory evolution of enzyme stereoselectivity: rigorous comparison with traditional methods.

scientific article

Iterative saturation mutagenesis on the basis of B factors as a strategy for increasing protein thermostability

Iterative saturation mutagenesis: a powerful approach to engineer proteins by systematically simulating Darwinian evolution

scientific article (publication date: 2014)

Knowledge-guided laboratory evolution of protein thermolability

scientific article

Laboratory evolution of enantiocomplementary Candida antarctica lipase B mutants with broad substrate scope

scholarly article by Manfred T. Reetz published in 2013

Laboratory evolution of robust and enantioselective Baeyer-Villiger monooxygenases for asymmetric catalysis

scientific article

Laboratory evolution of stereoselective enzymes: a prolific source of catalysts for asymmetric reactions

scientific article published on January 2011

Learning from directed evolution: Further lessons from theoretical investigations into cooperative mutations in lipase enantioselectivity

scientific article published on January 2007

Learning from directed evolution: theoretical investigations into cooperative mutations in lipase enantioselectivity

scientific article published in February 2004

Ligand-free Heck reactions using low Pd-loading

scientific article published on 01 July 2004

Light-driven biocatalytic oxidation and reduction reactions: scope and limitations.

scientific article

Lipases as practical biocatalysts

scientific article

Liquid poly(ethylene glycol) and supercritical carbon dioxide as a biphasic solvent system for lipase-catalyzed esterification

scientific article published on 18 October 2004

Machine Learning Enables Selection of Epistatic Enzyme Mutants for Stability Against Unfolding and Detrimental Aggregation

scientific article published on 22 October 2020

Manipulating the Stereoselectivity of Limonene Epoxide Hydrolase by Directed Evolution Based on Iterative Saturation Mutagenesis ⬇️

scientific article published on November 10, 2010

Manipulating the expression rate and enantioselectivity of an epoxide hydrolase by using directed evolution

scientific article

Manipulating the stereoselectivity of a thermostable alcohol dehydrogenase by directed evolution for efficient asymmetric synthesis of arylpropanols

scientific article published on 01 February 2019

Manipulating the stereoselectivity of the thermostable Baeyer-Villiger monooxygenase TmCHMO by directed evolution.

scientific article published on 13 November 2017

Many pathways in laboratory evolution can lead to improved enzymes: how to escape from local minima.

scientific article

Methodology Development in Directed Evolution: Exploring Options when Applying Triple-Code Saturation Mutagenesis.

scientific article published on 4 January 2018

Microbial Baeyer-Villiger oxidation: stereopreference and substrate acceptance of cyclohexanone monooxygenase mutants prepared by directed evolution

scientific article

Mixtures of chiral phosphorous acid diesters and achiral p ligands in the enantio- and diastereoselective hydrogenation of ketimines

scientific article published on 01 January 2007

Mixtures of configurationally stable and fluxional atropisomeric monodentate P ligands in asymmetric Rh-catalyzed olefin hydrogenation

scientific article published on 01 May 2005

Mixtures of monodentate P-ligands as a means to control the diastereoselectivity in Rh-catalyzed hydrogenation of chiral alkenes

scientific article published on 26 August 2005

Multiplex-PCR-based recombination as a novel high-fidelity method for directed evolution

scientific article

New Concepts for Increasing the Efficiency in Directed Evolution of Stereoselective Enzymes

scientific article published on 23 February 2016

New methods for the high-throughput screening of enantioselective catalysts and biocatalysts

scientific article published on 01 April 2002

Nonlinear effects in Rh-catalyzed asymmetric olefin hydrogenation using mixtures of chiral monodentate P ligands

scientific article published on 01 February 2006

One hundred years of the Max-Planck-Institut für Kohlenforschung

scientific article published on 24 June 2014

One-step combined focused epPCR and saturation mutagenesis for thermostability evolution of a new cold-active xylanase

scientific article

Organocatalysis. Berlin, April 2007. Preface

scientific article published on 01 January 2007

Overriding Traditional Electronic Effects in Biocatalytic Baeyer-Villiger Reactions by Directed Evolution

scientific article published on 13 August 2018

P450-BM3-Catalyzed Sulfoxidation versus Hydroxylation: A Common or Two Different Catalytically Active Species?

scientific article published on 21 January 2020

P450-Catalyzed Regio- and Diastereoselective Steroid Hydroxylation: Efficient Directed Evolution Enabled by Mutability Landscaping

P450-Catalyzed Regio- and Stereoselective Oxidative Hydroxylation of 6-Iodotetralone: Preparative-Scale Synthesis of a Key Intermediate for Pd-Catalyzed Transformations.

scientific article

PipPhos and MorfPhos: privileged monodentate phosphoramidite ligands for rhodium-catalyzed asymmetric hydrogenation

scientific article

Practical protocols for lipase immobilization via sol-gel techniques

scientific article published in January 2013

Protein engineering of stereoselective Baeyer-Villiger monooxygenases

Quantum Mechanical/Molecular Mechanical Study on the Mechanism of the Enzymatic Baeyer–Villiger Reaction

scientific article published in 2012

Quantum mechanical/molecular mechanical study on the enantioselectivity of the enzymatic Baeyer-Villiger reaction of 4-hydroxycyclohexanone

scientific article published on 19 April 2013

Rapid and Error-Free Site-Directed Mutagenesis by a PCR-Free In Vitro CRISPR/Cas9-Mediated Mutagenic System

scientific article published on 16 August 2018

Reducing codon redundancy and screening effort of combinatorial protein libraries created by saturation mutagenesis.

scientific article

Reduction of Functional Groups

Reduction of α,β-Unsaturated Ketones by Old Yellow Enzymes: Mechanistic Insights from Quantum Mechanics/Molecular Mechanics Calculations

scientific article published on 31 October 2015

Regio- and Stereoselective Steroid Hydroxylation at the C7-Position by Cytochrome P450 Monooxygenase Mutants

scientific article published on 03 April 2020

Regio- and stereoselectivity of P450-catalysed hydroxylation of steroids controlled by laboratory evolution

Reshaping an enzyme binding pocket for enhanced and inverted stereoselectivity: use of smallest amino acid alphabets in directed evolution

scientific article

Revisiting the lipase from Pseudomonas aeruginosa: directed evolution of substrate acceptance and enantioselectivity using iterative saturation mutagenesis

scientific article

Select protocols of high-throughput ee-screening systems for assaying enantioselective enzymes.

scientific article

Shedding light on the efficacy of laboratory evolution based on iterative saturation mutagenesis

scientific article

Simultaneous engineering of an enzyme's entrance tunnel and active site: the case of monoamine oxidase MAO-N

scientific article published on 31 March 2017

Single-cell high-throughput screening to identify enantioselective hydrolytic enzymes.

scientific article

Solid-Phase Gene Synthesis for Mutant Library Construction: The Future of Directed Evolution?

scholarly article by Aitao Li published in October 2018

Speeding up directed evolution: Combining the advantages of solid-phase combinatorial gene synthesis with statistically guided reduction of screening effort

scientific article

Stereodivergent Protein Engineering of a Lipase To Access All Possible Stereoisomers of Chiral Esters with Two Stereocenters

scientific article published on 02 May 2019

Super-High-Throughput Screening of Enantioselective Catalysts by Using Capillary Array Electrophoresis

scientific article published on 01 November 2000

Tetrabutylammonium Salts of 2-Nitropropane, Cyclopentadiene and 9-Ethylfluorene: Crystal Structures and Use in Anionic Polymerization

The Crucial Role of Methodology Development in Directed Evolution of Selective Enzymes

scientific article published on 02 July 2019

The importance of additive and non-additive mutational effects in protein engineering

scientific article published on 04 February 2013

The influence of mixtures of monodentate achiral ligands on the regioselectivity of transition-metal-catalyzed hydroformylation

scientific article published on 01 May 2005

Time-Resolved IR-Thermographic Detection and Screening of Enantioselectivity in Catalytic Reactions.

scientific article

Towards practical Baeyer-Villiger-monooxygenases: design of cyclohexanone monooxygenase mutants with enhanced oxidative stability.

scientific article

Towards practical biocatalytic Baeyer-Villiger reactions: applying a thermostable enzyme in the gram-scale synthesis of optically-active lactones in a two-liquid-phase system.

scientific article

Towards the Production of Universal Blood by Structure-Guided Directed Evolution of Glycoside Hydrolases

article

Trimethylsilyl cyanide promoted cyanation of tertiary alkyl chlorides and other SN1 active compounds

Tuning a p450 enzyme for methane oxidation

scientific article published on 17 February 2011

Utility of B-Factors in Protein Science: Interpreting Rigidity, Flexibility, and Internal Motion and Engineering Thermostability

scientific article published on 30 January 2019

Water-Soluble Colloidal Adams Catalyst: Preparation and Use in Catalysis

article published in 1999

What are the Limitations of Enzymes in Synthetic Organic Chemistry?

scientific article published on 15 June 2016

Whole-Cell-Catalyzed Multiple Regio- and Stereoselective Functionalizations in Cascade Reactions Enabled by Directed Evolution

scientific article

Why Are BINOL-Based Monophosphites Such Efficient Ligands in Rh-Catalyzed Asymmetric Olefin Hydrogenation?

scientific article published in 2005

tert-Alkylierung von Ketonen und Aldehyden

¹H, ¹³C and ¹⁵N resonance assignments of wild-type Bacillus subtilis Lipase A and its mutant evolved towards thermostability

scientific article

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