List of works - Martin Jínek

A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity

scientific article

A three-dimensional view of the molecular machinery of RNA interference

scientific article

ANGEL2 is a member of the CCR4 family of deadenylases with 2',3'-cyclic phosphatase activity

scientific article published on 01 July 2020

Activation and self-inactivation mechanisms of the cyclic oligoadenylate-dependent CRISPR ribonuclease Csm6

scientific article published on 27 March 2020

An RNA-induced conformational change required for CRISPR RNA cleavage by the endoribonuclease Cse3

scientific article

An internal promoter underlies the difference in disease severity between N- and C-terminal truncation mutations of Titin in zebrafish

scientific article

Author Correction: Structural basis of AAUAAA polyadenylation signal recognition by the human CPSF complex

scientific article published on 14 March 2018

Biotechnology. A prudent path forward for genomic engineering and germline gene modification

scientific article

CRISPR-Cas9 conformational activation as elucidated from enhanced molecular simulations

scientific article

Cas9 versus Cas12a/Cpf1: Structure-function comparisons and implications for genome editing

scientific article published on 22 May 2018

Coupled 5′ Nucleotide Recognition and Processivity in Xrn1-Mediated mRNA Decay

scientific article

Covalent linkage of the DNA repair template to the CRISPR-Cas9 nuclease enhances homology-directed repair.

scientific article published on 29 May 2018

CrispRVariants charts the mutation spectrum of genome engineering experiments

scientific article

Crystal structure of the C-terminal 2',5'-phosphodiesterase domain of group A rotavirus protein VP3.

scientific article published on 25 March 2015

DNA interrogation by the CRISPR RNA-guided endonuclease Cas9.

scientific article

DNA-guided DNA cleavage at moderate temperatures by Clostridium butyricum Argonaute.

scientific article published in June 2019

Data-collection strategy for challenging native SAD phasing

scientific article

Editorial overview: Protein-nucleic acid interactions - cryo-EM, what else?

scientific article published on 18 October 2019

Eukaryotic expression, purification, crystallization and preliminary X-ray analysis of murine Manic Fringe

scientific article published on 24 July 2006

Evolution of CRISPR RNA recognition and processing by Cas6 endonucleases

scientific article

Hakai is required for stabilization of core components of the m<sup>6</sup>A mRNA methylation machinery

scientific article published on 18 June 2021

Human MARF1 is an endoribonuclease that interacts with the DCP1:2 decapping complex and degrades target mRNAs

scientific article published on 01 December 2018

In Vitro Reconstitution and Crystallization of Cas9 Endonuclease Bound to a Guide RNA and a DNA Target

scientific article

In vitro enzymology of Cas9.

scientific article

Introducing gene deletions by mouse zygote electroporation of Cas12a/Cpf1

scientific article published on 03 September 2019

Mammalian miRNA RISC recruits CAF1 and PABP to affect PABP-dependent deadenylation

scientific article

Maximizing mutagenesis with solubilized CRISPR-Cas9 ribonucleoprotein complexes.

scientific article

Mechanistic Insights into the cis- and trans-Acting DNase Activities of Cas12a

scientific article published on 10 January 2019

Mechanistic insights into mRNA 3'-end processing

scientific article published on 06 September 2019

Molecular architecture of LSM14 interactions involved in the assembly of mRNA silencing complexes

scientific article published on 06 March 2018

Molecular architectures and mechanisms of Class 2 CRISPR-associated nucleases

scientific article

Molecular basis for cytoplasmic RNA surveillance by uridylation-triggered decay in Drosophila

scientific article published on 11 October 2016

Molecular mechanism of off-target effects in CRISPR-Cas9

scientific article

Molecular mechanism of the RNA helicase DHX37 and its activation by UTP14A in ribosome biogenesis

scientific article published on 25 March 2019

Protospacer Adjacent Motif-Induced Allostery Activates CRISPR-Cas9.

scientific article published on 2 August 2017

RNA-programmed genome editing in human cells

scientific article (publication date: 29 January 2013)

Sequence- and Structure-Specific RNA Processing by a CRISPR Endonuclease

scientific article

Specialized Weaponry: How a Type III-A CRISPR-Cas System Excels at Combating Phages

scientific article published in September 2017

Striking Plasticity of CRISPR-Cas9 and Key Role of Non-target DNA, as Revealed by Molecular Simulations.

scientific article

Structural Basis for Guide RNA Processing and Seed-Dependent DNA Targeting by CRISPR-Cas12a.

scientific article published in April 2017

Structural Plasticity of PAM Recognition by Engineered Variants of the RNA-Guided Endonuclease Cas9.

scientific article

Structural and Biochemical Studies of a Fluoroacetyl-CoA-Specific Thioesterase Reveal a Molecular Basis for Fluorine Selectivity

scientific article

Structural basis for DNase activity of a conserved protein implicated in CRISPR-mediated genome defense

scientific article

Structural basis for acceptor RNA substrate selectivity of the 3' terminal uridylyl transferase Tailor

Structural basis for the endoribonuclease activity of the type III-A CRISPR-associated protein Csm6

scientific article published on 13 January 2016

Structural basis of AAUAAA polyadenylation signal recognition by the human CPSF complex.

scientific article

Structural basis of PAM-dependent target DNA recognition by the Cas9 endonuclease

scientific article

Structural insights into the Notch-modifying glycosyltransferase Fringe

scientific article published on 10 September 2006

Structural insights into the assembly and polyA signal recognition mechanism of the human CPSF complex

scientific article published on 23 December 2017

Structural insights into the human GW182-PABC interaction in microRNA-mediated deadenylation

scientific article

Structural insights into the molecular mechanism of the m(6)A writer complex

scientific article published on 14 September 2016

Structural mimicry in transcription regulation of human RNA polymerase II by the DNA helicase RECQL5

scientific article

Structures of Cas9 Endonucleases Reveal RNA-Mediated Conformational Activation

scientific article

Structures of the tRNA export factor in the nuclear and cytosolic states

scientific article

The C-terminal region of Ge-1 presents conserved structural features required for P-body localization

scientific article

The superhelical TPR-repeat domain of O-linked GlcNAc transferase exhibits structural similarities to importin alpha

scientific article

Type III CRISPR-Cas systems produce cyclic oligoadenylate second messengers

scientific article published on 19 July 2017

Use of RNA tertiary interaction modules for the crystallisation of the spliceosomal snRNP core domain.

scientific article published on 17 July 2010

List of works by Martin Jínek

A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity

A three-dimensional view of the molecular machinery of RNA interference

ANGEL2 is a member of the CCR4 family of deadenylases with 2',3'-cyclic phosphatase activity

Activation and self-inactivation mechanisms of the cyclic oligoadenylate-dependent CRISPR ribonuclease Csm6

An RNA-induced conformational change required for CRISPR RNA cleavage by the endoribonuclease Cse3

An internal promoter underlies the difference in disease severity between N- and C-terminal truncation mutations of Titin in zebrafish

Author Correction: Structural basis of AAUAAA polyadenylation signal recognition by the human CPSF complex

Biotechnology. A prudent path forward for genomic engineering and germline gene modification

CRISPR-Cas9 conformational activation as elucidated from enhanced molecular simulations

Cas9 versus Cas12a/Cpf1: Structure-function comparisons and implications for genome editing

Coupled 5′ Nucleotide Recognition and Processivity in Xrn1-Mediated mRNA Decay

Covalent linkage of the DNA repair template to the CRISPR-Cas9 nuclease enhances homology-directed repair.

CrispRVariants charts the mutation spectrum of genome engineering experiments

Crystal structure of the C-terminal 2',5'-phosphodiesterase domain of group A rotavirus protein VP3.

DNA interrogation by the CRISPR RNA-guided endonuclease Cas9.

DNA-guided DNA cleavage at moderate temperatures by Clostridium butyricum Argonaute.

Data-collection strategy for challenging native SAD phasing

Editorial overview: Protein-nucleic acid interactions - cryo-EM, what else?

Eukaryotic expression, purification, crystallization and preliminary X-ray analysis of murine Manic Fringe

Evolution of CRISPR RNA recognition and processing by Cas6 endonucleases

Hakai is required for stabilization of core components of the m<sup>6</sup>A mRNA methylation machinery

Human MARF1 is an endoribonuclease that interacts with the DCP1:2 decapping complex and degrades target mRNAs

In Vitro Reconstitution and Crystallization of Cas9 Endonuclease Bound to a Guide RNA and a DNA Target

In vitro enzymology of Cas9.

Introducing gene deletions by mouse zygote electroporation of Cas12a/Cpf1

Mammalian miRNA RISC recruits CAF1 and PABP to affect PABP-dependent deadenylation

Maximizing mutagenesis with solubilized CRISPR-Cas9 ribonucleoprotein complexes.

Mechanistic Insights into the cis- and trans-Acting DNase Activities of Cas12a

Mechanistic insights into mRNA 3'-end processing

Molecular architecture of LSM14 interactions involved in the assembly of mRNA silencing complexes

Molecular architectures and mechanisms of Class 2 CRISPR-associated nucleases

Molecular basis for cytoplasmic RNA surveillance by uridylation-triggered decay in Drosophila

Molecular mechanism of off-target effects in CRISPR-Cas9

Molecular mechanism of the RNA helicase DHX37 and its activation by UTP14A in ribosome biogenesis

Protospacer Adjacent Motif-Induced Allostery Activates CRISPR-Cas9.

RNA-programmed genome editing in human cells

Sequence- and Structure-Specific RNA Processing by a CRISPR Endonuclease

Specialized Weaponry: How a Type III-A CRISPR-Cas System Excels at Combating Phages

Striking Plasticity of CRISPR-Cas9 and Key Role of Non-target DNA, as Revealed by Molecular Simulations.

Structural Basis for Guide RNA Processing and Seed-Dependent DNA Targeting by CRISPR-Cas12a.

Structural Plasticity of PAM Recognition by Engineered Variants of the RNA-Guided Endonuclease Cas9.

Structural and Biochemical Studies of a Fluoroacetyl-CoA-Specific Thioesterase Reveal a Molecular Basis for Fluorine Selectivity

Structural basis for DNase activity of a conserved protein implicated in CRISPR-mediated genome defense

Structural basis for acceptor RNA substrate selectivity of the 3' terminal uridylyl transferase Tailor

Structural basis for the endoribonuclease activity of the type III-A CRISPR-associated protein Csm6

Structural basis of AAUAAA polyadenylation signal recognition by the human CPSF complex.

Structural basis of PAM-dependent target DNA recognition by the Cas9 endonuclease

Structural insights into the Notch-modifying glycosyltransferase Fringe

Structural insights into the assembly and polyA signal recognition mechanism of the human CPSF complex

Structural insights into the human GW182-PABC interaction in microRNA-mediated deadenylation

Structural insights into the molecular mechanism of the m(6)A writer complex

Structural mimicry in transcription regulation of human RNA polymerase II by the DNA helicase RECQL5

Structures of Cas9 Endonucleases Reveal RNA-Mediated Conformational Activation

Structures of the tRNA export factor in the nuclear and cytosolic states

The C-terminal region of Ge-1 presents conserved structural features required for P-body localization

The superhelical TPR-repeat domain of O-linked GlcNAc transferase exhibits structural similarities to importin alpha

Type III CRISPR-Cas systems produce cyclic oligoadenylate second messengers

Use of RNA tertiary interaction modules for the crystallisation of the spliceosomal snRNP core domain.