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List of works by Heikki Ruskoaho

(Pro)renin receptor triggers distinct angiotensin II-independent extracellular matrix remodeling and deterioration of cardiac function.

scientific article

A novel dual reporter embryonic stem cell line for toxicological assessment of teratogen-induced perturbation of anterior-posterior patterning of the heart

scientific article published on 06 December 2019

A novel p38 MAPK target dyxin is rapidly induced by mechanical load in the heart

scientific article

AT1 receptor blockade improves vasorelaxation in experimental renal failure

scientific article published on 12 May 2003

Adrenomedullin modulates hemodynamic and cardiac effects of angiotensin II in conscious rats

scientific article published on 29 January 2004

Advanced Nanomedicines for the Treatment and Diagnosis of Myocardial Infarction and Heart Failure.

scientific article

Apelin increases cardiac contractility via protein kinase Cε- and extracellular signal-regulated kinase-dependent mechanisms

scientific article (publication date: 2014)

Apelin, the novel endogenous ligand of the orphan receptor APJ, regulates cardiac contractility

scientific article (publication date: 6 September 2002)

Atrial natriuretic peptide, B-type natriuretic peptide, and serum collagen markers after acute myocardial infarction ⬇️

scientific article published on November 7, 2003

BMP-4 expression has prognostic significance in advanced serous ovarian carcinoma and is affected by cisplatin in OVCAR-3 cells

scientific article published on 15 June 2011

BNP as a biomarker in heart disease

scientific article

Bone morphogenetic protein-2--a potential autocrine/paracrine factor in mediating the stretch activated B-type and atrial natriuretic peptide expression in cardiac myocytes

scientific article published on 10 September 2014

Calcium Carbonate versus Sevelamer Hydrochloride as Phosphate Binders after Long-Term Disease Progression in 5/6 Nephrectomized Rats

Cardiac Actions of a Small Molecule Inhibitor Targeting GATA4-NKX2-5 Interaction.

scientific article

Cardiac BNP gene activation by angiotensin II in vivo

scientific article published on 16 May 2007

Cardiac fibrosis in myocardial infarction-from repair and remodeling to regeneration

scientific article

Cardiac hormones as diagnostic tools in heart failure

scientific article

Characterization of molecular forms of N-terminal B-type natriuretic peptide in vitro.

scientific article published on 6 October 2010

Characterization of the regulatory mechanisms of activating transcription factor 3 by hypertrophic stimuli in rat cardiomyocytes

scientific article

Circulating and cardiac levels of apelin, the novel ligand of the orphan receptor APJ, in patients with heart failure

scientific article published in August 2003

Collagen XV is necessary for modeling of the extracellular matrix and its deficiency predisposes to cardiomyopathy

scientific article published on 16 September 2010

Connective Tissue Growth Factor Inhibition Enhances Cardiac Repair and Limits Fibrosis After Myocardial Infarction

scientific article published on 25 February 2019

Connective tissue growth factor inhibition attenuates left ventricular remodeling and dysfunction in pressure overload-induced heart failure.

scientific article

Decoy oligonucleotide characterization of GATA-4 transcription factor in hypertrophic agonist induced responses of cardiac myocytes

scientific article

Direct left ventricular wall stretch activates GATA4 binding in perfused rat heart: involvement of autocrine/paracrine pathways

scientific article published on 19 October 2001

Distinct regulation of B-type natriuretic peptide transcription by p38 MAPK isoforms

scientific article published on 24 February 2011

Distinct roles of mitogen-activated protein kinase pathways in GATA-4 transcription factor-mediated regulation of B-type natriuretic peptide gene

scientific journal article

Divergent effects of losartan and metoprolol on cardiac remodeling, c-kit+ cells, proliferation and apoptosis in the left ventricle after myocardial infarction

scientific article published on December 2009

Drug-Loaded Multifunctional Nanoparticles Targeted to the Endocardial Layer of the Injured Heart Modulate Hypertrophic Signaling

scientific article published on 17 July 2017

Dual-peptide functionalized acetalated dextran-based nanoparticles for sequential targeting of macrophages during myocardial infarction

scientific article published on 13 January 2020

Early left ventricular gene expression profile in response to increase in blood pressure.

scientific article published on January 2006

Effects of oxonic acid-induced hyperuricemia on mesenteric artery tone and cardiac load in experimental renal insufficiency

scientific article

Endothelin-1 contributes to the Frank-Starling response in hypertrophic rat hearts

scientific article

Endothelin-1-Independent and Angiotensin II-Independent Induction of Adrenomedullin Gene Expression

scientific article published on 01 January 2001

Endothelin-1-specific activation of B-type natriuretic peptide gene via p38 mitogen-activated protein kinase and nuclear ETS factors

scientific article

Evidence for a functional role of angiotensin II type 2 receptor in the cardiac hypertrophic process in vivo in the rat heart

scientific journal article

Expression and Localization of Granzymes and Perforin in Human Calcific Aortic Valve Disease

scientific article

Fabrication and Characterization of Drug-Loaded Conductive Poly(glycerol sebacate)/Nanoparticle-Based Composite Patch for Myocardial Infarction Applications

scientific article published on 03 February 2020

Functionally opposing roles of extracellular signal-regulated kinase 1/2 and p38 mitogen-activated protein kinase in the regulation of cardiac contractility.

scientific article

GATA transcription factors in the developing and adult heart

scientific article published in August 2004

GATA-4 is a nuclear mediator of mechanical stretch-activated hypertrophic program

scientific journal article

GATA4-targeted compound exhibits cardioprotective actions against doxorubicin-induced toxicity in vitro and in vivo: establishment of a chronic cardiotoxicity model using human iPSC-derived cardiomyocytes

scientific article published on 17 March 2020

Ghrelin induces vasoconstriction in the rat coronary vasculature without altering cardiac peptide secretion

scientific article

Hypoxia-induced expression of bradykinin type-2 receptors in endothelial cells triggers NO production, cell migration, and angiogenesis

scientific journal article

Identification of PKCalpha isoform-specific effects in cardiac myocytes using antisense phosphorothioate oligonucleotides

scientific article published on December 2002

Inhibition of Let-7 microRNA attenuates myocardial remodeling and improves cardiac function postinfarction in mice

scientific article

Intramyocardial BNP Gene Delivery Improves Cardiac Function Through Distinct Context-Dependent Mechanisms

article

Inverse regulation of preproendothelin-1 and endothelin-converting enzyme-1beta genes in cardiac cells by mechanical load

scientific journal article

Involvement of endogenous ouabain-like compound in the cardiac hypertrophic process in vivo.

scientific article

In vitro and in vivo assessment of heart-homing porous silicon nanoparticles

scientific article published on 11 April 2016

In vivo biocompatibility of porous silicon biomaterials for drug delivery to the heart.

scientific article published on 28 June 2014

Key roles of endothelin-1 and p38 MAPK in the regulation of atrial stretch response ⬇️

scientific article published on November 17, 2010

M-CAT element mediates mechanical stretch-activated transcription of B-type natriuretic peptide via ERK activation ⬇️

scientific article published on August 3, 2011

Mechanical stretch induced transcriptomic profiles in cardiac myocytes.

scientific article published on 16 March 2018

Mechanisms regulating adrenomedullin gene expression in the left ventricle: role of mechanical load

scientific article published in April 2003

Metoprolol treatment lowers thrombospondin-4 expression in rats with myocardial infarction and left ventricular hypertrophy.

scientific article published on 28 March 2010

MicroRNA-125b and chemokine CCL4 expression are associated with calcific aortic valve disease.

scientific article published on 23 July 2015

Mitogen-activated protein kinase p38 target regenerating islet-derived 3γ expression is upregulated in cardiac inflammatory response in the rat heart

scientific article published on 24 October 2016

Mitogen-activated protein kinases p38 and ERK 1/2 mediate the wall stress-induced activation of GATA-4 binding in adult heart

scientific article published on 29 March 2004

N(G)-nitro-L-arginine methyl ester-induced hypertension and natriuretic peptide gene expression: inhibition by angiotensin II type 1 receptor antagonism

scientific article published in September 2002

N-terminal probrain natriuretic peptide level inversely correlates with cardiac index after arterial switch operation in neonates.

scientific article published on August 2007

Neoplastic extracellular matrix environment promotes cancer invasion in vitro.

scientific article published on 15 April 2016

Neuronostatin, a novel peptide encoded by somatostatin gene, regulates cardiac contractile function and cardiomyocyte survival.

scientific article published on 14 December 2011

Nuclear Receptor-Like Structure and Interaction of Congenital Heart Disease-Associated Factors GATA4 and NKX2-5.

scientific article published on 7 December 2015

Nuclear factor-kappaB signaling contributes to severe, but not moderate, angiotensin II-induced left ventricular remodeling

scientific article published on September 2007

Pacing-induced calcineurin activation controls cardiac Ca2+ signalling and gene expression

scientific article published on 17 October 2003

Parthenolide inhibits STAT3 signaling and attenuates angiotensin II-induced left ventricular hypertrophy via modulation of fibroblast activity

scientific article published on 09 January 2011

Plasma B-type natriuretic peptide (BNP) in acute Puumala hantavirus infection

scientific article published on 6 January 2014

Plasma B-type natriuretic peptide reflects left ventricular hypertrophy and diastolic function in hypertension

scientific article published on 01 November 2004

Plasma N-terminal fragments of natriuretic propeptides predict the risk of cardiovascular events and mortality in middle-aged men.

scientific article published on 18 April 2006

Posttranscriptional control of BNP gene expression in angiotensin II-induced hypertension

scientific journal article

Pronatriuretic peptide is a sensitive marker of the endocrine function of teleost heart

scientific article published in April 2002

SDF1 gradient associates with the distribution of c-Kit+ cardiac cells in the heart.

scientific article

TSC-22 up-regulates collagen 3a1 gene expression in the rat heart

scientific article published on 13 October 2015

Targeting GATA4 for cardiac repair

scientific article published on 16 August 2019

Targeting vasoactive peptides for managing calcific aortic valve disease

scientific article

Tezosentan inhibits uptake of proinflammatory endothelin-1 in stenotic aortic valves

scientific article published on 01 January 2012

The Early-Onset Myocardial Infarction Associated PHACTR1 Gene Regulates Skeletal and Cardiac Alpha-Actin Gene Expression

scientific article published on 22 June 2015

Thrombospondin-4, tumour necrosis factor-like weak inducer of apoptosis (TWEAK) and its receptor Fn14: novel extracellular matrix modulating factors in cardiac remodelling

scientific article published on March 2012

Thrombospondins, potential drug targets for cardiovascular diseases

scientific article published on January 2013

Transcription factor PEX1 modulates extracellular matrix turnover through regulation of MMP-9 expression.

scientific article

WDR12, a Member of Nucleolar PeBoW-Complex, Is Up-Regulated in Failing Hearts and Causes Deterioration of Cardiac Function

scientific article

p38α regulates SERCA2a function.

scientific article

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