Search filters

List of works by Joan Brugge

3D Culture Models with CRISPR Screens Reveal Hyperactive NRF2 as a Prerequisite for Spheroid Formation via Regulation of Proliferation and Ferroptosis

scientific article published on 26 October 2020

A cytoskeleton-based functional genetic screen identifies Bcl-xL as an enhancer of metastasis, but not primary tumor growth

scientific article published in June 2004

A new mutational AKTivation in the PI3K pathway

scientific article published on August 2007

A non-genetic route to aneuploidy in human cancers

scientific article

A nonapoptotic cell death process, entosis, that occurs by cell-in-cell invasion.

scientific article

A protein interaction map for cell-cell adhesion regulators identifies DUSP23 as a novel phosphatase for β-catenin.

scientific article

A stiff blow from the stroma: collagen crosslinking drives tumor progression.

scientific article published in December 2009

A structure-guided approach to creating covalent FGFR inhibitors

scientific article

A two-gene expression ratio predicts clinical outcome in breast cancer patients treated with tamoxifen

scientific article published on June 2004

Activation of NF-kappaB following detachment delays apoptosis in intestinal epithelial cells

scientific article published on September 2005

Aging-Associated Alterations in Mammary Epithelia and Stroma Revealed by Single-Cell RNA Sequencing

scientific article published on 01 December 2020

Akt activation disrupts mammary acinar architecture and enhances proliferation in an mTOR-dependent manner

scientific article

Akt and ERK control the proliferative response of mammary epithelial cells to the growth factors IGF-1 and EGF through the cell cycle inhibitor p57Kip2.

scientific article

Akt regulation of glycolysis mediates bioenergetic stability in epithelial cells

scientific article published on 14 December 2017

Altered metabolic requirements in cancer cell migration and metastasis.

scientific article published in June 2012

Amplification of phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis.

scientific article published in June 2012

An active form of Vav1 induces migration of mammary epithelial cells by stimulating secretion of an epidermal growth factor receptor ligand

scientific article

Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment

scientific article

At the leading edge of cancer research: an interview with Joan Brugge. Interview by Sarah Allan

scientific article

Autocrine CSF-1R activation promotes Src-dependent disruption of mammary epithelial architecture

scientific article

BIM regulates apoptosis during mammary ductal morphogenesis, and its absence reveals alternative cell death mechanisms

scientific journal article

Bim regulation of lumen formation in cultured mammary epithelial acini is targeted by oncogenes.

scientific article

Breast cancer-associated PIK3CA mutations are oncogenic in mammary epithelial cells

scientific article published on December 2005

CRB3 and the FERM protein EPB41L4B regulate proliferation of mammary epithelial cells through the release of amphiregulin

scientific article published in PLoS ONE

Cancer Cells Co-opt the Neuronal Redox-Sensing Channel TRPA1 to Promote Oxidative-Stress Tolerance

scientific article published on 24 May 2018

Cancer: The enemy of my enemy is my friend.

scientific article published on 21 October 2015

Chaperone-mediated autophagy degrades mutant p53.

scientific article published on August 2013

Chaperone-mediated autophagy degrades mutant p53.

scientific article published in September 2013

Characterization of twenty-five ovarian tumour cell lines that phenocopy primary tumours

scientific article published on 17 June 2015

Combined MEK and BCL-2/XL Inhibition Is Effective in High-Grade Serous Ovarian Cancer Patient-Derived Xenograft Models and BIM Levels Are Predictive of Responsiveness

scientific article published on 24 January 2019

Cooperation of the ErbB2 receptor and transforming growth factor beta in induction of migration and invasion in mammary epithelial cells

scholarly article

Coordinate interactions of Csk, Src, and Syk kinases with [alpha]IIb[beta]3 initiate integrin signaling to the cytoskeleton

scientific article

Correction: Mapping the dynamics of force transduction at cell-cell junctions of epithelial clusters

scientific article published in January 2015

Corrigendum: Chaperone-mediated autophagy degrades mutant p53.

scientific article published on April 2016

Critical questions in ovarian cancer research and treatment: Report of an American Association for Cancer Research Special Conference

article

Cytokinesis involves a nontranscriptional function of the Hippo pathway effector YAP.

scientific article

Deubiquitinases Maintain Protein Homeostasis and Survival of Cancer Cells upon Glutathione Depletion

scientific article published on 21 February 2019

Differential Glutamate Metabolism in Proliferating and Quiescent Mammary Epithelial Cells.

scientific article

Differential remodeling of actin cytoskeleton architecture by profilin isoforms leads to distinct effects on cell migration and invasion

scientific article

Distinct roles of Akt1 and Akt2 in regulating cell migration and epithelial-mesenchymal transition

scientific article

Dose-dependent induction of distinct phenotypic responses to Notch pathway activation in mammary epithelial cells

scientific article

ERK and p38 MAPK Activities Determine Sensitivity to PI3K/mTOR Inhibition via Regulation of MYC and YAP.

scientific article published on 20 October 2016

Epidermal growth factor receptor-dependent regulation of integrin-mediated signaling and cell cycle entry in epithelial cells

scientific article

ErbB2 Stabilizes Epidermal Growth Factor Receptor (EGFR) Expression via Erk and Sprouty2 in Extracellular Matrix-detached Cells ⬇️

scientific article published on October 18, 2010

Erk regulation of pyruvate dehydrogenase flux through PDK4 modulates cell proliferation

scientific article

Erratum

scholarly article published in Cell

Erratum: Niche-localized tumor cells are protected from HER2-targeted therapy via upregulation of an anti-apoptotic program in vivo

scientific article published on 22 September 2017

Establishment of Patient-Derived Tumor Xenograft Models of Epithelial Ovarian Cancer for Preclinical Evaluation of Novel Therapeutics.

scientific article published on 29 August 2016

Evidence for a multipotent mammary progenitor with pregnancy-specific activity

scientific article published on January 2013

Fibroblast growth factor receptor 1-transformed mammary epithelial cells are dependent on RSK activity for growth and survival

scientific article

Fibroblast-tumor cell signaling limits HER2 kinase therapy response via activation of MTOR and antiapoptotic pathways

scientific article published on 29 June 2020

Frequency-modulated pulses of ERK activity transmit quantitative proliferation signals

scientific article

Functional proteomics approach to investigate the biological activities of cDNAs implicated in breast cancer

scientific article published on March 2006

Functional role and oncogene-regulated expression of the BH3-only factor Bmf in mammary epithelial anoikis and morphogenesis

scientific article

G1/S cell cycle arrest provides anoikis resistance through Erk-mediated Bim suppression

scientific article

IL-6 involvement in epithelial cancers

scientific article

Identification of cancer genes that are independent of dominant proliferation and lineage programs

scientific article published on 11 December 2017

Identification of genes that regulate epithelial cell migration using an siRNA screening approach

scientific article

In vitro mesothelial clearance assay that models the early steps of ovarian cancer metastasis

scientific article

Inhibition of PI3K/mTOR leads to adaptive resistance in matrix-attached cancer cells

scientific article published in February 2012

Integrins and EGFR coordinately regulate the pro-apoptotic protein Bim to prevent anoikis

scientific article published in August 2003

Joan Brugge: running rings around cancer. Interview by Caitlin Sedwick

scientific article published on June 2010

Large-Scale Characterization of Drug Responses of Clinically Relevant Proteins in Cancer Cell Lines

scientific article published on 26 October 2020

Live free or die: cell-cell adhesion regulates sensitivity to trail-induced apoptosis

article by Lisa L Gallegos et al published 1 July 2014 in Developmental Cell

Long-term culture, genetic manipulation and xenotransplantation of human normal and breast cancer organoids

scientific article published on 10 March 2021

Lumen formation during mammary epithelial morphogenesis: insights from in vitro and in vivo models

scientific article published on 09 October 2007

MYC regulation of a "poor-prognosis" metastatic cancer cell state

scientific article

Mapping the dynamics of force transduction at cell-cell junctions of epithelial clusters.

scientific article

Mesenchymal gene program-expressing ovarian cancer spheroids exhibit enhanced mesothelial clearance

scientific article

Metabolic changes promote rejection of oncogenic cells

scientific article published on 01 April 2017

Modelling glandular epithelial cancers in three-dimensional cultures

scientific article

Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures

scientific article (publication date: July 2003)

Moving Closer To Victory.

scientific article published on 17 April 2017

Mutant p53 drives invasion by promoting integrin recycling

scientific article

Mutant p53 regulates ovarian cancer transformed phenotypes through autocrine matrix deposition.

scientific article

Navitoclax enhances the effectiveness of EGFR-targeted antibody-drug conjugates in PDX models of EGFR-expressing triple-negative breast cancer

scientific article published on 30 November 2020

Neutralization of BCL-2/XL Enhances the Cytotoxicity of T-DM1 In Vivo

scientific article published on 08 April 2019

Niche-localized tumor cells are protected from HER2-targeted therapy via upregulation of an anti-apoptotic program in vivo.

scientific article

Not just Salk

scientific article published in September 2017

Novel role for PDEF in epithelial cell migration and invasion

scientific article

Oncogene-like induction of cellular invasion from centrosome amplification

scientific article

Organoid cultures from normal and cancer-prone human breast tissues preserve complex epithelial lineages

scientific article published on 06 April 2020

Outgrowth of single oncogene-expressing cells from suppressive epithelial environments.

scientific article published on 8 February 2012

Ovarian cancer spheroids use myosin-generated force to clear the mesothelium

scientific article

Overview of the Alliance for Cellular Signaling

scientific article

PDEF promotes luminal differentiation and acts as a survival factor for ER-positive breast cancer cells

scientific article published on June 2013

PTK6 Regulates IGF-1-Induced Anchorage-Independent Survival ⬇️

scientific article published on July 23, 2010

Pathologic and molecular responses to neoadjuvant trastuzumab and/or lapatinib from a phase II randomized trial in HER2-positive breast cancer (TRIO-US B07)

scientific article published on 17 November 2020

Phosphatidylinositol 3-Kinase Is Required for Integrin-Stimulated AKT and Raf-1/Mitogen-Activated Protein Kinase Pathway Activation ⬇️

scientific article published on August 1, 1997

Phosphatidylinositol 3-kinase regulates Raf1 through Pak phosphorylation of serine 338

scientific article published on 01 May 2000

Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis

scientific article

Profiling Y561-dependent and -independent substrates of CSF-1R in epithelial cells

scientific article (publication date: 26 October 2010)

Psidin, a conserved protein that regulates protrusion dynamics and cell migration

scientific article

Q&A: Joan Brugge on empowering post-docs

scientific article published on 5 July 2012

Rapid Sequential in Situ Multiplexing with DNA Exchange Imaging in Neuronal Cells and Tissues

scientific article published on 21 September 2017

Rational combination therapy with PARP and MEK inhibitors capitalizes on therapeutic liabilities in RAS mutant cancers.

scientific article published in May 2017

Regulation of cell adhesion and collective cell migration by hindsight and its human homolog RREB1

scientific article

Requirements for Vav guanine nucleotide exchange factors and Rho GTPases in FcgammaR- and complement-mediated phagocytosis

scientific article published in March 2006

Role for polo-like kinase 4 in mediation of cytokinesis

scientific article published on 16 May 2019

SePARating polarity and proliferation in ErbB2 oncogenesis

scientific article published on 01 November 2006

Sensing the environment: a historical perspective on integrin signal transduction

scientific article

Starved epithelial cells uptake extracellular matrix for survival

scientific article

Substrate stiffness regulates cadherin-dependent collective migration through myosin-II contractility.

scientific article

Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer

scientific article published on 07 May 2020

Systems analysis of apoptotic priming in ovarian cancer identifies vulnerabilities and predictors of drug response.

scientific article published on 28 August 2017

Tensins: a new switch in cell migration

scientific article

The PHD finger of the chromatin-associated protein ING2 functions as a nuclear phosphoinositide receptor

scientific article

The Role of Proliferation in Determining Response to Neoadjuvant Chemotherapy in Breast Cancer: A Gene Expression-Based Meta-Analysis.

scientific article published on 21 June 2016

The cell biology of cell-in-cell structures

scientific article published on 11 September 2008

The myosin-II-responsive focal adhesion proteome: a tour de force?

scientific article published on 20 March 2011

The role of apoptosis in creating and maintaining luminal space within normal and oncogene-expressing mammary acini.

scientific article published in October 2002

Transforming properties of YAP, a candidate oncogene on the chromosome 11q22 amplicon

scientific article

Transient commensal clonal interactions can drive tumor metastasis

scientific article published on 16 November 2020

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is required for induction of autophagy during lumen formation in vitro

scholarly article

Tumor self-seeding: bidirectional flow of tumor cells

scientific article published on 01 December 2009

Uncovering a tumor suppressor for triple-negative breast cancers

scientific article published on 01 March 2011

United They Stand, Divided They Fall

scientific article published on 01 October 2019

Use of three-dimensional basement membrane cultures to model oncogene-induced changes in mammary epithelial morphogenesis

scientific article

Vav GEFs are required for beta2 integrin-dependent functions of neutrophils

scientific article

Vav1/2/3-null Mice Define an Essential Role for Vav Family Proteins in Lymphocyte Development and Activation but a Differential Requirement in MAPK Signaling in T and B Cells ⬇️

scientific article published on November 17, 2003

YAP-dependent induction of amphiregulin identifies a non-cell-autonomous component of the Hippo pathway

scientific article

YB-1 translational control of epithelial-mesenchyme transition

scientific article published in May 2009

[Entosis, a cell death process related to cell cannibalism between tumor cells]

scientific article published on 01 March 2008

p63 regulates an adhesion programme and cell survival in epithelial cells

scientific article published on 21 May 2006

Paulina is supported by:

About Paulina

Help