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List of works by Peter Openshaw

A New Role for CXCL4 in RSV Disease

scientific article published on 09 July 2020

A gene expression signature for RSV: clinical implications and limitations.

scientific article

A high fat diet increases influenza A virus-associated cardiovascular damage

scientific article published on 04 April 2020

A potential molecular mechanism for hypersensitivity caused by formalin-inactivated vaccines

article

A prenylated dsRNA sensor protects against severe COVID-19

scientific article

A41 Deep sequencing of respiratory syncytial virus links viral diversity to disease severity

Absorption of Nasal and Bronchial Fluids: Precision Sampling of the Human Respiratory Mucosa and Laboratory Processing of Samples.

scientific article published on 21 January 2018

Abundant IFN-gamma production by local T cells in respiratory syncytial virus-induced eosinophilic lung disease ⬇️

scientific article published on July 1, 1998

Accumulation of human-adapting mutations during circulation of A(H1N1)pdm09 influenza virus in humans in the United Kingdom.

scientific article

Age at first viral infection determines the pattern of T cell-mediated disease during reinfection in adulthood

scientific article

Alpha/beta interferon receptor signaling amplifies early proinflammatory cytokine production in the lung during respiratory syncytial virus infection

scientific article

Alveolar macrophages are a major determinant of early responses to viral lung infection but do not influence subsequent disease development

scientific article published on 20 February 2008

Amplicon based MinION sequencing of SARS-CoV-2 and metagenomic characterisation of nasopharyngeal swabs from patients with COVID-19

scientific article (preprint)

Amplicon-Based Detection and Sequencing of SARS-CoV-2 in Nasopharyngeal Swabs from Patients With COVID-19 and Identification of Deletions in the Viral Genome That Encode Proteins Involved in Interferon Antagonism

scientific article published on 14 October 2020

An evaluation of community assessment tools (CATs) in predicting use of clinical interventions and severe outcomes during the A(H1N1)pdm09 pandemic.

scientific article

An improved protocol for measuring cytotoxic T cell activity in anatomic compartments with low cell numbers.

scientific article

Analysis of SARS-CoV-2 known and novel subgenomic mRNAs in cell culture, animal model, and clinical samples using LeTRS, a bioinformatic tool to identify unique sequence identifiers

scientific article published on 01 May 2022

Antiviral B cell and T cell immunity in the lungs.

scientific article

Antiviral and lung protective activity of a novel respiratory syncytial virus fusion inhibitor in a mouse model ⬇️

scientific article published on December 9, 2010

Antiviral immune responses and lung inflammation after respiratory syncytial virus infection.

scientific article

Antivirals for influenza: where now for clinical practice and pandemic preparedness?

scientific article

Attenuated Bordetella pertussis vaccine protects against respiratory syncytial virus disease via an IL-17-dependent mechanism

scientific article published on January 2014

Author Correction: Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses

scientific article published on 4 April 2024

Author Correction: Progression of whole-blood transcriptional signatures from interferon-induced to neutrophil-associated patterns in severe influenza

scientific article published on 01 March 2019

Benefit and harm from immunity to respiratory syncytial virus: implications for treatment

scientific article published on December 2012

Biphasic activation of complement and fibrinolysis during the human nasal allergic response

scientific article published on 7 February 2018

Broad and strong memory CD4+ and CD8+ T cells induced by SARS-CoV-2 in UK convalescent individuals following COVID-19

scientific article published on 04 September 2020

Bronchiolitis

scientific article published in The Lancet

CD25+ natural regulatory T cells are critical in limiting innate and adaptive immunity and resolving disease following respiratory syncytial virus infection

scientific article

CD8+ T cells control Th2-driven pathology during pulmonary respiratory syncytial virus infection

scientific article published in December 1997

COVID-19 and beyond: a call for action and audacious solidarity to all the citizens and nations, it is humanity’s fight

scientific article published in 2020

COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study

scientific article

COVID‐19: Lessons from SARS and MERS

scientific article published on 27 February 2020

Cancer datasets and the SARS-CoV-2 pandemic: establishing principles for collaboration

scientific article published on 01 May 2020

Childhood infections, the developing immune system, and the origins of asthma.

scientific article published in December 2004

Circulating SARS-CoV-2 spike N439K variants maintain fitness while evading antibody-mediated immunity

scientific article

Circulating histones play a central role in COVID-19-associated coagulopathy and mortality

scholarly article by Rebecca J Shaw published in 2021

Clinical and laboratory features distinguishing pandemic H1N1 influenza-related pneumonia from interpandemic community-acquired pneumonia in adults

scientific article

Clinical characteristics of children and young people admitted to hospital with covid-19 in United Kingdom: prospective multicentre observational cohort study

scientific article published on 27 August 2020

Comparison of CATs, CURB-65 and PMEWS as triage tools in pandemic influenza admissions to UK hospitals: case control analysis using retrospective data

scientific article (publication date: 2012)

Contribution of cytokines to pathology and protection in virus infection

scientific article published on 25 June 2011

Crossing barriers: infections of the lung and the gut

scientific article published on 24 December 2008

Current concepts and progress in RSV vaccine development.

scientific article

Current research on respiratory viral infections: Fifth International Symposium.

scientific article

Current research on respiratory viral infections: Fourth International Symposium

scientific article

Cytotoxic T cell specificity for respiratory syncytial virus proteins: fusion protein is an important target antigen

scientific article

Cytotoxic T cells clear virus but augment lung pathology in mice infected with respiratory syncytial virus

scientific article

Defective immunoregulation in RSV vaccine-augmented viral lung disease restored by selective chemoattraction of regulatory T cells

scientific article

Delayed sequelae of neonatal respiratory syncytial virus infection are dependent on cells of the innate immune system

scientific article published on 30 October 2013

Delivery of cytokines by recombinant virus in early life alters the immune response to adult lung infection

scientific article

Development and validation of the ISARIC 4C Deterioration model for adults hospitalised with COVID-19: a prospective cohort study

scientific article published in 2021

Development of vaccines against common colds.

scientific article

Differences between asthmatics and nonasthmatics hospitalised with influenza A infection

scientific article published on 16 August 2012

Differential chemokine expression following respiratory virus infection reflects Th1- or Th2-biased immunopathology.

scientific article

Do common childhood infections 'teach' the immune system not to be allergic?

scientific article published in March 2000

Doctors accepting flu vaccination is the sensible and responsible choice

scientific article published on 08 November 2011

EULAR provisional recommendations for the management of rheumatic and musculoskeletal diseases in the context of SARS-CoV-2

scientific article published on 05 June 2020

Effect of ethnicity on care pathway and outcomes in patients hospitalized with influenza A(H1N1)pdm09 in the UK.

scientific article

Eliminating a region of respiratory syncytial virus attachment protein allows induction of protective immunity without vaccine-enhanced lung eosinophilia.

scientific article

Emerging drugs for respiratory syncytial virus infection

scientific article published on June 2009

Endogenous IL-21 regulates pathogenic mucosal CD4 T-cell responses during enhanced RSV disease in mice

scientific article published on 21 November 2012

Enhanced IL-4 responses in children with a history of respiratory syncytial virus bronchiolitis in infancy

scientific article published in August 2002

Epitope-specific airway-resident CD4+ T cell dynamics during experimental human RSV infection

scientific article published on 01 January 2020

Erratum: RSV-specific airway resident memory CD8+ T cells and differential disease severity after experimental human infection

scientific article published on 9 March 2016

Evolution of epitope-specific memory CD4(+) T cells after clearance of hepatitis C virus.

scientific article published in August 2002

Fatal COVID-19 outcomes are associated with an antibody response targeting epitopes shared with endemic coronaviruses

scientific article published in 2022

Features of 16,749 hospitalised UK patients with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol

scientific article published on 28 April 2020

Flow cytometric measurement of intracellular cytokines.

scientific article

Functional characterization of alloreactive T cells identifies CD25 and CD71 as optimal targets for a clinically applicable allodepletion strategy.

scientific article published on 4 November 2009

Gene-gun DNA vaccination aggravates respiratory syncytial virus-induced pneumonitis.

scientific article published in October 2004

Genetic mechanisms of critical illness in Covid-19

scientific article published on 11 December 2020

Genetic susceptibility to the delayed sequelae of neonatal respiratory syncytial virus infection is MHC dependent.

scientific article published on 4 October 2010

Global Disease Burden Estimates of Respiratory Syncytial Virus-Associated Acute Respiratory Infection in Older Adults in 2015: A Systematic Review and Meta-Analysis

scientific article published on 18 March 2019

Global and Regional Burden of Hospital Admissions for Pneumonia in Older Adults: A Systematic Review and Meta-Analysis

scientific article published on 8 March 2019

Group B streptococcus and respiratory syncytial virus immunisation during pregnancy: a landscape analysis.

scientific article

Helper T cell recognition of respiratory syncytial virus in mice

scientific article published in February 1988

Heterogeneity of intracellular cytokine synthesis at the single-cell level in polarized T helper 1 and T helper 2 populations

scientific article published on November 1995

Host genetic determinants of vaccine-induced eosinophilia during respiratory syncytial virus infection

scientific article published in December 1998

Hot topics in the prevention of respiratory syncytial virus disease.

scientific article

How should influenza be treated? Focus on antivirals.

scientific article published on 6 August 2015

Human and murine cytotoxic T cells specific to respiratory syncytial virus recognize the viral nucleoprotein (N), but not the major glycoprotein (G), expressed by vaccinia virus recombinants

scientific article published in December 1986

Human cytotoxic T cells stimulated by antigen on dendritic cells recognize the N, SH, F, M, 22K, and 1b proteins of respiratory syncytial virus.

scientific article published on April 1992

Human microbial challenge: the ultimate animal model

article

IFITM3 restricts the morbidity and mortality associated with influenza

scientific article

IL-10 regulates viral lung immunopathology during acute respiratory syncytial virus infection in mice

scientific article

IL-12 treatment attenuates T helper cell type 2 and B cell responses but does not improve vaccine-enhanced lung illness

scientific article published on 01 July 1997

IL-12-activated NK cells reduce lung eosinophilia to the attachment protein of respiratory syncytial virus but do not enhance the severity of illness in CD8 T cell-immunodeficient conditions

scientific article published in December 2000

IL-9 regulates pathology during primary and memory responses to respiratory syncytial virus infection.

scientific article published on 13 November 2009

Immune responses and disease enhancement during respiratory syncytial virus infection

scientific article

Immunity to RSV in Early-Life.

scientific article

Immunological determinants of disease caused by respiratory syncytial virus

scientific article published in August 1996

Immunopathogenesis of vaccine-enhanced RSV disease.

scientific article published on October 2001

Impact of the 2009 influenza pandemic

scientific article published on 01 June 2010

Impaired Antibody-mediated Protection and Defective IgA B-Cell Memory in Experimental Infection of Adults with Respiratory Syncytial Virus

scientific article published on May 2015

Implementation of corticosteroids in treatment of COVID-19 in the ISARIC WHO Clinical Characterisation Protocol UK: prospective, cohort study

scientific article published in 2022

Increased aeroallergen-specific interleukin-4-producing T cells in asthmatic adults.

scientific article published in December 2002

Increased nasal mucosal interferon and CCL13 response to a TLR7/8 agonist in asthma and allergic rhinitis

scientific article published on 24 July 2020

Induction of innate cytokine responses by respiratory mucosal challenge with R848 in zebrafish, mice, and humans

scientific article published on 16 April 2019

Infections prevent the development of asthma--true, false or both?

scientific article published on 01 October 1999

Influenza burden, prevention, and treatment in asthma-A scoping review by the EAACI Influenza in asthma task force

scientific article published on 6 November 2017

Influenza vaccination: lessons learned from the pandemic (H1N1) 2009 influenza outbreak.

scientific article

Influenza virus lung infection protects from respiratory syncytial virus-induced immunopathology

scientific article

Inhibition of T1/ST2 during respiratory syncytial virus infection prevents T helper cell type 2 (Th2)- but not Th1-driven immunopathology

scientific article

Inhibition of tumor necrosis factor reduces the severity of virus-specific lung immunopathology

scientific article published in September 2001

Interleukin 18 coexpression during respiratory syncytial virus infection results in enhanced disease mediated by natural killer cells

scientific article

Intracellular IFN-gamma expression in natural killer cells precedes lung CD8+ T cell recruitment during respiratory syncytial virus infection

scientific article published in November 1998

Issues in vaccinology: Present challenges and future directions

scientific article published on September 2017

Latency and persistence of respiratory syncytial virus despite T cell immunity

scientific article published on 23 January 2004

Links between respiratory syncytial virus bronchiolitis and childhood asthma: clinical and research approaches

scientific article

Live attenuated B. pertussis BPZE1 rescues the immune functions of Respiratory Syncytial virus infected human dendritic cells by promoting Th1/Th17 responses

scientific article

Local and Systemic Immunity against Respiratory Syncytial Virus Induced by a Novel Intranasal Vaccine. A Randomized, Double-Blind, Placebo-controlled Clinical Trial

scientific article published on 01 August 2019

Long-term persistence and reactivation of T cell memory in the lung of mice infected with respiratory syncytial virus.

scientific article published in September 2001

M1-like monocytes are a major immunological determinant of severity in previously healthy adults with life-threatening influenza

scientific article published on 06 April 2017

Maternal immunisation: collaborating with mother nature

scientific article

Men and Women in Immunology: Closing the gap on gender parity?

scholarly article by Christina Helbig et al published November 2018 in European Journal of Immunology

Microbes and mucosal immune responses in asthma.

scientific article published on March 2013

Mouse γδ TCR+NK1.1+ thymocytes specifically produce interleukin-4, are major histocompatibility complex class I independent, and are developmentally related to αβ TCR+NK1.1+ thymocytes

scholarly article by Alain P. Vicari et al published July 1996 in European Journal of Immunology

Mucosal delivery of a respiratory syncytial virus CTL peptide with enterotoxin-based adjuvants elicits protective, immunopathogenic, and immunoregulatory antiviral CD8+ T cell responses

scientific article published in January 2001

Nasal Lipopolysaccharide Challenge and Cytokine Measurement Reflects Innate Mucosal Immune Responsiveness

scientific article published on 14 September 2015

Nasosorption as a Minimally Invasive Sampling Procedure: Mucosal Viral Load and Inflammation in Primary RSV Bronchiolitis.

scientific article

Natural killer cell NKG2D and granzyme B are critical for allergic pulmonary inflammation

scientific article published on 28 November 2013

Neonatal antibody responses are attenuated by interferon-γ produced by NK and T cells during RSV infection

scientific article published on 18 March 2013

Neuraminidase inhibitors for influenza complications--Authors' reply

scientific article published in October 2014

Neutrophilic inflammation in the respiratory mucosa predisposes to RSV infection

scientific article published on 01 October 2020

Non-steroidal anti-inflammatory drug use and outcomes of COVID-19 in the ISARIC Clinical Characterisation Protocol UK cohort: a matched, prospective cohort study

scientific article published in 2021

Nosocomial pandemic (H1N1) 2009, United Kingdom, 2009-2010

scientific article

OMIP-062: A 14-Color, 16-Antibody Panel for Immunophenotyping Human Innate Lymphoid, Myeloid and T Cells in Small Volumes of Whole Blood and Pediatric Airway Samples

scientific article published on 21 October 2019

OX40 ligand and programmed cell death 1 ligand 2 expression on inflammatory dendritic cells regulates CD4 T cell cytokine production in the lung during viral disease.

scientific article published on 20 January 2012

Offspring born to influenza A virus infected pregnant mice have increased susceptibility to viral and bacterial infections in early life

scientific article published on 16 August 2021

Open source clinical science for emerging infections

scientific article published in January 2014

Oseltamivir plus usual care versus usual care for influenza-like illness in primary care: an open-label, pragmatic, randomised controlled trial

scientific article published on 12 December 2019

Outcome of Hospitalization for COVID-19 in Patients with Interstitial Lung Disease: An International Multicenter Study

scientific article published on 02 October 2020

Outcomes of COVID-19 related hospitalization among people with HIV in the ISARIC WHO Clinical Characterization Protocol (UK): a prospective observational study

scientific article published on 23 October 2020

Partners in crime: co-infections in the developing world

article

Patterns of systemic and local inflammation in patients with asthma hospitalised with influenza

scientific article published on 24 October 2019

Polylactide-co-glycolide (PLG) microparticles modify the immune response to DNA vaccination

article

Potential therapeutic implications of new insights into respiratory syncytial virus disease

scientific article

Pre-admission statin use and in-hospital severity of 2009 pandemic influenza A(H1N1) disease

scientific article

Predictors of clinical outcome in a national hospitalised cohort across both waves of the influenza A/H1N1 pandemic 2009-2010 in the UK.

scientific article

Predominance of heterosubtypic IFN-γ-only-secreting effector memory T cells in pandemic H1N1 naive adults

scientific article

Preexposure to CpG protects against the delayed effects of neonatal respiratory syncytial virus infection

scientific article

Presumed Risk Factors and Biomarkers for Severe Respiratory Syncytial Virus Disease and Related Sequelae: Protocol for an Observational Multicenter, Case-Control Study From the Respiratory Syncytial Virus Consortium in Europe (RESCEU)

scientific article published on 14 August 2020

Prior exposure to live Mycobacterium bovis BCG decreases Cryptococcus neoformans-induced lung eosinophilia in a gamma interferon-dependent manner

scientific article

Progression of whole-blood transcriptional signatures from interferon-induced to neutrophil-associated patterns in severe influenza.

scientific article

Protective and Harmful Immunity to RSV Infection.

scientific article published on 6 February 2017

Protective and disease-enhancing immune responses induced by recombinant modified vaccinia Ankara (MVA) expressing respiratory syncytial virus proteins.

scientific article published in November 2004

Protective and dysregulated T cell immunity in RSV infection

scientific article

Pulmonary V gamma 4+ gamma delta T cells have proinflammatory and antiviral effects in viral lung disease

scientific article published on January 2009

Pulmonary defences to acute respiratory infection.

scientific article

RSV 2005: Global impact, changing concepts, and new challenges.

scientific article published in January 2005

RSV Takes Control of Neonatal Breg Cells: Two Hands on the Wheel

scientific article published on February 2017

RSV bronchiolitis, gammadelta T cells and asthma: are they linked?

scientific article published in February 2003

RSV-induced bronchial epithelial cell PD-L1 expression inhibits CD8+ T cell nonspecific antiviral activity

scientific article

RSV-specific airway resident memory CD8+ T cells and differential disease severity after experimental human infection

scientific article

Recent developments in the biology of respiratory syncytial virus: are vaccines and new treatments just round the corner?

scientific article

Recombinant respiratory syncytial virus lacking secreted glycoprotein G is attenuated, non-pathogenic but induces protective immunity

scientific article published on October 2004

Reduced Nasal Viral Load and IFN Responses in Infants with Respiratory Syncytial Virus Bronchiolitis and Respiratory Failure.

scientific article

Regulatory T cells expressing granzyme B play a critical role in controlling lung inflammation during acute viral infection.

scientific article published on 11 January 2012

Regulatory T cells prevent Th2 immune responses and pulmonary eosinophilia during respiratory syncytial virus infection in mice

scientific article published on 07 August 2013

Reply to rook

scientific article published on 01 May 2000

Respiratory Syncytial Virus

Respiratory Syncytial Virus (RSV): Targeting the G Protein Provides a New Approach for an Old Problem.

scientific article published on 8 November 2017

Respiratory syncytial virus (RSV): a scourge from infancy to old age

scientific article published on 05 August 2019

Respiratory syncytial virus and other pneumoviruses: a review of the international symposium--RSV 2003.

scientific article

Respiratory syncytial virus infection provokes airway remodelling in allergen-exposed mice in absence of prior allergen sensitization.

scientific article

Respiratory syncytial virus, airway inflammation, and FEV1 decline in patients with chronic obstructive pulmonary disease.

scientific article published on 2 February 2006

Reversibility of T helper 1 and 2 populations is lost after long-term stimulation

scientific article

Risk factors for hospitalisation and poor outcome with pandemic A/H1N1 influenza: United Kingdom first wave (May-September 2009)

scientific article

Risk of adverse outcomes in patients with underlying respiratory conditions admitted to hospital with COVID-19: a national, multicentre prospective cohort study using the ISARIC WHO Clinical Characterisation Protocol UK

scientific article published in 2021

Robust, reproducible clinical patterns in hospitalised patients with COVID-19

scientific article published on 16 August 2020

Role of CCL11 in eosinophilic lung disease during respiratory syncytial virus infection

scientific article

Role of CCL5 (RANTES) in viral lung disease.

scientific article

Safety and efficacy of immune-stimulating complex-based antigen delivery systems for neonatal immunisation against respiratory syncytial virus infection

scientific article published in June 2004

Safety, tolerability and viral kinetics during SARS-CoV-2 human challenge in young adults

scientific article published on 31 March 2022

Seasonal and pandemic influenza: 100 years of progress, still much to learn

scientific article published on 21 April 2020

Simultaneous Viral Whole-Genome Sequencing and Differential Expression Profiling in Respiratory Syncytial Virus Infection of Infants

scientific article published on 23 July 2020

Susan Elizabeth Openshaw (née Scott Stokes).

scientific article published in March 2008

T cells take the inside track

scientific article published in June 2006

Th1 and Th2 cytokine induction in pulmonary T cells during infection with respiratory syncytial virus

scientific article published in October 1996

The 1918 Influenza Pandemic: one hundred years of progress, but where now?

scientific article published on 22 June 2018

The 22,000-kilodalton protein of respiratory syncytial virus is a major target for Kd-restricted cytotoxic T lymphocytes from mice primed by infection.

scientific article published on April 1990

The Etiological Role of Common Respiratory Viruses in Acute Respiratory Infections in Older Adults: A Systematic Review and Meta-analysis

scholarly article by Ting Shi et al published 8 March 2019 in Journal of Infectious Diseases

The Helminth-Derived Immunomodulator AvCystatin Reduces Virus Enhanced Inflammation by Induction of Regulatory IL-10+ T Cells

scientific article

The Respiratory Mucosa: Front and Center in Respiratory Syncytial Virus Disease

scientific article published on 01 December 2019

The beta2 integrin CD11c distinguishes a subset of cytotoxic pulmonary T cells with potent antiviral effects in vitro and in vivo

scientific article

The chemokine MIP1alpha/CCL3 determines pathology in primary RSV infection by regulating the balance of T cell populations in the murine lung.

scientific article

The comparative clinical course of pregnant and non-pregnant women hospitalised with influenza A(H1N1)pdm09 infection.

scientific article

The effect of IL-12 treatment on vaccine-enhanced illness during infection with respiratory syncytial virus

scientific article published on January 1, 1998

The future of vaccines--cancer meets infectious diseases: immune mechanisms. 10-13 April 2003, Semmering, Austria

scientific article published in June 2003

The microbiology of asthma

scientific article published on 06 June 2012

The mouse model of respiratory syncytial virus disease.

scientific article published on January 2013

The respiratory syncytial virus vaccine landscape: lessons from the graveyard and promising candidates

scholarly article by Natalie I Mazur et al published October 2018 in Lancet Infectious Diseases

The role of T cells in the enhancement of respiratory syncytial virus infection severity during adult reinfection of neonatally sensitized mice

scientific article published on 13 February 2008

Therapeutic blockade of granulocyte macrophage colony-stimulating factor in COVID-19-associated hyperinflammation: challenges and opportunities

scientific article published on 16 June 2020

Third human challenge trial conference, Oxford, United Kingdom, February 6-7, 2020, a meeting report

scientific article published on 03 June 2020

Toward unified molecular surveillance of RSV: A proposal for genotype definition

scientific article published on 05 February 2020

Tracheostomy in the COVID-19 era: global and multidisciplinary guidance

scientific article published on 15 May 2020

Transcriptional profiling unveils type I and II interferon networks in blood and tissues across diseases

scientific article published on 28 June 2019

Using imaging to combat a pandemic: rationale for developing the UK National COVID-19 Chest Imaging Database

scientific article published on 02 July 2020

Vaccines for the prevention of respiratory viral infections: problems and current status

scientific article published on June 2004

Vaccines in the Prevention of Viral Pneumonia.

scientific article published on 18 December 2016

Virally delivered cytokines alter the immune response to future lung infections

scientific article

What does the peripheral blood tell you in SARS?

scientific article published in April 2004

Where is SARS now?

scientific article published in August 2003

World Immune Regulation Meeting II.

scientific article

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