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List of works by Anna-Leena Sirén

A goldfish model for evaluation of the neurotoxicity of ω-conotoxin GVI A and screening of monoclonal antibodies

scientific article published on 01 May 1991

A hematopoietic growth factor, thrombopoietin, has a proapoptotic role in the brain

scientific journal article

A novel role for an established player: anemia drug erythropoietin for the treatment of cerebral hypoxia/ischemia

scientific article

Adhesion molecules on normotensive and hypertensive rat brain endothelial cells

scientific article

Agonist-stimulated release of von Willebrand factor and procoagulant factor VIII in rats with and without risk factors for stroke

scientific article

Alleviation of secondary brain injury, posttraumatic inflammation, and brain edema formation by inhibition of factor XIIa

scientific article published on 20 February 2017

An experimental protocol for in vivo imaging of neuronal structural plasticity with 2-photon microscopy in mice

scientific article

An experimental protocol for mimicking pathomechanisms of traumatic brain injury in mice

scientific article published on 2 February 2012

Assessment of damage from implantation of microdialysis probes in the rat hippocampus with silver degeneration staining

scientific article published in May 1990

Biological activities of thionated thyrotropin-releasing hormone analogs.

scientific article published in April 1992

Blocking of bradykinin receptor B1 protects from focal closed head injury in mice by reducing axonal damage and astroglia activation.

scientific article

C1-Inhibitor protects from focal brain trauma in a cortical cryolesion mice model by reducing thrombo-inflammation

scientific article

Cardio-respiratory changes and mortality in the conscious rat induced by (+)- and (±)-anatoxin-a

scientific article published on 01 August 1992

Cardiovascular effects of TRH i.c.v. in conscious rats

scientific article published in January 1984

Cardiovascular effects of anatoxin-A in the conscious rat.

scientific article published in January 1990

Cardioventilator effects of TRH in anaesthetized rats: role of the brain stem

scientific article published in March 1986

Cell type specific signalling by hematopoietic growth factors in neural cells

scientific article published on 5 October 2006

Central cardiovascular and thermal effects of prostacyclin in rats

scientific article published on 01 December 1981

Central cardiovascular and thermal effects of prostaglandin D2 in rats

scientific article published in April 1982

Central cardiovascular and thermal effects of prostaglandin F2 alpha in rats.

scientific article published on March 1979

Central cardiovascular effects of the endoperoxide analogue U-46619 in rats

scientific article

Central ventilatory effects of thyrotropin-releasing hormone in the conscious rat.

scientific article published in February 1991

Characterization of binding kinetics of [3H]Tyr-D-Arg2-Phe-Sar4 at opioid receptors

scientific article

Chronophin is a glial tumor modifier involved in the regulation of glioblastoma growth and invasiveness

scientific article published on 9 November 2015

Combined [(18)F]DPA-714 micro-positron emission tomography and autoradiography imaging of microglia activation after closed head injury in mice

scientific article published on 07 June 2016

Comparison of stimulated tissue factor expression by brain microvascular endothelial cells from normotensive (WKY) and hypertensive (SHR) rats

scientific article published in December 1992

Differences in the central actions of arachidonic acid and prostaglandin F2 alpha between spontaneously hypertensive and normotensive rats

scientific article published in February 1982

Differential cellular expression of tumor necrosis factor-alpha and Type I tumor necrosis factor receptor after transient global forebrain ischemia

scientific article published in May 2001

Differential glial and vascular expression of endothelins and their receptors in rat brain after neurotrauma

scientific article published on 01 July 2000

Dissociation of the cardiovascular and prolactin-releasing activities of norvaline2-TRH

scientific article published on 01 July 1987

ETA and ETB receptor antagonists synergistically increase extracellular endothelin-1 levels in primary rat astrocyte cultures.

scientific article published on March 1998

Ectopic expression of neurogenin 2 alone is sufficient to induce differentiation of embryonic stem cells into mature neurons

scientific article

Effect of T-2 toxin on regional blood flow and vascular resistance in the conscious rat.

scientific article published in May 1986

Effect of endothelin-1 on astrocytic protein content

scientific article published in June 2003

Effect of erythropoietin axotomy-induced apoptosis in rat retinal ganglion cells

scientific article published in May 2004

Effect of thyrotropin releasing hormone and some of its histidine analogs on the cardiovascular system and prolactin release in the conscious rat

scientific article published on 01 July 1986

Effects of erythropoietin in murine-induced pluripotent cell-derived panneural progenitor cells

scientific article published on 8 November 2013

Endothelin B receptor deficiency augments neuronal damage upon exposure to hypoxia-ischemia in vivo

scientific article published in July 2002

Endothelin B receptor deficient transgenic rescue rats: a rescue phenomenon in the brain

scientific journal article

Endothelin converting enzyme activity in primary rat astrocytes is modulated by endothelin B receptors.

scientific article published on July 1999

Endothelins regulate astrocyte gap junctions in rat hippocampal slices

scientific article published in February 2004

Erratum to: Impaired sodium excretion, decreased glomerular filtration rate and elevated blood pressure in endothelin receptor type B deficient rats

scholarly article published in Journal of Molecular Medicine

Erythropoietin prevents neuronal apoptosis after cerebral ischemia and metabolic stress

scientific article

Erythropoietin therapy for acute stroke is both safe and beneficial

scientific article

Erythropoietin: a multimodal neuroprotective agent

scientific article published on 21 October 2009

Erythropoietin: not just about erythropoiesis

scientific article published on June 2010

Erythropoietin: novel approaches to neuroprotection in human brain disease

scientific article

Essential role for Stat5 in the neurotrophic but not in the neuroprotective effect of erythropoietin

scientific article published on 8 February 2008

Evidence for differential opioid mu 1- and mu 2-receptor-mediated regulation of heart rate in the conscious rat.

scientific article published in August 1992

Experimental heart failure causes depression-like behavior together with differential regulation of inflammatory and structural genes in the brain

scientific article published on 31 October 2014

Experimental traumatic brain injury

scientific article

Exploring recombinant human erythropoietin in chronic progressive multiple sclerosis

scientific article published on 29 August 2007

Expression patterns of erythropoietin and its receptor in the developing spinal cord and dorsal root ganglia

scientific article published on 18 October 2005

FTY720 does not protect from traumatic brain injury in mice despite reducing posttraumatic inflammation

scientific article published on 22 July 2014

Focal brain trauma in the cryogenic lesion model in mice

scientific article

Functional neuronal cells generated by human parthenogenetic stem cells

scientific article

Global brain atrophy after unilateral parietal lesion and its prevention by erythropoietin

article

Hemodynamic effects of endothelin after systemic and central nervous system administration in the conscious rat.

scientific article

Hippocampal cannabinoid-1 receptor upregulation upon endothelin-B receptor deficiency: a neuroprotective substitution effect?

scientific article

How is the formation of microthrombi after traumatic brain injury linked to inflammation?

scientific article published on 31 October 2018

Human Parthenogenetic Embryonic Stem Cell-Derived Neural Stem Cells Express HLA-G and Show Unique Resistance to NK Cell-Mediated Killing

scientific article

Hypothalamic opioid mu-receptors regulate discrete hemodynamic functions in the conscious rat.

scientific article

Impaired sodium excretion, decreased glomerular filtration rate and elevated blood pressure in endothelin receptor type B deficient rats

scientific article

In vitro gender differences in neuronal survival on hypoxia and in 17beta-estradiol-mediated neuroprotection

scientific article published in April 2005

Increased erythropoietin production after myocardial infarction in mice

scientific article published on June 2006

Inhibition of bradykinin receptor B1 protects mice from focal brain injury by reducing blood-brain barrier leakage and inflammation

scientific article

Ischemic stroke and traumatic brain injury: the role of the kallikrein-kinin system.

scientific article published on 27 December 2012

May 2004: newborn with intracranial mass

scientific article published on 01 October 2004

Melatonin as a candidate compound for neuroprotection in amyotrophic lateral sclerosis (ALS): high tolerability of daily oral melatonin administration in ALS patients

scientific article published in October 2002

Mesenteric vascular responses to i.v. administration of lipoxin A4 and lipoxin B4 in the conscious rat

article

N-Acetyl-leukotriene E4 is a potent constrictor of rat mesentric vessels

scientific article published on 01 February 1988

Neurobehavioral and cytotoxic effects of vanadium during oligodendrocyte maturation: a protective role for erythropoietin

scientific article published on 10 May 2014

Neuroprotection--what does it mean?--What means do we have?

scientific article published in August 2001

Phenotype and Stability of Neural Differentiation of Androgenetic Murine ES Cell-Derived Neural Progenitor Cells

scientific article published on 13 June 2013

Preexisting Serum Autoantibodies Against the NMDAR Subunit NR1 Modulate Evolution of Lesion Size in Acute Ischemic Stroke

scientific article published on 12 March 2015

Protective effect of a PAF-acether antagonist, BN 52021, in trichothecene toxicosis

scientific article published on 01 October 1987

Receptor binding and biological activity of the dermorphin analog Tyr-D-Arg(2)-Phe-Sar (TAPS).

scientific article

Reduced oxidative damage in ALS by high-dose enteral melatonin treatment

scientific article

Respiratory mu-opioid and benzodiazepine interactions in the unrestrained rat.

scientific article

Reversal of mu-opioid-mediated respiratory depression by alpha 2-adrenoceptor antagonism

scientific article

Revisiting adult neurogenesis and the role of erythropoietin for neuronal and oligodendroglial differentiation in the hippocampus

scientific article

Role of the astrocytic ET(B) receptor in the regulation of extracellular endothelin-1 during hypoxia

scientific article published in April 2001

Role of the kallikrein-kinin system in traumatic brain injury

scientific article

Skull Fractures Induce Neuroinflammation and Worsen Outcomes after Closed Head Injury in Mice

scientific article published on 08 November 2019

Soccer, neurotrauma and amyotrophic lateral sclerosis: is there a connection?

scientific article published on April 2004

Stiff person syndrome-associated autoantibodies to amphiphysin mediate reduced GABAergic inhibition

scientific article published on 30 September 2010

Targeting coagulation factor XII as a novel therapeutic option in brain trauma

scientific article published on 04 April 2016

Temporal profile of expression and cellular localization of inducible nitric oxide synthase, interleukin-1beta and interleukin converting enzyme after cryogenic lesion of the rat parietal cortex

scientific article

The brain erythropoietin system and its potential for therapeutic exploitation in brain disease

scientific article

The relationship between ventricular dilatation, neuropathological and neurobehavioural changes in hydrocephalic rats

scientific article

Therapeutic potential of erythropoietin and its structural or functional variants in the nervous system

scientific article published on January 2009

Thrombopoietin inhibits nerve growth factor-induced neuronal differentiation and ERK signalling

scientific article published on 12 October 2007

Tolerance and dependence following chronic intracerebroventricular infusions of Tyr-D-Arg2-Phe-Sar4 (TAPS).

scientific article

Two paternal genomes are compatible with dopaminergic in vitro and in vivo differentiation

scientific article

Uncoupling of neurodegeneration and gliosis in a murine model of juvenile cortical lesion

scientific article

Upregulation of intercellular adhesion molecule 1 (ICAM-1) on brain microvascular endothelial cells in rat ischemic cortex

scientific article published on 01 October 1994

Volume-dependent spatial distribution of microinjected thyrotropin-releasing hormone (TRH) into the medial preoptic nucleus of the rat: an autoradiographic study

scientific article published in May 1990

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