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List of works by Pierre De Meyts

A Novel Binding Site for the Human Insulin-like Growth Factor-II (IGF-II)/Mannose 6-Phosphate Receptor on IGF-II

scientific article published in Journal of Biological Chemistry

Activation of the insulin receptor (IR) by insulin and a synthetic peptide has different effects on gene expression in IR-transfected L6 myoblasts

scientific article published on 01 June 2008

Activation of the insulin receptor by insulin and a synthetic peptide leads to divergent metabolic and mitogenic signaling and responses

scientific article

Agonism and antagonism at the insulin receptor

scientific article

Alanine scanning of a putative receptor binding surface of insulin-like growth factor-I

scientific article

Biosensor measurement of the binding of insulin-like growth factors I and II and their analogues to the insulin-like growth factor-binding protein-3.

scientific article published in June 1996

Carbohydrate metabolism in women who used oral contraceptives containing levonorgestrel or desogestrel: a 6-month prospective study.

scientific article published in May 1986

Cooperative binding of insulin-like Peptide 3 to a dimeric relaxin family peptide receptor 2.

scientific article published on 6 December 2007

Cooperativity in ligand binding: a new graphic analysis

scientific article published on October 27, 1975

Crystal Structure of a"Nonfoldable"Insulin: IMPAIRED FOLDING EFFICIENCY DESPITE NATIVE ACTIVITY

scientific article

DOK4/IRS-5 expression is altered in clear cell renal cell carcinoma

scientific article

Dimerization and negative cooperativity in the relaxin family peptide receptors

scientific article published in April 2009

Down-regulation of cyclin G2 by insulin, IGF-I (insulin-like growth factor 1) and X10 (AspB10 insulin): role in mitogenesis

scientific article

Drosophila Insulin-Like Peptides DILP2 and DILP5 Differentially Stimulate Cell Signaling and Glycogen Phosphorylase to Regulate Longevity.

scientific article

Gene expression in skeletal muscle biopsies from people with type 2 diabetes and relatives: differential regulation of insulin signaling pathways

scientific article (publication date: 11 August 2009)

Genetic engineering in mice: impact on insulin signalling and action.

scientific article

Glycosylation of cell surface receptors: tunicamycin treatment decreases insulin and growth hormone binding to different levels in cultured lymphocytes

scientific article published on 01 July 1981

Growth failure in a child showing characteristics of Seckel syndrome: possible effects of IGF-I and endogenous IGFBP-3

scientific article published on 01 August 2002

Harmonic oscillator model of the insulin and IGF1 receptors' allosteric binding and activation

scientific article

How insulin binds: the B-chain alpha-helix contacts the L1 beta-helix of the insulin receptor.

scientific article

How ligand binds to the type 1 insulin-like growth factor receptor

scientific article published on 26 February 2018

Human insulin prepared by recombinant DNA techniques and native human insulin interact identically with insulin receptors

scientific article

IGF-I, IGF-II, and Insulin Stimulate Different Gene Expression Responses through Binding to the IGF-I Receptor

scientific article

IRS-4 mediated mitogenic signalling by insulin and growth hormone in LB cells, a murine T-cell lymphoma devoid of IGF-I receptors

scientific article published in April 2003

Immunological and metabolic responses of patients with history of antibody-induced beef insulin resistance to treatment with beef, pork, human, and sulfated beef insulin.

scientific article published in May 1992

Impaired negative cooperativity of the semisynthetic analogues human [LeuB24]- and [LeuB25]-insulins

scientific article published on 01 June 1981

In Memoriam: Guy Dodson (1937–2012)

scientific article published in 2013

Inhibition by Insulin of Glucocorticoid-Induced Gene Transcription: Involvement of the Ligand-Binding Domain of the Glucocorticoid Receptor and Independence from the Phosphatidylinositol 3-Kinase and Mitogen-Activated Protein Kinase Pathways ⬇️

scientific article published on September 1, 1998

Inhibition of insulin receptor binding by dimethyl sulfoxide

scientific article published on February 1, 1979

Insight into the molecular basis for the kinetic differences between the two insulin receptor isoforms

scientific article

Insulin and insulin-like growth factor-I receptor mediated differentiation of 3T3-F442A cells into adipocytes: effect of PI 3-kinase inhibition.

scientific article published on May 1998

Insulin and insulin-like growth factors: the paradox of signaling specificity

scientific article published on 01 April 2002

Insulin and its receptor: structure, function and evolution

scientific article

Insulin interactions with its receptors: experimental evidence for negative cooperativity.

scientific article

Insulin receptor substrates-5 and -6 are poor substrates for the insulin receptor.

scientific article

Insulin receptor-deficient cells as a new tool for dissecting complex interplay in insulin and insulin-like growth factors.

scientific article published on April 1998

Insulin-dependent regulation of insulin receptor concentrations: a direct demonstration in cell culture.

scientific article published on January 1974

Insulin-like growth factor I (IGF-I) is a more potent regulator of gene expression than insulin in primary human myoblasts and myotubes

scientific article

Insulin/receptor binding: the last piece of the puzzle? What recent progress on the structure of the insulin/receptor complex tells us (or not) about negative cooperativity and activation

scientific article

Logical analysis of timing-dependent receptor signalling specificity: application to the insulin receptor metabolic and mitogenic signalling pathways.

scientific article

Mapping of the residues responsible for the negative cooperativity of the receptor-binding region of insulin

scientific article published in Nature

Measuring Growth Hormone Activity through Receptor and Binding Protein Assays ⬇️

scientific article published on January 1, 1991

Mitogenic potential of insulin on lymphoma cells lacking IGF-1 receptor.

scientific article

Mitogenic properties of insulin and insulin analogues mediated by the insulin receptor ⬇️

scientific article published on July 1, 1997

Molecular mechanisms of differential intracellular signaling from the insulin receptor

scientific article published on January 2009

Mutation of arginine 86 to proline in the insulin receptor alpha subunit causes lack of transport of the receptor to the plasma membrane, loss of binding affinity and a constitutively activated tyrosine kinase in transfected cells

scientific article published on 01 April 1993

Negative cooperativity in H2 relaxin binding to a dimeric relaxin family peptide receptor 1

scientific article published on 03 August 2008

News

scientific article published on 01 June 2005

Pancreatic hormone receptors on islet cells

scientific article published on 01 September 1985

Pancreatic α-cell hyperplasia and hyperglucagonemia due to a glucagon receptor splice mutation

scientific article

Preparation and expression of biologically active prolactin and growth hormone receptors and suppressor of cytokine signaling proteins 1, 2, 3, and 6 tagged with cyan and yellow fluorescent proteins

scientific article published on August 2002

Receptor binding properties and biologic activity in vitro of biosynthetic human insulin.

scientific article published in March 1981

Receptor oligomerization in family B1 of G-protein-coupled receptors: focus on BRET investigations and the link between GPCR oligomerization and binding cooperativity

scientific article

Regulation of Receptor by Homologous Hormone Enhances Sensitivity and Broadens Scope of Radioreceptor Assay for Human Growth Hormone ⬇️

scientific article published on August 1, 1979

Reversal of insulin-induced negative cooperativity by monoclonal antibodies that stabilize the slowly dissociating ("Ksuper") state of the insulin receptor.

scientific article published in January 1988

Role of histone and transcription factor acetylation in diabetes pathogenesis

scientific article

Separation of fast from slow anabolism by site-specific PEGylation of insulin-like growth factor I (IGF-I).

scientific article

Short Stature Associated with a Novel Heterozygous Mutation in theInsulin-Like Growth Factor 1Gene ⬇️

scientific article published on July 28, 2010

Sphingosine, an inhibitor of protein kinase C, suppresses the insulin-like effects of growth hormone in rat adipocytes.

scientific article

Structural and Biological Properties of the Drosophila Insulin-like Peptide 5 Show Evolutionary Conservation

scientific article

Structural basis for the lower affinity of the insulin-like growth factors for the insulin receptor

scientific article

Structural basis for the poisonous activity of a predator's venom insulin

scientific article published on 01 October 2016

Structural basis of allosteric ligand-receptor interactions in the insulin/relaxin peptide family: implications for other receptor tyrosine kinases and G-protein-coupled receptors

scientific article

Structural basis of the aberrant receptor binding properties of hagfish and lamprey insulins.

scientific article published on December 2009

Structural biology of insulin and IGF1 receptors: implications for drug design

scientific article

Structure of growth hormone and its receptor: an unexpected stoichiometry

scientific article published on May 1, 1992

Structures of insect Imp-L2 suggest an alternative strategy for regulating the bioavailability of insulin-like hormones

scientific article published in Nature Communications

SysBioMed report: advancing systems biology for medical applications.

scientific article published on May 2009

The A-chain of insulin contacts the insert domain of the insulin receptor. Photo-cross-linking and mutagenesis of a diabetes-related crevice

scientific article

The Insulin Receptor Isoform A: A Mitogenic Proinsulin Receptor? ⬇️

scientific article published on May 1, 2012

The Insulin Receptor in Vertebrates Is Functionally More Conserved during Evolution than Insulin Itself ⬇️

scientific article published on May 1, 1979

The growth hormone (GH)-binding protein cloned from human IM-9 lymphocytes modulates the down-regulation of GH receptors by 22- and 20-kilodalton human GH in IM-9 lymphocytes and the biological effects of the hormone in Nb2 lymphoma cells

scientific article published on 01 December 1993

The insulin receptor: a prototype for dimeric, allosteric membrane receptors?

scientific article

The receptor binding properties of the 20K variant of human growth hormone explain its discrepant insulin-like and growth promoting activities

scientific article published on 01 January 1986

The severe short stature in two siblings with a heterozygous IGF1 mutation is not caused by a dominant negative effect of the putative truncated protein.

scientific article published on 14 January 2011

The structural basis of insulin and insulin-like growth factor-I receptor binding and negative co-operativity, and its relevance to mitogenic versus metabolic signalling.

scientific article

Timing-dependence of insulin-receptor mitogenic versus metabolic signalling: a plausible model based on coincidence of hormone and effector binding.

scientific article published in May 1999

Total Solid-Phase Synthesis of Biologically Active Drosophila Insulin-Like Peptide 2 (DILP2).

scientific article published on 12 December 2016

Viral insulin-like peptides activate human insulin and IGF-1 receptor signaling: A paradigm shift for host-microbe interactions

scientific article

p38 MAPK activation upregulates proinflammatory pathways in skeletal muscle cells from insulin-resistant type 2 diabetic patients

scientific article

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