List of works by Leroy Hood

A Cell-Surface Membrane Protein Signature for Glioblastoma

scientific article

A Third Approach to Gene Prediction Suggests Thousands of Additional Human Transcribed Regions

article

A combined genomewide linkage scan of 1,233 families for prostate cancer-susceptibility genes conducted by the international consortium for prostate cancer genetics

scientific article

A data integration methodology for systems biology

scientific article

A data integration methodology for systems biology: experimental verification

scientific article

A gain-of-function mutation in TRPV3 causes focal palmoplantar keratoderma in a Chinese family

article

A genomic regulatory network for development

scientific article (publication date: March 2002)

A molecular correlate to the Gleason grading system for prostate adenocarcinoma

scholarly article

A novel Fanconi anaemia subtype associated with a dominant-negative mutation in RAD51

scientific journal article

A personal view on systems medicine and the emergence of proactive P4 medicine: predictive, preventive, personalized and participatory

scientific article published on 18 March 2012

A physical map of the human genome

scientific article

A provisional regulatory gene network for specification of endomesoderm in the sea urchin embryo

scientific article

A systems approach to clinical oncology uses deep phenotyping to deliver personalized care

scientific article published on 16 October 2019

A systems approach to rheumatoid arthritis

scientific article

A third approach to gene prediction suggests thousands of additional human transcribed regions

scientific article

A unified test of linkage analysis and rare-variant association for analysis of pedigree sequence data.

scientific article

A wellness study of 108 individuals using personal, dense, dynamic data clouds

scientific article published on 17 July 2017

ACGT-a comparative genomics tool

scientific article

Activated Notch4 inhibits angiogenesis: role of beta 1-integrin activation

scientific article

An enigmatic fourth runt domain gene in the fugu genome: ancestral gene loss versus accelerated evolution

scientific article

An epigenetic biomarker panel for glioblastoma multiforme personalized medicine through DNA methylation analysis of human embryonic stem cell-like signature

scientific article

Analysis of acute myelogenous leukemia: preparation of samples for genomic and proteomic analyses

scientific article

Analysis of chemotherapy response programs in ovarian cancers by the next-generation sequencing technologies

scientific article

Analysis of genetic inheritance in a family quartet by whole-genome sequencing

scientific article

Analysis of the DNA sequence and duplication history of human chromosome 15

scientific article

Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse

scientific article

Analysis of the human neurexin genes: alternative splicing and the generation of protein diversity

scientific article (publication date: April 2002)

Atlas of Transcription Factor Binding Sites from ENCODE DNase Hypersensitivity Data Across 27 Tissue Types

Atlas of Transcription Factor Binding Sites from ENCODE DNase Hypersensitivity Data across 27 Tissue Types

scientific article published on 01 August 2020

Automated Validation of Results and Removal of Fragment Ion Interferences in Targeted Analysis of Data-independent Acquisition Mass Spectrometry (MS) using SWATHProphet

scientific article

BDQC: a general-purpose analytics tool for domain-blind validation of Big Data

Big biomedical data as the key resource for discovery science

scientific article published on 21 July 2015

Bioprocessing of human glioblastoma brain cancer tissue

scientific article

Blood metabolome predicts gut microbiome α-diversity in humans

scientific article published on 02 September 2019

Boosting signal-to-noise in complex biology: prior knowledge is power

scientific article

COVID-19 and beyond: a call for action and audacious solidarity to all the citizens and nations, it is humanity’s fight

scientific article published in 2020

Cancer as robust intrinsic state of endogenous molecular-cellular network shaped by evolution

scientific article

Cell population structure prior to bifurcation predicts efficiency of directed differentiation in human induced pluripotent cells

scientific article published on 06 February 2017

Cell type-specific genes show striking and distinct patterns of spatial expression in the mouse brain

scientific article published on 5 February 2013

Chromosomal haplotypes by genetic phasing of human families

scientific article

Complementary profiling of gene expression at the transcriptome and proteome levels in Saccharomyces cerevisiae

scientific article published in April 2002

Comprehensive de novo structure prediction in a systems-biology context for the archaea Halobacterium sp. NRC-1

scientific article

Conservation of Toll-Like Receptor Signaling Pathways in Teleost Fish

scientific article (publication date: March 2006)

Coordinate regulation of energy transduction modules in Halobacterium sp. analyzed by a global systems approach

scientific article

Correction: Optimal Scaling of Digital Transcriptomes.

scientific article published on 8 January 2014

Deep depletion of abundant serum proteins reveals low-abundant proteins as potential biomarkers for human ovarian cancer

scientific article

Deep phenotyping during pregnancy for predictive and preventive medicine

scientific article published on 01 January 2020

Detailed transcriptome atlas of the pancreatic beta cell

scientific article

Developmental biologist Eric H. Davidson, 1937-2015

scientific article

Differential gene expression profiling of adult murine hematopoietic stem cells

scientific article

Down-regulation of Shadoo in prion infections traces a pre-clinical event inversely related to PrP(Sc) accumulation

scientific article

Dysregulated gene expression networks in human acute myelogenous leukemia stem cells

scholarly article

ERG upregulation and related ETS transcription factors in prostate cancer

scientific article published on January 2007

Editorial: Systems biology and personalized medicine - the future is now.

scientific article published in August 2012

Efficient region-based test strategy uncovers genetic risk factors for functional outcome in bipolar disorder

scientific article published on 29 November 2018

Elevated expression of DKK1 is associated with cytoplasmic/nuclear beta-catenin accumulation and poor prognosis in hepatocellular carcinomas

scientific article published on 9 January 2009

Endogenous molecular-cellular hierarchical modeling of prostate carcinogenesis uncovers robust structure

scientific article published on January 2015

Evidence for the presence of disease-perturbed networks in prostate cancer cells by genomic and proteomic analyses: a systems approach to disease

scientific article

Evolutionary etiology of high-grade astrocytomas

scientific article published on 10 October 2013

Evolutionary history of Tibetans inferred from whole-genome sequencing.

scientific article

Extracellular microRNA: a new source of biomarkers

scientific article

Foreword: from the TRANSCRIPTOME conferences to the SYSTEMOSCOPE international consortium

scientific article published on October 2003

From functional genomics to systems biology: concepts and practices

scientific article published on October 2003

Gene expression relationship between prostate cancer cells of Gleason 3, 4 and normal epithelial cells as revealed by cell type-specific transcriptomes ⬇️

scientific article

Gene regulatory networks and embryonic specification

scientific article

Genetic mapping at 3-kilobase resolution reveals inositol 1,4,5-triphosphate receptor 3 as a risk factor for type 1 diabetes in Sweden

scientific article

Genome sequence of Haloarcula marismortui: a halophilic archaeon from the Dead Sea

scientific article

Genome-wide analysis of epigenetic silencing identifies BEX1 and BEX2 as candidate tumor suppressor genes in malignant glioma

scientific article

Genomic analysis of the olfactory receptor region of the mouse and human T-cell receptor alpha/delta loci

scientific article

Genomic and molecular characterization of preterm birth

article

Genomic architecture of inflammatory bowel disease in five families with multiple affected individuals

scientific article published on 7 January 2016

Genomic scan of 254 hereditary prostate cancer families

scientific article

Glycocapture-assisted global quantitative proteomics (gagQP) reveals multiorgan responses in serum toxicoproteome

scientific article published on 11 April 2013

High resolution time-course mapping of early transcriptomic, molecular and cellular phenotypes in Huntington's disease CAG knock-in mice across multiple genetic backgrounds

scientific article published on 27 February 2017

Highly accurate two-gene classifier for differentiating gastrointestinal stromal tumors and leiomyosarcomas

scientific article

Human SRMAtlas: A Resource of Targeted Assays to Quantify the Complete Human Proteome

scientific article

Human prostate epithelial cell-type cDNA libraries and prostate expression patterns

scientific article

Identification of Organ-Enriched Protein Biomarkers of Acute Liver Injury by Targeted Quantitative Proteomics of Blood in Acetaminophen- and Carbon-Tetrachloride-Treated Mouse Models and Acetaminophen Overdose Patients

scientific article published on 30 August 2016

Identification of a prostate cancer susceptibility locus on chromosome 7q11-21 in Jewish families

scholarly article

Identification of copy number variants in whole-genome data using Reference Coverage Profiles

scientific article

Identifying tightly regulated and variably expressed networks by Differential Rank Conservation (DIRAC).

scientific article

Initial proteome analysis of model microorganism Haemophilus influenzae strain Rd KW20.

scientific article

Initial sequencing and analysis of the human genome

scientific article published on 15 February 2001

Integrated barcode chips for rapid, multiplexed analysis of proteins in microliter quantities of blood

scientific article

Integrated expression profiling and ChIP-seq analyses of the growth inhibition response program of the androgen receptor

scientific article

Integrated genomic and proteomic analyses of gene expression in Mammalian cells

scientific article published on 6 July 2004

Integrating big data and actionable health coaching to optimize wellness

scientific article

Integration of biological networks and gene expression data using Cytoscape

scientific article (publication date: 2007)

Interchromosomal segmental duplications explain the unusual structure of PRSS3, the gene for an inhibitor-resistant trypsinogen.

scientific article

Issues in Computational Methods for Functional Genomics and Systems Biology

KLK31P is a novel androgen regulated and transcribed pseudogene of kallikreins that is expressed at lower levels in prostate cancer cells than in normal prostate cells

scientific article published on June 2006

Kaviar: an accessible system for testing SNV novelty

scientific article

Label-free detection with surface plasmon resonance imaging

scientific article published on January 2011

Label-free quantitative detection of tumor-derived exosomes through surface plasmon resonance imaging

scientific article

Landscape of the SOX2 protein-protein interactome

scientific article published on 31 January 2011

Long-range multilocus haplotype phasing of the MHC

scholarly article

Longitudinal analysis reveals transition barriers between dominant ecological states in the gut microbiome

scientific article published on 29 May 2020

Low-pass sequencing for microbial comparative genomics

scientific article

MS-BID: a Java package for label-free LC-MS-based comparative proteomic analysis

scientific article

Massively parallel signature sequencing and bioinformatics analysis identifies up-regulation of TGFBI and SOX4 in human glioblastoma

scientific article

Measurement of Organ-Specific and Acute-Phase Blood Protein Levels in Early Lyme Disease

scientific article published on 01 November 2019

Microarray based screening of peptide nano probes for HER2 positive tumor

scientific article published on 28 July 2015

Molecular evidence of stress-induced acute heart injury in a mouse model simulating posttraumatic stress disorder

scientific article published on 10 February 2014

Molecular profiling of stem cells

scientific article published on 3 January 2007

Multiomic blood correlates of genetic risk identify presymptomatic disease alterations

scientific article published on 19 August 2020

Mutations in STX1B, encoding a presynaptic protein, cause fever-associated epilepsy syndromes

scientific article published on 2 November 2014

N-glycoproteome of E14.Tg2a mouse embryonic stem cells

scientific article

NanoSystems biology

scientific article published on September 2003

Nanomedicine targets cancer

scientific article published on February 2009

New and improved proteomics technologies for understanding complex biological systems: addressing a grand challenge in the life sciences

scientific article published on September 2012

New paradigms for understanding and step changes in treating active and chronic, persistent apicomplexan infections ⬇️

scientific article published on 14 July 2016

Opening a SWATH Window on Posttranslational Modifications: Automated Pursuit of Modified Peptides

scientific article published on 24 December 2015

Optimal scaling of digital transcriptomes

scientific article

Origin of the PSEN1 E280A mutation causing early-onset Alzheimer's disease

scientific article

P4 medicine needs P4 education.

scientific article

P4 medicine: how systems medicine will transform the healthcare sector and society

scientific article

PTEN-deficient intestinal stem cells initiate intestinal polyposis

scientific article

Participatory medicine: a driving force for revolutionizing healthcare

scientific article

Pooled genome linkage scan of aggressive prostate cancer: results from the International Consortium for Prostate Cancer Genetics

scientific article published on 25 August 2006

Population-specific genetic modification of Huntington's disease in Venezuela.

scientific article

Predicting demographic group structures based on DNA sequence data

scientific article

Predictive Big Data Analytics: A Study of Parkinson's Disease Using Large, Complex, Heterogeneous, Incongruent, Multi-Source and Incomplete Observations

scientific article

Predictive, preventive, personalized and participatory medicine: back to the future

scientific article

Prequips--an extensible software platform for integration, visualization and analysis of LC-MS/MS proteomics data

scientific article

Principal network analysis: identification of subnetworks representing major dynamics using gene expression data

scientific article

Protein-centric N-glycoproteomics analysis of membrane and plasma membrane proteins

scientific article

Proteins associated with Cisplatin resistance in ovarian cancer cells identified by quantitative proteomic technology and integrated with mRNA expression levels

scientific article

Proteomic analysis identifies that 14-3-3zeta interacts with beta-catenin and facilitates its activation by Akt.

scholarly article

Proteomic analysis of an extreme halophilic archaeon, Halobacterium sp. NRC-1.

scientific article published on 18 July 2003

Proteomic analysis of human prostasomes ⬇️

scientific article published on July 1, 2003

Proteomics analysis of the interactome of N-myc downstream regulated gene 1 and its interactions with the androgen response program in prostate cancer cells

scientific article

Proteomics cataloging analysis of human expressed prostatic secretions reveals rich source of biomarker candidates

scientific article

Quantitative liver-specific protein fingerprint in blood: a signature for hepatotoxicity

scientific article published on 14 January 2014

Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry

scientific article

Quantitative proteomic approaches for biomarker discovery

scientific article published on 10 August 2007

Quantitative proteomics analysis integrated with microarray data reveals that extracellular matrix proteins, catenins, and p53 binding protein 1 are important for chemotherapy response in ovarian cancers.

scientific article

Rapid screening of peptide probes through in situ single-bead sequencing microarray

scientific article published on 14 November 2014

Rare variants in neuronal excitability genes influence risk for bipolar disorder

scientific article

Realistic artificial DNA sequences as negative controls for computational genomics

scientific article

Regulatory gene networks and the properties of the developmental process

scholarly article

Relationship estimation from whole-genome sequence data

scientific article

Reply to "Precision medicine in the clouds"

scientific article published on 01 August 2018

Revolutionizing medicine in the 21st century through systems approaches

scientific article published on 20 July 2012

SPR imaging for high throughput, label-free interaction analysis

scientific article published on September 2009

SRM targeted proteomics in search for biomarkers of HCV-induced progression of fibrosis to cirrhosis in HALT-C patients

scientific article published on April 2012

Self-organized living systems: conjunction of a stable organization with chaotic fluctuations in biological space-time.

scientific article

Sequence analysis of mouse vomeronasal receptor gene clusters reveals common promoter motifs and a history of recent expansion

scientific article

Sequence-Level Analysis of the Major European Huntington Disease Haplotype

scientific article

Shotgun glycopeptide capture approach coupled with mass spectrometry for comprehensive glycoproteomics

scientific article

Silencing SOX2 induced mesenchymal-epithelial transition and its expression predicts liver and lymph node metastasis of CRC patients

scientific article

Single-cell proteomic chip for profiling intracellular signaling pathways in single tumor cells

scientific article published on 27 December 2011

Suggestive genetic linkage to chromosome 11p11.2-q12.2 in hereditary prostate cancer families with primary kidney cancer

scientific article published on 01 May 2007

Systems approaches to biology and disease enable translational systems medicine

scientific article published on 23 August 2012

Systems biology and cancer stem cells

scientific article

Systems biology and new technologies enable predictive and preventative medicine.

scientific article

Systems biology and p4 medicine: past, present, and future

scientific article

Systems biology and the discovery of diagnostic biomarkers

scientific article published on January 2010

Systems biology at the Institute for Systems Biology

scientific article

Systems biology, proteomics, and the future of health care: toward predictive, preventative, and personalized medicine

scientific article

Systems genomics evaluation of the SH-SY5Y neuroblastoma cell line as a model for Parkinson's disease

scientific article

Systems level insights into the stress response to UV radiation in the halophilic archaeon Halobacterium NRC-1

scientific article

Systems medicine and integrated care to combat chronic noncommunicable diseases

scientific article

Systems medicine: the future of medical genomics and healthcare

scientific article

TGFβ-Responsive HMOX1 Expression Is Associated with Stemness and Invasion in Glioblastoma Multiforme

scientific article published on 29 June 2016

Targeting stem cells-clinical implications for cancer therapy

scientific article

The DNA sequence and analysis of human chromosome 14

scientific article (publication date: 6 February 2003)

The Human Genome Project: big science transforms biology and medicine

scientific article (publication date: 2013)

The Inferelator: an algorithm for learning parsimonious regulatory networks from systems-biology data sets de novo

scientific article

The P4 Health Spectrum - A Predictive, Preventive, Personalized and Participatory Continuum for Promoting Healthspan

scientific article

The Prion Disease Database: a comprehensive transcriptome resource for systems biology research in prion diseases

scientific article published on 17 September 2009

The SOX2 response program in glioblastoma multiforme: an integrated ChIP-seq, expression microarray, and microRNA analysis

scientific article

The digital code of DNA.

scientific article

The program of androgen-responsive genes in neoplastic prostate epithelium

scientific article

WDR19 expression is increased in prostate cancer compared with normal cells, but low-intensity expression in cancers is associated with shorter time to biochemical failures and local recurrence

scientific article

WaveletQuant, an improved quantification software based on wavelet signal threshold de-noising for labeled quantitative proteomic analysis

scientific article published on 29 April 2010

Whole genome sequence and comparative analysis of Borrelia burgdorferi MM1

Whole genome sequence and comparative analysis of Borrelia burgdorferi MM1.

scientific article

Whole-Genome Shotgun Assembly and Analysis of the Genome of Fugu rubripes

scientific article

Whole-genome sequencing of the world's oldest people

scientific article

Paulina is supported by:

About Paulina

Help