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List of works by David Ron

A J-Protein Co-chaperone Recruits BiP to Monomerize IRE1 and Repress the Unfolded Protein Response

scientific article

A Missense Mutation in PPP1R15B Causes a Syndrome Including Diabetes, Short Stature, and Microcephaly

scientific article

A Sephin1-insensitive tripartite holophosphatase dephosphorylates translation initiation factor 2α.

scientific article

A deregulated integrated stress response promotes interferon-γ-induced medulloblastoma.

scientific article

A family of constitutive C/EBP-like DNA binding proteins attenuate the IL-1 alpha induced, NF kappa B mediated trans-activation of the angiotensinogen gene acute-phase response element

scientific article

A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol

scientific article

A method to quantify FRET stoichiometry with phasor plot analysis and acceptor lifetime ingrowth

scientific article

A novel effector domain from the RNA-binding protein TLS or EWS is required for oncogenic transformation by CHOP

scientific article (publication date: November 1994)

A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress

scientific article

A small molecule inhibitor of endoplasmic reticulum oxidation 1 (ERO1) with selectively reversible thiol reactivity

scientific article

A survival pathway for Caenorhabditis elegans with a blocked unfolded protein response

scientific article

A topogenic role for the oncogenic N-terminus of TLS: nucleolar localization when transcription is inhibited

scientific article published on January 1997

ADP ribosylation adapts an ER chaperone response to short-term fluctuations in unfolded protein load

ADP ribosylation adapts an ER chaperone response to short-term fluctuations in unfolded protein load

scientific article

ALS/FTD Mutation-Induced Phase Transition of FUS Liquid Droplets and Reversible Hydrogels into Irreversible Hydrogels Impairs RNP Granule Function

scientific article

AMPylation matches BiP activity to client protein load in the endoplasmic reticulum

scientific article published on 17 December 2015

AMPylation targets the rate-limiting step of BiP's ATPase cycle for its functional inactivation.

scientific article published on 24 October 2017

ATF4 mediation of NF1 functions in osteoblast reveals a nutritional basis for congenital skeletal dysplasiae

scientific article published on December 2006

Ablation of the UPR-mediator CHOP restores motor function and reduces demyelination in Charcot-Marie-Tooth 1B mice

scientific article published in February 2008

Accumulation of lipoprotein remnants in patients with chronic renal failure

scientific article published on 01 January 1983

Actin dynamics tune the integrated stress response by regulating eukaryotic initiation factor 2α dephosphorylation

scientific article

Activating transcription factor 3 is integral to the eukaryotic initiation factor 2 kinase stress response

scientific journal article

Activating transcription factor 4 is translationally regulated by hypoxic stress

scientific article published on September 2004

Activation of GCN2 in UV-irradiated cells inhibits translation

scientific journal article

Activation-dependent substrate recruitment by the eukaryotic translation initiation factor 2 kinase PERK.

scientific article

Adaptive suppression of the ATF4-CHOP branch of the unfolded protein response by toll-like receptor signalling

scientific article

Alteration of the unfolded protein response modifies neurodegeneration in a mouse model of Marinesco-Sjögren syndrome

scientific article published on January 2010

Alterations in an IRE1-RNA complex in the mammalian unfolded protein response.

scientific article

Amino Acid Limitation Induces Expression ofCHOP, a CCAAT/Enhancer Binding Protein-related Gene, at Both Transcriptional and Post-transcriptional Levels

scientific article published in Journal of Biological Chemistry

Amino acid limitation regulates CHOP expression through a specific pathway independent of the unfolded protein response

scientific article

An arsenite-inducible 19S regulatory particle-associated protein adapts proteasomes to proteotoxicity

scientific journal article

An inducible 50-kilodalton NF kappa B-like protein and a constitutive protein both bind the acute-phase response element of the angiotensinogen gene

scientific article published on March 1990

An intact unfolded protein response in Trpt1 knockout mice reveals phylogenic divergence in pathways for RNA ligation

scientific journal article

An integrated stress response regulates amino acid metabolism and resistance to oxidative stress

scientific article (publication date: March 2003)

An oligomeric state-dependent switch in the ER enzyme FICD regulates AMPylation and deAMPylation of BiP

scientific article published on 18 September 2019

Angiotensinogen gene-inducible enhancer-binding protein 1, a member of a new family of large nuclear proteins that recognize nuclear factor kappa B-binding sites through a zinc finger motif

scientific article

Antiviral effect of the mammalian translation initiation factor 2alpha kinase GCN2 against RNA viruses

scientific journal article

Arginine deficiency causes runting in the suckling period by selectively activating the stress kinase GCN2.

scientific article published on 14 January 2011

Arsenite-inducible RNA-associated protein (AIRAP) protects cells from arsenite toxicity

scientific article

Association of SARFH (sarcoma-associated RNA-binding fly homolog) with regions of chromatin transcribed by RNA polymerase II.

scientific article published on August 1995

Author Correction: The molecular chaperones DNAJB6 and Hsp70 cooperate to suppress α-synuclein aggregation

scientific article published in Scientific Reports

Binding of ISRIB reveals a regulatory site in the nucleotide exchange factor eIF2B.

scientific article published in March 2018

Bioactive small molecules reveal antagonism between the integrated stress response and sterol-regulated gene expression

scientific article published on December 2005

Brain ischemia and reperfusion activates the eukaryotic initiation factor 2alpha kinase, PERK.

scientific article published in June 2001

C/ATF, a member of the activating transcription factor family of DNA-binding proteins, dimerizes with CAAT/enhancer-binding proteins and directs their binding to cAMP response elements

scientific article

C/EBP homologous protein is necessary for normal osteoblastic function

scientific article published in February 2006

CHOP (GADD153) and its oncogenic variant, TLS-CHOP, have opposing effects on the induction of G1/S arrest.

scientific article published on February 1994

CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum

scientific journal article

CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum

scientific journal article

CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription

scientific article

CHOP-Dependent stress-inducible expression of a novel form of carbonic anhydrase VI

scientific journal article

CHOP-independent apoptosis and pathway-selective induction of the UPR in developing plasma cells

scientific article

CHOP/GADD153 is a mediator of apoptotic death in substantia nigra dopamine neurons in an in vivo neurotoxin model of parkinsonism

scientific journal article

Calcium depletion challenges endoplasmic reticulum proteostasis by destabilising BiP-substrate complexes

scientific article published on 09 December 2020

Cell biology. A translational pause to localize

scientific article published in February 2011

Cell biology. Stressed cells cope with protein overload

scientific article published on July 2006

Characteristics of genomic breakpoints in TLS-CHOP translocations in liposarcomas suggest the involvement of Translin and topoisomerase II in the process of translocation

Characterization of phosphopeptides from protein digests using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and nanoelectrospray quadrupole time-of-flight mass spectrometry

scientific article

Characterization of the CHOP breakpoints and fusion transcripts in myxoid liposarcomas with the 12;16 translocation

scientific article (publication date: 15 December 1994)

Chop deletion reduces oxidative stress, improves beta cell function, and promotes cell survival in multiple mouse models of diabetes

scientific article published on October 2008

Cloning of mammalian Ire1 reveals diversity in the ER stress responses

scientific journal article

ClpP mediates activation of a mitochondrial unfolded protein response in C. elegans

scientific article published in October 2007

Compartment-specific perturbation of protein handling activates genes encoding mitochondrial chaperones

scientific article published on 27 July 2004

Complementary cell-based high-throughput screens identify novel modulators of the unfolded protein response

scientific article

Conformational disease

scientific article published in November 2000

Control of PERK eIF2alpha kinase activity by the endoplasmic reticulum stress-induced molecular chaperone P58IPK.

scientific article

Cotranslocational Degradation Protects the Stressed Endoplasmic Reticulum from Protein Overload

Cotranslocational degradation protects the stressed endoplasmic reticulum from protein overload

scientific journal article

Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1

scientific article

Crystal Structure of P58(IPK) TPR Fragment Reveals the Mechanism for its Molecular Chaperone Activity in UPR

scientific article

Cytoprotection by pre-emptive conditional phosphorylation of translation initiation factor 2

scientific article

Death protein 5 and p53-upregulated modulator of apoptosis mediate the endoplasmic reticulum stress-mitochondrial dialog triggering lipotoxic rodent and human β-cell apoptosis

scientific article

Defective ATG16L1-mediated removal of IRE1α drives Crohn's disease-like ileitis.

scientific article published on 12 January 2017

Dephosphorylation of translation initiation factor 2alpha enhances glucose tolerance and attenuates hepatosteatosis in mice

scientific article

Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survival

scientific journal article

Differentiation-specific element: a cis-acting developmental switch required for the sustained transcriptional expression of the angiotensinogen gene during hormonal-induced differentiation of 3T3-L1 fibroblasts to adipocytes

scientific article

Disulphide production by Ero1α-PDI relay is rapid and effectively regulated

scientific article

Divergent effects of PERK and IRE1 signaling on cell viability

scientific article (publication date: 2009)

Dual role of the integrated stress response in medulloblastoma tumorigenesis

scientific article published on September 2016

Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response

scientific article (publication date: June 2000)

ER stress disrupts Ca2+-signaling complexes and Ca2+ regulation in secretory and muscle cells from PERK-knockout mice

scientific journal article

ER stress-regulated translation increases tolerance to extreme hypoxia and promotes tumor growth

scientific article published on 8 September 2005

ERAD inhibitors integrate ER stress with an epigenetic mechanism to activate BH3-only protein NOXA in cancer cells

scientific article

ERO1-?, a pancreas-specific disulfide oxidase, promotes insulin biogenesis and glucose homeostasis.

scientific article published in May 2010

ERO1-beta, a pancreas-specific disulfide oxidase, promotes insulin biogenesis and glucose homeostasis

scientific journal article

ERO1-independent production of H2O2 within the endoplasmic reticulum fuels Prdx4-mediated oxidative protein folding

scientific article

Endoplasmic reticulum stress and the development of diabetes: a review

scientific article

Endoplasmic reticulum stress and the unfolded protein response in cellular models of Parkinson's disease.

scientific article

Endoplasmic reticulum stress modulates the response of myelinating oligodendrocytes to the immune cytokine interferon-gamma

scientific journal article

Endoplasmic reticulum stress signaling in disease

scientific article published on October 2006

Endoplasmic reticulum thiol oxidase deficiency leads to ascorbic acid depletion and noncanonical scurvy in mice

scientific journal article

Enhanced integrated stress response promotes myelinating oligodendrocyte survival in response to interferon-gamma

scientific article published on 25 September 2008

Ero1-α and PDIs constitute a hierarchical electron transfer network of endoplasmic reticulum oxidoreductases

scientific article

Establishing a Flow Process to Coumarin-8-Carbaldehydes as Important Synthetic Scaffolds

scientific article published on 10 July 2012

Expression patterns of the human sarcoma-associated genes FUS and EWS and the genomic structure of FUS

scientific article

Expression profiling and biochemical analysis suggest stress response as a potential mechanism inhibiting proliferation of polyamine-depleted cells

scientific article published on 31 August 2012

FICD acts bi-functionally to AMPylate and de-AMPylate the endoplasmic reticulum chaperone BiP

FICD acts bifunctionally to AMPylate and de-AMPylate the endoplasmic reticulum chaperone BiP.

scientific article published on 5 December 2016

Feedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2alpha

scientific journal article

Flavonol Activation Defines an Unanticipated Ligand-Binding Site in the Kinase-RNase Domain of IRE1

scientific article

Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma

scientific article

G-actin provides substrate-specificity to eukaryotic initiation factor 2α holophosphatases

scientific article

GCN2 kinase in T cells mediates proliferative arrest and anergy induction in response to indoleamine 2,3-dioxygenase.

scientific article published in May 2005

GCN2-dependent metabolic stress is essential for endotoxemic cytokine induction and pathology

scientific article

Generic membrane-spanning features endow IRE1α with responsiveness to membrane aberrancy

scientific article published on 14 June 2017

Heat shock protein 90 modulates the unfolded protein response by stabilizing IRE1alpha

scientific article

Heightened stress response in primary fibroblasts expressing mutant eIF2B genes from CACH/VWM leukodystrophy patients

scientific article

High density lipoprotein in octogenarians

scientific article published on 01 October 1983

Higher-order phosphatase-substrate contacts terminate the integrated stress response

scientific article published on 08 October 2021

How IRE1 reacts to ER stress

scientific article published on January 2008

Human 75-kDa DNA-pairing protein is identical to the pro-oncoprotein TLS/FUS and is able to promote D-loop formation

scientific article (publication date: 26 November 1999)

Hyperhomocysteinemia and function of the endoplasmic reticulum

scientific article

Hypothalamic eIF2α signaling regulates food intake

scientific article published on 30 January 2014

IRE1 and efferent signaling from the endoplasmic reticulum.

scientific article

IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA

scientific article (publication date: 3 January 2002)

IRE1beta inhibits chylomicron production by selectively degrading MTP mRNA.

scientific article

Identification of novel stress-induced genes downstream of chop

scientific article

Impaired eukaryotic translation initiation factor 2B activity specifically in oligodendrocytes reproduces the pathology of vanishing white matter disease in mice

scientific article

Increased insulin-like growth factor II production and consequent suppression of growth hormone secretion: a dual mechanism for tumor-induced hypoglycemia

scientific article published in April 1989

Increased intestinal lipid absorption caused by Ire1β deficiency contributes to hyperlipidemia and atherosclerosis in apolipoprotein E-deficient mice.

scientific article

Increased sensitivity to dextran sodium sulfate colitis in IRE1beta-deficient mice

scientific article

Inducible growth arrest: new mechanistic insights

scientific article

Induction of a secreted protein by the myxoid liposarcoma oncogene

scientific article

Infectious tolerance via the consumption of essential amino acids and mTOR signaling

scientific article published on 30 June 2009

Influence of the hepatic eukaryotic initiation factor 2alpha (eIF2alpha) endoplasmic reticulum (ER) stress response pathway on insulin-mediated ER stress and hepatic and peripheral glucose metabolism

scientific article

Inhibition of CHOP translation by a peptide encoded by an open reading frame localized in the chop 5'UTR

scientific article

Inhibition of a constitutive translation initiation factor 2alpha phosphatase, CReP, promotes survival of stressed cells

scientific journal article

Inhibition of adipogenesis by the stress-induced protein CHOP (Gadd153).

scientific article

Inhibition of nonsense-mediated RNA decay by the tumor microenvironment promotes tumorigenesis

scientific article

Insulin-like growth factor II and the riddle of tumor-induced hypoglycemia

scientific article published in December 1988

Intact protein folding in the glutathione-depleted endoplasmic reticulum implicates alternative protein thiol reductants

scientific article

Interferon-gamma inhibits central nervous system remyelination through a process modulated by endoplasmic reticulum stress

scientific article published on 27 February 2006

Keratin 10 gene expression during differentiation of mouse epidermis requires transcription factors C/EBP and AP-2

scientific journal article

Kinetic analysis of FTO (fat mass and obesity-associated) reveals that it is unlikely to function as a sensor for 2-oxoglutarate

scientific article published in June 2012

La kinase GCN2 régule le comportement alimentaire des omnivores afin de maintenir l’homéostasie des acides aminés

Lifetime imaging of a fluorescent protein sensor reveals surprising stability of ER thiol redox

scientific journal article

Linking of autophagy to ubiquitin-proteasome system is important for the regulation of endoplasmic reticulum stress and cell viability

scientific article published on 9 July 2007

Lipid phase perturbations and the unfolded protein response

scientific article published in September 2004

Lipid-dependent regulation of the unfolded protein response

scientific article published on 25 December 2014

Luciferase reporter gene assay in mammalian cells

scientific article published on January 1992

MANF antagonizes nucleotide exchange by the endoplasmic reticulum chaperone BiP

scientific article published in Nature Communications

Male sterility and enhanced radiation sensitivity in TLS(-/-) mice

scientific article

Mammalian stress granules represent sites of accumulation of stalled translation initiation complexes

scientific journal article

Mannose-6-phosphate regulates destruction of lipid-linked oligosaccharides

scientific article

Membrane biogenesis and the unfolded protein response

scientific article published on October 2004

Membrane lipid saturation activates endoplasmic reticulum unfolded protein response transducers through their transmembrane domains

scientific article published on 4 March 2013

Modeling the endoplasmic reticulum unfolded protein response

article

Modulation of Innate Immune Signalling by Lipid-Mediated MAVS Transmembrane Domain Oligomerization

scientific article

Modulation of the eukaryotic initiation factor 2 alpha-subunit kinase PERK by tyrosine phosphorylation

scientific article published on 12 November 2007

Multiple cis-acting DNA regulatory elements mediate hepatic angiotensinogen gene expression.

scientific article published on June 1989

Negative feedback by IRE1β optimizes mucin production in goblet cells

scientific article published on 5 February 2013

New Insights into Translational Regulation in the Endoplasmic Reticulum Unfolded Protein Response ⬇️

scientific article published on June 1, 2012

New developments in the molecular genetics of cancer ?, 17–21 ? 1997

New twists in the unfolded protein response

scientific article

Novel function of PERK as a mediator of force-induced apoptosis

scientific article published on 11 June 2008

Oligodendrocyte-specific activation of PERK signaling protects mice against experimental autoimmune encephalomyelitis

scientific article published on April 2013

Oligodendrocytes are a major target of the toxicity of spongiogenic murine retroviruses

scientific article

Oxidative protein folding by an endoplasmic reticulum-localized peroxiredoxin

scientific article

PERK Activation Promotes Medulloblastoma Tumorigenesis by Attenuating Premalignant Granule Cell Precursor Apoptosis

scientific article published on 12 May 2016

PERK activation preserves the viability and function of remyelinating oligodendrocytes in immune-mediated demyelinating diseases

scientific article

PPP1R15A-mediated dephosphorylation of eIF2α is unaffected by Sephin1 or Guanabenz.

scientific article published on 27 April 2017

Paradoxical Sensitivity to an Integrated Stress Response Blocking Mutation in Vanishing White Matter Cells.

scientific article

Partial restoration of protein synthesis rates by the small molecule ISRIB prevents neurodegeneration without pancreatic toxicity

scientific article

Perk is essential for translational regulation and cell survival during the unfolded protein response

scientific article (publication date: May 2000)

Perk-dependent translational regulation promotes tumor cell adaptation and angiogenesis in response to hypoxic stress

scientific article

Physiological modulation of BiP activity by trans-protomer engagement of the interdomain linker

scientific article

Polynomial algebra reveals diverging roles of the unfolded protein response in endothelial cells during ischemia-reperfusion injury

scientific article

Ppp1r15 gene knockout reveals an essential role for translation initiation factor 2 alpha (eIF2alpha) dephosphorylation in mammalian development

scholarly article

Preliminary X-ray crystallographic studies of mouse UPR responsive protein P58(IPK) TPR fragment

scientific article published on 31 January 2008

Prevention of acute renal failure in traumatic rhabdomyolysis

Prevention of acute renal failure in traumatic rhabdomyolysis

scientific article published on 01 February 1984

Proteasomal adaptation to environmental stress links resistance to proteotoxicity with longevity in Caenorhabditis elegans

scholarly article

Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase

scientific article

Protein translation and folding are coupled byan endoplasmic-reticulum-resident kinase

scientific article published in Nature

Protein-folding homeostasis in the endoplasmic reticulum and nutritional regulation

scientific article

Proteotoxicity in the endoplasmic reticulum: lessons from the Akita diabetic mouse

scientific article

RETRACTED: The unfolded protein response element IRE1α senses bacterial proteins invading the ER to activate RIG-I and innate immune signaling

retracted scientific article published on May 2013

Rapid B cell receptor-induced unfolded protein response in nonsecretory B cells correlates with pro- versus antiapoptotic cell fate

scientific article published on 27 September 2005

Rearrangement of the transcription factor gene CHOP in myxoid liposarcomas with t(12;16)(q13;p11)

scientific article (publication date: November 1992)

Regulated association of misfolded endoplasmic reticulum lumenal proteins with P58/DNAJc3

scientific article

Regulated translation initiation controls stress-induced gene expression in mammalian cells

scientific journal article

Resetting translational homeostasis restores myelination in Charcot-Marie-Tooth disease type 1B mice

scientific article published on April 2013

Retarded PDI diffusion and a reductive shift in poise of the calcium depleted endoplasmic reticulum

scientific article

Retraction Notice to: The Unfolded Protein Response Element IRE1α Senses Bacterial Proteins Invading the ER to Activate RIG-I and Innate Immune Signaling.

scientific article published in April 2018

Role for activating transcription factor 3 in stress-induced beta-cell apoptosis

scientific article

Role for the obesity-related FTO gene in the cellular sensing of amino acids

scientific article published on 28 January 2013

Role of ERO1-alpha-mediated stimulation of inositol 1,4,5-triphosphate receptor activity in endoplasmic reticulum stress-induced apoptosis

scientific journal article

Selective inhibition of a regulatory subunit of protein phosphatase 1 restores proteostasis

scientific article

Selective inhibition of the unfolded protein response: targeting catalytic sites for Schiff base modification

scientific article published on October 2013

Signal integration in the endoplasmic reticulum unfolded protein response

scientific article (publication date: July 2007)

Signals from the stressed endoplasmic reticulum induce C/EBP-homologous protein (CHOP/GADD153).

scientific article published on August 1996

Single particle trajectories reveal active endoplasmic reticulum luminal flow

scientific article published on 17 September 2018

Skeletal muscle-specific eukaryotic translation initiation factor 2α phosphorylation controls amino acid metabolism and fibroblast growth factor 21-mediated non-cell-autonomous energy metabolism

scientific article published on 20 October 2015

SnapShot: The Unfolded Protein Response

article

Somatic CALR mutations in myeloproliferative neoplasms with nonmutated JAK2

scientific article

Stress responses. Mutations in a translation initiation factor identify the target of a memory-enhancing compound

scientific article

Stress-induced binding of the transcriptional factor CHOP to a novel DNA control element

scientific journal article

Stress-induced gene expression requires programmed recovery from translational repression

scientific article

Stress-induced phosphorylation and activation of the transcription factor CHOP (GADD153) by p38 MAP Kinase

scientific article

Structural determinants of PERK inhibitor potency and selectivity

scientific article

Synergistic Enhansons Located within an Acute Phase Responsive Enhancer Modulate Glucocorticoid Induction of Angiotensinogen Gene Transcription

article

THE RETICULOENDOTHELIAL SYSTEM AND RHEUMATOID ARTHRITIS

scientific article published in The Lancet

TLS (FUS) binds RNA in vivo and engages in nucleo-cytoplasmic shuttling

scientific article (publication date: August 1997)

TLS (translocated-in-liposarcoma) is a high-affinity interactor for steroid, thyroid hormone, and retinoid receptors

scientific article

TLS-CHOP and the role of RNA-binding proteins in oncogenic transformation.

scientific article published on January 1997

Targeting of mRNAs to their sites of unconventional splicing in the unfolded protein response

scientific article published in April 2009

Targeting translation in hypoxic tumors

The ER stress transducer IRE1β is required for airway epithelial mucin production

scientific article

The GCN2 kinase biases feeding behavior to maintain amino acid homeostasis in omnivores

scientific journal article

The GCN2-ATF4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation.

scientific article published on 14 May 2010

The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation ⬇️

scientific article published on November 25, 2011

The amino acid sensor GCN2 biases macronutrient selection during aging

scientific article

The antipsychotic olanzapine induces apoptosis in insulin-secreting pancreatic β cells by blocking PERK-mediated translational attenuation

scientific article published on 28 June 2013

The dynamic ER: experimental approaches and current questions

scientific article

The endoplasmic reticulum is the site of cholesterol-induced cytotoxicity in macrophages

scientific article published on 10 August 2003

The endoplasmic reticulum stress response in the pancreatic β-cell

scientific article published on October 2010

The gadd and MyD genes define a novel set of mammalian genes encoding acidic proteins that synergistically suppress cell growth

scientific article

The integrated stress response prevents demyelination by protecting oligodendrocytes against immune-mediated damage

scientific article published on February 2007

The matrix peptide exporter HAF-1 signals a mitochondrial UPR by activating the transcription factor ZC376.7 in C. elegans

scientific article

The mitochondrial UPR - protecting organelle protein homeostasis

scientific article

The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule

scientific article

The molecular chaperones DNAJB6 and Hsp70 cooperate to suppress α-synuclein aggregation

scientific article

The permissive role of glucocorticoids on interleukin-1 stimulation of angiotensinogen gene transcription is mediated by an interaction between inducible enhancers

scientific article

The requirement of IRE1 and XBP1 in resolving physiological stress during Drosophila development

scientific article published on 3 August 2017

The ribosomal P-stalk couples amino acid starvation to GCN2 activation in mammalian cells

scientific article published on 21 November 2019

The sarcoplasmic reticulum luminal thiol oxidase ERO1 regulates cardiomyocyte excitation-coupled calcium release and response to hemodynamic load

scientific article

The structure of the PERK kinase domain suggests the mechanism for its activation

scientific article

The unfolded protein response in lung disease

scientific article

Thioredoxin-related Protein 32 is an arsenite-regulated Thiol Reductase of the proteasome 19 S particle.

scientific article published on 06 April 2009

Toward the discovery of new antifungal agents: the design and validation of a novel 2'P-RNA probe and high throughput screening assay against 2'-phosphotransferase Tpt1p

scientific article

Transcriptional and translational control in the Mammalian unfolded protein response

scientific article

Transcriptional regulation of VEGF-A by the unfolded protein response pathway

scientific article

Transcriptional regulation of hepatic angiotensinogen gene expression by the acute-phase response

scientific article published on December 1990

Translation attenuation by PERK balances ER glycoprotein synthesis with lipid-linked oligosaccharide flux

scientific article

Translation reinitiation at alternative open reading frames regulates gene expression in an integrated stress response

scientific article

Translational control in the endoplasmic reticulum stress response

scientific article

Translational control of hippocampal synaptic plasticity and memory by the eIF2alpha kinase GCN2

scientific journal article

Translational regulation in the cellular response to biosynthetic load on the endoplasmic reticulum.

scientific article

Translational repression mediates activation of nuclear factor kappa B by phosphorylated translation initiation factor 2

scientific article published on December 2004

Translocated in liposarcoma (TLS) is a substrate for fibroblast growth factor receptor-1.

scientific article published on April 2004

Translocation and coamplification of loci from chromosome arms 8p and 11q in the MDA-MB-175 mammary carcinoma cell line

scientific article

Transmission of cell stress from endoplasmic reticulum to mitochondria: enhanced expression of Lon protease

scientific article

Transmission of proteotoxicity across cellular compartments

article

TriPer, an optical probe tuned to the endoplasmic reticulum tracks changes in luminal H2O2.

scientific article

Tumor necrosis factor-induced reversal of adipocytic phenotype of 3T3-L1 cells is preceded by a loss of nuclear CCAAT/enhancer binding protein (C/EBP).

scientific article published on January 1992

Ubiquitin-like protein 5 positively regulates chaperone gene expression in the mitochondrial unfolded protein response

scientific article

Uncoupling proteostasis and development in vitro with a small molecule inhibitor of the pancreatic endoplasmic reticulum kinase, PERK.

scientific article

Unstructured regions in IRE1α specify BiP-mediated destabilisation of the luminal domain dimer and repression of the UPR

scientific article published on 24 December 2019

Upregulation of BiP and CHOP by the unfolded-protein response is independent of presenilin expression.

scientific article

Use of Firefly Luciferase Reporter Gene to Study Angiotensinogen Acute Phase Response Element

article

Vaccine activation of the nutrient sensor GCN2 in dendritic cells enhances antigen presentation

scientific article

Xbp1-independent Ire1 signaling is required for photoreceptor differentiation and rhabdomere morphogenesis in Drosophila

scientific article published on 31 October 2013

gamma-heregulin is the product of a chromosomal translocation fusing the DOC4 and HGL/NRG1 genes in the MDA-MB-175 breast cancer cell line

scientific article published on October 1999

pGSTag--a versatile bacterial expression plasmid for enzymatic labeling of recombinant proteins.

scientific article

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