List of works - Robert Tycko

A "special perspectives" issue: recent achievements and new directions in biomolecular solid state NMR.

scientific article published in April 2015

A Monte Carlo/simulated annealing algorithm for sequential resonance assignment in solid state NMR of uniformly labeled proteins with magic-angle spinning

scientific article

A general Monte Carlo/simulated annealing algorithm for resonance assignment in NMR of uniformly labeled biopolymers ⬇️

scientific article published on June 28, 2011

A structural model for Alzheimer's beta -amyloid fibrils based on experimental constraints from solid state NMR

scientific article

Abeta40-Lactam(D23/K28) models a conformation highly favorable for nucleation of amyloid

article

Absolute structural constraints on amyloid fibrils from solid-state NMR spectroscopy of partially oriented samples

scientific article

Adiabatic Rotational Splittings and Berry's Phase in Nuclear Quadrupole Resonance

scientific article

Alignment of Biopolymers in Strained Gels: A New Way To Create Detectable Dipole−Dipole Couplings in High-Resolution Biomolecular NMR

article

Alzheimer's disease: Structure of aggregates revealed

scientific article published on 14 September 2016

Amyloid of Rnq1p, the basis of the [PIN+] prion, has a parallel in-register beta-sheet structure

scientific article

Amyloid of the prion domain of Sup35p has an in-register parallel beta-sheet structure

scientific article

Amyloid polymorphism: structural basis and neurobiological relevance

scientific article published on May 2015

Amyloids of shuffled prion domains that form prions have a parallel in-register beta-sheet structure

article

An Achilles' heel in an amyloidogenic protein and its repair: insulin fibrillation and therapeutic design

scientific article

Antiparallel β-sheet architecture in Iowa-mutant β-amyloid fibrils ⬇️

scientific article published on March 8, 2012

Biomolecular solid state NMR with magic-angle spinning at 25K

scientific article

Broadband rotational resonance in solid state NMR spectroscopy

article

Characterization of amyloid structures at the molecular level by solid state nuclear magnetic resonance spectroscopy

scientific article

Characterization of beta-sheet structure in Ure2p1-89 yeast prion fibrils by solid-state nuclear magnetic resonance

scientific article published on 23 October 2007

Coexisting order and disorder within a common 40-residue amyloid-β fibril structure in Alzheimer's disease brain tissue

scholarly article by Ujjayini Ghosh et al published 15 May 2018 in Chemical Communications

Constraints on protein structure in HIV-1 Rev and Rev-RNA supramolecular assemblies from two-dimensional solid state nuclear magnetic resonance.

scientific article

Constraints on supramolecular structure in amyloid fibrils from two-dimensional solid-state NMR spectroscopy with uniform isotopic labeling

scientific article published in June 2003

Depletion of amyloid-β peptides from solution by sequestration within fibril-seeded hydrogels

scientific article published on 8 February 2018

Detection of a transient intermediate in a rapid protein folding process by solid-state nuclear magnetic resonance

scientific article

Dynamic nuclear polarization-enhanced 13C NMR spectroscopy of static biological solids ⬇️

scientific article published on February 27, 2013

Dynamic nuclear polarization-enhanced 1H–13C double resonance NMR in static samples below 20 K ⬇️

scientific article published on May 27, 2012

Evidence for novel beta-sheet structures in Iowa mutant beta-amyloid fibrils

scientific article

Evidence from Solid-State NMR for Nonhelical Conformations in the Transmembrane Domain of the Amyloid Precursor Protein ⬇️

scientific article published on February 2, 2011

Experimental constraints on quaternary structure in Alzheimer's beta-amyloid fibrils

scientific article published on 17 January 2006

Experimentally Derived Structural Constraints for Amyloid Fibrils of Wild-Type Transthyretin ⬇️

scientific article published on November 15, 2011

Expression and purification of a recombinant peptide from the Alzheimer's beta-amyloid protein for solid-state NMR.

scientific article published on 25 March 2005

Fiber diffraction data indicate a hollow core for the Alzheimer's aβ 3-fold symmetric fibril

scientific article

Frequency-selective homonuclear dipolar recoupling in solid state NMR

scientific article published on May 2006

Helical Conformation in the CA-SP1 Junction of the Immature HIV-1 Lattice Determined from Solid-State NMR of Virus-like Particles

scientific article

Increasing the amphiphilicity of an amyloidogenic peptide changes the beta-sheet structure in the fibrils from antiparallel to parallel

scientific article

Insights into the amyloid folding problem from solid-state NMR

article

Locating folds of the in-register parallel β-sheet of the Sup35p prion domain infectious amyloid

scientific article

Low-temperature dynamic nuclear polarization at 9.4 T with a 30 mW microwave source

scientific article

Low-temperature dynamic nuclear polarization with helium-cooled samples and nitrogen-driven magic-angle spinning.

scientific article

Low-temperature magnetic resonance imaging with 2.8 μm isotropic resolution

scientific article published on 20 December 2017

Major Variations in HIV-1 Capsid Assembly Morphologies Involve Minor Variations in Molecular Structures of Structurally Ordered Protein Segments

scientific article

Measurement of amyloid fibril mass-per-length by tilted-beam transmission electron microscopy

scientific article

Measurement of sample temperatures under magic-angle spinning from the chemical shift and spin-lattice relaxation rate of 79Br in KBr powder

scientific article published on 25 September 2008

Micron-scale magnetic resonance imaging based on low temperatures and dynamic nuclear polarization

scientific article published in November 2023

Micron-scale magnetic resonance imaging of both liquids and solids

scientific article

Millisecond Time-Resolved Solid-State NMR Reveals a Two-Stage Molecular Mechanism for Formation of Complexes between Calmodulin and a Target Peptide from Myosin Light Chain Kinase

scientific article published on 07 December 2020

Molecular Structure of Aggregated Amyloid-β: Insights from Solid-State Nuclear Magnetic Resonance

scientific article

Molecular Structure of β-Amyloid Fibrils in Alzheimer’s Disease Brain Tissue

scientific article

Molecular Structures of Amyloid and Prion Fibrils: Consensus versus Controversy ⬇️

scientific article published on January 7, 2013

Molecular alignment within beta-sheets in Abeta(14-23) fibrils: solid-state NMR experiments and theoretical predictions

scientific article published on 20 October 2006

Molecular dynamics simulations of Alzheimer's beta-amyloid protofilaments

scientific article

Molecular structural basis for polymorphism in Alzheimer's -amyloid fibrils

scientific article

Molecular structure and interactions within amyloid-like fibrils formed by a low-complexity protein sequence from FUS

scientific article published on 12 November 2020

Molecular structure of amyloid fibrils: insights from solid-state NMR.

scientific article published on February 2006

Molecular structure of monomorphic peptide fibrils within a kinetically trapped hydrogel network

scientific article

Molecular, Local, and Network-Level Basis for the Enhanced Stiffness of Hydrogel Networks Formed from Coassembled Racemic Peptides: Predictions from Pauling and Corey

scientific article published on 31 May 2017

NMR at Low and Ultralow Temperatures ⬇️

scientific article published on March 7, 2013

NMR studies of peptide T, an inhibitor of HIV infectivity, in an aqueous environment

scientific article

Oligomerization state and supramolecular structure of the HIV‐1 Vpu protein transmembrane segment in phospholipid bilayers ⬇️

scientific article published on October 1, 2010

On the problem of resonance assignments in solid state NMR of uniformly ¹⁵N,¹³C-labeled proteins

scientific article

Optimization of band-selective homonuclear dipolar recoupling in solid-state NMR by a numerical phase search

scientific article published on 01 April 2019

Parallel beta-sheets and polar zippers in amyloid fibrils formed by residues 10-39 of the yeast prion protein Ure2p

scientific article published in August 2005

Peptide conformation and supramolecular organization in amylin fibrils: constraints from solid-state NMR.

scientific article published on 3 November 2007

Perturbation of nuclear spin polarizations in solid state NMR of nitroxide-doped samples by magic-angle spinning without microwaves

scientific article

Physical and structural basis for polymorphism in amyloid fibrils

scientific article

Polymorph-Specific Kinetics and Thermodynamics of β-Amyloid Fibril Growth ⬇️

scientific article published on April 29, 2013

Polymorphic fibril formation by residues 10-40 of the Alzheimer's beta-amyloid peptide

scientific article

Preparation of Amyloid Fibrils Seeded from Brain and Meninges.

scientific article published in January 2016

Probing site-specific conformational distributions in protein folding with solid-state NMR

scientific article

Progress towards a molecular-level structural understanding of amyloid fibrils

scientific article published on February 2004

Prospects for sub-micron solid state nuclear magnetic resonance imaging with low-temperature dynamic nuclear polarization

scientific article

Quantitative determination of site-specific conformational distributions in an unfolded protein by solid-state nuclear magnetic resonance

scientific article

Remote sensing of sample temperatures in nuclear magnetic resonance using photoluminescence of semiconductor quantum dots

scientific article

Repeat Domains of Melanosome Matrix Protein Pmel17 Orthologs Form Amyloid Fibrils at the Acidic Melanosomal pH ⬇️

scientific article published on December 10, 2010

Restraints on backbone conformations in solid state NMR studies of uniformly labeled proteins from quantitative amide 15N–15N and carbonyl 13C–13C dipolar recoupling data ⬇️

scientific article published on March 9, 2012

Rotational resonance in uniformly 13C-labeled solids: effects on high-resolution magic-angle spinning NMR spectra and applications in structural studies of biomolecular systems

scientific article published in May 2004

Seeded growth of beta-amyloid fibrils from Alzheimer's brain-derived fibrils produces a distinct fibril structure

scholarly article

Segmental Polymorphism in a Functional Amyloid ⬇️

scientific article published on November 2, 2011

Segmental isotopic labeling of HIV-1 capsid protein assemblies for solid state NMR.

scientific article published on 18 January 2018

Sensitivity enhancement in structural measurements by solid state NMR through pulsed spin locking

article

Sensitivity enhancement in two-dimensional solid-state NMR spectroscopy by transverse mixing

scientific article published in June 2004

Side Chain Hydrogen-Bonding Interactions within Amyloid-like Fibrils Formed by the Low-Complexity Domain of FUS: Evidence from Solid State Nuclear Magnetic Resonance Spectroscopy

scientific article published on 10 January 2020

Simulated Self-Assembly of the HIV-1 Capsid: Protein Shape and Native Contacts Are Sufficient for Two-Dimensional Lattice Formation ⬇️

scientific article published on June 22, 2011

Site-Specific Identification of Non-β-Strand Conformations in Alzheimer's β-Amyloid Fibrils by Solid-State NMR ⬇️

scientific article published on May 1, 2003

Site-specific structural variations accompanying tubular assembly of the HIV-1 capsid protein

scientific article published on 24 December 2013

Solid state nuclear magnetic resonance with magic-angle spinning and dynamic nuclear polarization below 25 K ⬇️

scientific article

Solid-State NMR Spectroscopy Method for Determination of the Backbone Torsion Angle ψ in Peptides with Isolated Uniformly Labeled Residues ⬇️

scientific article published on October 1, 2003

Solid-State NMR Studies of Amyloid Fibril Structure ⬇️

scientific article published on January 1, 2011

Solid-state NMR as a probe of amyloid structure

scientific article

Solid-state NMR yields structural constraints on the V3 loop from HIV-1 Gp120 bound to the 447-52D antibody Fv fragment

scientific article

Stochastic dipolar recoupling in nuclear magnetic resonance of solids.

scientific article published on 2 November 2007

Structural Evolution of Iowa Mutant β-Amyloid Fibrils from Polymorphic to Homogeneous States under Repeated Seeded Growth ⬇️

scientific article published on February 28, 2011

Structural and dynamical characterization of tubular HIV-1 capsid protein assemblies by solid state nuclear magnetic resonance and electron microscopy

scientific article

Structural characterization of the D290V mutation site in hnRNPA2 low-complexity-domain polymers

article published in the Proceedings of the National Academy of Sciences of the United States of America

Structural differences in amyloid-β fibrils from brains of nondemented elderly individuals and Alzheimer's disease patients

scientific article published in 2021

Structural variation in amyloid-β fibrils from Alzheimer's disease clinical subtypes

scientific article published on 04 January 2017

Structure and dynamics of the HIV-1 Vpu transmembrane domain revealed by solid-state NMR with magic-angle spinning

article

Structure of FUS Protein Fibrils and Its Relevance to Self-Assembly and Phase Separation of Low-Complexity Domains

scientific article

Structure of the Dimerization Interface in the Mature HIV-1 Capsid Protein Lattice from Solid State NMR of Tubular Assemblies

scientific article

Successive Stages of Amyloid-β Self-Assembly Characterized by Solid-State Nuclear Magnetic Resonance with Dynamic Nuclear Polarization

scientific article

Supramolecular structural constraints on Alzheimer's beta-amyloid fibrils from electron microscopy and solid-state nuclear magnetic resonance

scientific article published in December 2002

Supramolecular structure in full-length Alzheimer's beta-amyloid fibrils: evidence for a parallel beta-sheet organization from solid-state nuclear magnetic resonance

scientific article

Symmetry-based constant-time homonuclear dipolar recoupling in solid state NMR

article

Synthesis and evaluation of nitroxide-based oligoradicals for low-temperature dynamic nuclear polarization in solid state NMR.

scientific article

Techniques: NMR on a chip

scientific article published in April 2005

Temperature-Dependent Nuclear Spin Relaxation Due to Paramagnetic Dopants Below 30 K: Relevance to DNP-Enhanced Magnetic Resonance Imaging

article by Hsueh-Ying Chen & Robert Tycko published 2 October 2018 in Journal of Physical Chemistry

The Japanese Mutant Aβ (ΔE22-Aβ1−39) Forms Fibrils Instantaneously, with Low-Thioflavin T Fluorescence: Seeding of Wild-Type Aβ1−40 into Atypical Fibrils by ΔE22-Aβ1−39 ⬇️

scientific article (publication date: 29 March 2011)

The core of Ure2p prion fibrils is formed by the N-terminal segment in a parallel cross-β structure: evidence from solid-state NMR.

scientific article

The functional curli amyloid is not based on in-register parallel beta-sheet structure

scientific article published on July 2009

The α-helical C-terminal domain of full-length recombinant PrP converts to an in-register parallel β-sheet structure in PrP fibrils: evidence from solid state nuclear magnetic resonance

scientific article

Theory for cross effect dynamic nuclear polarization under magic-angle spinning in solid state nuclear magnetic resonance: The importance of level crossings ⬇️

scientific article published on August 28, 2012

Theory of stochastic dipolar recoupling in solid-state nuclear magnetic resonance

scientific article published on 18 December 2007

Two prion variants of Sup35p have in-register parallel beta-sheet structures, independent of hydration

scientific article published on June 2009

What can solid state NMR contribute to our understanding of protein folding?

scientific article

Zero-quantum frequency-selective recoupling of homonuclear dipole-dipole interactions in solid state nuclear magnetic resonance

scientific article published on July 2009

Zero-quantum stochastic dipolar recoupling in solid state nuclear magnetic resonance ⬇️

scientific article published on September 14, 2012

List of works by Robert Tycko

A "special perspectives" issue: recent achievements and new directions in biomolecular solid state NMR.

A Monte Carlo/simulated annealing algorithm for sequential resonance assignment in solid state NMR of uniformly labeled proteins with magic-angle spinning

A general Monte Carlo/simulated annealing algorithm for resonance assignment in NMR of uniformly labeled biopolymers ⬇️

A structural model for Alzheimer's beta -amyloid fibrils based on experimental constraints from solid state NMR

Abeta40-Lactam(D23/K28) models a conformation highly favorable for nucleation of amyloid

Absolute structural constraints on amyloid fibrils from solid-state NMR spectroscopy of partially oriented samples

Adiabatic Rotational Splittings and Berry's Phase in Nuclear Quadrupole Resonance

Alignment of Biopolymers in Strained Gels: A New Way To Create Detectable Dipole−Dipole Couplings in High-Resolution Biomolecular NMR

Alzheimer's disease: Structure of aggregates revealed

Amyloid of Rnq1p, the basis of the [PIN+] prion, has a parallel in-register beta-sheet structure

Amyloid of the prion domain of Sup35p has an in-register parallel beta-sheet structure

Amyloid polymorphism: structural basis and neurobiological relevance

Amyloids of shuffled prion domains that form prions have a parallel in-register beta-sheet structure

An Achilles' heel in an amyloidogenic protein and its repair: insulin fibrillation and therapeutic design

Antiparallel β-sheet architecture in Iowa-mutant β-amyloid fibrils ⬇️

Biomolecular solid state NMR with magic-angle spinning at 25K

Broadband rotational resonance in solid state NMR spectroscopy

Characterization of amyloid structures at the molecular level by solid state nuclear magnetic resonance spectroscopy

Characterization of beta-sheet structure in Ure2p1-89 yeast prion fibrils by solid-state nuclear magnetic resonance

Coexisting order and disorder within a common 40-residue amyloid-β fibril structure in Alzheimer's disease brain tissue

Constraints on protein structure in HIV-1 Rev and Rev-RNA supramolecular assemblies from two-dimensional solid state nuclear magnetic resonance.

Constraints on supramolecular structure in amyloid fibrils from two-dimensional solid-state NMR spectroscopy with uniform isotopic labeling

Depletion of amyloid-β peptides from solution by sequestration within fibril-seeded hydrogels

Detection of a transient intermediate in a rapid protein folding process by solid-state nuclear magnetic resonance

Dynamic nuclear polarization-enhanced 13C NMR spectroscopy of static biological solids ⬇️

Dynamic nuclear polarization-enhanced 1H–13C double resonance NMR in static samples below 20 K ⬇️

Evidence for novel beta-sheet structures in Iowa mutant beta-amyloid fibrils

Evidence from Solid-State NMR for Nonhelical Conformations in the Transmembrane Domain of the Amyloid Precursor Protein ⬇️

Experimental constraints on quaternary structure in Alzheimer's beta-amyloid fibrils

Experimentally Derived Structural Constraints for Amyloid Fibrils of Wild-Type Transthyretin ⬇️

Expression and purification of a recombinant peptide from the Alzheimer's beta-amyloid protein for solid-state NMR.

Fiber diffraction data indicate a hollow core for the Alzheimer's aβ 3-fold symmetric fibril

Frequency-selective homonuclear dipolar recoupling in solid state NMR

Helical Conformation in the CA-SP1 Junction of the Immature HIV-1 Lattice Determined from Solid-State NMR of Virus-like Particles

Increasing the amphiphilicity of an amyloidogenic peptide changes the beta-sheet structure in the fibrils from antiparallel to parallel

Insights into the amyloid folding problem from solid-state NMR

Locating folds of the in-register parallel β-sheet of the Sup35p prion domain infectious amyloid

Low-temperature dynamic nuclear polarization at 9.4 T with a 30 mW microwave source

Low-temperature dynamic nuclear polarization with helium-cooled samples and nitrogen-driven magic-angle spinning.

Low-temperature magnetic resonance imaging with 2.8 μm isotropic resolution

Major Variations in HIV-1 Capsid Assembly Morphologies Involve Minor Variations in Molecular Structures of Structurally Ordered Protein Segments

Measurement of amyloid fibril mass-per-length by tilted-beam transmission electron microscopy

Measurement of sample temperatures under magic-angle spinning from the chemical shift and spin-lattice relaxation rate of 79Br in KBr powder

Micron-scale magnetic resonance imaging based on low temperatures and dynamic nuclear polarization

Micron-scale magnetic resonance imaging of both liquids and solids

Millisecond Time-Resolved Solid-State NMR Reveals a Two-Stage Molecular Mechanism for Formation of Complexes between Calmodulin and a Target Peptide from Myosin Light Chain Kinase

Molecular Structure of Aggregated Amyloid-β: Insights from Solid-State Nuclear Magnetic Resonance

Molecular Structure of β-Amyloid Fibrils in Alzheimer’s Disease Brain Tissue

Molecular Structures of Amyloid and Prion Fibrils: Consensus versus Controversy ⬇️

Molecular alignment within beta-sheets in Abeta(14-23) fibrils: solid-state NMR experiments and theoretical predictions

Molecular dynamics simulations of Alzheimer's beta-amyloid protofilaments

Molecular structural basis for polymorphism in Alzheimer's -amyloid fibrils

Molecular structure and interactions within amyloid-like fibrils formed by a low-complexity protein sequence from FUS

Molecular structure of amyloid fibrils: insights from solid-state NMR.

Molecular structure of monomorphic peptide fibrils within a kinetically trapped hydrogel network

Molecular, Local, and Network-Level Basis for the Enhanced Stiffness of Hydrogel Networks Formed from Coassembled Racemic Peptides: Predictions from Pauling and Corey

NMR at Low and Ultralow Temperatures ⬇️

NMR studies of peptide T, an inhibitor of HIV infectivity, in an aqueous environment

Oligomerization state and supramolecular structure of the HIV‐1 Vpu protein transmembrane segment in phospholipid bilayers ⬇️

On the problem of resonance assignments in solid state NMR of uniformly ¹⁵N,¹³C-labeled proteins

Optimization of band-selective homonuclear dipolar recoupling in solid-state NMR by a numerical phase search

Parallel beta-sheets and polar zippers in amyloid fibrils formed by residues 10-39 of the yeast prion protein Ure2p

Peptide conformation and supramolecular organization in amylin fibrils: constraints from solid-state NMR.

Perturbation of nuclear spin polarizations in solid state NMR of nitroxide-doped samples by magic-angle spinning without microwaves

Physical and structural basis for polymorphism in amyloid fibrils

Polymorph-Specific Kinetics and Thermodynamics of β-Amyloid Fibril Growth ⬇️

Polymorphic fibril formation by residues 10-40 of the Alzheimer's beta-amyloid peptide

Preparation of Amyloid Fibrils Seeded from Brain and Meninges.

Probing site-specific conformational distributions in protein folding with solid-state NMR

Progress towards a molecular-level structural understanding of amyloid fibrils

Prospects for sub-micron solid state nuclear magnetic resonance imaging with low-temperature dynamic nuclear polarization

Quantitative determination of site-specific conformational distributions in an unfolded protein by solid-state nuclear magnetic resonance

Remote sensing of sample temperatures in nuclear magnetic resonance using photoluminescence of semiconductor quantum dots

Repeat Domains of Melanosome Matrix Protein Pmel17 Orthologs Form Amyloid Fibrils at the Acidic Melanosomal pH ⬇️

Restraints on backbone conformations in solid state NMR studies of uniformly labeled proteins from quantitative amide 15N–15N and carbonyl 13C–13C dipolar recoupling data ⬇️

Rotational resonance in uniformly 13C-labeled solids: effects on high-resolution magic-angle spinning NMR spectra and applications in structural studies of biomolecular systems

Seeded growth of beta-amyloid fibrils from Alzheimer's brain-derived fibrils produces a distinct fibril structure

Segmental Polymorphism in a Functional Amyloid ⬇️

Segmental isotopic labeling of HIV-1 capsid protein assemblies for solid state NMR.

Low-temperature magnetic resonance imaging with 2.8 μm isotropic resolution