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List of works by Leena Bruckner-Tuderman

A Deep-Intronic FERMT1 Mutation Causes Kindler Syndrome: An Explanation for Genetically Unsolved Cases

scientific article published on 17 June 2015

A case of epidermolysis bullosa acquisita with clinical features of Brunsting-Perry pemphigoid showing an excellent response to colchicine

scientific article published on 13 August 2009

A hypomorphic mouse model of dystrophic epidermolysis bullosa reveals mechanisms of disease and response to fibroblast therapy

scientific article published on May 2008

A microinjected COL7A1-PAC vector restores synthesis of intact procollagen VII in a dystrophic epidermolysis bullosa keratinocyte cell line

scientific article published on September 2002

A novel large FERMT1 (KIND1) gene deletion in Kindler syndrome

scientific article published on 01 October 2008

A novel marker of tissue junctions, collagen XXII ⬇️

scientific article

A novel nonsense mutation in Kindler syndrome

scientific article published in January 2004

A simplified laminin nomenclature

scientific article

A single-center open-label long-term comparison of tacrolimus ointment and topical corticosteroids for treatment of atopic dermatitis

scientific article

Abstracts of the 52nd Workshop for Pediatric Research : Frankfurt, Germany. 27-28 October 2016.

scientific article

Abstracts of the 7th European Conference on Rare Diseases and Orphan Products (ERCD 2014), May 8-10, 2014, Berlin, Germany

article

Acral peeling skin syndrome with TGM5 gene mutations may resemble epidermolysis bullosa simplex in young individuals.

scientific article published on 18 February 2010

Alterations of collagen XVII expression during transformation of oral epithelium to dysplasia and carcinoma

scientific article published on July 2003

Altered MCM protein levels and autophagic flux in aged and systemic sclerosis dermal fibroblasts

scientific article

Animal models of epidermolysis bullosa: update 2010

scientific article published on 01 June 2010

Basement membranes and human disease.

scientific article published on 15 September 2009

Bullous pemphigoid associated with hypereosinophilic syndrome: simultaneous response to imatinib

scientific article published on 28 August 2006

Bullous pemphigoid autoantibodies preferentially recognize phosphoepitopes in collagen XVII

scientific article published on 12 June 2008

C-terminal truncation impairs glycosylation of transmembrane collagen XVII and leads to intracellular accumulation

scientific article published on 09 August 2006

Can type VII collagen injections cure dystrophic epidermolysis bullosa?

scientific article

Cell- and protein-based therapy approaches for epidermolysis bullosa

scientific article published in January 2013

Cell‐based therapies for epidermolysis bullosa – from bench to bedside ⬇️

scientific article published on November 1, 2012

Cetuximab therapy of metastasizing cutaneous squamous cell carcinoma in a patient with severe recessive dystrophic epidermolysis bullosa

scientific article

Changing the mindset in life sciences toward translation: a consensus

scientific article published on November 2014

Childhood epidermolysis bullosa acquisita with autoantibodies against all 3 structural domains of type VII collagen.

scientific article published in March 2004

Cleavage and oligomerization of gliomedin, a transmembrane collagen required for node of ranvier formation

scientific journal article

Cloning of Genes for Basement Membrane Proteins and Discovery of Mutations in Epidermolysis Bullosa ⬇️

scientific article published on 05 March 2008

Coiled Coils Ensure the Physiological Ectodomain Shedding of Collagen XVII ⬇️

scientific article published on July 3, 2012

Collagen VII Half-Life at the Dermal-Epidermal Junction Zone: Implications for Mechanisms and Therapy of Genodermatoses.

scientific article published on 18 February 2016

Collagen VII plays a dual role in wound healing

scientific article published on 8 July 2013

Collagen XVII Shedding Suppresses Re-Epithelialization by Directing Keratinocyte Migration and Dampening mTOR Signaling

scientific article

Collagen XVII and BPAG1 expression in the retina: evidence for an anchoring complex in the central nervous system

scientific article

Collagen XVII expression correlates with the invasion and metastasis of colorectal cancer

scientific article

Collagen XVII is expressed in human CNS neurons.

scientific article

Collagenous transmembrane proteins: collagen XVII as a prototype

scientific article

Collagenous transmembrane proteins: recent insights into biology and pathology

scientific article

Comparative quantitation of proteome alterations induced by aging or immortalization in primary human fibroblasts and keratinocytes for clinical applications

scientific article published on 10 May 2010

Compound heterozygous desmoplakin mutations result in a phenotype with a combination of myocardial, skin, hair, and enamel abnormalities

scientific article

Conceptualization and Implementation of the Central Information Portal on Rare Diseases: Protocol for a Qualitative Study.

scientific article

Consistency of the proteome in primary human keratinocytes with respect to gender, age, and skin localization

scientific article published on 30 May 2013

Cutaneous metastases of visceral tumours: a review

scientific article published on 17 June 2008

Cytokines as genetic modifiers in K5-/- mice and in human epidermolysis bullosa simplex

scientific article published on May 2009

Definitions and outcome measures for mucous membrane pemphigoid: recommendations of an international panel of experts.

scientific article

Deletion of the cytoplasmatic domain of BP180/collagen XVII causes a phenotype with predominant features of epidermolysis bullosa simplex

scientific article

Deletion of the major bullous pemphigoid epitope region of collagen XVII induces blistering, autoimmunization, and itching in mice

scientific article published on 13 October 2014

Demonstration of Epitope-Spreading Phenomena in Bullous Pemphigoid: Results of a Prospective Multicenter Study

scientific article published on 23 June 2011

Desmoplakin mutations with palmoplantar keratoderma, woolly hair and cardiomyopathy.

scientific article published on March 2015

Development of an ELISA for sensitive and specific detection of IgA autoantibodies against BP180 in pemphigoid diseases

scientific article published on 28 May 2011

Differential Proteomic Analysis Distinguishes Tissue Repair Biomarker Signatures in Wound Exudates Obtained from Normal Healing and Chronic Wounds ⬇️

scientific article published on 01 September 2010

Differential expression of basement membrane components in lymphatic tissues

scientific article published on 01 August 2004

Discrete integration of collagen XVI into tissue-specific collagen fibrils or beaded microfibrils

scientific article (publication date: April 2003)

Disorders of the cutaneous basement membrane zone—The paradigm of epidermolysis bullosa ⬇️

scientific article published on 03 August 2013

Disruption of ERBB2IP is not associated with dystrophic epidermolysis bullosa in both father and son carrying a balanced 5;13 translocation

scientific article published in October 2005

Distribution of basement membrane anchoring molecules in normal and transformed endometrium: altered expression of laminin gamma2 chain and collagen type XVII in endometrial adenocarcinomas

scientific article

Dominant-negative effects of COL7A1 mutations can be rescued by controlled overexpression of normal collagen VII.

scientific article

Dynamic interactions of epidermal collagen XVII with the extracellular matrix: laminin 332 as a major binding partner

scientific article

Dystroglycan in skin and cutaneous cells: beta-subunit is shed from the cell surface

scientific article published on June 2004

Dystrophic Epidermolysis Bullosa Inversa with COL7A1 Mutations and Absence of GDA-J/F3 Protein

Dystrophic epidermolysis bullosa: pathogenesis and clinical features

scientific article published on January 2010

Ectodomain shedding generates Neoepitopes on collagen XVII, the major autoantigen for bullous pemphigoid.

scientific article published on 22 September 2010

Epidermal ADAM17 maintains the skin barrier by regulating EGFR ligand-dependent terminal keratinocyte differentiation

scholarly article by Claus-Werner Franzke et al published 26 November 2012 in Journal of Experimental Medicine

Epidermal ADAM17 maintains the skin barrier by regulating EGFR ligand-dependent terminal keratinocyte differentiation

scientific article

Epidermolysis bullosa care in Germany

scientific article published on April 2010

Epidermolysis bullosa simplex ogna revisited.

scientific article

Epidermotropic scrotal metastasis of colorectal cancer

scientific article published on 11 May 2006

Esophageal stenosis in childhood: Dystrophic epidermolysis bullosa without skin blistering due to collagen VII mutations ⬇️

scientific article published on January 1, 2002

Expanding the COL7A1 mutation database: novel and recurrent mutations and unusual genotype-phenotype constellations in 41 patients with dystrophic epidermolysis bullosa.

scientific article

Expression of innate defense antimicrobial peptides in hidradenitis suppurativa ⬇️

scientific article published on October 7, 2011

Extensive postzygotic mosaicism for a novel keratin 10 mutation in epidermolytic ichthyosis

scientific article published on 01 May 2014

Extracellular phosphorylation of collagen XVII by ecto-casein kinase 2 inhibits ectodomain shedding

scientific article

Frequency, function and CLA expression of CD4+CD25+FOXP3+ regulatory T cells in bullous pemphigoid

scientific article published on 01 January 2007

Gas chromatography-mass spectrometry and molecular genetic studies in families with the Conradi-Hünermann-Happle syndrome.

scientific article published in May 2002

Gene Therapy for Epidermolysis Bullosa: Sticky Business

scientific article published in December 2016

Generation of a Functional Non-Shedding Collagen XVII Mouse Model: Relevance of Collagen XVII Shedding in Wound Healing

scientific article

Genetic correction of canine dystrophic epidermolysis bullosa mediated by retroviral vectors

scientific article published in August 2003

Genetically corrected iPSCs as cell therapy for recessive dystrophic epidermolysis bullosa

scientific article

Genotype, Clinical Course, and Therapeutic Decision Making in 76 Infants with Severe Generalized Junctional Epidermolysis Bullosa.

scientific article published on 29 June 2016

Global proteome analyses of SILAC-labeled skin cells.

scientific article published on January 2013

Global remodelling of cellular microenvironment due to loss of collagen VII.

scientific article published on 16 April 2013

High Local Concentrations of Intradermal MSCs Restore Skin Integrity and Facilitate Wound Healing in Dystrophic Epidermolysis Bullosa.

scientific article published on 10 April 2015

Iatrogenic vitamin D deficiency in a patient with Gorlin syndrome: the conundrum of photoprotection

scientific article published on July 2014

Imatinib mesylate as a novel treatment option for hypereosinophilic syndrome: two case reports and a comprehensive review of the literature

scientific article

Immunomapping of EBA sera to multiple epitopes on collagen VII: further evidence that anchoring fibrils originate and terminate in the lamina densa

scientific article published on 01 June 2003

Induction of phenotype modifying cytokines by FERMT1 mutations.

scientific article published in March 2011

Inherited epidermolysis bullosa: updated recommendations on diagnosis and classification

scientific article

Injury- and inflammation-driven skin fibrosis: The paradigm of epidermolysis bullosa.

scientific article published on 29 January 2018

Injury-Driven Stiffening of the Dermis Expedites Skin Carcinoma Progression.

scientific article published on 16 December 2015

Integrin α3 mutations with kidney, lung, and skin disease

scientific article published in April 2012

Invariant natural killer T cells are enriched at the site of cutaneous inflammation in lupus erythematosus

scientific article published on 19 April 2013

Involvement of the ubiquitin-proteasome system in the stabilization of cell-cell contacts in human keratinocytes

scientific article published on 07 August 2012

Isolated NC16a-ELISA testing is of little value to identify bullous pemphigoid in elderly patients with chronic pruritus

scientific article published on 20 July 2009

Junctional epidermolysis bullosa with LAMB3 splice-site mutations.

scientific article published on 24 February 2015

Keratinocytes from patients lacking collagen XVII display a migratory phenotype

scientific article

Kindler syndrome: extension of FERMT1 mutational spectrum and natural history.

scientific article published on 20 September 2011

Kindlin-1 Is required for RhoGTPase-mediated lamellipodia formation in keratinocytes

scientific article

Kindlin-1 and -2 have overlapping functions in epithelial cells implications for phenotype modification.

scientific article published on March 2011

Kindlin-1 is a phosphoprotein involved in regulation of polarity, proliferation, and motility of epidermal keratinocytes

scientific article

Lack of plakoglobin leads to lethal congenital epidermolysis bullosa: a novel clinico-genetic entity

scientific article

Laminin 332 in junctional epidermolysis bullosa

scientific article

Laminin-332 coordinates mechanotransduction and growth cone bifurcation in sensory neurons

scientific article published on 3 July 2011

Loss of collagen VII is associated with reduced transglutaminase 2 abundance and activity

scientific article published on 14 April 2014

Lupus vulgaris--a case diagnosed more than 20 years after onset.

scientific article

Mechanisms of fibroblast cell therapy for dystrophic epidermolysis bullosa: high stability of collagen VII favors long-term skin integrity

scientific article

Memory B cells specific for the NC16A domain of the 180 kDa bullous pemphigoid autoantigen can be detected in peripheral blood of bullous pemphigoid patients and induced in vitro to synthesize autoantibodies

scientific article published on 01 March 2003

Metadata Correction: Conceptualization and Implementation of the Central Information Portal on Rare Diseases: Protocol for a Qualitative Study

scientific article published on 19 September 2018

Mild recessive dystrophic epidermolysis bullosa associated with two compound heterozygous COL7A1 mutations

scientific article published on March 1, 2011

Molecular and diagnostic aspects of genetic skin fragility.

scientific article published on 22 September 2006

Molecular basis of Kindler syndrome in Italy: novel and recurrent Alu/Alu recombination, splice site, nonsense, and frameshift mutations in the KIND1 gene.

scientific article

Molecular basis of inherited skin-blistering disorders, and therapeutic implications

scientific article published on 13 October 2006

Molecular consequences of deletion of the cytoplasmic domain of bullous pemphigoid 180 in a patient with predominant features of epidermolysis bullosa simplex

scientific article published on January 2004

Molecular diagnostics facilitate distinction between lethal and non-lethal subtypes of junctional epidermolysis bullosa: a case report and review of the literature.

scientific article

Molecular heterogeneity of blistering disorders: the paradigm of epidermolysis bullosa

scientific article

Molecular mechanisms of junctional epidermolysis bullosa: Col 15 domain mutations decrease the thermal stability of collagen XVII.

scientific article

Molecular mechanisms of phenotypic variability in junctional epidermolysis bullosa.

scientific article

Moving medicine forward faster

scientific article published in March 2015

Multicenter prospective study of the humoral autoimmune response in bullous pemphigoid

scientific article published on 20 June 2008

Mutations in the gene encoding the RER protein FKBP65 cause autosomal-recessive osteogenesis imperfecta

scientific article

Network epidermolysis bullosa: molecular pathomechanisms and novel therapeutic approaches

scientific article published on April 2007

Newer treatment modalities in epidermolysis bullosa

scientific article published on 01 May 2019

No evidence that human papillomavirus is responsible for the aggressive nature of recessive dystrophic epidermolysis bullosa-associated squamous cell carcinoma.

scientific article

Novel and recurrent AAGAB mutations: clinical variability and molecular consequences.

scientific article published on 5 April 2013

Novel and recurrent KIND1 mutations in two patients with Kindler syndrome and severe mucosal involvement

scientific article published on 01 January 2007

Novel and recurrent mutations in keratin KRT5 and KRT14 genes in epidermolysis bullosa simplex: implications for disease phenotype and keratin filament assembly.

scientific article

Novel and recurrent mutations in the laminin-5 genes causing lethal junctional epidermolysis bullosa: molecular basis and clinical course of Herlitz disease

scientific article published on 5 November 2004

Novel keratin 14 mutations in patients with severe recessive epidermolysis bullosa simplex

scientific article published on 13 April 2006

One goal, different strategies – molecular and cellular approaches for the treatment of inherited skin fragility disorders ⬇️

scientific article published on March 1, 2013

Overexpression of the Flii gene increases dermal-epidermal blistering in an autoimmune ColVII mouse model of epidermolysis bullosa acquisita

scientific article published on 26 September 2011

Overlap of IgA pemphigus and linear IgA dermatosis in a patient with ulcerative colitis: a mere coincidence?

scientific article

Patients with recessive dystrophic epidermolysis bullosa develop squamous-cell carcinoma regardless of type VII collagen expression.

scientific article published on 10 May 2007

Pemphigoid gestationis autoantigen, transmembrane collagen XVII, promotes the migration of cytotrophoblastic cells of placenta and is a structural component of fetal membranes

scientific article published on 12 November 2007

Plasmin plays a role in the in vitro generation of the linear IgA dermatosis antigen LADB97.

scientific article published on 22 January 2009

Plectin expression patterns determine two distinct subtypes of epidermolysis bullosa simplex

scientific article published in March 2010

Prevalence of collagen VII-specific autoantibodies in patients with autoimmune and inflammatory diseases

scientific article

Pro-inflammatory immunity supports fibrosis advancement in epidermolysis bullosa: intervention with Ang-(1-7)

scientific article published on 30 August 2021

Progress in Epidermolysis bullosa research: summary of DEBRA International Research Conference 2012.

scientific article published in September 2013

Progress in epidermolysis bullosa research: toward treatment and cure

scientific article published on 15 April 2010

Progress toward Treatment and Cure of Epidermolysis Bullosa: Summary of the DEBRA International Research Symposium EB2015

scientific article

Proteinases of the bone morphogenetic protein-1 family convert procollagen VII to mature anchoring fibril collagen

scientific article (publication date: 19 July 2002)

Rat model for dominant dystrophic epidermolysis bullosa: glycine substitution reduces collagen VII stability and shows gene-dosage effect

scientific article

Recalcitrant pemphigus vulgaris responding to systemic tacrolimus

scientific article published on 26 June 2010

Recommendations for the use of rituximab (anti-CD20 antibody) in the treatment of autoimmune bullous skin diseases

scientific article published on 14 January 2008

Reduced numbers of circulating gammadelta T cells in patients with bullous pemphigoid

scientific article

Research funding for rare diseases in Germany

scientific article published on 13 March 2017

Results of a survey of German dermatologists on the therapeutic approaches to pemphigus and bullous pemphigoid

scientific article

Revertant mosaicism in a human skin fragility disorder results from slipped mispairing and mitotic recombination.

scientific article published on 2 April 2012

RhoA activation by CNFy restores cell-cell adhesion in kindlin-2-deficient keratinocytes.

scientific article published on 12 May 2014

Role of kindlin-2 in fibroblast functions: implications for wound healing.

scientific article published on 23 September 2010

Secondary modifiers and the phenotypic variability of junctional epidermolysis bullosa

scientific article published on 01 January 2008

Severe mucous membrane involvement in epidermolysis bullosa simplex with muscular dystrophy due to a novel plectin gene mutation

scientific article published on 13 February 2004

Shedding of collagen XVII ectodomain depends on plasma membrane microenvironment

scientific article

Shedding of collagen XVII/BP180 in skin depends on both ADAM10 and ADAM9. ⬇️

scientific article published on July 2009

Shedding of collagen XXIII is mediated by furin and depends on the plasma membrane microenvironment

scientific article

Small-molecule therapies for genetic skin fragility

scientific article published on October 2014

Spliceosome-mediated RNA trans-splicing facilitates targeted delivery of suicide genes to cancer cells.

scientific article published on 5 January 2011

Substrate-specific modulation of a multisubstrate proteinase. C-terminal processing of fibrillar procollagens is the only BMP-1-dependent activity to be enhanced by PCPE-1.

scientific article

Supramolecular interactions in the dermo-epidermal junction zone: anchoring fibril-collagen VII tightly binds to banded collagen fibrils

scientific article published on 3 July 2008

Systemic Therapy for a Genetic Skin Disease ⬇️

scientific article published on August 12, 2010

TGM5 mutations impact epidermal differentiation in acral peeling skin syndrome

scientific article published on 24 May 2012

Tacrolimus--a new therapeutic option for Hailey-Hailey-disease?

scientific article published in April 2005

Targeting epidermal lipids for treatment of Mendelian disorders of cornification.

scientific article published on 07 March 2014

The Epidermal Basement Membrane Is a Composite of Separate Laminin- or Collagen IV-containing Networks Connected by Aggregated Perlecan, but Not by Nidogens ⬇️

scientific article published on April 9, 2012

The autoantigen in anti-p200 pemphigoid is synthesized by keratinocytes and fibroblasts and is distinct from nidogen-2

scientific article published on 19 July 2007

The classification of inherited epidermolysis bullosa (EB): Report of the Third International Consensus Meeting on Diagnosis and Classification of EB

scientific article

The flavonoid luteolin inhibits Fcγ-dependent respiratory burst in granulocytes, but not skin blistering in a new model of pemphigoid in adult mice.

scientific article

The genetics of skin fragility

scientific article published on 29 May 2014

The missense mutation p.R1303Q in type XVII collagen underlies junctional epidermolysis bullosa resembling Kindler syndrome

scientific article published on 04 September 2013

The ubiquitin ligase CHIP/STUB1 targets mutant keratins for degradation.

scientific article

Tight junctions and compression therapy in chronic venous insufficiency

scientific article published in July 2006

Transmembrane collagen XVII is a novel component of the glomerular filtration barrier ⬇️

scientific article published on March 29, 2012

Transmembrane collagen XVII modulates integrin dependent keratinocyte migration via PI3K/Rac1 signaling

scientific article

Transmembrane collagen XVII, an epithelial adhesion protein, is shed from the cell surface by ADAMs

scientific article published on October 2002

Trigeminal trophic syndrome with extensive ulceration following herpes zoster

scientific article

Type 1 segmental Galli-Galli disease resulting from a previously unreported keratin 5 mutation

scientific article published on 22 March 2012

Venous leg ulcers and apoptosis: a TIMP-3-mediated pathway?

scientific article published on 01 December 2004

Whole-exome sequencing in patients with ichthyosis reveals modifiers associated with increased IgE levels and allergic sensitizations

scientific article published on 11 November 2014

Why human pemphigoid autoantibodies do not trigger disease by the passive transfer into mice?

scientific article published on 25 January 2012

Wound healing in epidermolysis bullosa

scientific article published on 18 July 2017

[Dealing with rare diseases in medicine and dermatology -- new developments]

scientific article published on 01 February 2014

[For the 125th anniversary of the German Society of Dermatology]

scientific article published on 01 November 2014

[Skin and teeth]

scientific article published on 01 May 2005

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