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List of works by Hiroshi Hamada

A GPI processing phospholipase A2, PGAP6, modulates Nodal signaling in embryos by shedding CRIPTO.

scientific article

A Wnt5 Activity Asymmetry and Intercellular Signaling via PCP Proteins Polarize Node Cells for Left-Right Symmetry Breaking.

scientific article

Absence of Radial Spokes in Mouse Node Cilia Is Required for Rotational Movement but Confers Ultrastructural Instability as a Trade-Off.

scientific article

An Nkx2-5/Bmp2/Smad1 negative feedback loop controls heart progenitor specification and proliferation

scientific article

Antagonism between Smad1 and Smad2 signaling determines the site of distal visceral endoderm formation in the mouse embryo.

scientific article published on 19 January 2009

Asymmetric rotational stroke in mouse node cilia during left-right determination

scientific article published on 15 May 2013

Baf60c is a nuclear Notch signaling component required for the establishment of left-right asymmetry

scientific article

Both Nodal signalling and stochasticity select for prospective distal visceral endoderm in mouse embryos

scientific article published on 14 November 2017

Breakthroughs and future challenges in left-right patterning

scientific article published on June 2008

CFAP45 deficiency causes situs abnormalities and asthenospermia by disrupting an axonemal adenine nucleotide homeostasis module

scientific article published on 02 November 2020

CFAP53 regulates mammalian cilia-type motility patterns through differential localization and recruitment of axonemal dynein components

scientific article published on 21 December 2020

CYP26A1 and CYP26C1 cooperate in degrading retinoic acid within the equatorial retina during later eye development

scientific journal article

Cell fate decisions and axis determination in the early mouse embryo.

scientific article published on January 2012

Changes in bacterial community structure in a full-scale membrane bioreactor for municipal wastewater treatment

scientific article

Characterization of Pitx2c expression in the mouse heart using a reporter transgene.

scientific article

Cilia at the node of mouse embryos sense fluid flow for left-right determination via Pkd2

scientific article published on 13 September 2012

Cilia in Left-Right Symmetry Breaking

scientific article published on 17 February 2017

Ciliogenesis-coupled accumulation of IFT-B proteins in a novel cytoplasmic compartment

scientific article published on 16 October 2019

Cloning of inv, a gene that controls left/right asymmetry and kidney development.

scientific article published in September 1998

Cluap1 localizes preferentially to the base and tip of cilia and is required for ciliogenesis in the mouse embryo

scientific journal article

Comparison of gene expression in male and female mouse blastocysts revealed imprinting of the X-linked gene, Rhox5/Pem, at preimplantation stages.

scientific article published in January 2006

Conserved regulation and role of Pitx2 in situs-specific morphogenesis of visceral organs

scientific article

Coordinated ciliary beating requires Odf2-mediated polarization of basal bodies via basal feet

scientific article

De novo formation of left-right asymmetry by posterior tilt of nodal cilia

scientific article

Deletion of the Dishevelled family of genes disrupts anterior-posterior axis specification and selectively prevents mesoderm differentiation

scientific article published on 21 June 2020

Determination of left–right patterning of the mouse embryo by artificial nodal flow

scientific article published in Nature

Diversity of left-right symmetry breaking strategy in animals

scientific article published on 19 February 2020

Dysregulation of the PDGFRA gene causes inflow tract anomalies including TAPVR: integrating evidence from human genetics and model organisms

scientific article (publication date: April 2010)

EpCAM contributes to formation of functional tight junction in the intestinal epithelium by recruiting claudin proteins

scientific article published on 20 July 2012

Establishment of vertebrate left-right asymmetry

scientific article (publication date: February 2002)

Fluid flow and interlinked feedback loops establish left-right asymmetric decay of Cerl2 mRNA.

scientific article published in January 2012

Fluid flow-induced left-right asymmetric decay of Dand5 mRNA in the mouse embryo requires a Bicc1-Ccr4 RNA degradation complex

scientific article published on 01 July 2021

Generation of robust left-right asymmetry in the mouse embryo requires a self-enhancement and lateral-inhibition system.

scientific article published in October 2006

Genetic Analysis Reveals a Hierarchy of Interactions between Polycystin-Encoding Genes and Genes Controlling Cilia Function during Left-Right Determination

scientific article

Haemodynamics determined by a genetic programme govern asymmetric development of the aortic arch.

scientific article published in November 2007

Hyaluronan Works on the Right for Directional Gut Looping

scientific article published on 01 September 2018

Hydrodynamic phase locking in mouse node cilia

scientific article published on 14 June 2013

Identification of a novel left-right asymmetrically expressed gene in the mouse belonging to the BPI/PLUNC superfamily.

scientific article published in February 2004

In search of Turing in vivo: understanding Nodal and Lefty behavior.

scientific article published in May 2012

Increased retinoic acid levels through ablation of Cyp26b1 determine the processes of embryonic skin barrier formation and peridermal development

scientific journal article

Inhibition of Nodal signalling by Lefty mediated through interaction with common receptors and efficient diffusion

scientific article published in April 2002

Interplay of SOX and POU factors in regulation of the Nestin gene in neural primordial cells

scientific journal article

Left-right asymmetric expression of the TGF beta-family member lefty in mouse embryos

scientific article

Left-right asymmetry in the level of active Nodal protein produced in the node is translated into left-right asymmetry in the lateral plate of mouse embryos.

scientific article

Left-right patterning of the mouse lateral plate requires nodal produced in the node

scientific journal article

Left-right patterning: conserved and divergent mechanisms

scientific article published on September 2012

Localization of Inv in a distinctive intraciliary compartment requires the C-terminal ninein-homolog-containing region.

scientific article published on 2 December 2008

Long-range action of Nodal requires interaction with GDF1.

scientific article published on December 2007

Loss of Cited2 causes congenital heart disease by perturbing left-right patterning of the body axis

scientific article published on 28 December 2010

Loss of Fam60a, a Sin3a subunit, results in embryonic lethality and is associated with aberrant methylation at a subset of gene promoters

article

Loss of PYCR2 Causes Neurodegeneration by Increasing Cerebral Glycine Levels via SHMT2

scientific article published on 22 April 2020

Making the Right Loop for the heart

scientific article published on 01 November 2020

Mechanisms of left-right asymmetry and patterning: driver, mediator and responder

scientific article

Meteorin: a secreted protein that regulates glial cell differentiation and promotes axonal extension

scientific journal article

Molecular and cellular basis of left-right asymmetry in vertebrates

scientific article published on 01 January 2020

Nodal antagonists in the anterior visceral endoderm prevent the formation of multiple primitive streaks

scientific article (publication date: November 2002)

Nodal antagonists regulate formation of the anteroposterior axis of the mouse embryo

scientific journal article

Nodal paralogues underlie distinct mechanisms for visceral left-right asymmetry in reptiles and mammals

scientific article published on 06 January 2020

Nodal signaling induces the midline barrier by activating Nodal expression in the lateral plate

scientific journal article

Nodal/activin signaling promotes male germ cell fate and suppresses female programming in somatic cells

scientific article published on 5 December 2012

Notch signaling regulates left-right asymmetry determination by inducing Nodal expression

scientific journal article

Origin and role of distal visceral endoderm, a group of cells that determines anterior-posterior polarity of the mouse embryo.

scientific article

Origin of body axes in the mouse embryo

scientific article (publication date: August 2007)

Origin of cellular asymmetries in the pre-implantation mouse embryo: a hypothesis.

scientific article

Overall Architecture of the Intraflagellar Transport (IFT)-B Complex Containing Cluap1/IFT38 as an Essential Component of the IFT-B Peripheral Subcomplex

scientific article published on 15 March 2016

Pih1d3 is required for cytoplasmic preassembly of axonemal dynein in mouse sperm

scientific article

Planar polarization of node cells determines the rotational axis of node cilia.

scientific article

Pleiotropic and isoform-specific functions for Pitx2 in superior colliculus and hypothalamic neuronal development

scientific article

Rab7-Mediated Endocytosis Establishes Patterning of Wnt Activity through Inactivation of Dkk Antagonism

scientific article published on 01 June 2020

Regulation of retinoic acid distribution is required for proximodistal patterning and outgrowth of the developing mouse limb

scientific journal article

Removal of maternal retinoic acid by embryonic CYP26 is required for correct Nodal expression during early embryonic patterning

scientific article published on July 2009

Retinoic acid signaling regulates sonic hedgehog and bone morphogenetic protein signalings during genital tubercle development.

scientific article published on 29 November 2011

Retinoid signaling determines germ cell fate in mice

scientific journal article

Reversal of left-right asymmetry induced by aberrant Nodal signaling in the node of mouse embryos.

scientific article published in December 2009

Role of Ca2+ transients at the node of the mouse embryo in breaking of left-right symmetry

scientific article published on 22 July 2020

Role of physical forces in embryonic development.

scientific article published on 14 October 2015

Roles of Motile and Immotile Cilia in Left-Right Symmetry Breaking

Roles of cilia, fluid flow, and Ca2+ signaling in breaking of left-right symmetry.

scientific article published on 30 September 2013

Rsph4a is essential for the triplet radial spoke head assembly of the mouse motile cilia

scientific article published on 23 March 2020

SHH propagates distal limb bud development by enhancing CYP26B1-mediated retinoic acid clearance via AER-FGF signalling

scientific article

Self-regulated left-right asymmetric expression of Pitx2c in the developing mouse limb

scientific article published on 16 September 2014

Shape meets polarity in Japan.

scientific article published in August 2009

Simulation of the nodal flow of mutant embryos with a small number of cilia: comparison of mechanosensing and vesicle transport hypotheses

article

Single-Cell Expression Profiling Reveals a Dynamic State of Cardiac Precursor Cells in the Early Mouse Embryo

scientific article published on 15 October 2015

Single-oocyte transcriptome analysis reveals aging-associated effects influenced by life stage and calorie restriction

scientific article published on 10 July 2021

Situs inversus and ciliary abnormalities: 20 years later, what is the connection?

scientific article

Spatial restriction of bone morphogenetic protein signaling in mouse gastrula through the mVam2-dependent endocytic pathway

scientific article published in June 2012

Sulfated glycosaminoglycans are necessary for Nodal signal transmission from the node to the left lateral plate in the mouse embryo.

scientific article published on 3 October 2007

TGFβ signaling in establishing left-right asymmetry

scientific article published on 02 April 2014

TTC25 Deficiency Results in Defects of the Outer Dynein Arm Docking Machinery and Primary Ciliary Dyskinesia with Left-Right Body Asymmetry Randomization

scientific article published on August 2016

Tbx6 controls left-right asymmetry through regulation of Gdf1.

scientific article published on 12 April 2018

The Motion of An Inv Nodal Cilium: a Realistic Model Revealing Dynein-Driven Ciliary Motion with Microtubule Mislocalization

scientific article published on 14 December 2018

The dynamic right-to-left translocation of Cerl2 is involved in the regulation and termination of Nodal activity in the mouse node.

scientific article published on 27 March 2013

The dynein-triggered ciliary motion in embryonic nodes: an exploratory study based on computational models

scientific article published in January 2014

The left-right axis in the mouse: from origin to morphology

scientific article

The left-right determinant Inversin is a component of node monocilia and other 9+0 cilia.

scientific article published in May 2003

The mouse embryo autonomously acquires anterior-posterior polarity at implantation

scientific article published on April 2006

Translation of anterior-posterior polarity into left-right polarity in the mouse embryo.

scientific article

Transport of the outer dynein arm complex to cilia requires a cytoplasmic protein Lrrc6.

scientific article published on 28 June 2016

Two nodal-responsive enhancers control left-right asymmetric expression of Nodal.

scientific article published in April 2005

Two rotating cilia in the node cavity are sufficient to break left-right symmetry in the mouse embryo.

scientific article

Ways, means and consequences of shaping morphogen gradients

scientific article published on 07 August 2013

Wnt signalling escapes to cilia

scientific article published on 01 June 2011

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