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List of works by Klaus-Michael Debatin

4-hydroperoxy-cyclophosphamide mediates caspase-independent T-cell apoptosis involving oxidative stress-induced nuclear relocation of mitochondrial apoptogenic factors AIF and EndoG.

scientific article published on 23 November 2007

5-Aza-2'-deoxycytidine and IFN-gamma cooperate to sensitize for TRAIL-induced apoptosis by upregulating caspase-8.

scientific article published on 10 April 2006

A Potential Role for the Inhibition of PI3K Signaling in Glioblastoma Therapy

scientific article published on 29 June 2015

A critical evaluation of PI3K inhibition in Glioblastoma and Neuroblastoma therapy

scientific article

A critical role of glutathione in determining apoptosis sensitivity and resistance in leukemia cells

scientific article published on July 2004

A new missense mutation in the leptin gene causes mild obesity and hypogonadism without affecting T cell responsiveness

scientific article

A novel method for the combined flow cytometric analysis of cell cycle and cytochrome c release

article

A novel paradigm to trigger apoptosis in chronic lymphocytic leukemia

scientific article

A paired comparison between glioblastoma "stem cells" and differentiated cells

scientific article published on 30 October 2015

A patient with hematuria and cystic renal mass: Answer

A patient with hematuria and cystic renal mass: Question

article

A potential role of PI3K inhibition in radiotherapy of glioblastoma multiforme.

scientific article

A sensitive, non- radioactive and fast method for detection of JNK/SAPK activity in leukemic T cells

scientific article published on 01 October 2000

AAV-encoded expression of TRAIL in experimental human colorectal cancer leads to tumor regression.

scientific article published on March 2004

ABL-specific tyrosine kinase inhibitor imatinib as salvage therapy in a child with Philadelphia chromosome-positive acute mixed lineage leukemia (AMLL).

scientific article published in July 2002

AML bearing the translocation t(11;17)(q23;q21): involvement of MLL and a region close to RARA, with no differentiation response to retinoic acid

scientific article published on 12 November 2005

APO-1 (CD95) and Bcl-2: determinants of cell death in the human thymus

scientific article published in February 1994

APO-1 (CD95) mediated apoptosis in human T-ALL engrafted in SCID mice

scientific article published on November 1994

APO-1-induced apoptosis of leukemia cells from patients with adult T-cell leukemia

scientific article published on 01 June 1993

APO-I-mediated apoptosis in normal and malignant lymphocytes

scientific article published on August 1994

Abstracts of the 52nd Workshop for Pediatric Research : Frankfurt, Germany. 27-28 October 2016.

scientific article

Activation interferes with the APO-1 pathway in mature human T cells.

scientific article

Activation of Akt predicts poor outcome in neuroblastoma

scientific article published on January 2007

Activation of CD95 (APO-1/Fas) signaling by ceramide mediates cancer therapy-induced apoptosis

scientific article published on October 1997

Activation of Mitochondria and Release of Mitochondrial Apoptogenic Factors by Betulinic Acid

scientific article published in Journal of Biological Chemistry

Activation of T cell cytotoxicity against autologous common acute lymphoblastic leukemia (cALL) blasts by CD3xCD19 bispecific antibody

scientific article published on 01 November 1996

Activation of apoptosis pathways by anticancer drugs

scientific article

Activation of apoptosis pathways by anticancer treatment.

scientific article

Activation of apoptosis pathways in peripheral blood lymphocytes by in vivo chemotherapy

scientific article published in November 2001

Activation of intrinsic apoptotic pathway by Re-188 irradiation and paclitaxel in coronary artery smooth muscle cells.

scientific article published on 25 March 2007

Activation of macrophages by lymphokines from T-cell clones: Evidence for different macrophage-activating factors

article

Activation of the CD95 (APO-1/Fas) pathway in drug- and gamma-irradiation-induced apoptosis of brain tumor cells

scientific article published in October 1998

Activation of the CD95 (APO-1/Fas) system in T cells from human immunodeficiency virus type-1-infected children.

scientific article published on September 1996

Activation of the CD95 system increases with disease progression in human immunodeficiency virus type 1-infected children and adolescents

scientific article published in August 1997

Acute lymphoblastic leukemia cells treated with CpG oligodeoxynucleotides, IL-4 and CD40 ligand facilitate enhanced anti-leukemic CTL responses.

scientific article published on 29 April 2011

Adaptation von Eltern an eine chronische Erkrankung ihres Kindes nach der Diagnosestellung

article by Lutz Goldbeck et al published February 2001 in Psychotherapie Psychosomatik Medizinische Psychologie

Adipocytes in hematopoiesis and acute leukemia: friends, enemies, or innocent bystanders?

scientific article published on 30 May 2020

Age at onset and long-term metabolic control affect height in type-1 diabetes mellitus

scientific article published in December 1998

Age- and BMI-Associated Expression of Angiogenic Factors in White Adipose Tissue of Children

scientific article published on 21 October 2019

Age-of-onset-dependent influence of NOD2 gene variants on disease behaviour and treatment in Crohn's disease

scientific article

An inflammatory micro-environment promotes human adipocyte apoptosis

scientific article published on 9 April 2011

Analysis of the CD95 ligand gene in 20 children with autoimmune lymphoproliferative syndrome (ALPS)

article

Angiotensin I converting enzyme and angiotensinogen gene polymorphisms related to 24-h blood pressure in paediatric type I diabetes mellitus

article

Anti-CD95 (APO-1/Fas) autoantibodies and T cell depletion in human immunodeficiency virus type 1 (HIV-1)-infected children

scientific article published in March 1998

Antiviral vaccines license T cell responses by suppressing granzyme B levels in human plasmacytoid dendritic cells

scientific article published on 19 June 2013

Apoptose

Apoptosis in hematological disorders.

scientific article

Apoptosis induction in peripheral leukemia cells by remission induction treatment in vivo: selective depletion and apoptosis in a CD34+ subpopulation of leukemia cells.

scientific article published in November 2003

Apoptosis mediated by lentiviral TRAIL transfer involves transduction-dependent and -independent effects

scientific article published on 22 December 2006

Apoptosis pathways in cancer and cancer therapy

scientific article published on 29 January 2004

Apoptosis pathways in neuroblastoma therapy

scientific article

Apoptosis pathways: turned on their heads?

scientific article published on 01 February 2003

Apoptosis signaling in tumor therapy

scientific article

Apoptosis-Inducing Cellular Vehicles for Cancer Gene Therapy

article

Apoptotic cell death induced by a mouse-human anti-APO-1 chimeric antibody leads to tumor regression.

scientific article published on August 1994

Apoptotic responsiveness of the Ewing's sarcoma family of tumours to tumour necrosis factor-related apoptosis-inducing ligand (TRAIL).

scientific article published on October 2000

Artesunate enhances the antiproliferative effect of temozolomide on U87MG and A172 glioblastoma cell lines

scientific article published on February 2014

Attenuated measles virus controls pediatric acute B-lineage lymphoblastic leukemia in NOD/SCID mice

scientific article published on 3 April 2014

Attenuated measles virus controls pediatric acute B-lineage lymphoblastic leukemia in NOD/SCID mice.

scientific article published in August 2014

Autoamplification of apoptosis following ligation of CD95-L, TRAIL and TNF-α

article published in 2000

Autocrine T-cell suicide mediated by APO-1/(Fas/CD95)

scientific article published on February 1995

Autocrine growth factors secreted by the malignant human B-cell-line BJAB are distinct from other known cytokines.

scientific article published on March 1990

Bcl-2/Bcl-xL inhibition predominantly synergistically enhances the anti-neoplastic activity of a low-dose CUSP9 repurposed drug regime against glioblastoma

scientific article published on 30 July 2019

Beta-carotene cleavage products after oxidation mediated by hypochlorous acid--a model for neutrophil-derived degradation

scientific article

Beta-irradiation used for systemic radioimmunotherapy induces apoptosis and activates apoptosis pathways in leukaemia cells

Betulinic acid as new activator of NF-kappaB: molecular mechanisms and implications for cancer therapy

scientific article

Betulinic acid induces apoptosis through a direct effect on mitochondria in neuroectodermal tumors.

scientific article published in December 2000

Betulinic acid triggers CD95 (APO-1/Fas)- and p53-independent apoptosis via activation of caspases in neuroectodermal tumors

scientific article

Betulinic acid-induced apoptosis in leukemia cells

scientific article

Betulinic acid: a new chemotherapeutic agent in the treatment of neuroectodermal tumors

Betulinic acid: a new cytotoxic agent against malignant brain-tumor cells

scientific article

Biologically inactive leptin and early-onset extreme obesity

scientific article

Biomarker profile for prediction of response to SMAC mimetic monotherapy in pediatric precursor B-cell acute lymphoblastic leukemia

scientific article published on 10 December 2019

Blocking distinct interactions between Glioblastoma cells and their tissue microenvironment: A novel multi-targeted therapeutic approach

scientific article published on 3 April 2018

Bone marrow failure unresponsive to bone marrow transplant is caused by mutations in THPO.

scientific article

Boolean modeling identifies Greatwall/MASTL as an important regulator in the AURKA network of neuroblastoma

scientific article published on 23 November 2015

Bortezomib primes glioblastoma, including glioblastoma stem cells, for TRAIL by increasing tBid stability and mitochondrial apoptosis

scientific article

Bortezomib primes neuroblastoma cells for TRAIL-induced apoptosis by linking the death receptor to the mitochondrial pathway

scientific article

Breaking Chemoresistance and Radioresistance with [213Bi]anti-CD45 Antibodies in Leukemia Cells

CD57(high) neuroblastoma cells have aggressive attributes ex situ and an undifferentiated phenotype in patients

scientific article

CD90 Is Dispensable for White and Beige/Brown Adipocyte Differentiation

scientific article published on 24 October 2020

CD95 (APO-1/FAS)-mediated apoptosis in cytokine-activated hematopoietic cells

scientific article published in August 1998

CD95 (APO-1/Fas) expression on naive CD4(+) T cells increases with disease progression in HIV-infected children and adolescents: effect of highly active antiretroviral therapy (HAART).

scientific article

CD95 (APO-1/Fas) mutations in childhood T-lineage acute lymphoblastic leukemia

scientific article published in May 1998

CD95 System Counter Attack and Prognostic Impact

article

CD95 co-stimulation blocks activation of naive T cells by inhibiting T cell receptor signaling

scientific article published on June 2009

CD95 ligand (Fas-L/APO-1L) and tumor necrosis factor-related apoptosis-inducing ligand mediate ischemia-induced apoptosis in neurons

scientific article published in May 1999

CD95(APO-1/Fas)-mediated apoptosis in normal and malignant liver, colon, and hematopoietic cells

scientific article published on 01 January 1998

CD95-induced apoptosis contributes to loss of primed/memory but not resting/naive T cells in children infected with human immunodeficiency virus type 1.

scientific article published in June 1997

CD95/Apo-1/Fas: independent cell death induced by doxorubicin in normal cultured cardiomyocytes.

scientific article published on 10 February 2005

CHD5 inhibits metastasis of neuroblastoma

scientific article published on 17 November 2021

CNS complications in children receiving chemotherapy or hematopoietic stem cell transplantation: Retrospective analysis and clinical study of survivors

article

Cancer therapy: know your enemy?

scientific article published on 31 October 2014

Caspase-8L expression protects CD34+ hematopoietic progenitor cells and leukemic cells from CD95-mediated apoptosis.

scientific article

Cell Death Induction in Cancer Therapy - Past, Present, and Future

scientific article published on January 2016

Cell death in T- and B-cell development ⬇️

scientific article published on January 1, 2001

Cell death induction by betulinic acid, ceramide and TRAIL in primary glioblastoma multiforme cells

scientific article

Cell death sensitization of leukemia cells by opioid receptor activation

scientific article published on May 2013

Cell death-based treatment of childhood cancer

scientific article published on 25 January 2018

Cell death: From initial concepts to pathways to clinical applications - Personal reflections of a clinical researcher

scientific article published in January 2017

Cell type specific involvement of death receptor and mitochondrial pathways in drug-induced apoptosis

scientific article published in March 2001

Cellular stress response and apoptosis in cancer therapy.

scientific article

Central hypothyroidism due to malnutrition in a 6-year old girl

scientific article published on 22 March 2010

Central nervous system acute lymphoblastic leukemia: role of natural killer cells

scientific article

Central nervous system involvement in acute lymphoblastic leukemia is mediated by vascular endothelial growth factor

scientific article

Characterization and identification of leukemia initiating cells in pediatric acute lymphoblastic leukemia

scientific article published on 11 September 2014

Characterization of a human preadipocyte cell strain with high capacity for adipose differentiation

scientific article (publication date: 2001)

Characterization of sonic hedgehog as a novel NF-kappaB target gene that promotes NF-kappaB-mediated apoptosis resistance and tumor growth in vivo

scientific article published on 4 September 2008

Chemosensitivity of solid tumor cellsin vitro is related to activation of the CD95 system

scientific article published on 01 March 1998

Chemosensitization of glioblastoma cells by the histone deacetylase inhibitor MS275.

scientific article published on July 2011

Chemotherapeutic drugs sensitize pre-B ALL cells for CD95- and cytotoxic T-lymphocyte-mediated apoptosis

scientific article published on 01 March 1999

Chemotherapy: targeting the mitochondrial cell death pathway

scientific article

Childhood cancer predisposition syndromes-A concise review and recommendations by the Cancer Predisposition Working Group of the Society for Pediatric Oncology and Hematology

scientific article published on 7 February 2017

Chloroquine overcomes resistance of lung carcinoma cells to the dual PI3K/mTOR inhibitor PI103 by lysosome-mediated apoptosis

scientific article

Chronic Lymphocytic Leukemia: Keeping Cell Death at Bay

Circular RNA differential expression in blood cell populations and exploration of circRNA deregulation in pediatric acute lymphoblastic leukemia

scientific article published on 11 October 2019

Circulating haematopoietic progenitors during treatment of renal anaemia with recombinant human erythropoietin

Circulating haematopoietic progenitors during treatment of renal anaemia with recombinant human erythropoietin

scientific article published on 01 January 1994

Clinical and mechanistic aspects of glucocorticoid-induced chemotherapy resistance in the majority of solid tumors

scientific article published on 27 February 2007

Clinical and molecular characterisation of a prospectively collected cohort of children and adolescents with polycythemia vera

scientific article

Codon 104(-G), a dominant 0-thalassemia-like phenotype in a German Caucasian family is associated with mild chronic hemolytic anemia but influenced in severity by co-inherited genetic factors

article

Coexpression of Multiple ABC-Transporters is Strongly Associated with Treatment Response in Childhood Acute Myeloid Leukemia

scientific article published on 29 October 2015

Coincidence of recurrent hemiparesis and detection of ALL in a 4-year-old girl: one or two diseases?

scientific article published on 4 November 2009

Combination of Chemotherapy and Death Ligands in Cancer Therapy

Combined inhibition of HER1/EGFR and RAC1 results in a synergistic antiproliferative effect on established and primary cultured human glioblastoma cells

scientific article published on 5 July 2013

Combined inhibition of RAC1 and Bcl-2/Bcl-xL synergistically induces glioblastoma cell death through down-regulation of the Usp9X/Mcl-1 axis

scientific article published on 11 March 2019

Comparative gene array analysis of progenitor cells from human paired deep neck and subcutaneous adipose tissue

scientific article published on 4 August 2014

Compare and contrast: pediatric cancer versus adult malignancies

scientific article published on 01 December 2019

Complete long-term recovery of beta-cell function in autoimmune type 1 diabetes after insulin treatment

scientific article published in May 2004

Compound heterozygous and homozygous mutations of the TSHbeta gene as a cause of congenital central hypothyroidism in Europe

scientific article

Compound heterozygous variants in OTULIN are associated with fulminant atypical late-onset ORAS

scientific article published on 16 February 2022

Congenital erythrocytosis and polycythemia vera in childhood and adolescence

scientific article

Congenital neuroblastoma mimicking early onset sepsis

scientific article published on July 2001

Congenital null mutations of the FOLR1 gene: a progressive neurologic disease and its treatment

scientific article published in December 2009

Conjugated Linoleic Acids Promote Human Fat Cell Apoptosis

Constitutive and induced expression of APO-1, a new member of the nerve growth factor/tumor necrosis factor receptor superfamily, in normal and neoplastic cells.

scientific article published on October 1993

Constitutive caspase activation and impaired death-inducing signaling complex formation in CD95-resistant, long-term activated, antigen-specific T cells

scientific article published in August 2003

Contributions of age, gender and insulin administration to weight gain in subjects with IDDM.

scientific article

Cooperation of betulinic acid and TRAIL to induce apoptosis in tumor cells

scientific article published on October 2004

Correction of complete interferon-gamma receptor 1 deficiency by bone marrow transplantation

scientific article (publication date: December 2002)

Corticosteroid co-treatment induces resistance to chemotherapy in surgical resections, xenografts and established cell lines of pancreatic cancer

scientific article

Corticosteroid-induced chemotherapy resistance in urological cancers

scientific article

Corticosteroids induce chemotherapy resistance in the majority of tumour cells from bone, brain, breast, cervix, melanoma and neuroblastoma.

scientific article published on November 2006

Cross-resistance of CD95- and drug-induced apoptosis as a consequence of deficient activation of caspases (ICE/Ced-3 proteases).

scientific article published in October 1997

Cytochrome c-related caspase-3 activation determines treatment response and relapse in childhood precursor B-cell ALL

article

Cytosine deaminase/5-fluorocytosine gene therapy and Apo2L/TRAIL cooperate to kill TRAIL-resistant tumor cells

scientific article published on 20 April 2007

Cytotoxic Drugs, Programmed Cell Death, and the Immune System: Defining New Roles in an Old Play

scientific article published on 01 June 1997

Cytotoxic drug-induced, p53-mediated upregulation of caspase-8 in tumor cells

scientific article

Cytotoxic drugs and the CD95 pathway

scientific article

DNA-ligase IV and DNA-protein kinase play a critical role in deficient caspases activation in apoptosis-resistant cancer cells by using doxorubicin

scientific article

Dataset of clinical, immunohistopathological and laboratory features of patients with MHC II deficiency suffering from enteropathy

scientific article published on 28 August 2019

Death Receptor Pathways As Targets for Anticancer Therapy

Death receptor signaling in cancer therapy

scientific article

Death receptors in chemotherapy and cancer

scientific article published on April 2004

Decreased sensitivity of drug-resistant cells towards T cell cytotoxicity

scientific article published on March 1999

Defibrotide for prophylaxis of hepatic veno-occlusive disease in paediatric haemopoietic stem-cell transplantation: an open-label, phase 3, randomised controlled trial

scientific article published on 23 February 2012

Deficient activation of the CD95 (APO-1/Fas) system in drug-resistant cells

scientific article published on 01 November 1997

Definition of a critical T cell threshold for prevention of GVHD after HLA non-identical PBPC transplantation in children

scientific article published on 01 September 1999

Depressed mediator release by inflammatory exudate cells in immunized rats following antigen challenge

scientific article published on 01 December 1981

Dexamethasone desensitizes hepatocellular and colorectal tumours toward cytotoxic therapy

scientific article published on 9 December 2005

Diabetic retinopathy in pediatric patients with type-1 diabetes: Effect of diabetes duration, prepubertal and pubertal onset of diabetes, and metabolic control

scientific article published on 01 May 1998

Diagnosis of Diabetes in Cystic Fibrosis and Thalassemia Major

scientific article published on 01 April 1998

Diagnostics and Experimental Therapy

Diagnostik und Experimentelle Therapie

Differential expression of APO-1 on human thymocytes: Implications for negative selection?

scholarly article by Klaus-Michael Debatin et al published March 1994 in European Journal of Immunology

Differential function of Akt1 and Akt2 in human adipocytes

scientific article

Digenic Inheritance of Hepatocyte Nuclear Factor-1 and -1 With Maturity-Onset Diabetes of the Young, Polycystic Thyroid, and Urogenital Malformations

scientific article published on 02 March 2007

Dihydrofolate reductase deficiency due to a homozygous DHFR mutation causes megaloblastic anemia and cerebral folate deficiency leading to severe neurologic disease

scientific article

Disproportionately elevated fasting proinsulin levels in normoglycemic patients with thalassemia major are correlated to the degree of iron overload

scientific article published in January 2003

Diversity of Human Leukemia Xenograft Mouse Models: Implications for Disease Biology ⬇️

scientific article published on November 16, 2011

Downregulation of FLIP by cycloheximide sensitizes human fat cells to CD95-induced apoptosis.

scientific article published on 2 July 2011

Downregulation of increased CD95 (APO-1/Fas) ligand in T cells from human immunodeficiency virus-type 1-infected children after antiretroviral therapy

scientific article published in July 1997

Drug-induced apoptosis in osteosarcoma cell lines is mediated by caspase activation independent of CD95-receptor/ligand interaction

scientific article published on 01 January 2000

Early Relapse in ALL Is Identified by Time to Leukemia in NOD/SCID Mice and Is Characterized by a Gene Signature Involving Survival Pathways

article

Early childhood BMI trajectories in monogenic obesity due to leptin, leptin receptor, and melanocortin 4 receptor deficiency

scientific article published on 27 February 2018

Early effects of antiretroviral combination therapy on activation, apoptosis and regeneration of T cells in HIV-1-infected children and adolescents

scientific article published in May 1999

Educational and vocational achievement among long-term survivors of adolescent cancer in Germany

scientific article published in March 2011

Elevated UCP1 levels are sufficient to improve glucose uptake in human white adipocytes

scientific article published on 27 July 2019

Embryonic endothelial progenitor cells armed with a suicide gene target hypoxic lung metastases after intravenous delivery

scientific article

Endothelial progenitor cell culture and differentiation in vitro: a methodological comparison using human umbilical cord blood

article

Endothelial progenitor cells for cancer gene therapy.

scientific article published on 27 March 2008

Eradication of a dysfunctional HLA-haploidentical T cell system by a second HLA-identical BMT

scientific article published on 01 November 2001

Essential versus accessory aspects of cell death: recommendations of the NCCD 2015.

scientific article

Establishment of lipofection for studying miRNA function in human adipocytes

scientific article

Estimated prevalence of potentially damaging variants in the leptin gene

scientific article published on 3 November 2017

Evaluation of an outpatient treatment program for obese children and adolescents

scientific article published on 01 March 2003

Ewing's sarcoma cells with CD57-associated increase of tumorigenicity and with neural crest-like differentiation capacity

Exploiting death receptor signaling pathways for tumor therapy

scientific article

Expression of CD69 on T-cells from HIV-1-infected children and adolescents increases with increasing viral load

article

Expression of the APO-1 antigen in Burkitt lymphoma cell lines correlates with a shift towards a lymphoblastoid phenotype

FTO deficiency induces UCP-1 expression and mitochondrial uncoupling in adipocytes

scientific article published on 10 June 2013

Familial polycythemia vera with Budd-Chiari syndrome in childhood

scientific article published in October 2003

Fehlregulation von Apoptose als Grundlage für Krankheit

scientific article published on 01 August 2001

Functional CD95 ligand and CD95 death-inducing signaling complex in activation-induced cell death and doxorubicin-induced apoptosis in leukemic T cells.

scientific article

GDC-0941 enhances the lysosomal compartment via TFEB and primes glioblastoma cells to lysosomal membrane permeabilization and cell death

scientific article

Generation of murine sympathoadrenergic progenitor-like cells from embryonic stem cells and postnatal adrenal glands

scientific article

Genotyping circulating tumor DNA of pediatric Hodgkin lymphoma

scientific article published on 20 August 2019

Glomerulonephritis associated with chronic granulomatous disease and systemic lupus erythematosus

scientific article published on 01 January 1995

Glucocorticoid cotreatment induces apoptosis resistance toward cancer therapy in carcinomas.

scientific article published in June 2003

Glucocorticoid-mediated inhibition of chemotherapy in ovarian carcinomas.

scientific article published on February 2006

Graft-Versus-Host Disease Prevention by <i>In Vitro</i>-Generated Myeloid-Derived Suppressor Cells Is Exclusively Mediated by the CD11b+CD11c+ MDSC Subpopulation

scientific article published on 14 October 2021

Granzyme B produced by human plasmacytoid dendritic cells suppresses T-cell expansion.

scientific article

Growth inhibition of murine neuroblastoma cells by C-Myc with cell cycle arrest in G2/M

scientific article published on 08 February 2005

HDAC inhibitors: Double edge sword for TRAIL cancer therapy?

scientific article published on 30 October 2005

HIF-1-regulated glucose metabolism: a key to apoptosis resistance?

scientific article published on 27 April 2007

HIPK2 associates with RanBPM

scientific article

HIPK2 overexpression leads to stabilization of p53 protein and increased p53 transcriptional activity by decreasing Mdm2 protein levels

scientific article

HLA-haploidentical blood progenitor cell transplantation in osteopetrosis

scientific article published in May 2002

HSCT cures ADA2 deficiency

scientific article

Hematopoietic stem cell transplantation from matched unrelated donors in chronic granulomatous disease

scientific article published in January 2009

Hereditary hyperferritinemia cataract syndrome: clinical, genetic, and laboratory findings in 5 families.

scientific article

Herpes simplex virus thymidine kinase/ganciclovir-induced apoptosis involves ligand-independent death receptor aggregation and activation of caspases.

scientific article published on July 1999

Heterogeneity in disease severity in a family with a novel G68V GCK activating mutation causing persistent hyperinsulinaemic hypoglycaemia of infancy.

scientific article published in November 2007

High expression of APO-1 (CD95) on T lymphocytes from human immunodeficiency virus-1-infected children.

scientific article

Histone deacetylase inhibitors cooperate with IFN-gamma to restore caspase-8 expression and overcome TRAIL resistance in cancers with silencing of caspase-8.

scientific article

Histone deacetylase inhibitors prime medulloblastoma cells for chemotherapy-induced apoptosis by enhancing p53-dependent Bax activation.

scientific article

Histone deacetylase inhibitors sensitize glioblastoma cells to TRAIL-induced apoptosis by c-myc-mediated downregulation of cFLIP

scientific article

Human blood late outgrowth endothelial cells for gene therapy of cancer: determinants of efficacy

scientific article published on 5 October 2006

ICF syndrome: High variability of the chromosomal phenotype and association with classical Hodgkin lymphoma

scientific article published on 01 September 2007

IFNgamma sensitizes for apoptosis by upregulating caspase-8 expression through the Stat1 pathway

scientific article published in April 2002

IGF-I- and IGFBP-3-expression in cultured human preadipocytes and adipocytes

article

IL7R is associated with CNS infiltration and relapse in pediatric B-cell precursor acute lymphoblastic leukemia

scientific article published on 28 August 2018

Identification of a newVHLexon and complex splicing alterations in familial erythrocytosis or von Hippel-Lindau disease

scientific article published on 11 June 2018

Identification of a novel pro-apopotic function of NF-kappaB in the DNA damage response

scientific article published in September 2009

Identification of a novel proapoptotic function of resveratrol in fat cells: SIRT1-independent sensitization to TRAIL-induced apoptosis

scientific article

Identification of a novel switch in the dominant forms of cell adhesion-mediated drug resistance in glioblastoma cells

scientific article

Identification of c-FLIP(L) and c-FLIP(S) as critical regulators of death receptor-induced apoptosis in pancreatic cancer cells

scientific article published on 28 September 2010

Identification of deficient mitochondrial signaling in apoptosis resistant leukemia cells by flow cytometric analysis of intracellular cytochrome c, caspase-3 and apoptosis.

scientific article

Identification of soluble APO-1 in supernatants of human B- and T-cell lines and increased serum levels in B- and T-cell leukemias.

scientific article published on March 1995

Immunodeficiency and EBV-induced lymphoproliferation caused by 4-1BB deficiency

scientific article published on 11 March 2019

Immunological mechanisms associated with long-term remission of human type 1 diabetes

scientific article published in May 2006

Immunological reconstitution in a patient with ZAP-70 deficiency following transfusion of blood lymphocytes from a previously transplanted sibling without conditioning

scientific article published on 28 March 2011

Immunostimulatory functions of adoptively transferred MDSCs in experimental blunt chest trauma.

scientific article

Impaired gastric acidification negatively affects calcium homeostasis and bone mass.

scientific article published in June 2009

Impairment of lysosomal integrity by B10, a glycosylated derivative of betulinic acid, leads to lysosomal cell death and converts autophagy into a detrimental process.

scientific article

In vitro-established alloantigen-specific CD8+ CTLs mediate graft-versus-tumor activity in the absence of graft-versus-host disease

scientific article published on 18 February 2011

In vitro-generated MDSCs prevent murine GVHD by inducing type 2 T cells without disabling antitumor cytotoxicity

scientific article published on 16 July 2015

In vitro-generated alloantigen-specific Th9 cells mediate antileukemia cytotoxicity in the absence of graft-versus-host disease

scientific article published on 07 February 2020

Induction of CD95 ligand and apoptosis by doxorubicin is modulated by the redox state in chemosensitive- and drug-resistant tumor cells

article by Claudia Friesen et al published May 1999 in Cell Death & Differentiation

Induction of adipocyte differentiation by a thiazolidinedione in cultured, subepidermal, fibroblast-like cells of an infant with congenital generalized lipodystrophy

scientific article

Induction of apoptosis and modulation of activation and effector function in T cells by immunosuppressive drugs

scientific article published in May 2002

Induction of apoptosis by IFNγ in human neuroblastoma cell lines through the CD95/CD95L autocrine circuit

scientific article published on September 2015

Induction of apoptosis by IFNγ in human neuroblastoma cell lines through the CD95/CD95L autocrine circuit

article by Francesca Bernassola et al published July 1999 in Cell Death & Differentiation

Infantile hepatic hemangiomas: first-line propranolol monotherapy as new treatment strategy?

scientific article published in October 2012

Infiltration of blood outgrowth endothelial cells into tumor spheroids: role of matrix metalloproteinases and irradiation

scientific article published on 01 May 2007

Inhibition of JNK signaling diminishes early but not late cellular stress-induced apoptosis

scientific article published on November 2003

Inhibition of NF-κB signaling ablates the invasive phenotype of glioblastoma

scientific article published on 21 October 2013

Inhibition of PI3K signalling increases the efficiency of radiotherapy in glioblastoma cells

scientific article published on 16 August 2018

Inhibition of TRAIL-induced apoptosis by Bcl-2 overexpression.

scientific article published in April 2002

Inhibition of clonogenic tumor growth: a novel function of Smac contributing to its antitumor activity

scientific article published on November 2005

Inhibition of death-receptor mediated apoptosis in human adipocytes by the insulin-like growth factor I (IGF-I)/IGF-I receptor autocrine circuit

scientific article published on 22 December 2003

Inhibition of nuclear factor kappa B and induction of apoptosis in T-lymphocytes by sulfasalazine

scientific article

Inhibition of nuclear factor kappaB activation attenuates apoptosis resistance in lymphoid cells

scientific article published on June 1998

Injection of acidic or neutral insulin and pain: a single-center, prospective, controlled, noninterventional study in pediatric patients with type 1 diabetes mellitus

scientific article published in December 2006

Insulin sensitivity and beta-cell secretion in thalassaemia major with secondary haemochromatosis: assessment by oral glucose tolerance test

scientific article published on 15 January 2003

Intact apoptosis signaling in myeloid leukemia cells determines treatment outcome in childhood AML

scientific article published on 14 December 2007

Intrinsic and chemo-sensitizing activity of SMAC-mimetics on high-risk childhood acute lymphoblastic leukemia.

scientific article published on 14 January 2016

Involvement of CD95/Apo1/Fas in Cell Death After Myocardial Ischemia

scientific article published on 01 August 2000

Involvement of the CD95 (APO–1/Fas) receptor/ligand system in drug–induced apoptosis in leukemia cells

scientific article published on 01 May 1996

Isolation and characterization of cDNAs for the protein kinase HIPK2

scientific article (publication date: 19 March 2001)

JNK/SAPK activity contributes to TRAIL-induced apoptosis

scientific article published on February 1999

JNK/SAPK activity is not sufficient for anticancer therapy-induced apoptosis involving CD95-L, TRAIL and TNF-?

JNK/SAPK activity is not sufficient for anticancer therapy-induced apoptosis involving CD95-L, TRAIL and TNF-alpha

scientific article published on 01 January 1999

Juvenile dermatomyositis (JDM) sine myositis

scientific article

KIT mutations in primary mediastinal B-cell lymphoma.

scientific article published on 22 August 2014

Key treatment questions in childhood acute lymphoblastic leukemia: results in 5 consecutive trials performed by the ALL-BFM study group from 1981 to 2000.

scientific article published on 22 May 2013

Killing me softly--future challenges in apoptosis research

scientific article

LDHA in Neuroblastoma Is Associated with Poor Outcome and Its Depletion Decreases Neuroblastoma Growth Independent of Aerobic Glycolysis

Lack of interleukin-2 (IL-2) dependent growth of TAC positive T-ALL/NHL cells is due to the expression of only low affinity receptors for IL-2

Late thymic deficiency after HLA-haploidentical hematopoietic stem cell transplantation for severe combined immunodeficiency

scientific article published on 07 December 2018

Leptin substitution results in the induction of menstrual cycles in an adolescent with leptin deficiency and hypogonadotropic hypogonadism

scientific article published on 14 February 2012

Lesson from hypomorphic recombination-activating gene (RAG) mutations: Why asymptomatic siblings should also be tested

scientific article published on 10 December 2013

Leukemia reconstitution in vivo is driven by cells in early cell cycle and low metabolic state

scientific article published on 8 March 2018

Levothyroxine in Euthyroid Autoimmune Thyroiditis and Type 1 Diabetes: A Randomized, Controlled Trial

Life satisfaction in adult survivors of cancer during adolescence: what contributes to the latter satisfaction with life?

scientific article

Long term survival in children with acute leukaemia and complications requiring mechanical ventilation

scientific article

Long-term remission of APL with a second allogeneic BMT after CNS relapse following HLA-identical allogeneic BMT.

scientific article

Loss of caspase-8 expression does not correlate with MYCN amplification, aggressive disease, or prognosis in neuroblastoma

scientific article published on October 2006

Loss of enteroendocrine cells in autoimmune-polyendocrine-candidiasis-ectodermal-dystrophy (APECED) syndrome with gastrointestinal dysfunction

scientific article published on 7 December 2011

Low discomfort and pain associated with intensified insulin therapy in children and adolescents

scientific article published on 26 December 2007

Lymphohematopoiesis in health and disease

article

MCM3AP and POMP Mutations Cause a DNA-Repair and DNA-Damage-Signaling Defect in an Immunodeficient Child.

scientific article published on 30 November 2015

MDSCs are induced after experimental blunt chest trauma and subsequently alter antigen-specific T cell responses

scientific article published on 9 October 2017

MYCN and survivin cooperatively contribute to malignant transformation of fibroblasts.

scientific article

Macrophage-activating factors from different T cell clones induce distinct macrophage functions

scientific article published on 01 August 1983

Membrane-bound CD95 ligand expressed on human antigen-presenting cells prevents alloantigen-specific T cell response without impairment of viral and third-party T cell immunity

article

Metabolic inhibitors sensitize for CD95 (APO-1/Fas)-induced apoptosis by down-regulating Fas-associated death domain-like interleukin 1-converting enzyme inhibitory protein expression.

scientific article

Minimal requirements for the diagnosis, classification, and evaluation of the treatment of childhood acute lymphoblastic leukemia (ALL) in the "BFM Family" Cooperative Group

scientific article

Mitochondrial amplification of death signals determines thymidine kinase/ganciclovir-triggered activation of apoptosis.

scientific article published in June 2000

Mitochondrial genome variants in non-remitting ALL of childhood

scientific article published on 25 May 2011

Mitophagy enhances oncolytic measles virus replication by mitigating DDX58/RIG-I-like receptor signaling

scientific article published on 26 February 2014

Modulation of TRAIL Signaling for Cancer Therapy

Modulation of TRAIL signaling for cancer therapy

scientific article published on January 2004

Modulation of apoptosis signaling for cancer therapy

scientific article

Modulation of resistance to anti-APO-1-induced apoptosis in osteosarcoma cells by cytokines

scientific article published on July 1997

Modulation of the granzyme B inhibitor proteinase inhibitor 9 (PI-9) by activation of lymphocytes and monocytes in vitro and by Epstein-Barr virus and bacterial infection.

scientific article

Molecular Control of Programmed Cell Death in HIV Infection

article

Molecular and Cellular Pediatrics

scientific article published on 4 September 2014

Molecular determinants of apoptosis induced by cytotoxic drugs

article

Molecular genetic analyses in familial and sporadic congenital primary erythrocytosis

scientific article published on 01 May 2007

Molecular mechanisms of APO-1/Fas(CD95)-mediated apoptosis in tolerance and AIDS.

scientific article

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

scientific article

Molecular mechanisms of sulfasalazine-induced T-cell apoptosis

scientific article

Molecular ordering of apoptosis induced by anticancer drugs in neuroblastoma cells

scientific article published on 01 October 1998

Monitoring of CD95 (APO-1/Fas) ligand expression in human T cells by quantitative RT-PCR

scientific article published on 01 July 1996

Monoclonal antibody-mediated tumor regression by induction of apoptosis.

scientific article

Monoclonal-antibody-mediated apoptosis in adult T-cell leukaemia

scientific article published on March 1990

Monogenic forms of childhood obesity due to mutations in the leptin gene

scientific article

Monogenic interferonopathy presenting as CMV infection in infancy

scientific article

Murine models for experimental therapy of pediatric solid tumors with poor prognosis

scientific article

Mutation analysis of CD95 (APO-1/Fas) in childhood B-lineage acute lymphoblastic leukaemia.

scientific article

Mutation analysis of the apoptotic "death-receptors" and the adaptors TRADD and FADD/MORT-1 in osteosarcoma tumor samples and osteosarcoma cell lines

scientific article published on May 2004

Mutations in Fas associated with human lymphoproliferative syndrome and autoimmunity

scientific article

Mutations in the von Hippel-Lindau (VHL) tumor suppressor gene and VHL-haplotype analysis in patients with presumable congenital erythrocytosis.

scientific article published in January 2005

MycN and IFNgamma cooperate in apoptosis of human neuroblastoma cells.

scientific article published on July 1998

MycN sensitizes neuroblastoma cells for drug-induced apoptosis

scientific article published on February 1999

MycN sensitizes neuroblastoma cells for drug-triggered apoptosis

scientific article

N-myc augments death and attenuates protective effects of Bcl-2 in trophically stressed neuroblastoma cells

scientific article

NF-kappaB-independent sensitization of glioblastoma cells for TRAIL-induced apoptosis by proteasome inhibition.

scientific article published on 7 August 2006

NF-κB is required for Smac mimetic-mediated sensitization of glioblastoma cells for γ-irradiation-induced apoptosis

scientific article

Natural killer resistance of a drug-resistant leukemia cell line, mediated by up-regulation of HLA class I expression.

scientific article published on May 2003

Near-drowning during baby swimming lesson

scientific article published on 30 November 2012

Neurotoxic side effects in children with refractory or relapsed T-cell malignancies treated with nelarabine based therapy

scientific article

Newly identified c-KIT receptor tyrosine kinase ITD in childhood AML induces ligand-independent growth and is responsive to a synergistic effect of imatinib and rapamycin

scientific article published on 13 July 2006

No conference critique

scientific article published in Nature

Novel Approaches to Apoptosis-Inducing Therapies

scientific article

Novel homozygous AIRE mutation in a German patient with severe APECED.

scientific article published in October 2008

Obesity and inflammation: reduced cytokine expression due to resveratrol in a human in vitro model of inflamed adipose tissue

scientific article

Objective assessment of smoking habits by urinary cotinine measurement in adolescents and young adults with type 1 diabetes. Reliability of reported cigarette consumption and relationship to urinary albumin excretion

scientific article published in May 1998

Occult thyroid pathology in a child with acquired immunodeficiency syndrome. Case report and review of the drug-related pathology in pediatric acquired immunodeficiency syndrome

scientific article

Olanzapine inhibits proliferation, migration and anchorage-independent growth in human glioblastoma cell lines and enhances temozolomide's antiproliferative effect

scientific article published on 19 December 2014

Opioid receptor activation triggering downregulation of cAMP improves effectiveness of anti-cancer drugs in treatment of glioblastoma

scientific article

Overcoming apoptosis resistance in high risk acute lymphoblastic leukemia by SMAC mimetics in a preclinical ALL xenograft model in vivo.

scientific article

Patients with adenosine deaminase deficiency surviving after hematopoietic stem cell transplantation are at high risk of CNS complications

scientific article published on 21 December 2006

Patients with early relapse of primary hemophagocytic syndromes or with persistent CNS involvement may benefit from immediate hematopoietic stem cell transplantation

Persistent defective membrane trafficking in epithelial cells of patients with familial hemophagocytic lymphohistiocytosis type 5 due to STXBP2/MUNC18-2 mutations

scientific article published on 4 February 2013

Persisting enteropathy and disturbed adaptive mucosal immunity due to MHC class II deficiency

scientific article published on 24 April 2019

Pharmacokinetics of orally administered zidovudine in HIV-infected children and adults

article

Pharmacokinetics, pharmacodynamics, safety and tolerability of APG101, a CD95-Fc fusion protein, in healthy volunteers and two glioma patients

scientific article

Phosphatidylinositol 3-kinase inhibition broadly sensitizes glioblastoma cells to death receptor- and drug-induced apoptosis

scientific article

Polymorphism of interleukin-23 receptor gene but not of NOD2/CARD15 is associated with graft-versus-host disease after hematopoietic stem cell transplantation in children

scientific article

Posttraumatic stress, depression and anxiety among adult long-term survivors of cancer in adolescence

scientific article

Precision medicine in pediatric oncology

Prediction of venetoclax activity in precursor B-ALL by functional assessment of apoptosis signaling

scientific article published on 29 July 2019

Prenatal origin of childhood acute lymphoblastic leukemia, association with birth weight and hyperdiploidy

scientific article published on 12 June 2008

Preserved in vitro immunoreactivity in children receiving long-term immunosuppressive therapy due to inflammatory bowel disease or autoimmune hepatitis

scientific article published on 19 January 2018

Proof-of-principle that a decoy virus protects oncolytic measles virus against neutralizing antibodies.

scientific article published on 30 April 2018

Prospective validation of a new method of monitoring minimal residual disease in childhood acute myelogenous leukemia

scientific article published on 11 December 2014

Prostaglandin E2 inhibits IFN-alpha secretion and Th1 costimulation by human plasmacytoid dendritic cells via E-prostanoid 2 and E-prostanoid 4 receptor engagement

scientific article published on 16 December 2009

RIST: a potent new combination therapy for glioblastoma

scientific article published on September 2014

Radiation and Brain Tumors: An Overview.

scientific article

Radioimmunotherapy-based conditioning for hematopoietic cell transplantation in children with malignant and nonmalignant diseases

scientific article published on 15 February 2011

Rapamycin-based GVHD prophylaxis increases the immunosuppressivity of MDSCs without affecting T cells and anti-tumor cytotoxicity

scientific article published on 18 July 2020

Rapid improvement of hepatic steatosis after initiation of leptin substitution in a leptin-deficient girl

scientific article published on 7 May 2013

Recombinant CD95-Fc (APG101) prevents graft-versus-host disease in mice without disabling antitumor cytotoxicity and T-cell functions

article

Regulation of TRAIL-induced apoptosis by XIAP in pancreatic carcinoma cells

scientific article published on 10 July 2006

Regulation of apoptosis in the immune system

scientific article published on April 1994

Regulation of apoptosis through CD95 (APO-I/Fas) receptor-ligand interaction

scientific article published on May 1997

Requirement of nuclear factor κB for Smac mimetic-mediated sensitization of pancreatic carcinoma cells for gemcitabine-induced apoptosis

scientific article published on December 2011

Rescue of death receptor and mitochondrial apoptosis signaling in resistant human NSCLCin vivo

article by Stella Okouoyo et al published 2003 in International Journal of Cancer

Residual CD95-pathway function in children with autoimmune lymphoproliferative syndrome is independent from clinical state and genotype of CD95 mutation

scientific article published in February 2009

Resistance of chimpanzee T cells to human immunodeficiency virus type 1 Tat-enhanced oxidative stress and apoptosis

scientific article

Resistance of cultured peripheral T cells towards activation-induced cell death involves a lack of recruitment of FLICE (MACH/caspase 8) to the CD95 death-inducing signaling complex

scholarly article by Marcus E. Peter et al published May 1997 in European Journal of Immunology

Resistance to APO-1 (CD95) induced apoptosis in T-ALL is determined by a BCL-2 independent anti-apoptotic program.

scientific article published in May 1995

Resveratrol as Inhibitor of Cell Survival Signal Transduction

Resveratrol modulates DNA double-strand break repair pathways in an ATM/ATR-p53- and -Nbs1-dependent manner

scientific article published on 3 January 2008

Resveratrol modulation of signal transduction in apoptosis and cell survival: A mini-review

article

Resveratrol regulates human adipocyte number and function in a Sirt1-dependent manner

scientific article published on 12 May 2010

Resveratrol-mediated sensitisation to TRAIL-induced apoptosis depends on death receptor and mitochondrial signalling

scientific article

Reticular dysgenesis: international survey on clinical presentation, transplantation, and outcome

scientific article

Rhodamine 110-Linked Amino Acids and Peptides as Substrates To Measure Caspase Activity upon Apoptosis Induction in Intact Cells†

scientific article published on 01 October 1999

Rocaglamide derivatives are potent inhibitors of NF-kappa B activation in T-cells

scientific article published on 16 September 2002

Role of CD95 (APO-1/Fas) System in Chemotherapy

Role of CD95-Mediated Adipocyte Loss in Autoimmune Lipodystrophy

article published in 2006

Role of apoptosis in congenital hematologic disorders and bone marrow failure

scientific article published on March 2003

Role of hypoxia inducible factor-1 alpha in modulation of apoptosis resistance

scientific article published on 16 October 2006

SCID patients with ARTEMIS vs RAG deficiencies following HCT: increased risk of late toxicity in ARTEMIS-deficient SCID.

scientific article published on 21 October 2013

Screening, identification, and functional analysis of three novel missense mutations in the TRADD gene in children with ALL and ALPS.

scientific article

Selective and nonselective toxicity of TRAIL/Apo2L combined with chemotherapy in human bone tumour cells vs. normal human cells

scientific article published in December 2003

Sensitivity and Resistance to Apoptosis in the APO-1 (Fas/CD95) System

Sensitivity of CD4+ peripheral blood T cells toward spontaneous and CD95 (APO-1/Fas)-induced apoptosis in pediatric human immunodeficiency virus infection

scientific article published in September 1999

Sensitivity of Epstein-Barr virus-induced B cell tumor to apoptosis mediated by anti-CD95/Apo-1/fas antibody

scientific article published in February 1997

Sensitization for anticancer drug-induced apoptosis by betulinic Acid

scientific article published on February 2005

Sensitization for anticancer drug-induced apoptosis by the chemopreventive agent resveratrol

scientific article

Sensitization for death receptor- or drug-induced apoptosis by re-expression of caspase-8 through demethylation or gene transfer

scientific article

Sensitization for gamma-irradiation-induced apoptosis by second mitochondria-derived activator of caspase

scientific article published on November 2005

Sensitization for tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by the chemopreventive agent resveratrol

scientific article published on January 2004

Sensitization of T cells to CD95-mediated apoptosis by HIV-1 Tat and gp120.

scientific article

Sensitization of neuroblastoma cells for TRAIL-induced apoptosis by NF-kappaB inhibition

scientific article

Sensitization of pancreatic carcinoma cells for γ-irradiation-induced apoptosis by XIAP inhibition

scientific article published on 30 April 2007

Sequential dosing in chemosensitization: targeting the PI3K/Akt/mTOR pathway in neuroblastoma

scientific article

Serum uric acid levels in obese children and adolescents: linkage to testosterone levels and pre-metabolic syndrome

scientific article

Severe Early-Onset Obesity Due to Bioinactive Leptin Caused by a p.N103K Mutation in the Leptin Gene

scientific article

Severe persistent neuropsychiatric toxicity after a human leucocyte antigen-non-identical peripheral blood stem cell transplantation (total body irradiation, etoposide, thiotepa) and interleukin 2-based experimental therapy for poor prognosis relaps

scientific article

Signal Transduction Therapy Targeting Apoptosis Pathways in Cancers

Signaling through death receptors in cancer therapy

scientific article published in August 2004

Similar pattern of thymic-dependent T-cell reconstitution in infants with severe combined immunodeficiency after human leukocyte antigen (HLA)-identical and HLA-nonidentical stem cell transplantation

scientific article published on 01 December 2000

Simultaneous Interference with HER1/EGFR and RAC1 Signaling Drives Cytostasis and Suppression of Survivin in Human Glioma Cells in Vitro.

scientific article

Smac agonists sensitize for Apo2L/TRAIL- or anticancer drug-induced apoptosis and induce regression of malignant glioma in vivo

scientific article

Smac mimetic sensitizes glioblastoma cells to Temozolomide-induced apoptosis in a RIP1- and NF-κB-dependent manner.

scientific article

Small molecule XIAP inhibitors cooperate with TRAIL to induce apoptosis in childhood acute leukemia cells and overcome Bcl-2-mediated resistance

scientific article published on 25 November 2008

Small molecule XIAP inhibitors enhance TRAIL-induced apoptosis and antitumor activity in preclinical models of pancreatic carcinoma

scientific article published on 3 March 2009

Small molecule XIAP inhibitors sensitize childhood acute leukemia cells for CD95-induced apoptosis

scientific article

Small-molecule XIAP inhibitors enhance gamma-irradiation-induced apoptosis in glioblastoma

scientific article published on August 2009

Social outcomes of long-term survivors of adolescent cancer

scientific article published in December 2010

Specific resistance upon lentiviral TRAIL transfer by intracellular retention of TRAIL receptors

scientific article published on 10 February 2006

Spontan aufgetretenes Pneumomediastinum, assoziiert mit Pneumoperikard, Pneumothorax und Hautemphysem bei einem 12-jährigen Jungen

scientific article published on 18 January 2010

Spontaneous complete and sustained remission of a rearrangement CBP (16p13)-positive disseminated congenital myelosarcoma

article by Carl Friedrich Classen et al published 17 December 2004 in Annals of Hematology

Stable and reproducible engraftment of primary adult and pediatric acute myeloid leukemia in NSG mice

scientific article published on 07 June 2011

Stem cell transplantation for osteopetrosis in patients beyond the age of 5 years ⬇️

scientific article published on 01 March 2019

Successful HLA haploidentical hematopoietic SCT in chronic granulomatous disease

scientific article published on 23 June 2014

Successful HLA-identical bone marrow transplantation in a patient with PNP deficiency using busulfan and fludarabine for conditioning

scientific article

Successful hematopoietic stem-cell transplantation in a patient with chronic granulomatous disease and McLeod phenotype sensitized to Kx and K antigens

scientific article published on 8 June 2009

Suicide gene therapy for pediatric tumors.

scientific article

Suppression of Growth Hormone by Oral Glucose in the Evaluation of Tall Stature

T cell activation deficiencies.

scientific article published on September 1995

T-cell apoptosis in HIV-1-infected individuals receiving highly active antiretroviral therapy

article

TNF-related apoptosis-inducing ligand promotes human preadipocyte proliferation via ERK1/2 activation

scientific article published on 9 April 2015

TRAIL (TNF-related apoptosis-inducing ligand) inhibits human adipocyte differentiation via caspase-mediated downregulation of adipogenic transcription factors

scientific article published on 13 October 2016

TRAIL enhances thymidine kinase/ganciclovir gene therapy of neuroblastoma cells

scientific article published in April 2002

TRAIL induced survival and proliferation in cancer cells resistant towards TRAIL-induced apoptosis mediated by NF-kappaB.

scientific article

TRAIL induces apoptosis and activation of NFkappaB

article

TRAIL-induced apoptosis is preferentially mediated via TRAIL receptor 1 in pancreatic carcinoma cells and profoundly enhanced by XIAP inhibitors

scientific article published on 12 October 2010

TRAIL-receptor costimulation inhibits proximal TCR signaling and suppresses human T cell activation and proliferation

scientific article published on 12 September 2014

TRAIL/Apo-2-ligand-induced apoptosis in human T cells.

scientific article

TSH receptor mutation V509A causes familial hyperthyroidism by release of interhelical constraints between transmembrane helices TMH3 and TMH5.

scientific article published on August 2005

Targeted release of oncolytic measles virus by blood outgrowth endothelial cells in situ inhibits orthotopic gliomas

scientific article published on 27 September 2007

Targeting XIAP Bypasses Bcl-2-Mediated Resistance to TRAIL and Cooperates with TRAIL to Suppress Pancreatic Cancer Growth In vitro and In vivo

scientific article published on 01 October 2008

Targeting aberrant PI3K/Akt activation by PI103 restores sensitivity to TRAIL-induced apoptosis in neuroblastoma.

scientific article

Targeting apoptosis pathways in cancer therapy

scientific article

Targeting inhibitor of apoptosis proteins (IAPs) for diagnosis and treatment of human diseases

scientific article published on January 2006

Targeting of hyperactivated mTOR signaling in high-risk acute lymphoblastic leukemia in a pre-clinical model

scientific article

Temozolomide and Other Alkylating Agents in Glioblastoma Therapy

scientific article published on 09 September 2019

Teneurin-2 (TENM2) deficiency induces UCP1 expression in differentiating human fat cells

scientific article

Terminal differentiation in vitro of patient-derived post-TMD megakaryoblastic AML cells

scientific article published on 21 June 2003

The CD95 (APO-1/Fas) system mediates drug-induced apoptosis in neuroblastoma cells

scientific article published on September 1997

The Cause of Acute Respiratory Failure Predicts the Outcome of Noninvasive Ventilation in Immunocompromised Children

scientific article published on 4 February 2015

The Combination of the PARP Inhibitor Rucaparib and 5FU Is an Effective Strategy for Treating Acute Leukemias

scientific article

The effect of the HIV protease inhibitor ritonavir on proliferation, differentiation, lipogenesis, gene expression and apoptosis of human preadipocytes and adipocytes

scientific article published in October 2005

The effects of PI3K-mediated signalling on glioblastoma cell behaviour

scientific article published on 29 November 2017

The granzyme B inhibitor PI-9 is differentially expressed in all main subtypes of pediatric acute lymphoblastic leukemias

scientific article

The mitochondrial genetic landscape in neuroblastoma from tumor initiation to relapse

scientific article published on 28 December 2015

The pyridinylfuranopyrimidine inhibitor, PI-103, chemosensitizes glioblastoma cells for apoptosis by inhibiting DNA repair.

scientific article

The role of CD95 system in chemotherapy

The role of the cell membrane in the killing mechanism of polymorphonuclear leucocytes (PMN)

scientific article published on 01 January 1982

The secretion of lysosomal enzymes by human polymorphonuclear leucocytes (PMN) and its modulation by serum complement

scientific article published on 01 January 1982

Therapeutic Modulation of Apoptosis in Cancer Therapy

Therapeutic approaches to pediatric COVID-19: an online survey of pediatric rheumatologists

scientific article published on 08 March 2021

Therapeutic modulation of death receptor- or drug-mediated apoptosis

article published in 2002

Therapeutic targeting of mutant p53 in pediatric acute lymphoblastic leukemia

scientific article published on 09 May 2019

Tight regulation of FOXO1 is essential for maintenance of B-cell precursor acute lymphoblastic leukemia

scholarly article by Fan Wang et al published 5 April 2018 in Blood

Toll-Like 4 Receptor Variant, Asp299Gly, and Reduced Risk of Hemorrhagic Cystitis after Hematopoietic Stem Cell Transplantation

Trail (TNF-related apoptosis-inducing ligand) induces an inflammatory response in human adipocytes

scientific article published on 18 July 2017

Transitory dasatinib-resistant states in KIT(mut) t(8;21) acute myeloid leukemia cells correlate with altered KIT expression

scientific article published on 6 November 2013

Treatment with hydroxyurea in thalassemia intermedia with paravertebral pseudotumors of extramedullary hematopoiesis

scientific article published on 15 August 2002

Tumor necrosis factor-related apoptosis-inducing ligand-mediated proliferation of tumor cells with receptor-proximal apoptosis defects

scientific article published on September 2005

Tumorstammzellen - ein neues Konzept in der Tumorbiologie

scientific article published on 01 August 2007

Tumorstammzellen: Grundlagen, klinische Implikationen und Kontroversen

Two CD95 (APO-1/Fas) signaling pathways

scientific article (publication date: 16 March 1998)

Up-regulation of Bcl-2 during adipogenesis mediates apoptosis resistance in human adipocytes

scientific article published on 26 October 2013

Urticaria, fever, and hypofibrinogenemia

scientific article published on May 2014

Vaccination rate and immunity of children and adolescents with inflammatory bowel disease or autoimmune hepatitis in Germany

scientific article published on 24 December 2019

Viability of glioblastoma stem cells is effectively reduced by diisothiocyanate-derived mercapturic acids

scientific article published on 21 August 2018

What do we mean by sensitivity when we talk about detecting minimal residual disease?

scientific article published on 28 February 2008

When apoptosis fails.

scientific article

Whole genome amplification of single cells from clinical peripheral blood smears ⬇️

scientific article published on October 1, 1997

[Intermediate results of a multicenter study in long-term management of HIV exposed and infected children]

scientific article published on 01 March 1993

[Lipodystrophies].

scientific article

[Multicenter study of long-term management of HIV exposed and HIV infected children. Study organization and aims]

scientific article published on 01 February 1990

[Symptomatic HIV infection. Approaches to rational therapy]

scientific article published on 01 May 1990

[The role of CD95 (APO-1/Fas) mutations in lymphoproliferative and malignant lymphatic diseases]

scientific article published on 01 July 1998

c-Jun-dependent CD95-L expression is a rate-limiting step in the induction of apoptosis by alkylating agents

scientific article

mAb 33 from Transduction Laboratories specifically binds to human CD95-L

scientific article published on 01 January 2000

miR-146a regulates insulin sensitivity via NPR3

scientific article published on 18 November 2020

miR-146a-mediated suppression of the inflammatory response in human adipocytes

scientific article published on 06 December 2016

γ-Secretase inhibitor I inhibits neuroblastoma cells, with NOTCH and the proteasome among its targets

scientific article published on 30 August 2016

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