List of works - Gabriel Rabinovich

"Time sweet time": circadian characterization of galectin-1 null mice.

scientific article

A galectin-specific signature in the gut delineates Crohn's disease and ulcerative colitis from other human inflammatory intestinal disorders

scientific article published in January 2016

A pivotal role for galectin-1 in fetomaternal tolerance

scientific article published on 18 November 2007

A unique galectin signature in human prostate cancer progression suggests galectin-1 as a key target for treatment of advanced disease.

scientific article

Antitumor Responses Stimulated by Dendritic Cells Are Improved by Triiodothyronine Binding to the Thyroid Hormone Receptor β

scientific article published on 11 February 2015

Apoptosis resistance in HIV-1 persistently-infected cells is independent of active viral replication and involves modulation of the apoptotic mitochondrial pathway

scientific article published on 8 February 2008

Assembly, organization and regulation of cell-surface receptors by lectin-glycan complexes

scientific article published on July 2015

Binding of galectin-1 to αIIbβ3 integrin triggers “outside-in” signals, stimulates platelet activation, and controls primary hemostasis

scientific article published on 27 March 2012

Cell-type specific regulation of galectin-3 expression by glucocorticoids in lung Clara cells and macrophages

scientific article published on 01 June 2011

Characterization and functionality of proliferative human Sertoli cells

scientific article

Characterization of a neutralizing anti-human galectin-1 monoclonal antibody with angioregulatory and immunomodulatory activities

scientific article published on 01 October 2020

Classification of current anticancer immunotherapies

scientific article

Differential glycosylation of TH1, TH2 and TH-17 effector cells selectively regulates susceptibility to cell death

article

Differential response of myeloid-derived suppressor cells to the nonsteroidal anti-inflammatory agent indomethacin in tumor-associated and tumor-free microenvironments

scientific article published on 4 March 2015

Disrupting galectin-1 interactions with N-glycans suppresses hypoxia-driven angiogenesis and tumorigenesis in Kaposi's sarcoma

scientific article

Dissecting the pathophysiologic role of endogenous lectins: glycan-binding proteins with cytokine-like activity?

scientific article published on 22 February 2007

Dissecting the signal transduction pathways triggered by galectin-glycan interactions in physiological and pathological settings

scientific article published on January 2010

Driving CARs into Sweet Roads: Targeting Glycosylated Antigens in Cancer

scientific article published in June 2016

Dynamic cross-talk between tumor and immune cells in orchestrating the immunosuppressive network at the tumor microenvironment

scientific article published on 15 June 2007

Endogenous lectins shape the function of dendritic cells and tailor adaptive immunity: mechanisms and biomedical applications.

scientific article published on 04 February 2011

Expanding the Universe of Cytokines and Pattern Recognition Receptors: Galectins and Glycans in Innate Immunity ⬇️

scientific article published on December 24, 2010

Expression profile of shelterin components in plasma cell disorders. Clinical significance of POT1 overexpression.

scientific article

Fucans, but not fucomannoglucuronans, determine the biological activities of sulfated polysaccharides from Laminaria saccharina brown seaweed

scientific article

Functions of cell surface galectin-glycoprotein lattices

scientific article

Galectin-1 Prevents Infection and Damage Induced by Trypanosoma cruzi on Cardiac Cells

scientific article (publication date: 2015)

Galectin-1 as a potential therapeutic target in autoimmune disorders and cancer

scientific article published on January 2008

Galectin-1 as an Emerging Mediator of Cardiovascular Inflammation: Mechanisms and Therapeutic Opportunities

article

Galectin-1 confers immune privilege to human trophoblast: implications in recurrent fetal loss.

scientific article

Galectin-1 confers resistance to doxorubicin in hepatocellular carcinoma cells through modulation of P-glycoprotein expression ⬇️

scientific article published on 24 January 2022

Galectin-1 controls cardiac inflammation and ventricular remodeling during acute myocardial infarction

scientific article published on 9 November 2012

Galectin-1 deactivates classically activated microglia and protects from inflammation-induced neurodegeneration

scientific article

Galectin-1 expression imprints a neurovascular phenotype in proliferative retinopathies and delineates responses to anti-VEGF

scientific article

Galectin-1 fosters an immunosuppressive microenvironment in colorectal cancer by reprogramming CD8 regulatory T cells

Galectin-1 is essential for efficient liver regeneration following hepatectomy

scientific article published on 05 May 2016

Galectin-1 markedly reduces the incidence of resorptions in mice missing immunophilin FKBP52

scientific article published on 13 March 2012

Galectin-1 suppresses autoimmune retinal disease by promoting concomitant Th2- and T regulatory-mediated anti-inflammatory responses

scientific article

Galectin-3 and soluble fibrinogen act in concert to modulate neutrophil activation and survival: involvement of alternative MAPK pathways.

scientific article published on 15 December 2004

Galectin-8 Ameliorates Murine Autoimmune Ocular Pathology and Promotes a Regulatory T Cell Response

scientific article published on 30 June 2015

Galectin-8 promotes regulatory T-cell differentiation by modulating IL-2 and TGFβ signaling

scientific article published on 18 August 2015

Galectins and their ligands: amplifiers, silencers or tuners of the inflammatory response?

scientific article

Galectins as modulators of tumour progression

scientific article

Galectins in hematological malignancies

scientific article published on 01 July 2013

Galectins: emerging regulatory checkpoints linking tumor immunity and angiogenesis

scientific article published on 11 January 2017

Galectins: regulators of acute and chronic inflammation

scientific article

Galectins: structure, function and therapeutic potential

scientific article

Glyco-nano-oncology: Novel therapeutic opportunities by combining small and sweet

scientific article published on 4 February 2016

Glycosylation-dependent lectin-receptor interactions preserve angiogenesis in anti-VEGF refractory tumors

scientific article

Histone deacetylase inhibitors impair NK cell viability and effector functions through inhibition of activation and receptor expression.

scientific article

How do protein-glycan interactions regulate T-cell physiology?

scientific article

IRE1α-XBP1 controls T cell function in ovarian cancer by regulating mitochondrial activity

scientific article published in Nature

Immune-Mediated and Hypoxia-Regulated Programs: Accomplices in Resistance to Anti-angiogenic Therapies

scientific article

Impact of protein-glycan interactions in the regulation of autoimmunity and chronic inflammation.

scientific article published on 9 March 2006

Inflammation Controls Sensitivity of Human and Mouse Intestinal Epithelial Cells to Galectin-1.

scientific article published on 28 December 2015

Integrating structure and function of tandem-repeat galectins ⬇️

scientific article published on January 1, 2012

Lack of TNFR p55 Results in Heightened Expression of IFN-γ and IL-17 during the Development of Reactive Arthritis ⬇️

scientific article published on October 1, 2010

Lack of galectin-3 increases Jagged1/Notch activation in bone marrow-derived dendritic cells and promotes dysregulation of T helper cell polarization

scientific article published on 22 June 2016

Ligand-mediated Galectin-1 endocytosis prevents intraneural H2O2 production promoting F-actin dynamics reactivation and axonal re-growth

scientific article published on 10 June 2016

Linking the structure and thermal stability of beta-galactoside-binding protein galectin-1 to ligand binding and dimerization equilibria

scientific article published on September 2010

Linking tumor hypoxia with VEGFR2 signaling and compensatory angiogenesis: Glycans make the difference

scientific article published on 25 June 2014

Low-dose cyclophosphamide modulates galectin-1 expression and function in an experimental rat lymphoma model

scientific article

MLL-rearranged B lymphoblastic leukemias selectively express the immunoregulatory carbohydrate-binding protein galectin-1.

scientific article

Melatonin Contributes to the Seasonality of Multiple Sclerosis Relapses

scientific article

Microbially driven TLR5-dependent signaling governs distal malignant progression through tumor-promoting inflammation.

scientific article

Modulation of endothelial cell migration and angiogenesis: a novel function for the "tandem-repeat" lectin galectin-8.

scientific article published on 27 September 2010

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

scientific article

Multiple functional targets of the immunoregulatory activity of galectin-1: Control of immune cell trafficking, dendritic cell physiology, and T-cell fate.

scientific article published on January 2010

Neuroendocrine-immune disequilibrium and endometriosis: an interdisciplinary approach.

scientific article published on June 2007

Novel roles of galectin-1 in hepatocellular carcinoma cell adhesion, polarization, and in vivo tumor growth.

scientific article published on June 2011

Nuclear factor (NF)-kappaB-dependent thyroid hormone receptor beta1 expression controls dendritic cell function via Akt signaling

scientific article

Nuclear factor (NF)-κB controls expression of the immunoregulatory glycan-binding protein galectin-1.

scientific article published in September 2011

Overcoming the hurdles of tumor immunity by targeting regulatory pathways in innate and adaptive immune cells.

scientific article published on January 2010

Prognostic value of the interaction between galectin-3 and antigen carbohydrate 125 in acute heart failure

scientific article

Proteomic and functional analysis identifies galectin-1 as a novel regulatory component of the cytotoxic granule machinery.

scientific article published on 7 December 2017

Re-wiring regulatory cell networks in immunity by galectin-glycan interactions

scientific article published on 06 September 2015

Regulated expression of galectin-1 during T-cell activation involves Lck and Fyn kinases and signaling through MEK1/ERK, p38 MAP kinase and p70S6 kinase

scientific article published in December 2004

Regulated expression of galectin-3, a multifunctional glycan-binding protein, in haematopoietic and non-haematopoietic tissues

scientific article published on February 2011

Regulation of eosinophilia and allergic airway inflammation by the glycan-binding protein galectin-1

scientific article published on 25 July 2016

Regulation of galectin-1 expression by transforming growth factor beta1 in metastatic mammary adenocarcinoma cells: implications for tumor-immune escape.

scientific article published on 10 August 2006

Regulation of galectins by hypoxia and their relevance in angiogenesis: strategies and methods

scientific article

Regulatory Circuits Mediated by Lectin-Glycan Interactions in Autoimmunity and Cancer ⬇️

scientific article published on March 23, 2012

Regulatory role of glycans in the control of hypoxia-driven angiogenesis and sensitivity to anti-angiogenic treatment

scientific article

Role of galectins in inflammatory and immunomodulatory processes

scientific article

Satb1 Overexpression Drives Tumor-Promoting Activities in Cancer-Associated Dendritic Cells.

scientific article published on 10 February 2016

Shedding light on the immunomodulatory properties of galectins: novel regulators of innate and adaptive immune responses.

scientific article published on January 2004

Silencing survivin gene expression promotes apoptosis of human breast cancer cells through a caspase-independent pathway

scientific article published on 01 October 2008

Single-cell profiling reveals an endothelium-mediated immunomodulatory pathway in the eye choroid

scientific article published on 01 June 2020

Study of galectins in tumor immunity: strategies and methods

scientific article published on January 2015

Systems-level effects of ectopic galectin-7 reconstitution in cervical cancer and its microenvironment

scientific article

TSLP1: a new piece in the puzzle of tumor-associated Th2-type inflammation

scientific article

Targeted inhibition of galectin-1 gene expression in tumor cells results in heightened T cell-mediated rejection; A potential mechanism of tumor-immune privilege

scientific article published in March 2004

Targeting Galectin-1 Overcomes Breast Cancer-Associated Immunosuppression and Prevents Metastatic Disease ⬇️

scientific article published on November 29, 2012

Targeting galectin-1-induced angiogenesis mitigates the severity of endometriosis

scientific article published on 08 August 2014

The AP1-dependent secretion of galectin-1 by Reed Sternberg cells fosters immune privilege in classical Hodgkin lymphoma

scholarly article

The aggressiveness of murine lymphomas selected in vivo by growth rate correlates with galectin-1 expression and response to cyclophosphamide

scientific article published on 27 September 2011

The galectin-1-glycan axis controls sperm fertilizing capacity by regulating sperm motility and membrane hyperpolarization.

scientific article published in July 2015

The immunoregulatory glycan-binding protein galectin-1 triggers human platelet activation

scientific article published on 5 November 2007

Thwarting galectin-induced immunosuppression in breast cancer

scientific article published on May 2013

Tolerance signaling molecules and pregnancy: IDO, galectins, and the renaissance of regulatory T cells.

scientific article published on September 2007

Tolerogenic signals delivered by dendritic cells to T cells through a galectin-1-driven immunoregulatory circuit involving interleukin 27 and interleukin 10.

scientific article

Translating the 'Sugar Code' into Immune and Vascular Signaling Programs

scientific article published on 13 December 2016

Trypanosoma cruzi Infection Imparts a Regulatory Program in Dendritic Cells and T Cells via Galectin-1-Dependent Mechanisms.

scientific article published on 31 August 2015

Turning 'sweet' on immunity: galectin-glycan interactions in immune tolerance and inflammation

scientific article published on May 2009

Turning-Off Signaling by Siglecs, Selectins, and Galectins: Chemical Inhibition of Glycan-Dependent Interactions in Cancer

scientific article

Unlocking the secrets of galectins: a challenge at the frontier of glyco-immunology.

scientific article

Untangling Galectin-Driven Regulatory Circuits in Autoimmune Inflammation

scientific article published on 16 March 2018

When galectins recognize glycans: from biochemistry to physiology and back again

scientific article

‘Sweetening’ Pregnancy: Galectins at the Fetomaternal Interface ⬇️

scientific article published on February 14, 2013

List of works by Gabriel Rabinovich

"Time sweet time": circadian characterization of galectin-1 null mice.

A galectin-specific signature in the gut delineates Crohn's disease and ulcerative colitis from other human inflammatory intestinal disorders

A pivotal role for galectin-1 in fetomaternal tolerance

A unique galectin signature in human prostate cancer progression suggests galectin-1 as a key target for treatment of advanced disease.

Antitumor Responses Stimulated by Dendritic Cells Are Improved by Triiodothyronine Binding to the Thyroid Hormone Receptor β

Apoptosis resistance in HIV-1 persistently-infected cells is independent of active viral replication and involves modulation of the apoptotic mitochondrial pathway

Assembly, organization and regulation of cell-surface receptors by lectin-glycan complexes

Binding of galectin-1 to αIIbβ3 integrin triggers “outside-in” signals, stimulates platelet activation, and controls primary hemostasis

Cell-type specific regulation of galectin-3 expression by glucocorticoids in lung Clara cells and macrophages

Characterization and functionality of proliferative human Sertoli cells

Characterization of a neutralizing anti-human galectin-1 monoclonal antibody with angioregulatory and immunomodulatory activities

Classification of current anticancer immunotherapies

Differential glycosylation of TH1, TH2 and TH-17 effector cells selectively regulates susceptibility to cell death

Differential response of myeloid-derived suppressor cells to the nonsteroidal anti-inflammatory agent indomethacin in tumor-associated and tumor-free microenvironments

Disrupting galectin-1 interactions with N-glycans suppresses hypoxia-driven angiogenesis and tumorigenesis in Kaposi's sarcoma

Dissecting the pathophysiologic role of endogenous lectins: glycan-binding proteins with cytokine-like activity?

Dissecting the signal transduction pathways triggered by galectin-glycan interactions in physiological and pathological settings

Driving CARs into Sweet Roads: Targeting Glycosylated Antigens in Cancer

Dynamic cross-talk between tumor and immune cells in orchestrating the immunosuppressive network at the tumor microenvironment

Endogenous lectins shape the function of dendritic cells and tailor adaptive immunity: mechanisms and biomedical applications.

Expanding the Universe of Cytokines and Pattern Recognition Receptors: Galectins and Glycans in Innate Immunity ⬇️

Expression profile of shelterin components in plasma cell disorders. Clinical significance of POT1 overexpression.

Fucans, but not fucomannoglucuronans, determine the biological activities of sulfated polysaccharides from Laminaria saccharina brown seaweed

Functions of cell surface galectin-glycoprotein lattices

Galectin-1 Prevents Infection and Damage Induced by Trypanosoma cruzi on Cardiac Cells

Galectin-1 as a potential therapeutic target in autoimmune disorders and cancer

Galectin-1 as an Emerging Mediator of Cardiovascular Inflammation: Mechanisms and Therapeutic Opportunities

Galectin-1 confers immune privilege to human trophoblast: implications in recurrent fetal loss.

Galectin-1 confers resistance to doxorubicin in hepatocellular carcinoma cells through modulation of P-glycoprotein expression ⬇️

Galectin-1 controls cardiac inflammation and ventricular remodeling during acute myocardial infarction

Galectin-1 deactivates classically activated microglia and protects from inflammation-induced neurodegeneration

Galectin-1 expression imprints a neurovascular phenotype in proliferative retinopathies and delineates responses to anti-VEGF

Galectin-1 fosters an immunosuppressive microenvironment in colorectal cancer by reprogramming CD8 regulatory T cells

Galectin-1 is essential for efficient liver regeneration following hepatectomy

Galectin-1 markedly reduces the incidence of resorptions in mice missing immunophilin FKBP52

Galectin-1 suppresses autoimmune retinal disease by promoting concomitant Th2- and T regulatory-mediated anti-inflammatory responses

Galectin-3 and soluble fibrinogen act in concert to modulate neutrophil activation and survival: involvement of alternative MAPK pathways.

Galectin-8 Ameliorates Murine Autoimmune Ocular Pathology and Promotes a Regulatory T Cell Response

Galectin-8 promotes regulatory T-cell differentiation by modulating IL-2 and TGFβ signaling

Galectins and their ligands: amplifiers, silencers or tuners of the inflammatory response?

Galectins as modulators of tumour progression

Galectins in hematological malignancies

Galectins: emerging regulatory checkpoints linking tumor immunity and angiogenesis

Galectins: regulators of acute and chronic inflammation

Galectins: structure, function and therapeutic potential

Glyco-nano-oncology: Novel therapeutic opportunities by combining small and sweet

Glycosylation-dependent lectin-receptor interactions preserve angiogenesis in anti-VEGF refractory tumors

Histone deacetylase inhibitors impair NK cell viability and effector functions through inhibition of activation and receptor expression.

How do protein-glycan interactions regulate T-cell physiology?

IRE1α-XBP1 controls T cell function in ovarian cancer by regulating mitochondrial activity

Immune-Mediated and Hypoxia-Regulated Programs: Accomplices in Resistance to Anti-angiogenic Therapies

Impact of protein-glycan interactions in the regulation of autoimmunity and chronic inflammation.

Inflammation Controls Sensitivity of Human and Mouse Intestinal Epithelial Cells to Galectin-1.

Integrating structure and function of tandem-repeat galectins ⬇️

Lack of TNFR p55 Results in Heightened Expression of IFN-γ and IL-17 during the Development of Reactive Arthritis ⬇️

Lack of galectin-3 increases Jagged1/Notch activation in bone marrow-derived dendritic cells and promotes dysregulation of T helper cell polarization

Ligand-mediated Galectin-1 endocytosis prevents intraneural H2O2 production promoting F-actin dynamics reactivation and axonal re-growth

Linking the structure and thermal stability of beta-galactoside-binding protein galectin-1 to ligand binding and dimerization equilibria

Linking tumor hypoxia with VEGFR2 signaling and compensatory angiogenesis: Glycans make the difference

Low-dose cyclophosphamide modulates galectin-1 expression and function in an experimental rat lymphoma model

MLL-rearranged B lymphoblastic leukemias selectively express the immunoregulatory carbohydrate-binding protein galectin-1.

Melatonin Contributes to the Seasonality of Multiple Sclerosis Relapses

Microbially driven TLR5-dependent signaling governs distal malignant progression through tumor-promoting inflammation.

Modulation of endothelial cell migration and angiogenesis: a novel function for the "tandem-repeat" lectin galectin-8.

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

Multiple functional targets of the immunoregulatory activity of galectin-1: Control of immune cell trafficking, dendritic cell physiology, and T-cell fate.

Neuroendocrine-immune disequilibrium and endometriosis: an interdisciplinary approach.

Novel roles of galectin-1 in hepatocellular carcinoma cell adhesion, polarization, and in vivo tumor growth.

Nuclear factor (NF)-kappaB-dependent thyroid hormone receptor beta1 expression controls dendritic cell function via Akt signaling

Nuclear factor (NF)-κB controls expression of the immunoregulatory glycan-binding protein galectin-1.

Overcoming the hurdles of tumor immunity by targeting regulatory pathways in innate and adaptive immune cells.

Prognostic value of the interaction between galectin-3 and antigen carbohydrate 125 in acute heart failure

Proteomic and functional analysis identifies galectin-1 as a novel regulatory component of the cytotoxic granule machinery.

Re-wiring regulatory cell networks in immunity by galectin-glycan interactions

Regulated expression of galectin-1 during T-cell activation involves Lck and Fyn kinases and signaling through MEK1/ERK, p38 MAP kinase and p70S6 kinase

Regulated expression of galectin-3, a multifunctional glycan-binding protein, in haematopoietic and non-haematopoietic tissues

Regulation of eosinophilia and allergic airway inflammation by the glycan-binding protein galectin-1

Regulation of galectin-1 expression by transforming growth factor beta1 in metastatic mammary adenocarcinoma cells: implications for tumor-immune escape.

Regulation of galectins by hypoxia and their relevance in angiogenesis: strategies and methods