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List of works by Konrad Beyreuther

A novel epsilon-cleavage within the transmembrane domain of the Alzheimer amyloid precursor protein demonstrates homology with Notch processing

scientific article published in February 2002

A presenilin 1 mutation in the first case of Alzheimer's disease: revisited

scientific article published on 15 August 2014

APP anterograde transport requires Rab3A GTPase activity for assembly of the transport vesicle

scientific article

APP intracellular domain is increased and soluble Abeta is reduced with diet-induced hypercholesterolemia in a transgenic mouse model of Alzheimer disease

scientific article published on June 2004

Additive effects of fatty acid mixtures on the levels and ratio of amyloid β40/42 peptides differ from the effects of individual fatty acids ⬇️

scientific article published on July 11, 2011

Alternative transcripts of presenilin-1 associated with frontotemporal dementia

scientific article

Alzheimer beta-amyloid homodimers facilitate A beta fibrillization and the generation of conformational antibodies

scientific article published on July 2003

Alzheimer's centennial legacy: prospects for rational therapeutic intervention targeting the Abeta amyloid pathway

scientific article published on 29 September 2006

Alzheimer's disease amyloid beta and prion protein amyloidogenic peptides promote macrophage survival, DNA synthesis and enhanced proliferative response to CSF-1 (M-CSF).

scientific article published in June 2002

Alzheimer's disease amyloid precursor protein (ApPP): proteolytic processing, secretases and βA4 amyloid production

article

Alzheimer's disease-associated presenilin 1 in neuronal cells: Evidence for localization to the endoplasmic reticulum-Golgi intermediate compartment

Amyloid-beta-anti-amyloid-beta complex structure reveals an extended conformation in the immunodominant B-cell epitope

scientific article

Cerebrospinal fluid 24S-hydroxycholesterol is increased in patients with Alzheimer's disease compared to healthy controls

scientific article published in May 2002

Corrigendum to "Detrimental effects of arachidonic acid and its metabolites in cellular and mouse models of Alzheimer's disease: structural insight" [Neurobiol. Aging 33 (2012) 831.e21-831.e31].

scientific article published in February 2018

Crystal structure of the human Fe65-PTB1 domain

scientific article

Delineating common molecular mechanisms in Alzheimer's and prion diseases

scientific article published on 3 July 2006

Detrimental effects of arachidonic acid and its metabolites in cellular and mouse models of Alzheimer's disease: structural insight ⬇️

scientific article published on September 13, 2011

Diverse fibrillar peptides directly bind the Alzheimer's amyloid precursor protein and amyloid precursor-like protein 2 resulting in cellular accumulation

scientific article published in March 2003

Evidence for a copper-binding superfamily of the amyloid precursor protein

scientific article (publication date: 30 July 2002)

GM1 up-regulates Ubiquilin 1 expression in human neuroblastoma cells and rat cortical neurons

scientific article published in September 2006

Homo- and heterodimerization of APP family members promotes intercellular adhesion

scientific article

In vitro and in vivo products of E. coli lactose permease gene are identical

scientific article published in Nature

Increased expression of the amyloid precursor beta-secretase in Alzheimer's disease

scientific article

Independent inhibition of Alzheimer disease beta- and gamma-secretase cleavage by lowered cholesterol levels

scientific article

Iron inhibits neurotoxicity induced by trace copper and biological reductants

scientific article published on 3 February 2004

Locomotor activity and evoked dopamine release are reduced in mice overexpressing A30P-mutated human alpha-synuclein

scientific article published in November 2005

Mechanisms of peripheral microvascular dysfunction in transgenic mice overexpressing the Alzheimer's disease amyloid Abeta protein

scientific article

Mercury-induced crystallization and SAD phasing of the human Fe65-PTB1 domain

scientific article published on 05 April 2008

Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial

scientific article

No alterations of hippocampal neuronal number and synaptic bouton number in a transgenic mouse model expressing the beta-cleaved C-terminal APP fragment

scientific article published in March 2003

Overexpression of Alzheimer's disease amyloid-beta opposes the age-dependent elevations of brain copper and iron

scientific article published on 4 September 2002

Overproduction, purification, crystallization and preliminary X-ray analysis of human Fe65-PTB2 in complex with the amyloid precursor protein intracellular domain

scientific article published on 24 April 2008

PAT1a modulates intracellular transport and processing of amyloid precursor protein (APP), APLP1, and APLP2.

scientific article

Pathways to the discovery of the Abeta amyloid of Alzheimer's disease.

scientific article published in January 2006

Platelet alpha- and gamma-synucleins in Parkinson's disease and normal control subjects

scientific article

Profile of cholesterol-related sterols in aged amyloid precursor protein transgenic mouse brain

scientific article published in July 2002

Selecting cells with different Alzheimer's disease gamma-secretase activity using FACS. Differential effect on presenilin exon 9 gamma- and epsilon-cleavage

scientific article published in February 2003

Specific binding of the alzheimer βA4 amyloid precursor to collagen, laminin, and heparin

Structural insight into the differential effects of omega-3 and omega-6 fatty acids on the production of Abeta peptides and amyloid plaques

scientific article published on 22 October 2010

Structure of the Alzheimer's disease amyloid precursor protein copper binding domain. A regulator of neuronal copper homeostasis

scientific article (publication date: 9 May 2003)

Structure of the intracellular domain of the amyloid precursor protein in complex with Fe65-PTB2

scientific article

Subcellular trafficking of the amyloid precursor protein gene family and its pathogenic role in Alzheimer's disease

scientific article published on January 2006

Teasing out the tangles

scientific article published in July 2006

Tenuigenin treatment decreases secretion of the Alzheimer's disease amyloid beta-protein in cultured cells

scientific article published in August 2004

The amplifying effect of beta-amyloid on cellular calcium signalling is reduced in Alzheimer's disease

scientific article

The intramembrane cleavage site of the amyloid precursor protein depends on the length of its transmembrane domain

scientific article

The proteolytic processing of the amyloid precursor protein gene family members APLP-1 and APLP-2 involves alpha-, beta-, gamma-, and epsilon-like cleavages: modulation of APLP-1 processing by n-glycosylation

scientific article (publication date: 30 April 2004)

The transmembrane domain of the amyloid precursor protein in microsomal membranes is on both sides shorter than predicted

scientific article published on 25 November 2002

Toxicity of substrate-bound amyloid peptides on vascular smooth muscle cells is enhanced by homocysteine

scientific article

Treatment with simvastatin in normocholesterolemic patients with Alzheimer's disease: A 26-week randomized, placebo-controlled, double-blind trial

scientific article published in September 2002

Tyrosine gated electron transfer is key to the toxic mechanism of Alzheimer's disease beta-amyloid

scientific article

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