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List of works by Andrea Musacchio

"4D Biology for health and disease" workshop report

scientific article published on 15 October 2010

A Molecular View of Kinetochore Assembly and Function

scientific article published on 24 January 2017

A general framework for inhibitor resistance in protein kinases.

scientific article

A high throughput, whole cell screen for small molecule inhibitors of the mitotic spindle checkpoint identifies OM137, a novel Aurora kinase inhibitor

scientific article

A molecular basis for the differential roles of Bub1 and BubR1 in the spindle assembly checkpoint

scientific article published on 22 January 2015

A mutation in the pleckstrin homology (PH) domain of the FGD1 gene in an Italian family with faciogenital dysplasia (Aarskog-Scott syndrome)

scientific article (publication date: 4 August 2000)

A novel peptide-SH3 interaction.

scientific article

A screen for kinetochore-microtubule interaction inhibitors identifies novel antitubulin compounds

scientific article

A small-molecule inhibitor of Haspin alters the kinetochore functions of Aurora B

scientific article

Abnormal kinetochore-generated pulling forces from expressing a N-terminally modified Hec1.

scientific article

Accumulation of Mad2-Cdc20 complex during spindle checkpoint activation requires binding of open and closed conformers of Mad2 in Saccharomyces cerevisiae

scientific article

Andrea Musacchio ⬇️

scientific article published on July 24, 2012

Architecture of the human ndc80-hec1 complex, a critical constituent of the outer kinetochore

scientific article

Atomic structure of clathrin: a beta propeller terminal domain joins an alpha zigzag linker

scientific article

Backwards and forwards binding

scientific article published on 01 December 1994

Basis of catalytic assembly of the mitotic checkpoint complex

scientific article published on 19 January 2017

Bub3 interaction with Mad2, Mad3 and Cdc20 is mediated by WD40 repeats and does not require intact kinetochores

scientific article

Bub3 reads phosphorylated MELT repeats to promote spindle assembly checkpoint signaling

scientific article

BubR1 Promotes Bub3-Dependent APC/C Inhibition during Spindle Assembly Checkpoint Signaling.

scientific article published on 14 September 2017

CDC20 assists its catalytic incorporation in the mitotic checkpoint complex

scientific article published on 01 January 2021

CDK-regulated dimerization of M18BP1 on a Mis18 hexamer is necessary for CENP-A loading

scientific article

CENP-C is a blueprint for constitutive centromere-associated network assembly within human kinetochores

scientific article published on 29 June 2015

Cell Cycle: Deconstructing Tension ⬇️

scientific article published on August 10, 2010

Cell cycle, differentiation and disease

scientific article published on 16 October 2013

Characterization of the interaction of natural proline-rich peptides with five different SH3 domains.

scientific article

Closing the Mad2 cycle

scientific article

Comment on "A centrosome-independent role for gamma-TuRC proteins in the spindle assembly checkpoint"

scientific article published on May 2007

Complex assembly, crystallization and preliminary X-ray crystallographic analysis of the human Rod-Zwilch-ZW10 (RZZ) complex

scientific article

Coupling PAF Signaling to Dynein Regulation

Coupling PAF signaling to dynein regulation: structure of LIS1 in complex with PAF-acetylhydrolase

scientific article

Crystal Structure of Human Aurora B in Complex with INCENP and VX-680

scientific article

Crystal structure of a Src-homology 3 (SH3) domain

scientific article

Crystal structure of the SH3 domain in human Fyn; comparison of the three-dimensional structures of SH3 domains in tyrosine kinases and spectrin

scientific article

Crystal structure of the breakpoint cluster region-homology domain from phosphoinositide 3-kinase p85 alpha subunit

scientific article

Crystal structure of the catalytic domain of Haspin, an atypical kinase implicated in chromatin organization

scientific article

Crystal structure of the tetrameric Mad1-Mad2 core complex: implications of a 'safety belt' binding mechanism for the spindle checkpoint

scientific article

Crystal structure of the ubiquitin binding domains of rabex-5 reveals two modes of interaction with ubiquitin

scientific article

Crystallization and Preliminary X-ray Investigation of a Recombinant Outer Membrane Protein from Neisseria meningitidis

scientific article published on 01 January 1994

Crystallization and preliminary X-ray analysis of the periplasmic fragment of CyoA-a subunit of the Escherichia coli cytochrome o complex.

scientific article

Cyclin B1 scaffolds MAD1 at the kinetochore corona to activate the mitotic checkpoint

scientific article published on 23 March 2020

DNA-Directed Assembly of Capture Tools for Constitutional Studies of Large Protein Complexes

scientific article published on 3 February 2015

Decoding the centromeric nucleosome through CENP-N.

scientific article

Defining Cdk5 ligand chemical space with small molecule inhibitors of tau phosphorylation.

scientific article published in July 2005

Determinants of conformational dimerization of Mad2 and its inhibition by p31comet

scientific article

Development of an assay to screen for inhibitors of tau phosphorylation by cdk5.

scientific article published in March 2004

Direct binding of Cenp-C to the Mis12 complex joins the inner and outer kinetochore

scientific article

Discovery of selective aminothiazole aurora kinase inhibitors

scientific article

Dissecting the role of MPS1 in chromosome biorientation and the spindle checkpoint through the small molecule inhibitor reversine

scientific article

Dynamic Kinetochore Size Regulation Promotes Microtubule Capture And Chromosome Biorientation In Mitosis

Dynamic kinetochore size regulation promotes microtubule capture and chromosome biorientation in mitosis

scientific article published on 18 June 2018

Electroporated recombinant proteins as tools for in vivo functional complementation, imaging and chemical biology

scientific article published on 16 July 2019

Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant

scientific article

Evidence that Aurora B is implicated in spindle checkpoint signalling independently of error correction ⬇️

scientific article

Explaining the oligomerization properties of the spindle assembly checkpoint protein Mad2.

scientific article published on March 2005

Expression, crystallization and preliminary X-ray diffraction studies of recombinantBacillus anthracislethal factor

scientific article published on 01 November 2000

Functional organization of clathrin in coats: combining electron cryomicroscopy and X-ray crystallography

scientific journal article

GSK-3-selective inhibitors derived from Tyrian purple indirubins

scientific article

HJURP Involvement in De Novo CenH3CENP-A and CENP-C Recruitment

scientific article published on 02 April 2015

HORMA domains at the heart of meiotic chromosome dynamics

scientific article

High-resolution crystal structures of tyrosine kinase SH3 domains complexed with proline-rich peptides

scientific article

Homeostatic Control of Mitotic Arrest

scientific article published on 01 December 2011

How SH3 domains recognize proline

scientific article

Implications for kinetochore-microtubule attachment from the structure of an engineered Ndc80 complex

scientific article

In vitro FRAP identifies the minimal requirements for Mad2 kinetochore dynamics

scientific article

Inhibitor-3 ensures bipolar mitotic spindle attachment by limiting association of SDS22 with kinetochore-bound protein phosphatase-1.

scientific article published on 8 October 2014

Insights from biochemical reconstitution into the architecture of human kinetochores.

scientific article published on 31 August 2016

Insights from the reconstitution of the divergent outer kinetochore of Drosophila melanogaster

scientific article

Invariant tryptophan at a shielded site promotes folding of the conformational unit of spectrin

scientific article

Investigating a macromolecular complex: the toolkit of methods

scientific article published on 18 May 2011

JIP3 interacts with dynein and kinesin-1 to regulate bidirectional organelle transport

scientific article published in 2022

KI motifs of human Knl1 enhance assembly of comprehensive spindle checkpoint complexes around MELT repeats

scientific article published on 19 December 2013

Loss of Survivin influences liver regeneration and is associated with impaired Aurora B function.

scientific article

MAD contortions: conformational dimerization boosts spindle checkpoint signaling

scientific article published on 24 October 2007

Mad2 binding to Mad1 and Cdc20, rather than oligomerization, is required for the spindle checkpoint

scientific article

Mechanism of Aurora B activation by INCENP and inhibition by hesperadin

scientific article

Mechanism of CDK5/p25 binding by CDK inhibitors

scientific article

Microtubules: 50 years on from the discovery of tubulin

scientific article published on April 2016

Modular assembly of RWD domains on the Mis12 complex underlies outer kinetochore organization

scientific article

Molecular basis for the specificity of p27 toward cyclin-dependent kinases that regulate cell division

scientific article

Molecular basis of drug resistance in aurora kinases

scientific article

Molecular basis of outer kinetochore assembly on CENP-T

Molecular basis of outer kinetochore assembly on CENP-T.

scientific article published on 24 December 2016

Molecular biology. Surfing chromosomes (and Survivin).

scientific article

Molecular determinants of the Ska-Ndc80 interaction and their influence on microtubule tracking and force-coupling

scientific article published on 5 December 2019

Molecular requirements for the inter-subunit interaction and kinetochore recruitment of SKAP and Astrin

scientific article

Multivalency of NDC80 in the outer kinetochore is essential to track shortening microtubules and generate forces

scientific article published on 9 April 2018

NDC80 clustering modulates microtubule dynamics under force

article

Overlap of NatA and IAP substrates implicates N-terminal acetylation in protein stabilization

scientific article published on 15 January 2021

PH domain: the first anniversary

scientific article (publication date: September 1994)

PLK1 inhibitors: setting the mitotic death trap

scientific article published in April 2007

Panta rhei: the APC/C at steady state

scientific article published on April 2013

Progress in the structural and functional characterization of kinetochores

scientific article

Reconstitution and use of highly active human CDK1:Cyclin-B:CKS1 complexes

scientific article published on 27 November 2021

Reconstitution of a 26-Subunit Human Kinetochore Reveals Cooperative Microtubule Binding by CENP-OPQUR and NDC80

scientific article published on 30 August 2018

Regulation of cytoplasmic dynein ATPase by Lis1.

scientific article

Requirement for PLK1 kinase activity in the maintenance of a robust spindle assembly checkpoint

scientific article published on 18 December 2015

Restoration of a lost metal-binding site: construction of two different copper sites into a subunit of the E. coli cytochrome o quinol oxidase complex

scientific article

Reversine, a novel Aurora kinases inhibitor, inhibits colony formation of human acute myeloid leukemia cells

scientific article

Role of Intrinsic and Extrinsic Factors in the Regulation of the Mitotic Checkpoint Kinase Bub1.

scientific article published on 10 December 2015

Role of the Mad2 dimerization interface in the spindle assembly checkpoint independent of kinetochores.

scientific article published on 20 September 2012

SH3 domain recognition of a proline-independent tyrosine-based RKxxYxxY motif in immune cell adaptor SKAP55

scientific article

SH3--an abundant protein domain in search of a function

scientific article

Selection of antibody ligands from a large library of oligopeptides expressed on a multivalent exposition vector.

scientific article

Selective Aurora Kinase Inhibitors Identified Using a Taxol-Induced Checkpoint Sensitivity Screen

scientific article

Sgt1 is required for human kinetochore assembly

scientific article

Simplified Protocol for Cross-linking Mass Spectrometry Using the MS-Cleavable Cross-linker DSBU with Efficient Cross-link Identification

scientific article published on 29 August 2018

Sister chromatid tension and the spindle assembly checkpoint

scientific article published on 19 October 2009

Spatial exclusivity combined with positive and negative selection of phosphorylation motifs is the basis for context-dependent mitotic signaling

scientific article

Spindle assembly checkpoint: the third decade

scientific article published on December 2011

Spindly attachments

scientific article published on September 2008

Structural Analysis of Multiprotein Complexes by Cross-linking, Mass Spectrometry, and Database Searching

article

Structural analysis of the RZZ complex reveals common ancestry with multisubunit vesicle tethering machinery

scientific article

Structural analysis reveals features of the spindle checkpoint kinase Bub1-kinetochore subunit Knl1 interaction

scientific article

Structural basis for the synthesis of indirubins as potent and selective inhibitors of glycogen synthase kinase-3 and cyclin-dependent kinases

scientific article published in February 2004

Structural organization of the kinetochore-microtubule interface

scientific article published on 10 December 2011

Structure and function of the SH3 domain

scientific article

Structure and regulation of the CDK5-p25(nck5a) complex

scientific article

Structure of the HECT:ubiquitin complex and its role in ubiquitin chain elongation

scientific article

Structure of the MIS12 Complex and Molecular Basis of Its Interaction with CENP-C at Human Kinetochores

scientific article published on 27 October 2016

Structure of the RZZ complex and molecular basis of its interaction with Spindly.

scientific article

Structure of the human KMN complex and implications for regulation of its assembly

scientific article published on 8 March 2024

Structure of the pleckstrin homology domain from beta-spectrin.

scientific article

Sustained Mps1 activity is required in mitosis to recruit O-Mad2 to the Mad1-C-Mad2 core complex

scientific article

The (phospho) needle in the (MELT) Haystack

scientific article published in March 2015

The Aurora B Kinase in Chromosome Bi-Orientation and Spindle Checkpoint Signaling

scientific article

The Aurora B kinase activity is required for the maintenance of the differentiated state of murine myoblasts.

scientific article

The C-terminal domain of CENP-C displays multiple and critical functions for mammalian centromere formation

scientific article

The MIS12 complex is a protein interaction hub for outer kinetochore assembly

scientific article

The Mad1/Mad2 complex as a template for Mad2 activation in the spindle assembly checkpoint

scientific article

The Mad2 conformational dimer: structure and implications for the spindle assembly checkpoint

scientific article

The Molecular Biology of Spindle Assembly Checkpoint Signaling Dynamics

scientific article

The Ndc80 complex: hub of kinetochore activity

scientific article published on 11 May 2007

The Ndc80 kinetochore complex forms oligomeric arrays along microtubules

scientific article

The Ndc80 loop region facilitates formation of kinetochore attachment to the dynamic microtubule plus end.

scientific article published on 20 January 2011

The PH domain: a common piece in the structural patchwork of signalling proteins

scientific article

The greatest kinetochore show on earth

scientific article

The influence of catalysis on mad2 activation dynamics

scientific article

The kinetochore proteins CENP-E and CENP-F directly and specifically interact with distinct BUB mitotic checkpoint Ser/Thr kinases.

scientific article

The life and miracles of kinetochores

scientific article

The pseudo GTPase CENP-M drives human kinetochore assembly

scientific article published on 8 July 2014

The spindle assembly checkpoint

The spindle checkpoint: structural insights into dynamic signalling

scientific article

The spindle-assembly checkpoint and the beauty of self-destruction

scientific article published in November 2012

The spindle-assembly checkpoint in space and time

scientific article (publication date: May 2007)

The structural perspective on CDK5.

scientific article published on September 2003

The structure of the GTPase-activating domain from p50rhoGAP

scientific article

The structure of the coiled-coil domain of Ndel1 and the basis of its interaction with Lis1, the causal protein of Miller-Dieker lissencephaly

scientific article

Travel Notes from the Equatorial Circle ⬇️

scientific article published on August 19, 2011

Ubiquitin-Independent Disassembly by a p97 AAA-ATPase Complex Drives PP1 Holoenzyme Formation

scientific article published on 18 October 2018

When Mad met Bub.

scientific article published on 21 February 2014

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