List of works by Michelle Haber

A Myc Activity Signature Predicts Poor Clinical Outcomes in Myc-Associated Cancers.

scientific article published on 06 December 2016

A novel small molecule that kills a subset of MLL-rearranged leukemia cells by inducing mitochondrial dysfunction

scientific article published on 22 January 2019

A risk score including microdeletions improves relapse prediction for standard and medium risk precursor B-cell acute lymphoblastic leukaemia in children.

scientific article published on 30 November 2017

A simple method for the isolation of genomic DNA from mouse tail free of real-time PCR inhibitors

scientific article published on 01 July 2002

A xenograft model of infant leukaemia reveals a complex MLL translocation

scientific article published on 23 January 2008

ABC transporters and neuroblastoma

scientific article published on 8 January 2015

ABC transporters as mediators of drug resistance and contributors to cancer cell biology.

scientific article published on 17 March 2016

ABC transporters in cancer: more than just drug efflux pumps.

scientific article published on 15 January 2010

ABCA transporter gene expression and poor outcome in epithelial ovarian cancer

scientific article

ABCB1 (MDR1) polymorphisms and ovarian cancer progression and survival: a comprehensive analysis from the Ovarian Cancer Association Consortium and The Cancer Genome Atlas

scientific article published on August 2013

ABCC multidrug transporters in childhood neuroblastoma: clinical and biological effects independent of cytotoxic drug efflux.

scientific article

ABCC1 G2012T single nucleotide polymorphism is associated with patient outcome in primary neuroblastoma and altered stability of the ABCC1 gene transcript.

scientific article published in May 2011

ABCC4/MRP4: a MYCN-regulated transporter and potential therapeutic target in neuroblastoma.

scientific article

ATP7A is a novel target of retinoic acid receptor beta2 in neuroblastoma cells.

scientific article published on January 2009

Absence of MEN2A- or 2B-typeRETmutations in primary neuroblastoma tumour tissue

scientific article published on 01 August 1998

Abstracts

article by L. Bie et al published 1 April 2013 in Neuro-Oncology

Activation of tissue transglutaminase transcription by histone deacetylase inhibition as a therapeutic approach for Myc oncogenesis.

scholarly article

An assay for the determination of reduced methotrexate accumulation in cells displaying limited viability in vitro

scientific article published on 01 October 1995

An unexpected role for caspase-2 in neuroblastoma.

scientific article published on 21 August 2014

Brief Report: Potent clinical and radiological response to larotrectinib in TRK fusion-driven high-grade glioma

scientific article published on 17 September 2018

CCI-007, a novel small molecule with cytotoxic activity against infant leukemia with MLL rearrangements.

scientific article

Cell lines from MYCN transgenic murine tumours reflect the molecular and biological characteristics of human neuroblastoma.

scientific article

Cell-based methods for the identification of MYC-inhibitory small molecules

scientific article

Clinical Importance of Myc Family Oncogene Aberrations in Epithelial Ovarian Cancer

scientific article published on 01 July 2018

Clinical significance of minimal residual disease at day 15 and at the end of therapy in childhood acute lymphoblastic leukaemia.

scientific article

Cloning and characterization of the human neural cell adhesion molecule, CNTN4 (alias BIG-2)

scientific article

Combined RAR alpha- and RXR-specific ligands overcome N-myc-associated retinoid resistance in neuroblastoma cells.

scientific article published on March 2003

Determination of N-myc gene amplification in neuroblastoma by differential polymerase chain reaction

article

Determining the repertoire of IGH gene rearrangements to develop molecular markers for minimal residual disease in B-lineage acute lymphoblastic leukemia.

scientific article published on 26 March 2009

Dextran-Catechin: An anticancer chemically-modified natural compound targeting copper that attenuates neuroblastoma growth

scientific article published on 21 June 2016

Direct effects of Bmi1 on p53 protein stability inactivates oncoprotein stress responses in embryonal cancer precursor cells at tumor initiation.

scientific article published on 20 August 2012

Drugging MYCN Oncogenic Signaling through the MYCN-PA2G4 Binding Interface

scientific article published on 09 September 2019

Early responses to chemotherapy of normal and malignant hematologic cells are prognostic in children with acute lymphoblastic leukemia.

scientific article

Expression of multidrug transporter MRP4/ABCC4 is a marker of poor prognosis in neuroblastoma and confers resistance to irinotecan in vitro.

scientific article

Expression of the putative tumour suppressor gene,p73, in neuroblastoma and other childhood tumours

article

Extensive Proliferation of Human Cancer Cells with Ever-Shorter Telomeres.

scientific article published in June 2017

FBXW7 regulates glucocorticoid response in T-cell acute lymphoblastic leukaemia by targeting the glucocorticoid receptor for degradation.

scientific article published on 11 December 2012

Favorable prognostic significance of high-level retinoic acid receptor beta expression in neuroblastoma mediated by effects on cell cycle regulation.

scientific article published in August 1998

Folate Pathway Gene Polymorphisms, Maternal Folic Acid Use, and Risk of Childhood Acute Lymphoblastic Leukemia

article

GPR84 sustains aberrant β-catenin signaling in leukemic stem cells for maintenance of MLL leukemogenesis.

scientific article published on 7 October 2014

Gaq signaling is required for the maintenance of MLL-AF9-induced acute myeloid leukemia

scientific article published on 9 February 2016

Genomic Profiling of Childhood Tumor Patient-Derived Xenograft Models to Enable Rational Clinical Trial Design

scientific article published on 01 November 2019

Genomic imbalances in drug-resistant T-cell acute lymphoblastic CEM leukemia cell lines.

scientific article published on July 2002

Germline polymorphisms in an enhancer of PSIP1 are associated with progression-free survival in epithelial ovarian cancer

scientific article published on 31 January 2016

Glutathione biosynthesis is upregulated at the initiation of MYCN-driven neuroblastoma tumorigenesis.

scientific article published on 2 March 2016

Growth inhibitory retinoid effects after recruitment of retinoid X receptor beta to the retinoic acid receptor beta promoter

scientific article

HLA-G polymorphisms, genetic susceptibility, and clinical outcome in childhood neuroblastoma

scientific article published on 03 October 2011

High TDP43 expression is required for TRIM16-induced inhibition of cancer cell growth and correlated with good prognosis of neuroblastoma and breast cancer patients

scientific article

High level resistance to glucocorticoids, associated with a dysfunctional glucocorticoid receptor, in childhood acute lymphoblastic leukemia cells selected for methotrexate resistance.

scientific article

High-risk childhood acute lymphoblastic leukemia in first remission treated with novel intensive chemotherapy and allogeneic transplantation.

scientific article

High-throughput screening identifies Ceefourin 1 and Ceefourin 2 as highly selective inhibitors of multidrug resistance protein 4 (MRP4).

scientific article

Histone deacetylase 2 and N-Myc reduce p53 protein phosphorylation at serine 46 by repressing gene transcription of tumor protein 53-induced nuclear protein 1

scientific article

Identification of plasma complement C3 as a potential biomarker for neuroblastoma using a quantitative proteomic approach.

scientific article published on 4 November 2013

Importance of minimal residual disease testing during the second year of therapy for children with acute lymphoblastic leukemia.

scientific article

Improved PCR assay for the detection of antigen receptor gene rearrangements

scientific article published on 01 December 1997

Improving minimal residual disease detection in precursor B-ALL based on immunoglobulin-kappa and heavy-chain gene rearrangements

scientific article published on 22 May 2008

Improving the identification of high risk precursor B acute lymphoblastic leukemia patients with earlier quantification of minimal residual disease

scientific article

Increased retinoic acid receptor gamma expression suppresses the malignant phenotype and alters the differentiation potential of human neuroblastoma cells

scientific article published on August 3, 1995

Inhibition of polyamine synthesis and uptake reduces tumor progression and prolongs survival in mouse models of neuroblastoma

scientific article published on 01 January 2019

Integration of genomics, high throughput drug screening, and personalized xenograft models as a novel precision medicine paradigm for high risk pediatric cancer

scientific article published on 09 October 2018

International consensus for neuroblastoma molecular diagnostics: report from the International Neuroblastoma Risk Group (INRG) Biology Committee

scientific article published on May 2009

Intra-tumoral copper modulates PD-L1 expression and influences tumor immune evasion

scientific article published on 18 August 2020

Involvement ofMDR1 P-glycoprotein in multifactorial resistance to methotrexate

scientific article published on 01 March 1996

Isolated testicular relapse after allo-SCT in boys with ALL: outcome without second transplant

scientific article published on 22 June 2009

JMJD1C-mediated metabolic dysregulation contributes to HOXA9-dependent leukemogenesis

scientific article published on 08 January 2019

JMJD6 is a tumorigenic factor and therapeutic target in neuroblastoma

scientific article published on 25 July 2019

Limitations on the stability of benzoylated DEAE-cellulose

scientific article published on 01 June 1984

MAX to MYCN intracellular ratio drives the aggressive phenotype and clinical outcome of high risk neuroblastoma.

scientific article published on 2 February 2018

MRP1 gene expression level regulates the death and differentiation response of neuroblastoma cells

scientific article

MRP1 modulators synergize with buthionine sulfoximine to exploit collateral sensitivity and selectively kill MRP1-expressing cancer cells

scientific article published on 11 July 2019

MYC-Driven Neuroblastomas Are Addicted to a Telomerase-Independent Function of Dyskerin.

scientific article published on 13 April 2016

MYCN amplification confers enhanced folate dependence and methotrexate sensitivity in neuroblastoma

scientific article

MYCN expression is not prognostic of adverse outcome in advanced-stage neuroblastoma with nonamplified MYCN

scientific article published on 01 November 2000

MYCN promotes neuroblastoma malignancy by establishing a regulatory circuit with transcription factor AP4.

scientific article published on 19 July 2016

MYCN-mediated regulation of the MRP1 promoter in human neuroblastoma.

scientific article published on January 2004

Macrophage-Derived IL1β and TNFα Regulate Arginine Metabolism in Neuroblastoma

scientific article published on 13 December 2018

Mechanism of relapse in pediatric acute lymphoblastic leukemia.

scientific article

Mechanisms of embryonal tumor initiation: distinct roles for MycN expression and MYCN amplification.

scholarly article

Molecular characteristics and therapeutic vulnerabilities across paediatric solid tumours

scientific article published on 12 July 2019

Molecular profiling of childhood cancer: Biomarkers and novel therapies

scientific article

N-Myc regulates expression of the detoxifying enzyme glutathione transferase GSTP1, a marker of poor outcome in neuroblastoma.

scientific article published on 27 December 2011

Network modeling of microRNA-mRNA interactions in neuroblastoma tumorigenesis identifies miR-204 as a direct inhibitor of MYCN.

scientific article published on 2 April 2018

Optimization of the antitumor efficacy of a synthetic mitochondrial toxin by increasing the residence time in the cytosol.

scientific article published on October 2009

Over-expression of clusterin is a resistance factor to the anti-cancer effect of histone deacetylase inhibitors.

scientific article

Patched1 deletion increases N-Myc protein stability as a mechanism of medulloblastoma initiation and progression.

scientific article published on 23 February 2009

Patterns of structural change in DNA during tissue necrosis indicated by benzoylated DEAE-cellulose chromatography

article published in 1985

Persistent MRD before and after allogeneic BMT predicts relapse in children with acute lymphoblastic leukaemia

scientific article published on 14 October 2014

Polyamine Antagonist Therapies Inhibit Neuroblastoma Initiation and Progression

scientific article

Polyamine pathway inhibition as a novel therapeutic approach to treating neuroblastoma.

scientific article published on 16 November 2012

Polymorphisms in genes encoding drug metabolizing enzymes and their influence on the outcome of children with neuroblastoma

scientific article published on 01 September 2007

Potent antileukemic activity of curaxin CBL0137 against MLL-rearranged leukemia

scientific article published on 08 August 2019

Preclinical small molecule WEHI-7326 overcomes drug resistance and elicits response in patient-derived xenograft models of human treatment-refractory tumors

scientific article published on 12 March 2021

Prognostic significance of promoter DNA methylation in patients with childhood neuroblastoma

scientific article published on 28 August 2012

Recommendations for the standardization of bone marrow disease assessment and reporting in children with neuroblastoma on behalf of the International Neuroblastoma Response Criteria Bone Marrow Working Group. ⬇️

scientific article published on 16 December 2016

Recurrent SPECC1L-NTRK fusions in paediatric sarcoma and brain tumours

scientific article published on 03 November 2020

Reduced folate carrier and methylenetetrahydrofolate reductase gene polymorphisms: associations with clinical outcome in childhood acute lymphoblastic leukemia

scientific article (publication date: July 2009)

Relapse in children with acute lymphoblastic leukemia involving selection of a preexisting drug-resistant subclone

scientific article published on 19 March 2007

Resistance to tetracycline, a hydrophilic antibiotic, is mediated by P-glycoprotein in human multidrug-resistant cells.

scientific article

Role of the E45K-reduced folate carrier gene mutation in methotrexate resistance in human leukemia cells.

scientific article published on December 2002

Sensitive non-radioactive PCR detection of clonal T-cell receptor-gamma gene rearrangements in childhood acute lymphoblastic leukaemia

scientific article published on 01 September 1997

Simultaneous detection and quantification of minimal residual disease in childhood acute lymphoblastic leukaemia using real-time polymerase chain reaction

scientific article published on 01 May 2000

Single-strand-specific degradation of DNA during isolation of rat liver nuclei

scientific article published on 01 October 1985

Sizing of DNA fragments by preparative, benzoylated DEAE-cellulose chromatography

scientific article published on 01 October 1981

Suppression of ABCE1-mediated mRNA translation limits N-MYC-driven cancer progression

scientific article published on 10 July 2020

Suppression of the ATP-binding cassette transporter ABCC4 impairs neuroblastoma tumour growth and sensitises to irinotecan in vivo.

scientific article published on 20 July 2017

Synergy between 5′ and 3′ flanking regions of the human tyrosine hydroxylase gene ensures specific, high-level expression in neuroblastoma cells

article

TRIM16 acts as a tumour suppressor by inhibitory effects on cytoplasmic vimentin and nuclear E2F1 in neuroblastoma cells

scientific article

Targeted therapy of <i>TERT</i>-rearranged neuroblastoma with BET bromodomain inhibitor and proteasome inhibitor combination therapy

scientific article published on 11 December 2020

Targeting TSLP-induced tyrosine kinase signaling pathways in CRLF2-rearranged Ph-like ALL

scientific article published on 14 August 2020

Taxol-resistant epithelial ovarian tumors are associated with altered expression of specific beta-tubulin isotypes ⬇️

scientific article published on September 1, 1997

Testing of new agents in childhood cancer preclinical models: meeting summary

scientific article published on 01 December 2002

The Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation

scientific article published in 2024

The estrogen-responsive B box protein is a novel regulator of the retinoid signal

scientific article

The histone demethylase JMJD1A induces cell migration and invasion by up-regulating the expression of the long noncoding RNA MALAT1

scientific article

The long noncoding RNA MALAT1 promotes tumor-driven angiogenesis by up-regulating pro-angiogenic gene expression

scientific article published on 02 February 2016

The long noncoding RNA lncNB1 promotes tumorigenesis by interacting with ribosomal protein RPL35

scientific article published on 05 November 2019

The nonobese diabetic/severe combined immunodeficient (NOD/SCID) mouse model of childhood acute lymphoblastic leukemia reveals intrinsic differences in biologic characteristics at diagnosis and relapse

scientific article published on 01 June 2002

The p53 pathway and its inactivation in neuroblastoma.

scientific article

The retinoid anticancer signal: mechanisms of target gene regulation.

scientific article published on August 2005

Therapeutic targeting of the MYC signal by inhibition of histone chaperone FACT in neuroblastoma.

scientific article

Thymosin-β4 is a determinant of drug sensitivity for Fenretinide and Vorinostat combination therapy in neuroblastoma.

scientific article published on 29 April 2015

Too many targets, not enough patients: rethinking neuroblastoma clinical trials.

scientific article published on 9 April 2018

Transcriptome profiling of caspase-2 deficient EμMyc and Th-MYCN mouse tumors identifies distinct putative roles for caspase-2 in neuronal differentiation and immune signaling

scientific article published on 22 January 2019

Translational development of difluoromethylornithine (DFMO) for the treatment of neuroblastoma

scientific article

Two cases of hypereosinophilia and high-risk acute lymphoblastic leukemia

scientific article published on 17 January 2008

c-MYC oncoprotein dictates transcriptional profiles of ATP-binding cassette transporter genes in chronic myelogenous leukemia CD34+ hematopoietic progenitor cells.

scientific article published on 21 June 2011

miR-101 suppresses the development of MLL-rearranged acute myeloid leukemia

scientific article published on 21 February 2019

miR-380-5p represses p53 to control cellular survival and is associated with poor outcome in MYCN-amplified neuroblastoma.

scientific article

Paulina is supported by:

About Paulina

Help