List of works by Amanda Fosang

3D Bioprinting of Cartilage for Orthopedic Surgeons: Reading between the Lines

scientific article

A Disintegrin and Metalloproteinase with Thrombospondin Motifs-5 (ADAMTS-5) Forms Catalytically Active Oligomers

scientific article published on 14 December 2015

ADAMTS-1-knockout mice do not exhibit abnormalities in aggrecan turnover in vitro or in vivo

scientific article published on 01 May 2005

ADAMTS-5 deficiency does not block aggrecanolysis at preferred cleavage sites in the chondroitin sulfate-rich region of aggrecan.

scientific article

ADAMTS-5 takes centre stage in new developments for aggrecanase inhibitors.

scientific article published on 28 May 2015

ADAMTS-9 in Mouse Cartilage Has Aggrecanase Activity That Is Distinct from ADAMTS-4 and ADAMTS-5 ⬇️

scientific article published on 29 January 2019

ADAMTS4 cleaves at the aggrecanase site (Glu373-Ala374) and secondarily at the matrix metalloproteinase site (Asn341-Phe342) in the aggrecan interglobular domain

scientific article

ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro

scientific article

Abundant LacZ activity in the absence of Cre expression in the normal and inflamed synovium of adult Col2a1-Cre; ROSA26RLacZ reporter mice

scientific article published on 04 December 2012

Adamts5-/- Mice Exhibit Altered Aggrecan Proteolytic Profiles That Correlate With Ascending Aortic Anomalies

scientific article published on 01 August 2019

Aggrecanase cleavage in juvenile idiopathic arthritis patients is minimally detected in the aggrecan interglobular domain but robust at the aggrecan C-terminus.

scientific article published in December 2012

Altered endochondral bone development in matrix metalloproteinase 13-deficient mice

scientific article published on December 2004

An aggrecan fragment drives osteoarthritis pain through Toll-like receptor 2.

scientific article published on 22 March 2018

Bioactivity in an Aggrecan 32-mer Fragment Is Mediated via Toll-like Receptor 2.

scientific article

Blocking aggrecanase cleavage in the aggrecan interglobular domain abrogates cartilage erosion and promotes cartilage repair

scientific article published on 17 May 2007

Blocking aggrecanase cleavage in the aggrecan interglobular domain abrogates cartilage erosion and promotes cartilage repair.

scientific article

Brief Report: JNK-2 Controls Aggrecan Degradation in Murine Articular Cartilage and the Development of Experimental Osteoarthritis.

scientific article published on 14 December 2015

Cartilage degradation is fully reversible in the presence of aggrecanase but not matrix metalloproteinase activity

scientific article

Cartilage microRNA dysregulation during the onset and progression of mouse osteoarthritis is independent of aggrecanolysis and overlaps with candidates from end-stage human disease.

scientific article published on 16 November 2017

Changes in versican and chondroitin sulfate proteoglycans during structural development of the lung.

scientific article published on 23 May 2007

Connective tissue remodelling in the ovine cervix during pregnancy and at term

scientific article published on 01 January 1988

Cortisol enhances structural maturation of the hypoplastic fetal lung in sheep

scientific article published on 24 October 2003

Cytokine-induced increases in ADAMTS-4 messenger RNA expression do not lead to increased aggrecanase activity in ADAMTS-5-deficient mice.

scientific article

Degradation of cartilage aggrecan by collagenase-3 (MMP-13)

scientific article published on 01 February 1996

Distinguishing aggrecan loss from aggrecan proteolysis in ADAMTS-4 and ADAMTS-5 single and double deficient mice.

scientific article published on 15 October 2007

Drug insight: aggrecanases as therapeutic targets for osteoarthritis.

scientific article published on 24 June 2008

Emerging Frontiers in cartilage and chondrocyte biology

scientific article published on December 2011

Employing molecular genetics of chondrodysplasias to inform the study of osteoarthritis

scientific article published on February 2009

Evidence for lysosomal exocytosis and release of aggrecan-degrading hydrolases from hypertrophic chondrocytes, in vitro and in vivo

scientific article

Evidence of a novel aggrecan-degrading activity in cartilage: Studies of mice deficient in both ADAMTS-4 and ADAMTS-5.

scientific article published in June 2008

Gelatinase A possesses a beta-secretase-like activity in cleaving the amyloid protein precursor of Alzheimer's disease.

scientific article published in December 1995

Glucocorticoids influence versican and chondroitin sulphate proteoglycan levels in the fetal sheep lung

scientific article published on 20 August 2018

High-bandwidth AFM-based rheology is a sensitive indicator of early cartilage aggrecan degradation relevant to mouse models of osteoarthritis

scientific article

Identifying the human aggrecanase.

scientific article published on 13 July 2010

Increased hyaluronan production in the glomeruli from diabetic rats: a link between glucose-induced prostaglandin production and reduced sulphated proteoglycan

scientific article published on 01 March 1995

Induction of increased cAMP levels in articular chondrocytes blocks matrix metalloproteinase-mediated cartilage degradation, but not aggrecanase-mediated cartilage degradation.

scientific article published in May 2007

Internalization of aggrecan G1 domain neoepitope ITEGE in chondrocytes requires CD44

scientific article

Investigating ADAMTS-mediated aggrecanolysis in mouse cartilage.

scientific article published on 3 March 2011

Is cartilage matrix breakdown an appropriate therapeutic target in osteoarthritis--insights from studies of aggrecan and collagen proteolysis?

scientific article published on May 2010

Keratan sulphate in the interglobular domain has a microstructure that is distinct from keratan sulphate elsewhere on pig aggrecan

scientific article published on 12 November 2008

MMP and non-MMP-mediated release of aggrecan and its fragments from articular cartilage: a comparative study of three different aggrecan and glycosaminoglycan assays

scientific article published on 25 September 2006

Mast cell-restricted, tetramer-forming tryptases induce aggrecanolysis in articular cartilage by activating matrix metalloproteinase-3 and -13 zymogens

scientific article published on 24 June 2013

Matrilin-4 is processed by ADAMTS-5 in late Golgi vesicles present in growth plate chondrocytes of defined differentiation state.

scientific article published on 22 April 2011

Matrix metalloproteinase 13-deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development.

scientific article

Matrix metalloproteinases are active following guanidine hydrochloride extraction of cartilage: generation of DIPEN neoepitope during dialysis.

scientific article published in August 2002

Matrix metalloproteinases are not essential for aggrecan turnover during normal skeletal growth and development

scientific article

Membrane-type 1 MMP (MMP-14) cleaves at three sites in the aggrecan interglobular domain

scientific article

Metalloprotease inhibitor TIMP proteins control FGF-2 bioavailability and regulate skeletal growth

scientific article published on 01 August 2019

N-linked keratan sulfate in the aggrecan interglobular domain potentiates aggrecanase activity.

scientific article published on 22 April 2005

Neoepitope Antibodies Against MMP-Cleaved and Aggrecanase-Cleaved Aggrecan

scientific article published on 01 January 2010

Novel Elements of the Chondrocyte Stress Response Identified Using an in Vitro Model of Mouse Cartilage Degradation

scientific article published on 12 February 2016

Perlecan from human epithelial cells is a hybrid heparan/chondroitin/keratan sulfate proteoglycan.

scientific article published on September 2005

Proteoglycan degradation by the ADAMTS family of proteinases

scientific article

Proteomic characterization of mouse cartilage degradation in vitro

scientific article published in October 2008

Recombinant human aggrecan G1-G2 exhibits native binding properties and substrate specificity for matrix metalloproteinases and aggrecanase

scientific article published on 01 November 1999

Reduction of arthritis severity in protease-activated receptor-deficient mice.

scientific article published in April 2005

The 45 kDa collagen-binding fragment of fibronectin induces matrix metalloproteinase-13 synthesis by chondrocytes and aggrecan degradation by aggrecanases.

scientific article published on May 2002

The accumulation of intracellular ITEGE and DIPEN neoepitopes in bovine articular chondrocytes is mediated by CD44 internalization of hyaluronan.

scientific article

The role of hepatocyte growth factor in the humoral regulation of inguinal hernia closure.

scientific article published in December 2005

The sulphation pattern in chondroitin sulphate chains investigated by chondroitinase ABC and ACII digestion and reactivity with monoclonal antibodies

scientific article published on 01 March 1994

To clot or not

scientific article published in Nature

Transcriptomics of wild-type mice and mice lacking ADAMTS-5 activity identifies genes involved in osteoarthritis initiation and cartilage destruction.

scientific article published in June 2013

Transparency Is the Key to Quality

scientific article published in December 2015

Wide bandwidth nanomechanical assessment of murine cartilage reveals protection of aggrecan knock-in mice from joint-overuse.

scientific article published on 3 April 2016

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