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List of works by Josephine M. Forbes

A breaker of advanced glycation end products attenuates diabetes-induced myocardial structural changes

scientific article published on 6 March 2003

A developmental nephron deficit in rats is associated with increased susceptibility to a secondary renal injury due to advanced glycation end-products.

scientific article published on 23 February 2006

A drop in the circulating concentrations of soluble receptor for advanced glycation end products is associated with seroconversion to autoantibody positivity but not with subsequent progression to clinical disease in children en route to type 1 diab

scientific article published on 24 November 2016

A new perspective on therapeutic inhibition of advanced glycation in diabetic microvascular complications: common downstream endpoints achieved through disparate therapeutic approaches?

scientific article published on 29 June 2009

A rapid extraction method for glycogen from formalin-fixed liver

AGE, RAGE, and ROS in diabetic nephropathy.

scientific article published on March 2007

Abdominal Obesity and Brain Atrophy in Type 2 Diabetes Mellitus.

scientific article published on 11 November 2015

Accelerated nephropathy in diabetic apolipoprotein e-knockout mouse: role of advanced glycation end products.

scientific article

Additive effects of hypertension and diabetes on renal cortical expression of PKC-alpha and -epsilon and alpha-tubulin but not PKC-beta 1 and -beta 2.

scientific article

Advanced glycation end product interventions reduce diabetes-accelerated atherosclerosis.

scientific article

Advanced glycation end products (AGEs) are cross-sectionally associated with insulin secretion in healthy subjects.

scientific article published on 6 July 2013

Advanced glycation end products and diabetic nephropathy.

scientific article

Advanced glycation end products and esRAGE are associated with bone turnover and incidence of hip fracture in older men

scientific article published on 20 August 2018

Advanced glycation end products are direct modulators of β-cell function

scientific article

Advanced glycation end products as environmental risk factors for the development of type 1 diabetes

scientific article published on April 2012

Advanced glycation end products augment experimental hepatic fibrosis

scientific article published on 01 February 2013

Advanced glycation end products cause epithelial-myofibroblast transdifferentiation via the receptor for advanced glycation end products (RAGE)

scientific article

Advanced glycation end products cause epithelial-myofibroblast transdifferentiation via the receptor for advanced glycation end products (RAGE)

Advanced glycation end-products (AGEs) and functionality of reverse cholesterol transport in patients with type 2 diabetes and in mouse models

scientific article published on 10 May 2012

Advanced glycation end-products induce vascular dysfunction via resistance to nitric oxide and suppression of endothelial nitric oxide synthase

scientific article published in April 2010

Advanced glycation of apolipoprotein A-I impairs its anti-atherogenic properties.

scientific article

Advanced glycation urinary protein-bound biomarkers and severity of diabetic nephropathy in man.

scientific article published on 26 August 2011

Advanced glycation: how are we progressing to combat this web of sugar anomalies in diabetic nephropathy

scientific article

Advanced glycation: implications in tissue damage and disease

scientific article published in January 2008

Agents in development for the treatment of diabetic nephropathy

scientific article

Angiotensin type 2 receptor is expressed in the adult rat kidney and promotes cellular proliferation and apoptosis.

scientific article published in December 2000

Antigen-encoding bone marrow terminates islet-directed memory CD8+ T-cell responses to alleviate islet transplant rejection

scientific article published on 9 March 2016

Attenuation of extracellular matrix accumulation in diabetic nephropathy by the advanced glycation end product cross-link breaker ALT-711 via a protein kinase C-alpha-dependent pathway.

scientific article published in November 2004

Below the radar: advanced glycation end products that detour "around the side". Is HbA1c not an accurate enough predictor of long term progression and glycaemic control in diabetes?

scientific article

Brain atrophy in type 2 diabetes: regional distribution and influence on cognition

scientific article published on 12 August 2013

Can advanced glycation end product inhibitors modulate more than one pathway to enhance renoprotection in diabetes?

scientific article

Cardiac inflammation associated with a Western diet is mediated via activation of RAGE by AGEs.

scientific article published on 13 May 2008

Characterization of renal angiotensin-converting enzyme 2 in diabetic nephropathy.

scientific article published on 24 February 2003

Circulating Levels of the Soluble Receptor for AGE (sRAGE) during Escalating Oral Glucose Dosages and Corresponding Isoglycaemic i.v. Glucose Infusions in Individuals with and without Type 2 Diabetes

scientific article published on 24 September 2020

Circulating concentrations of soluble receptor for AGE are associated with age and AGER gene polymorphisms in children with newly diagnosed type 1 diabetes

article

Circulating high-molecular-weight RAGE ligands activate pathways implicated in the development of diabetic nephropathy

scientific article published on 12 May 2010

Coenzyme Q10 attenuates diastolic dysfunction, cardiomyocyte hypertrophy and cardiac fibrosis in the db/db mouse model of type 2 diabetes.

scientific article published on 29 February 2012

Combination Therapy with the Advanced Glycation End Product Cross-Link Breaker, Alagebrium, and Angiotensin Converting Enzyme Inhibitors in Diabetes: Synergy or Redundancy?

scientific article published on 16 November 2006

Coming full circle in diabetes mellitus: from complications to initiation.

scientific article published on 08 January 2013

Complement C5a Induces Renal Injury in Diabetic Kidney Disease Via Disruption in Mitochondrial Metabolic Agility

scientific article published on 17 October 2019

Connective tissue growth factor plays an important role in advanced glycation end product-induced tubular epithelial-to-mesenchymal transition: implications for diabetic renal disease.

scientific article published on 16 August 2006

Contrasting association of circulating sCD14 with insulin sensitivity in non-obese and morbidly obese subjects

scientific article published on 26 June 2015

Decrease in circulating concentrations of soluble receptors for advanced glycation end products at the time of seroconversion to autoantibody positivity in children with prediabetes

scientific article published on 8 January 2015

Deficiency in Apoptosis-Inducing Factor Recapitulates Chronic Kidney Disease via Aberrant Mitochondrial Homeostasis

scientific article published on 28 January 2016

Deficiency in mitochondrial complex I activity due to Ndufs6 gene trap insertion induces renal disease.

scientific article

Deletion of bone-marrow-derived receptor for AGEs (RAGE) improves renal function in an experimental mouse model of diabetes

Delineating a role for the mitochondrial permeability transition pore in diabetic kidney disease by targeting cyclophilin D

scientific article published on 01 January 2020

Development and Progression of Non-Alcoholic Fatty Liver Disease: The Role of Advanced Glycation End Products

scientific article published on 11 October 2019

Diabetes-Specific Formulae Versus Standard Formulae as Enteral Nutrition to Treat Hyperglycemia in Critically Ill Patients: Protocol for a Randomized Controlled Feasibility Trial

Diabetes-Specific Formulae Versus Standard Formulae as Enteral Nutrition to Treat Hyperglycemia in Critically Ill Patients: Protocol for a Randomized Controlled Feasibility Trial

Diabetes-Specific Formulae Versus Standard Formulae as Enteral Nutrition to Treat Hyperglycemia in Critically Ill Patients: Protocol for a Randomized Controlled Feasibility Trial.

scientific article published on 9 April 2018

Diabetic kidney disease: a role for advanced glycation end-product receptor 1 (AGE-R1)?

scientific article

Diet low in advanced glycation end products increases insulin sensitivity in healthy overweight individuals: a double-blind, randomized, crossover trial.

scientific article published on 30 March 2016

Dietary Advanced Glycation End Products Consumption as a Direct Modulator of Insulin Sensitivity in Overweight Humans: A Study Protocol for a Double-Blind, Randomized, Two Period Cross-Over Trial.

scientific article published on 29 July 2015

Dietary advanced glycation end-products aggravate non-alcoholic fatty liver disease

scientific article published on September 2016

Dietary glycotoxins exacerbate progression of experimental fatty liver disease

scientific article published on 6 December 2013

Disparate effects on renal and oxidative parameters following RAGE deletion, AGE accumulation inhibition, or dietary AGE control in experimental diabetic nephropathy.

scientific article published on 16 December 2009

Disparity in the micronutrient content of diets high or low in advanced glycation end products (AGEs) does not explain changes in insulin sensitivity.

scientific article published on 2 May 2017

Disruption of Glycogen Utilization Markedly Improves the Efficacy of Carboplatin against Preclinical Models of Clear Cell Ovarian Carcinoma

scientific article published on 03 April 2020

Early vitamin E supplementation attenuates diabetes-associated vascular dysfunction and the rise in protein kinase C-beta in mesenteric artery and ameliorates wall stiffness in femoral artery of Wistar rats.

scientific article

Effect of dietary advanced glycation end products on inflammation and cardiovascular risks in healthy overweight adults: a randomised crossover trial

scientific article

Effects of SGLT2 inhibition in human kidney proximal tubular cells--renoprotection in diabetic nephropathy?

scientific article

Effects of high-density lipoprotein elevation with cholesteryl ester transfer protein inhibition on insulin secretion.

scientific article published on 15 May 2013

Erratum: Corrigendum: Methylglyoxal modification of Nav1.8 facilitates nociceptive neuron firing and causes hyperalgesia in diabetic neuropathy

scholarly article published in Nature Medicine

Erratum: Once daily administration of the SGLT2 inhibitor, empagliflozin, attenuates markers of renal fibrosis without improving albuminuria in diabetic db/db mice

scientific article published on 07 July 2016

Evolving concepts in advanced glycation, diabetic nephropathy, and diabetic vascular disease

scientific article published on November 2003

Genetic characterization of early renal changes in a novel mouse model of diabetic kidney disease

scientific article published on 30 May 2019

Globally elevating the AGE clearance receptor, OST48, does not protect against the development of diabetic kidney disease, despite improving insulin secretion

scientific article published on 20 September 2019

Glucose and glycogen in the diabetic kidney: Heroes or villains?

scientific article published on 10 August 2019

Glucose homeostasis can be differentially modulated by varying individual components of a western diet.

scientific article published on 11 January 2013

Glycaemic variability and its association with enteral and parenteral nutrition in critically ill ventilated patients

scientific article published on 16 August 2018

Glycation in diabetic nephropathy

scientific article published on 21 October 2010

Glycemic control in diabetes is restored by therapeutic manipulation of cytokines that regulate beta cell stress

article by Sumaira Z Hasnain et al published December 2014 in Nature Medicine

Going in Early: Hypoxia as a Target for Kidney Disease Prevention in Diabetes?

scientific article published on 01 December 2020

Heat shock protein expression in diabetic nephropathy

scientific article

High glucose-induced impairment in insulin secretion is associated with reduction in islet glucokinase in a mouse model of susceptibility to islet dysfunction

scientific article published on August 2005

High-density lipoprotein modulates glucose metabolism in patients with type 2 diabetes mellitus

scientific article

Hypoxic human proximal tubular epithelial cells undergo ferroptosis and elicit an NLRP3 inflammasome response in CD1c+ dendritic cells

scientific article published in 2022

Identification of angiotensin converting enzyme 2 in the rodent retina.

scientific article

Impairment of Liver Glycogen Storage in the db/db Animal Model of Type 2 Diabetes: A Potential Target for Future Therapeutics?

scientific article published on 27 July 2015

Increased liver AGEs induce hepatic injury mediated through an OST48 pathway

scientific article published on 25 September 2017

Increased renal vascular endothelial growth factor and angiopoietins by angiotensin II infusion is mediated by both AT1 and AT2 receptors

scientific article published in December 2003

Increased risk of cardiovascular disease in Type 1 diabetes: arterial exposure to remnant lipoproteins leads to enhanced deposition of cholesterol and binding to glycated extracellular matrix proteoglycans

scientific article published in January 2011

Inhibition of NADPH oxidase prevents advanced glycation end product-mediated damage in diabetic nephropathy through a protein kinase C-alpha-dependent pathway

scientific journal article

Insulin infusion reduces hepatocyte growth factor in lean humans

scientific article published on 26 November 2012

Interactions between advanced glycation end-products (AGE) and their receptors in the development and progression of diabetic nephropathy - are these receptors valid therapeutic targets.

scientific article published on January 2009

Interactions between angiotensin II and NF-kappaB-dependent pathways in modulating macrophage infiltration in experimental diabetic nephropathy.

scientific article

Interactions between renin angiotensin system and advanced glycation in the kidney.

scientific article published on 17 August 2005

Ischemic acute renal failure: Long-term histology of cell and matrix changes in the rat

scientific article published on 01 June 2000

Kidney disease risk factors do not explain impacts of low dietary protein on kidney function and structure

scientific article published in November 2021

Low-molecular weight advanced glycation end products: markers of tissue AGE accumulation and more?

scientific article

MKK3 signalling plays an essential role in leukocyte-mediated pancreatic injury in the multiple low-dose streptozotocin model

scientific article

Macrophage and myofibroblast involvement in ischemic acute renal failure is attenuated by endothelin receptor antagonists

scientific article published on 01 January 1999

Mapping time-course mitochondrial adaptations in the kidney in experimental diabetes

scientific article published on February 2016

Mechanisms of diabetic complications.

scientific article published on January 2013

Methylglyoxal modification of Nav1.8 facilitates nociceptive neuron firing and causes hyperalgesia in diabetic neuropathy

scientific article

Methylglyoxal, cognitive function and cerebral atrophy in older people.

scientific article published on 10 April 2012

Mitochondria-Power Players in Kidney Function?

scientific article published on 20 May 2016

Mitochondrial Dysfunction and Signaling in Diabetic Kidney Disease: Oxidative Stress and Beyond

scientific article published on 01 March 2018

Mitochondrial dysfunction in diabetic kidney disease

scientific article

Modulation of nephrin in the diabetic kidney: association with systemic hypertension and increasing albuminuria

scientific article

Modulation of soluble receptor for advanced glycation end products by angiotensin-converting enzyme-1 inhibition in diabetic nephropathy.

scientific article

Modulation of the cellular expression of circulating advanced glycation end-product receptors in type 2 diabetic nephropathy

scientific article

Novel therapeutics for diabetic micro- and macrovascular complications.

scientific article published on January 2006

Nox-4 deletion reduces oxidative stress and injury by PKC-α-associated mechanisms in diabetic nephropathy

scientific article

Obesity-induced renal impairment is exacerbated in interleukin-6-knockout mice

scientific article published on 01 March 2012

Once daily administration of the SGLT2 inhibitor, empagliflozin, attenuates markers of renal fibrosis without improving albuminuria in diabetic db/db mice

scientific article published on 26 May 2016

Oxidative stress and advanced glycation in diabetic nephropathy.

scientific article published on April 2008

Oxidative stress as a major culprit in kidney disease in diabetes

scientific article

Perinatal exposure to high dietary advanced glycation end products in transgenic NOD8.3 mice leads to pancreatic beta cell dysfunction.

scientific article published on 20 November 2017

Plasma advanced glycation end products (AGEs) and NF-κB activity are independent determinants of diastolic and pulse pressure

scientific article published in January 2014

Preservation of kidney function with combined inhibition of NADPH oxidase and angiotensin-converting enzyme in diabetic nephropathy.

scientific article published on 11 June 2010

Prolyl hydroxylase inhibitors: a breath of fresh air for diabetic kidney disease?

scientific article published on 01 May 2020

RAGE Deletion Confers Renoprotection by Reducing Responsiveness to Transforming Growth Factor-β and Increasing Resistance to Apoptosis

scientific article published on 15 February 2018

RAGE-induced cytosolic ROS promote mitochondrial superoxide generation in diabetes.

scientific article published on 21 January 2009

Ramipril inhibits AGE-RAGE-induced matrix metalloproteinase-2 activation in experimental diabetic nephropathy

scientific article

Ramipril prevents microtubular changes in proximal tubules from streptozotocin diabetic rats.

scientific article published in August 2003

Receptor for AGEs (RAGE) blockade may exert its renoprotective effects in patients with diabetic nephropathy via induction of the angiotensin II type 2 (AT2) receptor.

scientific article published on 15 July 2010

Receptor for Advanced Glycation End Products (RAGE) in Type 1 Diabetes Pathogenesis.

scientific article published on October 2016

Receptor for advanced glycation end products (RAGE) deficiency attenuates the development of atherosclerosis in diabetes

scientific article published on 28 May 2008

Receptor for advanced glycation end-products (RAGE) provides a link between genetic susceptibility and environmental factors in type 1 diabetes

scientific article

Reduced tubular cation transport in diabetes: prevented by ACE inhibition

scientific article published in June 2003

Reduction of the accumulation of advanced glycation end products by ACE inhibition in experimental diabetic nephropathy

scientific article published in November 2002

Renal connective tissue growth factor induction in experimental diabetes is prevented by aminoguanidine

scientific article

Renal microvascular injury in diabetes: RAGE and redox signaling.

scientific article published on March 2007

Reply

Report on ISN Forefronts, Melbourne, Australia, 4-7 October 2012: tubulointerstitial disease in diabetic nephropathy

article

Response to Letter: Advanced glycation end products and esRAGE are associated with bone turnover and incidence of hip fracture in older men

scientific article published on 01 March 2019

Reversible Angiotensin II-Mediated Albuminuria in Rat Kidneys Is Dynamically Associated with Cytoskeletal Organization

scientific article

Role of advanced glycation end products in diabetic nephropathy.

scientific article

Rosiglitazone attenuates atherosclerosis in a model of insulin insufficiency independent of its metabolic effects

scientific article published on 14 July 2005

SYNbiotics Easing Renal failure by improving Gut microbiologY (SYNERGY): a protocol of placebo-controlled randomised cross-over trial

scientific article

SaO035SYNBIOTIC THERAPY IN PRE-DIALYSIS: A RANDOMISED CONTROLLED TRIAL

Serum 25-hydroxyvitamin D concentrations are associated with nuclear factor kappa-B activity but not with inflammatory markers in healthy normoglycemic adults.

scientific article published on 18 July 2017

Serum carboxymethyllysine concentrations are reduced in diabetic men with abdominal aortic aneurysms: Health In Men Study.

scientific article published on 22 July 2009

Stress in the kidney is the road to pERdition: is endoplasmic reticulum stress a pathogenic mediator of diabetic nephropathy?

scientific article

Superior renoprotective effects of combination therapy with ACE and AGE inhibition in the diabetic spontaneously hypertensive rat.

scientific article

Synbiotics Easing Renal Failure by Improving Gut Microbiology (SYNERGY): A Randomized Trial.

scientific article published on 15 January 2016

Tapping into Mitochondria to Find Novel Targets for Diabetes Complications

scientific article published on 27 July 2015

Targeted mitochondrial therapy using MitoQ shows equivalent renoprotection to angiotensin converting enzyme inhibition but no combined synergy in diabetes.

scientific article published on 9 November 2017

Targeted reduction of advanced glycation improves renal function in obesity

scientific article published on 16 March 2011

Targeting advanced glycation endproducts and mitochondrial dysfunction in cardiovascular disease.

scientific article published on 16 July 2013

Targeting advanced glycation with pharmaceutical agents: where are we now?

scientific article

Targeting the AGE-RAGE axis improves renal function in the context of a healthy diet low in advanced glycation end-product content

scientific article published in January 2013

Targeting the receptor for advanced glycation end products (RAGE) in type 1 diabetes

scientific article published on 28 February 2020

Temporal Increases in Urinary Carboxymethyllysine Correlate with Albuminuria Development in Diabetes

article

Temporal renal expression of angiogenic growth factors and their receptors in experimental diabetes: role of the renin-angiotensin system.

scientific article published in January 2005

The advanced glycation end product-lowering agent ALT-711 is a low-affinity inhibitor of thiamine diphosphokinase.

scientific article published on 25 May 2011

The breakdown of preexisting advanced glycation end products is associated with reduced renal fibrosis in experimental diabetes.

scientific article published on 18 July 2003

The cross-link breaker, N-phenacylthiazolium bromide prevents vascular advanced glycation end-product accumulation.

scientific article

The effect of a low carbohydrate formula on glycaemia in critically ill enterally-fed adult patients with hyperglycaemia: A blinded randomised feasibility trial

scientific article published on 11 March 2019

The effect of salsalate on insulin action and glucose tolerance in obese non-diabetic patients: results of a randomised double-blind placebo-controlled study.

scientific article

The effects of valsartan on the accumulation of circulating and renal advanced glycation end products in experimental diabetes.

scientific article published in November 2004

The physiological deadlock between AMPK and gluconeogenesis: SOGA, a novel protein, may provide the key.

scientific article published on 2 September 2010

The pleiotropic actions of rosuvastatin confer renal benefits in the diabetic Apo-E knockout mouse.

scientific article published on 16 June 2010

The relationship between heat shock protein 72 expression in skeletal muscle and insulin sensitivity is dependent on adiposity.

scientific article published on 4 March 2010

The role of advanced glycation in reduced organic cation transport associated with experimental diabetes

scientific article

Therapeutic interruption of advanced glycation in diabetic nephropathy: do all roads lead to Rome?

scientific article published on April 2008

Transient Intermittent Hyperglycemia Accelerates Atherosclerosis by Promoting Myelopoiesis

scientific article published on 22 June 2020

Type 2 diabetes, skin autofluorescence, and brain atrophy.

scientific article published on 22 July 2014

Ubiquinone (coenzyme Q10) prevents renal mitochondrial dysfunction in an experimental model of type 2 diabetes

scientific article published on 21 November 2011

Vascular complications in diabetes: old messages, new thoughts

scientific article

c-Jun NH2-terminal kinase activity in subcutaneous adipose tissue but not nuclear factor-kappaB activity in peripheral blood mononuclear cells is an independent determinant of insulin resistance in healthy individuals

scientific article published on 03 March 2009

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