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List of works by Mikhail Blagosklonny

"Targeting the absence" and therapeutic engineering for cancer therapy

scientific article published on 08 May 2008

A Phase II study of high-dose tamoxifen in patients with hormone-refractory prostate cancer.

scientific article

A new science-business paradigm in anticancer drug development.

scientific article

A node between proliferation, apoptosis, and growth arrest

scientific article

Accumulation of hypoxia-inducible factor-1alpha is limited by transcription-dependent depletion.

scientific article

Acute overexpression of wt p53 facilitates anticancer drug-induced death of cancer and normal cells

scientific article published on 01 March 1998

Aging and immortality: quasi-programmed senescence and its pharmacologic inhibition

scientific article published on 15 September 2006

Aging is not programmed: genetic pseudo-program is a shadow of developmental growth

scientific article

Aging, stem cells, and mammalian target of rapamycin: a prospect of pharmacologic rejuvenation of aging stem cells

scientific article published on August 2008

Aging-suppressants: cellular senescence (hyperactivation) and its pharmacologic deceleration.

scientific article published on 21 June 2009

Aging: ROS or TOR.

scientific article

Aging: past, present and future

scientific article published on 7 January 2009

An anti-aging drug today: from senescence-promoting genes to anti-aging pill

scientific article published on 9 February 2007

Analysis of FDA approved anticancer drugs reveals the future of cancer therapy.

scientific article published on 16 August 2004

Answering the ultimate question "what is the proximal cause of aging?"

scientific article published on December 2012

Antagonistic drug combinations that select against drug resistance: from bacteria to cancer

scientific article published on 01 July 2007

Antiangiogenic therapy and tumor progression

scientific article published on January 2004

Apoptosis, proliferation, differentiation: in search of the order

scientific article

Are p27 and p21 cytoplasmic oncoproteins?

scientific article

At concentrations that inhibit mTOR, resveratrol suppresses cellular senescence.

scientific article published on 21 June 2009

Basic cell cycle and cancer research: is harmony impossible?

scientific article

Bcl-xL is phosphorylated in malignant cells following microtubule disruption ⬇️

scientific article published on August 1, 1998

Big mice die young but large animals live longer ⬇️

scientific article (publication date: April 2013)

CDK4/6-inhibiting drug substitutes for p21 and p16 in senescence: duration of cell cycle arrest and MTOR activity determine geroconversion

scientific article published on 22 August 2013

Calorie restriction: decelerating mTOR-driven aging from cells to organisms (including humans).

scientific article

Cancer and aging: more puzzles, more promises?

scientific article

Cancer stem cell and cancer stemloids: from biology to therapy

scientific article published on 10 October 2007

Carcinogenesis, cancer therapy and chemoprevention

scientific article

Carcinogenic metals induce hypoxia-inducible factor-stimulated transcription by reactive oxygen species-independent mechanism

scientific article

Carcinogenic nickel induces genes involved with hypoxic stress

scientific article

Caveolin-1 and accelerated host aging in the breast tumor microenvironment: chemoprevention with rapamycin, an mTOR inhibitor and anti-aging drug

scientific article

Cell cycle arrest is not senescence ⬇️

scientific article published on February 1, 2011

Cell cycle arrest is not yet senescence, which is not just cell cycle arrest: terminology for TOR-driven aging ⬇️

scientific article published on March 1, 2012

Cell death beyond apoptosis

scientific article

Cell immortality and hallmarks of cancer.

scientific article

Cell senescence and hypermitogenic arrest

scientific article

Cell senescence: hypertrophic arrest beyond the restriction point

scientific article published on December 2006

Cellular quiescence caused by the Mdm2 inhibitor nutlin-3A.

scientific article published on 23 November 2009

Classification of cell death: recommendations of the Nomenclature Committee on Cell Death

scientific article

Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009

scientific article

Combining phorbol ester (PMA) with UCN-01: fueling fire with water

scientific article published in July 2002

Common drugs and treatments for cancer and age-related diseases: revitalizing answers to NCI's provocative questions ⬇️

scientific article published on December 1, 2012

Comparison of rapamycin schedules in mice on high-fat diet

scientific article

Complementation of two mutant p53: implications for loss of heterozygosity in cancer

scientific article

Conceptual biology: unearthing the gems

scientific article

Conceptual research and phenomenology--harmonizing slices

scientific article

Contact inhibition and high cell density deactivate the mammalian target of rapamycin pathway, thus suppressing the senescence program

scientific article (publication date: 2 June 2014)

Correction: Librarians against scientists: Oncotarget's lesson.

scientific article

Cross-talk between protein kinase C-alpha (PKC-alpha) and -delta (PKC-delta): PKC-alpha elevates the PKC-delta protein level, altering its mRNA transcription and degradation

scientific article published on 01 April 1998

Cyclotherapy: protection of normal cells and unshielding of cancer cells

scientific article

Cytostatic activity of paclitaxel in coronary artery smooth muscle cells is mediated through transient mitotic arrest followed by permanent post-mitotic arrest: comparison with cancer cells

scientific article published on 17 July 2006

Cytostatic and cytotoxic activity of sex steroids against human leukemia cell lines

scientific article published in January 1994

DNA damaging agents and p53 do not cause senescence in quiescent cells, while consecutive re-activation of mTOR is associated with conversion to senescence ⬇️

scientific article (publication date: 31 December 2010)

Damage-induced aging and perpetual motion

scientific article published on 5 August 2013

Defects in p21WAF1/CIP1, Rb, and c-myc signaling in phorbol ester-resistant cancer cells

scientific article published on 01 January 1997

Depletion of mutant p53 and cytotoxicity of histone deacetylase inhibitors

scientific article published on August 2005

Depletion of p185erbB2, Raf-1 and mutant p53 proteins by geldanamycin derivatives correlates with antiproliferative activity

scientific article published on January 1997

Destabilization of Raf-1 by geldanamycin leads to disruption of the Raf-1-MEK-mitogen-activated protein kinase signalling pathway

scientific article

Differential sensitivity of cancer cells to inhibitors of the epidermal growth factor receptor family.

scientific article published on January 2002

Disease or not, aging is easily treatable

article published in 2018

Disruption of the Raf-1-Hsp90 Molecular Complex Results in Destabilization of Raf-1 and Loss of Raf-1-Ras Association ⬇️

scientific article published on October 13, 1995

Do VHL and HIF-1 mirror p53 and Mdm-2? Degradation-transactivation loops of oncoproteins and tumor suppressors

scientific article

Do cells need CDK2 and ... Bcr-Abl?

scientific article published in March 2004

Does rapamycin slow down time?

scientific article published on 13 July 2018

Drug-resistance enables selective killing of resistant leukemia cells: exploiting of drug resistance instead of reversal.

scientific article

Dual mTORC1/C2 inhibitors suppress cellular geroconversion (a senescence program).

scientific article

Dysregulation of the mTOR pathway in p53-deficient mice

scientific article

Effects of p53-expressing adenovirus on the chemosensitivity and differentiation of anaplastic thyroid cancer cells

scientific article

Efficacy of microtubule-active drugs followed by ketoconazole in human metastatic prostate cancer cell lines

scientific article

Elimination of proliferating cells unmasks the shift from senescence to quiescence caused by rapamycin

scientific article (publication date: 2011)

Enhanced microtubule-dependent trafficking and p53 nuclear accumulation by suppression of microtubule dynamics

scientific article

Essential versus accessory aspects of cell death: recommendations of the NCCD 2015.

scientific article

Exploiting cancer cell cycling for selective protection of normal cells.

scientific article published in June 2001

Exploring long-term protection of normal human fibroblasts and epithelial cells from chemotherapy in cell culture ⬇️

scientific article published on March 1, 2011

Fasting and rapamycin: diabetes versus benevolent glucose intolerance

scientific article published on 13 August 2019

Fasting levels of hepatic p-S6 are increased in old mice

scientific article

Flavopiridol induces p53 via initial inhibition of Mdm2 and p21 and, independently of p53, sensitizes apoptosis-reluctant cells to tumor necrosis factor

scientific article published on May 2004

Flavopiridol inversely affects p21(WAF1/CIP1) and p53 and protects p21-sensitive cells from paclitaxel

scientific article published on July 2002

Flavopiridol, an inhibitor of transcription: implications, problems and solutions

scientific article

Four Birds with One Stone: RAPA as Potential Anticancer

scholarly article by Mikhail V. Blagosklonny & Zbyszek Darzynkiewicz published 9 July 2002 in Cancer Biology and Therapy

Four birds with one stone: RAPA as potential anticancer therapy.

scientific article published in July 2002

From causes of aging to death from COVID-19

scientific article published on 12 June 2020

From cytometry to cell cycle: a portrait of Zbigniew Darzynkiewicz.

scientific article

From rapalogs to anti-aging formula

scientific article

From the war on cancer to translational oncology

scientific article

Gefitinib (iressa) in oncogene-addictive cancers and therapy for common cancers

scientific article published on 20 May 2004

Geldanamycin selectively destabilizes and conformationally alters mutated p53

scientific article published on September 7, 1995

Geldanamycin-stimulated destabilization of mutated p53 is mediated by the proteasome in vivo

scientific article published on June 1997

Geroconversion: irreversible step to cellular senescence

scientific article

Gerosuppression by pan-mTOR inhibitors

scientific article published on December 2016

Gerosuppression in confluent cells

scientific article

Growth and aging: a common molecular mechanism

scientific article

Growth stimulation leads to cellular senescence when the cell cycle is blocked

scientific article published on 12 November 2008

Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes.

scientific article published on 17 April 2009

Histone deacetylase inhibitors all induce p21 but differentially cause tubulin acetylation, mitotic arrest, and cytotoxicity.

scientific article published on September 2002

Hormesis does not make sense except in the light of TOR-driven aging ⬇️

scientific article published on November 1, 2011

Hormonal and differentiation agents in cancer growth suppression

scientific article

How Avastin potentiates chemotherapeutic drugs: action and reaction in antiangiogenic therapy

scientific article

How cancer could be cured by 2015.

scientific article

How carcinogens (or telomere dysfunction) induce genetic instability: associated-selection model

scientific article

How to save Medicare: the anti-aging remedy ⬇️

scientific article published on August 1, 2012

Hsp-90-associated oncoproteins: multiple targets of geldanamycin and its analogs

scientific article

Hyper-mitogenic drive coexists with mitotic incompetence in senescent cells ⬇️

scientific article published on November 27, 2012

Hyperinducibility of hypoxia-responsive genes without p53/p21-dependent checkpoint in aggressive prostate cancer

scientific article published on 01 October 2000

Hypoxia and gerosuppression: The mTOR saga continues ⬇️

scientific article published on September 17, 2012

Hypoxia suppresses conversion from proliferative arrest to cellular senescence

scientific article

Hypoxia, MTOR and autophagy: converging on senescence or quiescence

scientific article

Hypoxia-inducible factor: Achilles' heel of antiangiogenic cancer therapy (review).

scientific article

Immunosuppressants in cancer prevention and therapy

scientific article

Impact papers on aging in 2009.

scientific article

In vitro evaluation of a p53-expressing adenovirus as an anti-cancer drug

scientific article published in July 1996

Increasing healthy lifespan by suppressing aging in our lifetime: preliminary proposal

scientific article published on 15 December 2010

Inhibition of HIF-1- and wild-type p53-stimulated transcription by codon Arg175 p53 mutants with selective loss of functions

scientific article published in June 2001

Inhibition of S6K by resveratrol: in search of the purpose

scientific article

Inhibition of transcription results in accumulation of Wt p53 followed by delayed outburst of p53-inducible proteins: p53 as a sensor of transcriptional integrity.

scientific article published in January 2002

Inhibitors of Transcription, Proteasome Inhibitors, and DNA-Damaging Drugs Differentially Affect Feedback of p53 Degradation ⬇️

scientific article published on October 10, 1998

Introducing Oncotarget

Kinase-addiction and bi-phasic sensitivity-resistance of Bcr-Abl- and Raf-1-expressing cells to imatinib and geldanamycin

scientific article published on 5 April 2005

Koschei the immortal and anti-aging drugs

scientific article

Librarians against scientists: Oncotarget's lesson

scientific article published on 19 January 2018

Lifespan extension and cancer prevention in HER-2/neu transgenic mice treated with low intermittent doses of rapamycin

scientific article

Like p53, the Proliferation-Associated Protein p120 Accumulates in Human Cancer Cells Following Exposure to Anticancer Drugs ⬇️

scientific article published on March 17, 1998

Linking calorie restriction to longevity through sirtuins and autophagy: any role for TOR ⬇️

scientific article published on January 1, 2010

Loss of cell cycle control allows selective microtubule-active drug-induced Bcl-2 phosphorylation and cytotoxicity in autonomous cancer cells

scientific article published on 01 July 2000

Loss of function and p53 protein stabilization ⬇️

scientific article published on October 16, 1997

Lovastatin induces apoptosis in a primitive neuroectodermal tumor cell line in association with RB down-regulation and loss of the G1 checkpoint

scientific article

Low concentrations of paclitaxel induce cell type-dependent p53, p21 and G1/G2 arrest instead of mitotic arrest: molecular determinants of paclitaxel-induced cytotoxicity

scientific article

M(o)TOR of aging: MTOR as a universal molecular hypothalamus

scientific article published on July 2013

M(o)TOR of pseudo-hypoxic state in aging: rapamycin to the rescue

scientific article published on 23 January 2014

MEK drives cyclin D1 hyperelevation during geroconversion

scientific article published on 12 July 2013

MTOR-driven quasi-programmed aging as a disposable soma theory: blind watchmaker vs. intelligent designer

scientific article published on 12 June 2013

Matching targets for selective cancer therapy

scientific article

Mechanism of G1-like arrest by low concentrations of paclitaxel: next cell cycle p53-dependent arrest with sub G1 DNA content mediated by prolonged mitosis

scientific article

Mechanistic or mammalian target of rapamycin (mTOR) may determine robustness in young male mice at the cost of accelerated aging ⬇️

scientific article published on December 1, 2012

Metformin and sex: Why suppression of aging may be harmful to young male mice

scientific article

Mitogen-activated protein kinase pathway is dispensable for microtubule-active drug-induced Raf-1/Bcl-2 phosphorylation and apoptosis in leukemia cells

scientific article published on 01 July 1999

Mitotic arrest and cell fate: why and how mitotic inhibition of transcription drives mutually exclusive events

scientific article published on 9 January 2007

Molecular damage in cancer: an argument for mTOR-driven aging ⬇️

scientific article published on December 1, 2011

Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012

scientific article (publication date: 2012)

Molecular effects of paclitaxel: myths and reality (a critical review).

scientific article

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

scientific article

Molecular theory of cancer

scientific article

Mutant conformation of p53 translated in vitro or in vivo requires functional HSP90.

scientific article published on August 1996

NCI's provocative questions on cancer: some answers to ignite discussion

scientific article published on December 2011

New nanoformulation of rapamycin Rapatar extends lifespan in homozygous p53−/− mice by delaying carcinogenesis ⬇️

scientific article published on October 1, 2012

Nickel-induced transformation shifts the balance between HIF-1 and p53 transcription factors

scientific article

No restriction points in life and science.

scientific article published in March 2002

Oligonucleotides protect cells from the cytotoxicity of several anti-cancer chemotherapeutic drugs

scientific article published on 01 August 1994

Once again on rapamycin-induced insulin resistance and longevity: despite of or owing to ⬇️

scientific article published on May 1, 2012

Oncogenic resistance to growth-limiting conditions

scientific article

Overcoming limitations of natural anticancer drugs by combining with artificial agents

scientific article

P21-dependent g(1)arrest with downregulation of cyclin D1 and upregulation of cyclin E by the histone deacetylase inhibitor FR901228

scientific article published on September 2000

P53: an ubiquitous target of anticancer drugs

scientific article

Paclitaxel induces primary and postmitotic G1 arrest in human arterial smooth muscle cells.

scientific article published on 24 August 2004

Paclitaxel selects for mutant or pseudo-null p53 in drug resistance associated with tubulin mutations in human cancer

scientific article published in June 2000

Paclitaxel-induced FasL-independent apoptosis and slow (non-apoptotic) cell death.

scientific article published in March 2002

Paradox of Bcl-2 (and p53): why may apoptosis-regulating proteins be irrelevant to cell death?

scientific article

Paradoxes of aging

scientific article published on 04 October 2007

Paradoxes of senolytics

Paradoxical suppression of cellular senescence by p53

scientific article

Pharmacologic inhibition of MEK and PI-3K converges on the mTOR/S6 pathway to decelerate cellular senescence

scientific article

Pharmacological induction of Hsp70 protects apoptosis-prone cells from doxorubicin: comparison with caspase-inhibitor- and cycle-arrest-mediated cytoprotection

scientific article published on 25 November 2005

Phase I trial of the histone deacetylase inhibitor, depsipeptide (FR901228, NSC 630176), in patients with refractory neoplasms

scientific article

Phosphorylation of paxillin tyrosines 31 and 118 controls polarization and motility of lymphoid cells and is PMA-sensitive

scientific article published on 13 July 2004

Pretreatment with DNA-damaging agents permits selective killing of checkpoint-deficient cells by microtubule-active drugs

scientific article

Prevention of age-related macular degeneration-like retinopathy by rapamycin in rats.

scientific article published on 7 June 2012

Prevention of cancer by inhibiting aging

scientific article published on 21 October 2008

Progeria, rapamycin and normal aging: recent breakthrough

scientific article published on July 2011

Program-like aging and mitochondria: instead of random damage by free radicals

scientific article published on December 2007

Prolonged mitosis versus tetraploid checkpoint: how p53 measures the duration of mitosis.

scientific article

Prospective Treatment of Age-Related Diseases by Slowing Down Aging ⬇️

scientific article published on July 27, 2012

Prospective strategies to enforce selectively cell death in cancer cells

scientific article published on April 2004

Prostate cancer cell growth inhibition by tamoxifen is associated with inhibition of protein kinase C and induction of p21waf1/cip1 ⬇️

scientific article published on September 15, 1998

Prostate cancer chemoprevention agents exhibit selective activity against early stage prostate cancer cells.

scientific article published in January 2001

Protease inhibitor-induced apoptosis: accumulation of wt p53, p21WAF1/CIP1, and induction of apoptosis are independent markers of proteasome inhibition

scientific article published on July 2000

Proteasome-dependent regulation of p21WAF1/CIP1 expression

scientific article published on October 1996

Pseudo-DNA damage response in senescent cells

scientific journal article

Quantifying pharmacologic suppression of cellular senescence: prevention of cellular hypertrophy versus preservation of proliferative potential

scientific article

Raf-1 and Bcl-2 induce distinct and common pathways that contribute to breast cancer drug resistance

scientific article published in March 2003

Raf-1/bcl-2 phosphorylation: a step from microtubule damage to cell death

scientific article published in January 1997

Rapalogs in cancer prevention: anti-aging or anticancer?

scientific article

Rapamycin and quasi-programmed aging: four years later

scientific article published on 15 May 2010

Rapamycin decelerates cellular senescence

scientific article

Rapamycin extends life- and health span because it slows aging

scientific article published on August 2013

Rapamycin extends lifespan and delays tumorigenesis in heterozygous p53+/- mice

scientific article

Rapamycin extends maximal lifespan in cancer-prone mice

scientific article

Rapamycin for longevity: opinion article

scientific article published on 04 October 2019

Rapamycin for the aging skin

scientific article published on 27 December 2019

Rapamycin increases lifespan and inhibits spontaneous tumorigenesis in inbred female mice ⬇️

scientific article published on December 15, 2011

Rapamycin reverses insulin resistance (IR) in high-glucose medium without causing IR in normoglycemic medium

scientific article published on 8 May 2014

Rapamycin suppresses brain aging in senescence-accelerated OXYS rats

scientific article published on June 2013

Rapamycin, proliferation and geroconversion to senescence

scientific article published on 12 December 2018

Rapamycin-induced glucose intolerance: Hunger or starvation diabetes ⬇️

scientific article published on December 15, 2011

Rapatar, a nanoformulation of rapamycin, decreases chemically-induced benign prostate hyperplasia in rats

scientific article published on April 2015

Re: Role of the heat shock response and molecular chaperones in oncogenesis and cell death.

scientific article published in February 2001

Regulation of BRCA1 by protein degradation

scientific article published on November 1999

Regulation of actin cytoskeleton in lymphocytes: PKC-delta disrupts IL-3-induced membrane ruffles downstream of Rac1.

scientific article published on May 1999

Rejuvenating immunity: "anti-aging drug today" eight years later

scientific article

Research by retrieving experiments

scientific article published on 26 June 2007

Resistance to growth inhibitory and apoptotic effects of phorbol ester and UCN-01 in aggressive cancer cell lines

scientific article published on April 2001

Resveratrol potentiates rapamycin to prevent hyperinsulinemia and obesity in male mice on high fat diet ⬇️

scientific article published on January 24, 2013

Revisiting the antagonistic pleiotropy theory of aging: TOR-driven program and quasi-program ⬇️

scientific article published on August 20, 2010

S6K in geroconversion

scientific article published on 09 September 2013

STI-571 must select for drug-resistant cells but 'no cell breathes fire out of its nostrils like a dragon'.

scientific article

Selective anti-cancer agents as anti-aging drugs

scientific article

Selective killing of adriamycin-resistant (G2 checkpoint-deficient and MRP1-expressing) cancer cells by docetaxel

scientific article published in May 2005

Sensitive and simple bioassay for human tumour necrosis factor-alpha

scientific article published on July 1993

Sequential activation and inactivation of G2 checkpoints for selective killing of p53-deficient cells by microtubule-active drugs

scientific article published on 01 September 2002

Spotlight on apoptosis. Introduction

scientific article published on 01 August 2000

Stabilization of wild-type p53 by hypoxia-inducible factor 1α ⬇️

scientific article published on March 26, 1998

Strategies of Protection of Normal Cells During Chemo- and Radio-Therapy Based on Modulation of Cell Cycle and Apoptotic Pathways

Suppression of cancer cell growth by adenovirus expressing p21(WAF1/CIP1) deficient in PCNA interaction

scientific article published on 01 July 1996

Suppression of replicative senescence by rapamycin in rodent embryonic cells ⬇️

scientific article published on June 15, 2012

TOR-centric view on insulin resistance and diabetic complications: perspective for endocrinologists and gerontologists

scientific article

TOR-driven aging: speeding car without brakes

scientific article published on 9 December 2009

Target for cancer therapy: proliferating cells or stem cells

scientific article

Targeting cancer cells by exploiting their resistance

scientific article

Taxol induction of p21WAF1 and p53 requires c-raf-1.

scientific article published on October 1995

Taxol-induced apoptosis and phosphorylation of Bcl-2 protein involves c-Raf-1 and represents a novel c-Raf-1 signal transduction pathway

scientific article published on April 1996

Teratogens as anti-cancer drugs

scientific article

The Hsp90 inhibitor geldanamycin selectively sensitizes Bcr-Abl-expressing leukemia cells to cytotoxic chemotherapy

scientific article

The P-glycoprotein antagonist PSC 833 increases the plasma concentrations of 6alpha-hydroxypaclitaxel, a major metabolite of paclitaxel.

scientific article published in June 2001

The choice between p53-induced senescence and quiescence is determined in part by the mTOR pathway

scientific article published on June 2010

The dilemma of apoptosis in myelodysplasia and leukemia: a new promise of therapeutic intervention?

scientific article published in December 2000

The histone deacetylase inhibitor FR901228 (desipeptide) restores expression and function of pseudo-null p53.

scientific article

The interaction of p53 with replication protein A mediates suppression of homologous recombination

scientific article

The mitogen-activated protein kinase pathway mediates growth arrest or E1A-dependent apoptosis in SKBR3 human breast cancer cells ⬇️

scientific article published on 01 November 1998

The mystery of the ketogenic diet: benevolent pseudo-diabetes

scientific article published on 01 August 2019

The power of chemotherapeutic engineering: arresting cell cycle and suppressing senescence to protect from mitotic inhibitors

scientific article published on 15 July 2011

The purpose of the HIF-1/PHD feedback loop: To limit mTOR-induced HIF-1α ⬇️

scientific article published on May 15, 2011

The regulation of hypoxic genes by calcium involves c-Jun/AP-1, which cooperates with hypoxia-inducible factor 1 in response to hypoxia

scientific article

The restriction point of the cell cycle

scientific article

The role of Bcl-2 protein and autocrine growth factors in a human follicular lymphoma-derived B cell line.

scientific article published on January 1995

The second international conference "genetics of aging and longevity".

scientific article published on May 2012

Tissue-selective therapy of cancer ⬇️

scientific article published on October 6, 2003

Treatment with inhibitors of caspases, that are substrates of drug transporters, selectively permits chemotherapy-induced apoptosis in multidrug-resistant cells but protects normal cells

scientific article

Tumor promoter-induced cellular senescence: cell cycle arrest followed by geroconversion

scientific article

Tumor suppression by p53 without apoptosis and senescence: conundrum or rapalog-like gerosuppression?

scientific article

UCN-01, a protein kinase C inhibitor, inhibits endothelial cell proliferation and angiogenic hypoxic response

scientific article

Unwinding the loop of Bcl-2 phosphorylation

scientific article

Validation of anti-aging drugs by treating age-related diseases

scientific article

Weak p53 permits senescence during cell cycle arrest ⬇️

scientific article published on November 10, 2010

Weekly administration of rapamycin improves survival and biomarkers in obese male mice on high-fat diet

scientific article

While reinforcing cell cycle arrest, rapamycin and Torins suppress senescence in UVA-irradiated fibroblasts

scientific article published on 11 May 2017

Why Iressa failed: toward novel use of kinase inhibitors (outlook).

scientific article

Why human lifespan is rapidly increasing: solving "longevity riddle" with "revealed-slow-aging" hypothesis

scientific article

Why men age faster but reproduce longer than women: mTOR and evolutionary perspectives

scientific article (publication date: May 2010)

Why the disposable soma theory cannot explain why women live longer and why we age ⬇️

scientific article published on December 1, 2010

Why therapeutic response may not prolong the life of a cancer patient: selection for oncogenic resistance

scientific article

Wild-type p53 is not sufficient for serum starvation-induced apoptosis in cancer cells but accelerates apoptosis in sensitive cells

scientific article published on 01 December 1997

Wild-type p53 marginally induces endogenous MDR-1 mRNA without causing a measurable drug resistance in human cancer cells

scientific article

Wt p53 impairs response to chemotherapy: make lemonade to spare normal cells ⬇️

scientific article published on June 1, 2012

Yeast-like chronological senescence in mammalian cells: phenomenon, mechanism and pharmacological suppression ⬇️

scientific article published on November 1, 2011

bcl-2 protein downregulation is not required for differentiation of multidrug resistant HL60 leukemia cells

scientific article published on February 1996

p21 (CDKN1A) is a negative regulator of p53 stability.

scientific article

p21(Waf1/Cip1/Sdi1) mediates retinoblastoma protein degradation.

scientific article

p53 Inhibits Hypoxia-inducible Factor-stimulated Transcription ⬇️

scientific article published on May 15, 1998

p53 from complexity to simplicity: mutant p53 stabilization, gain-of-function, and dominant-negative effect

scientific article

p53 is associated with cellular microtubules and is transported to the nucleus by dynein

scientific article published on 01 October 2000

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