Search filters

List of works by Liang Tong

5' End Nicotinamide Adenine Dinucleotide Cap in Human Cells Promotes RNA Decay through DXO-Mediated deNADding.

scientific article

A Mammalian Pre-mRNA 5′ End Capping Quality Control Mechanism and an Unexpected Link of Capping to Pre-mRNA Processing

scientific article

A bidirectional system for the dynamic small molecule control of intracellular fusion proteins.

scientific article

A community resource of experimental data for NMR / X-ray crystal structure pairs.

scientific article

A different mechanism for the inhibition of the carboxyltransferase domain of acetyl-coenzyme A carboxylase by tepraloxydim

scientific article

A distinct holoenzyme organization for two-subunit pyruvate carboxylase

scientific article published on 06 October 2016

A highly specific inhibitor of human p38 MAP kinase binds in the ATP pocket

scientific article

A histone H3K9M mutation traps histone methyltransferase Clr4 to prevent heterochromatin spreading

scientific article

A human mitochondrial poly(A) polymerase mutation reveals the complexities of post-transcriptional mitochondrial gene expression.

scientific article

A large conformational change in the putative ATP pyrophosphatase PF0828 induced by ATP binding

scientific article

A mechanism for the potent inhibition of eukaryotic acetyl-coenzyme A carboxylase by soraphen A, a macrocyclic polyketide natural product.

scientific article

A novel 5'-hydroxyl dinucleotide hydrolase activity for the DXO/Rai1 family of enzymes

scientific article published on 01 January 2020

A rational approach towards successful crystallization and crystal treatment of human cytomegalovirus protease and its inhibitor complex

article

A serendipitous discovery that in situ proteolysis is essential for the crystallization of yeast CPSF-100 (Ydh1p).

scientific article

A symmetrical tetramer for S. aureus pyruvate carboxylase in complex with coenzyme A

scientific article

A unified molecular mechanism for the regulation of acetyl-CoA carboxylase by phosphorylation.

scientific article

Acetyl-CoA carboxylase inhibition by ND-630 reduces hepatic steatosis, improves insulin sensitivity, and modulates dyslipidemia in rats.

scientific article published on 14 March 2016

Acetyl-coenzyme A carboxylase: crucial metabolic enzyme and attractive target for drug discovery

scientific article

Allosteric regulation and substrate activation in cytosolic nucleotidase II fromLegionella pneumophila

scientific article

An HD-domain phosphodiesterase mediates cooperative hydrolysis of c-di-AMP to affect bacterial growth and virulence

scientific article

An allosteric mechanism for potent inhibition of human ATP-citrate lyase

scientific article published on 03 April 2019

An inhibited conformation for the protein kinase domain of the Saccharomyces cerevisiae AMPK homolog Snf1

scientific article

An unanticipated architecture of the 750-kDa α6β6 holoenzyme of 3-methylcrotonyl-CoA carboxylase ⬇️

scientific article published on December 11, 2011

An unexpected binding mode for a Pol II CTD peptide phosphorylated at Ser7 in the active site of the CTD phosphatase Ssu72

scientific article

Arabidopsis DXO1 links RNA turnover and chloroplast function independently of its enzymatic activity

Aspartate dehydrogenase, a novel enzyme identified from structural and functional studies of TM1643

scientific article

Bacterial neuraminidase facilitates mucosal infection by participating in biofilm production

scientific article

Binding site elucidation of hydantoin-based antagonists of LFA-1 using multidisciplinary technologies: evidence for the allosteric inhibition of a protein--protein interaction

scientific article published in June 2001

Biochemical and functional studies on the regulation of the Saccharomyces cerevisiae AMPK homolog SNF1.

scientific article published on 31 May 2010

Biophysical characterizations of the recognition of the AAUAAA polyadenylation signal

scientific article published on 28 August 2019

COMO: a program for combined molecular replacement

scientific article published on 23 July 2001

Carboxymethyl-phenylalanine as a replacement for phosphotyrosine in SH2 domain binding

scientific article

Characterization of the monomer-dimer equilibrium of human cytomegalovirus protease by kinetic methods

scientific article

Characterizing the Importance of the Biotin Carboxylase Domain Dimer for Staphylococcus aureus Pyruvate Carboxylase Catalysis ⬇️

scientific article published on January 9, 2013

Computational Design of Catalytic Dyads and Oxyanion Holes for Ester Hydrolysis

scientific article

Computational Design of a Protein-Based Enzyme Inhibitor

scientific article

Computational Design of an Unnatural Amino Acid Dependent Metalloprotein with Atomic Level Accuracy

scientific article

Conserved mode of peptidomimetic inhibition and substrate recognition of human cytomegalovirus protease

scientific article published on September 1, 1998

Conserved surface features form the double-stranded RNA binding site of non-structural protein 1 (NS1) from influenza A and B viruses

scientific article

Cryo-EM analysis reveals new insights into the mechanism of action of pyruvate carboxylase.

scientific article

Crystal Structure of Urea Carboxylase Provides Insights into the Carboxyltransfer Reaction ⬇️

scientific article published on January 25, 2012

Crystal Structure of the SPOC Domain of the Arabidopsis Flowering Regulator FPA.

scientific article

Crystal Structures of Malonyl-Coenzyme A Decarboxylase Provide Insights into Its Catalytic Mechanism and Disease-Causing Mutations

scientific article

Crystal structure of 1-deoxy-D-xylulose 5-phosphate synthase, a crucial enzyme for isoprenoids biosynthesis.

scientific article

Crystal structure of MTH169, a crucial component of phosphoribosylformylglycinamidine synthetase

scientific article published in November 2002

Crystal structure of a Pseudomonas malonate decarboxylase holoenzyme hetero-tetramer.

scientific article published on 31 July 2017

Crystal structure of an active form of RAS protein, a complex of a GTP analog and the HRAS p21 catalytic domain

scientific article

Crystal structure of biotin carboxylase in complex with substrates and implications for its catalytic mechanism

scientific article

Crystal structure of carnitine acetyltransferase and implications for the catalytic mechanism and fatty acid transport

scientific article

Crystal structure of dimeric HIV-1 capsid protein

scientific article

Crystal structure of human DJ-1, a protein associated with early onset Parkinson's disease

scientific article (publication date: 15 August 2003)

Crystal structure of human immunodeficiency virus (HIV) type 2 protease in complex with a reduced amide inhibitor and comparison with HIV-1 protease structures

scientific article

Crystal structure of human mitochondrial NAD(P)(+)-dependent malic enzyme: a new class of oxidative decarboxylases

scientific article

Crystal structure of human mitochondrial acyl-CoA thioesterase (ACOT2)

scientific article

Crystal structure of human nicotinamide riboside kinase

scientific article

Crystal structure of human retinoblastoma binding protein 9

scientific article

Crystal structure of murine CstF-77: dimeric association and implications for polyadenylation of mRNA precursors

scientific article

Crystal structure of the 500-kDa yeast acetyl-CoA carboxylase holoenzyme dimer

scientific article published on 12 October 2015

Crystal structure of the BEACH domain reveals an unusual fold and extensive association with a novel PH domain

scientific article

Crystal structure of the MAP kinase binding domain and the catalytic domain of human MKP5

scientific article

Crystal structure of the PH-BEACH domains of human LRBA/BGL.

scientific article

Crystal structure of the Toll/interleukin-1 receptor domain of human IL-1RAPL.

scientific article

Crystal structure of the carboxyltransferase domain of acetyl-coenzyme A carboxylase in complex with CP-640186

scientific journal article

Crystal structure of the heterotrimer core of Saccharomyces cerevisiae AMPK homologue SNF1

scientific article

Crystal structure of the human symplekin-Ssu72-CTD phosphopeptide complex

scientific article

Crystal structure of the protein kinase domain of yeast AMP-activated protein kinase Snf1.

scientific article published on 7 October 2005

Crystal structure of the α6β6 holoenzyme of propionyl-coenzyme A carboxylase ⬇️

scientific article published on August 19, 2010

Crystal structures of HIV-2 protease in complex with inhibitors containing the hydroxyethylamine dipeptide isostere

scientific article

Crystal structures of MTH1187 and its yeast ortholog YBL001c

scientific article

Crystal structures of human and Staphylococcus aureus pyruvate carboxylase and molecular insights into the carboxyltransfer reaction

scientific article

Crystal structures of murine carnitine acetyltransferase in ternary complexes with its substrates

scientific article

Crystal structures of respiratory pathogen neuraminidases

scientific article

Crystal structures of substrate complexes of malic enzyme and insights into the catalytic mechanism

scientific article

Crystal structures of the human p56lck SH2 domain in complex with two short phosphotyrosyl peptides at 1.0 A and 1.8 A resolution

scientific article

Crystallization and preliminary X-ray crystallographic studies of wild-type human ornithine transcarbamylase and two naturally occurring mutants at position 277

scientific article published on 24 April 2001

Crystallization and preliminary crystallographic analysis of recombinant human P38 MAP kinase

scientific article

Cyclic di-AMP targets the cystathionine beta-synthase domain of the osmolyte transporter OpuC

scientific article

Delineating the structural blueprint of the pre-mRNA 3'-end processing machinery

scientific article

Determination of the mechanism of human malic enzyme with natural and alternate dinucleotides by isotope effects

scientific article published in December 2001

Determination of the ribosome structure to a resolution of 2.5 Å by single-particle cryo-EM.

scientific article

Discovery of New Classes of Compounds that Reactivate Acetylcholinesterase Inhibited by Organophosphates

scientific article

Discovery of small molecule isozyme non-specific inhibitors of mammalian acetyl-CoA carboxylase 1 and 2

scientific article

Distinct domains in ORF52 tegument protein mediate essential functions in murine gammaherpesvirus 68 virion tegumentation and secondary envelopment

scientific article published on 16 November 2011

Dual functional roles of ATP in the human mitochondrial malic enzyme

scientific article

Dxo1 is a new type of eukaryotic enzyme with both decapping and 5′-3′ exoribonuclease activity ⬇️

scientific article published on September 9, 2012

Engineering d-amino acid containing novel protease inhibitors using catalytic site architecture.

scientific article

Experiences from the Structure Determination of Human Cytomegalovirus Protease

scientific article published on 01 November 1997

Exploration of Alternate Catalytic Mechanisms and Optimization Strategies for Retroaldolase Design

scientific article

Expression system for structural and functional studies of human glycosylation enzymes

scientific article published on 18 December 2017

Expression, purification, and crystallization of Toll/interleukin-1 receptor (TIR) domains

scientific article published in January 2009

Functional and structural basis of carnitine palmitoyltransferase 1A deficiency.

scientific article published on 29 September 2003

Functional conformations for pyruvate carboxylase during catalysis explored by cryoelectron microscopy

scientific article

Heme Oxygenase 2 Binds Myristate to Regulate Retrovirus Assembly and TLR4 Signaling

scientific article published on 16 January 2017

High resolution crystal structures of recombinant human renin in complex with polyhydroxymonoamide inhibitors

scientific article

High-Throughput PIXE as an Essential Quantitative Assay for Accurate Metalloprotein Structural Analysis: Development and Application

scientific article published on 20 December 2019

High-resolution structures of inhibitor complexes of human indoleamine 2,3-dioxygenase 1 in a new crystal form

scientific article published on 17 October 2018

Histidine 55 of tryptophan 2,3-dioxygenase is not an active site base but regulates catalysis by controlling substrate binding

scientific article

How Does Polymerization Regulate Human Acetyl-CoA Carboxylase 1?

scientific article published on 13 September 2018

How to Get All “A”s in Polyadenylation

scientific article published on 01 September 2007

How to take advantage of non-crystallographic symmetry in molecular replacement: 'locked' rotation and translation functions

scientific article published on 21 September 2001

Identification of SERPINB1 as a physiological inhibitor of human granzyme H

scientific article

Identification of Three Sequence Motifs in the Transcription Termination Factor Sen1 that Mediate Direct Interactions with Nrd1

scientific article published on 16 May 2019

Identification of a quality-control mechanism for mRNA 5'-end capping

scientific article

Insulin Hexamer-Caged Gadolinium Ion as MRI Contrast-o-phore

scientific article published on 04 July 2018

Integrator subunit 4 is a 'Symplekin-like' scaffold that associates with INTS9/11 to form the Integrator cleavage module.

scientific article published on 20 February 2018

Is dimerization required for the catalytic activity of bacterial biotin carboxylase?

scientific article

Ligands for the Tyrosine Kinase p56lckSH2 Domain: Discovery of Potent Dipeptide Derivatives with Monocharged, Nonhydrolyzable Phosphate Replacements

Mechanism for the inhibition of the carboxyltransferase domain of acetyl-coenzyme A carboxylase by pinoxaden

scientific article

Methyl esterase 1 (StMES1) is required for systemic acquired resistance in potato

scientific article published on September 2010

Microtube batch protein crystallization: applications to human immunodeficiency virus type 2 (HIV-2) protease and human renin

scientific article

Mitochondrial COQ9 is a lipid-binding protein that associates with COQ7 to enable coenzyme Q biosynthesis

scientific article

Mitochondrial poly(A) polymerase and polyadenylation ⬇️

scientific article published on December 7, 2011

Molecular Insights into the Biosynthesis of the F 420 Coenzyme

scientific article

Molecular basis for the inhibition of human NMPRTase, a novel target for anticancer agents.

scientific article

Molecular basis for the inhibition of the carboxyltransferase domain of acetyl-coenzyme-A carboxylase by haloxyfop and diclofop.

scholarly article

Molecular basis for the interaction between Integrator subunits IntS9 and IntS11 and its functional importance

scientific article published on 10 April 2017

Molecular basis for the recognition of cyclic-di-AMP by PstA, a PII-like signal transduction protein.

scientific article published on 18 February 2015

Molecular basis for the recognition of methylated adenines in RNA by the eukaryotic YTH domain.

scientific article

Molecular basis for the recognition of the human AAUAAA polyadenylation signal.

scientific article published on 5 December 2017

Molecular basis for the role of oncogenic histone mutations in modulating H3K36 methylation.

scientific article published on 03 March 2017

Molecular mechanism for self-protection against the type VI secretion system in Vibrio cholerae

scientific article

Molecular mechanism for the inhibition of DXO by adenosine 3',5'-bisphosphate

scientific article published on 01 September 2018

Molecular mechanism for the interaction between human CPSF30 and hFip1

scientific article published on 29 October 2020

Molecular mechanism for the regulation of yeast separase by securin

scientific article published on February 2017

Molecular mechanism of the assembly of an acid-sensing receptor ion channel complex.

scientific article

Molecular mechanisms for the regulation of histone mRNA stem-loop-binding protein by phosphorylation.

scientific article

Molecular switch for signal transduction: structural differences between active and inactive forms of protooncogenic ras proteins

scientific article

Multivalent Small-Molecule Pan-RAS Inhibitors.

scientific article

NMR Signal Quenching from Bound Biradical Affinity Reagents in DNP Samples.

scientific article published on 8 November 2017

Nicotinamide adenine dinucleotide metabolism as an attractive target for drug discovery

scientific article

Optimal alignment for enzymatic proton transfer: structure of the Michaelis complex of triosephosphate isomerase at 1.2-A resolution.

scientific article

P-TEFb regulation of transcription termination factor Xrn2 revealed by a chemical genetic screen for Cdk9 substrates.

scientific article

Phase refinement and extension by means of non-crystallographic symmetry averaging using parallel computers

scientific article published in September 1995

Potent HIV Protease Inhibitors Containing a Novel (Hydroxyethyl)amide Isostere ⬇️

scientific article published on July 4, 1997

Preliminary Crystallographic Studies of Human Mitochondrial NAD(P)+-Dependent Malic Enzyme

scientific article published on 01 August 1999

Protein factors in pre-mRNA 3'-end processing.

scientific article published on April 2008

Protein production and purification

scientific article

Real-time fluorescence detection of exoribonucleases

scientific article published on 18 September 2009

Recent molecular insights into canonical pre-mRNA 3'-end processing

scientific article published on 11 June 2020

Reciprocal-space molecular-replacement averaging

scientific article published in May 1995

Sensing of Bacterial Cyclic Dinucleotides by the Oxidoreductase RECON Promotes NF-κB Activation and Shapes a Proinflammatory Antibacterial State

scientific article published on March 2017

Slow Binding of Metal Ions to Pigeon Liver Malic Enzyme: A General Case†

scientific article published on 01 November 2000

Solution NMR and X-ray crystal structures of Pseudomonas syringae Pspto_3016 from protein domain family PF04237 (DUF419) adopt a “double wing” DNA binding motif

scientific article

Solution-state NMR investigations of triosephosphate isomerase active site loop motion: ligand release in relation to active site loop dynamics

scientific article

Striking Diversity in Holoenzyme Architecture and Extensive Conformational Variability in Biotin-Dependent Carboxylases.

scientific article

Structural Conservation of the Myoviridae Phage Tail Sheath Protein Fold ⬇️

scientific article published on December 7, 2011

Structural Evidence of Amyloid Fibril Formation in the Putative Aggregation Domain of TDP-43.

scientific article

Structural Insights into the Substrate Specificity of Human Granzyme H: The Functional Roles of a Novel RKR Motif ⬇️

scientific article published on December 9, 2011

Structural and Biochemical Studies on the Regulation of Biotin Carboxylase by Substrate Inhibition and Dimerization

scientific article

Structural and biochemical studies of the 5′→3′ exoribonuclease Xrn1

scientific article

Structural and biochemical studies of the distinct activity profiles of Rai1 enzymes.

scientific article published on 22 June 2015

Structural and functional studies of pyruvate carboxylase regulation by cyclic di-AMP in lactic acid bacteria

scientific article published on 14 August 2017

Structural and mechanistic basis of mammalian Nudt12 RNA deNADding

scientific article published on 17 May 2019

Structural and molecular basis of the assembly of the TRPP2/PKD1 complex

scientific article

Structural basis for dimerization and activity of human PAPD1, a noncanonical poly(A) polymerase

scientific article

Structural basis for self-association and receptor recognition of human TRAF2

scientific article

Structural basis for signal transduction by the Toll/interleukin-1 receptor domains

scientific article

Structural basis of dual Ca2+/pH regulation of the endolysosomal TRPML1 channel

scientific article published on 23 January 2017

Structural basis of the alpha1-beta subunit interaction of voltage-gated Ca2+ channels

scientific article

Structural biology of the separase-securin complex with crucial roles in chromosome segregation.

scientific article published on 13 February 2018

Structural evidence: a single charged residue affects substrate binding in cytochrome P450 BM-3

scientific article

Structural insights into the functions of the FANCM-FAAP24 complex in DNA repair

scientific article

Structural studies of the pigeon cytosolic NADP+‐dependent malic enzyme ⬇️

scientific article published on February 1, 2002

Structure and Mechanisms of NT5C2 Mutations Driving Thiopurine Resistance in Relapsed Lymphoblastic Leukemia

Structure and function of a single-chain, multi-domain long-chain acyl-CoA carboxylase.

scientific article

Structure and function of biotin-dependent carboxylases

scientific article

Structure and function of carnitine acyltransferases

scientific article

Structure and function of malic enzymes, a new class of oxidative decarboxylases

scientific article published on November 2003

Structure and function of pre-mRNA 5'-end capping quality control and 3'-end processing

scientific article published on 20 March 2014

Structure and function of the 5′→3′ exoribonuclease Rat1 and its activating partner Rai1

scientific article

Structure and substrate selectivity of the 750-kDa α6β6 holoenzyme of geranyl-CoA carboxylase

scientific article

Structure determination and biochemical characterization of a putative HNH endonuclease from Geobacter metallireducens GS-15

scientific article (publication date: 2013)

Structure of Sindbis virus core protein reveals a chymotrypsin-like serine proteinase and the organization of the virion

scientific article

Structure of a closed form of human malic enzyme and implications for catalytic mechanism

scientific article

Structure of an active human histone pre-mRNA 3'-end processing machinery

scientific article

Structure of histone mRNA stem-loop, human stem-loop binding protein, and 3'hExo ternary complex

scientific article

Structure of ras proteins

scientific article

Structure of the Arabidopsis thaliana TOP2 oligopeptidase

scientific article

Structure of the DNA-binding and RNA-polymerase-binding region of transcription antitermination factor λQ.

scientific article published on 16 January 2014

Structure solution of a cubic crystal of concanavalin A complexed with methyl α-D-glucopyranoside

scientific article published on 01 January 1996

Structure-Guided Functional Characterization of Enediyne Self-Sacrifice Resistance Proteins, CalU16 and CalU19

scientific article

Structures of 5'-3' Exoribonucleases

scientific article published on 29 September 2012

Structures of human phosphofructokinase-1 and atomic basis of cancer-associated mutations

scientific article published on 18 May 2015

Target highlights in CASP9: Experimental target structures for the critical assessment of techniques for protein structure prediction

scientific article

The 1.7 Å resolution structure of At2g44920, a pentapeptide-repeat protein in the thylakoid lumen of Arabidopsis thaliana

scientific article

The Cytoplasmic Domain of Rat Synaptotagmin I Enhances Synaptic Transmission

article

The N-terminal domains of FLASH and Lsm11 form a 2:1 heterotrimer for histone pre-mRNA 3'-end processing

scientific article published on 11 October 2017

The RAS-Binding Domain of Human BRAF Protein Serine/Threonine Kinase Exhibits Allosteric Conformational Changes upon Binding HRAS

scientific article

The cyclic dinucleotide c-di-AMP is an allosteric regulator of metabolic enzyme function

scientific article

The locked rotation function

scientific article published on 01 October 1990

The structure determination of Sindbis virus core protein using isomorphous replacement and molecular replacement averaging between two crystal forms

scientific article published on 01 July 1992

The structure of human ubiquitin in 2-methyl-2,4-pentanediol: A new conformational switch

scientific article

The use of in situ proteolysis in the crystallization of murine CstF-77.

scientific article published on 27 January 2007

The yeast regulator of transcription protein Rtr1 lacks an active site and phosphatase activity ⬇️

scientific article published on July 10, 2012

Three structural representatives of the PF06855 protein domain family from Staphyloccocus aureus and Bacillus subtilis have SAM domain-like folds and different functions ⬇️

scientific article published on July 29, 2012

Two poplar methyl salicylate esterases display comparable biochemical properties but divergent expression patterns

scientific article published on 10 January 2009

Use of a synthetic salicylic acid analog to investigate the roles of methyl salicylate and its esterases in plant disease resistance

scientific article published on 8 January 2009

WASH maintains NKp46+ ILC3 cells by promoting AHR expression

scientific article

X-ray crystal structures of transforming p21 ras mutants suggest a transition-state stabilization mechanism for GTP hydrolysis ⬇️

scientific article published on April 15, 1992

c-di-AMP modulates Listeria monocytogenes central metabolism to regulate growth, antibiotic resistance and osmoregulation

scientific article published on 18 January 2017

ras oncogene proteins: three-dimensional structures, functional implications, and a model for signal transducer.

scientific article published in January 1988

Paulina is supported by:

About Paulina

Help