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List of works by Klaus Aktories

A bacterial toxin catalyzing tyrosine glycosylation of Rho and deamidation of Gq and Gi proteins

scientific article

A cell-permeable fusion toxin as a tool to study the consequences of actin-ADP-ribosylation caused by the salmonella enterica virulence factor SpvB in intact cells

scientific article published on 5 February 2007

A cysteine protease-like domain enhances the cytotoxic effects of the toxin PaTox

scientific article published on 26 November 2018

A syringe-like injection mechanism in Photorhabdus luminescens toxins

scientific article published on 20 March 2013

A systemic Pasteurella multocida toxin aggravates cardiac hypertrophy and fibrosis in mice

scientific article

ADP-ribosylation by Clostridium botulinum C3 exoenzyme increases steady-state GTPase activities of recombinant rhoA and rhoB proteins

scientific article published on 01 February 1992

ADP-ribosylation of rho proteins is inhibited by melittin, mast cell degranulating peptide and compound 48/80

scientific article published on May 12, 1992

ADP-ribosylation of small GTP-binding proteins by Bacillus cereus

scientific article published on March 31, 1992

Actin as target for modification by bacterial protein toxins

scientific article published on 04 May 2011

Action of Pasteurella multocida toxin depends on the helical domain of Galphaq

scientific article

Action of Pasteurella multocida toxin on Galpha(q) is persistent and independent of interaction with G-protein-coupled receptors

scientific article published on 29 June 2007

Activation of Galpha (i) and subsequent uncoupling of receptor-Galpha(i) signaling by Pasteurella multocida toxin

scientific article

Activation of RhoA,B,C by Yersinia Cytotoxic Necrotizing Factor (CNFy) induces apoptosis in LNCaP prostate cancer cells

scientific article published on 21 November 2013

Activation of human neutrophils by mastoparan. Reorganization of the cytoskeleton, formation of phosphatidylinositol 3,4,5-trisphosphate, secretion up-regulation of complement receptor type 3 and superoxide anion production are stimulated by mastopa ⬇️

scientific article published on March 1, 1992

Activation of phospholipase D1 by ADP-ribosylated RhoA

scientific article (publication date: 28 February 2003)

Adenosine receptor-mediated stimulation of GTP hydrolysis in adipocyte membranes ⬇️

scientific article published on January 18, 1982

Adenylate cyclase inhibition and GTPase stimulation by somatostatin in S49 lymphoma cyc− variants are prevented by islet-activating protein ⬇️

scientific article published on July 11, 1983

Adrenergic Repression of the Epigenetic Reader MeCP2 Facilitates Cardiac Adaptation in Chronic Heart Failure

scientific article

Agents That Inhibit Rho, Rac, and Cdc42 Do Not Block Formation of Actin Pedestals in HeLa Cells Infected with Enteropathogenic Escherichia coli ⬇️

scientific article published on April 1, 1998

Amino acid residues involved in membrane insertion and pore formation of Clostridium botulinum C2 toxin

scientific article published on 18 July 2008

Aminoacyl-tRNA-charged eukaryotic elongation factor 1A is the bona fide substrate for Legionella pneumophila effector glucosyltransferases

scientific article

Anion secretion evoked by Pasteurella multocida toxin across rat colon

scientific article

Auranofin Inhibits the Enzyme Activity of Pasteurella multocida Toxin PMT in Human Cells and Protects Cells from Intoxication

scientific article published on 13 January 2017

Auto-ADP-ribosylation of Pseudomonas aeruginosa ExoS.

scientific article published on 30 January 2002

Autocatalytic processing of Clostridium difficile toxin B. Binding of inositol hexakisphosphate

scientific article

Autoregulatory control of actin synthesis in cultured rat hepatocytes ⬇️

scientific article published on July 29, 1991

Bacillus sphaericus mosquitocidal toxin (MTX) and pierisin: the enigmatic offspring from the family of ADP-ribosyltransferases

scientific article published on November 2006

Bacterial Cytotoxins Target Rho GTPases ⬇️

scientific article published on 01 June 1998

Bacterial cytotoxins: targeting eukaryotic switches

scientific article

Bacterial glycosyltransferase toxins

scientific article published on 07 October 2015

Bacterial protein toxins that modify host regulatory GTPases ⬇️

scientific article published on June 16, 2011

Bacterial toxin and effector glycosyltransferases

scientific article published on 30 July 2009

Bacterial toxins that modify the actin cytoskeleton

scientific article

Bidirectional attack on the actin cytoskeleton. Bacterial protein toxins causing polymerization or depolymerization of actin

scientific article published on 19 April 2012

Binary bacterial toxins: biochemistry, biology, and applications of common Clostridium and Bacillus proteins

scientific article

C3 exoenzymes, novel insights into structure and action of Rho-ADP-ribosylating toxins

scientific article published on 5 December 2006

C3stau, a new member of the family of C3-like ADP-ribosyltransferases ⬇️

scientific article published on 01 January 2002

Cell-free synthesis and characterization of a novel cytotoxic pierisin-like protein from the cabbage butterfly Pieris rapae

scientific article published on 26 November 2010

Cellular uptake of Clostridium botulinum C2 toxin requires oligomerization and acidification

scientific article

Cellular uptake of Clostridium botulinum C2 toxin: membrane translocation of a fusion toxin requires unfolding of its dihydrofolate reductase domain

scientific article published in December 2003

Cellular uptake of Clostridium difficile toxin B. Translocation of the N-terminal catalytic domain into the cytosol of eukaryotic cells

scientific article

Change in substrate specificity of cytotoxic necrotizing factor unmasks proteasome-independent down-regulation of constitutively active RhoA.

scientific article published on 12 February 2007

Change of the donor substrate specificity of Clostridium difficile toxin B by site-directed mutagenesis

scientific article

Channel formation by the binding component of Clostridium botulinum C2 toxin: glutamate 307 of C2II affects channel properties in vitro and pH-dependent C2I translocation in vivo

scientific article published on May 2003

Characterization of the Catalytic Site of the ADP-Ribosyltransferase Clostridium botulinum C2 Toxin by Site-directed Mutagenesis ⬇️

scientific article published on 01 November 1998

Characterization of the glucosyltransferase activity of Legionella pneumophila effector SetA

scientific article published on 17 September 2018

Chimeric Clostridial Cytotoxins: Identification of the N-Terminal Region Involved in Protein Substrate Recognition ⬇️

scientific article published on March 1, 1998

Cholesterol- and sphingolipid-rich microdomains are essential for microtubule-based membrane protrusions induced by Clostridium difficile transferase (CDT).

scientific article published on 25 June 2011

Cholesterol-dependent pore formation of Clostridium difficile toxin A.

scientific article published on 2 March 2006

Cleavage of Escherichia coli cytotoxic necrotizing factor 1 is required for full biologic activity

scientific article

Clostridial glucosylating toxins enter cells via clathrin-mediated endocytosis

scientific article

Clostridium botulinum C2 toxin--new insights into the cellular up-take of the actin-ADP-ribosylating toxin

scientific article published on April 2004

Clostridium botulinum C2 toxin. Identification of the binding site for chloroquine and related compounds and influence of the binding site on properties of the C2II channel

scientific article published on 11 December 2007

Clostridium botulinum C2 toxin: low pH-induced pore formation is required for translocation of the enzyme component C2I into the cytosol of host cells

scientific article published on 17 July 2003

Clostridium difficile Toxin Biology

scientific article published on 28 June 2017

Clostridium difficile binary toxin CDT induces clustering of the lipolysis-stimulated lipoprotein receptor into lipid rafts

scientific article published on 30 April 2013

Clostridium difficile binary toxin CDT: mechanism, epidemiology, and potential clinical importance

scientific article

Clostridium difficile glucosyltransferase toxin B-essential amino acids for substrate binding

scientific article published on 27 September 2007

Clostridium difficile toxin B inhibits carbachol‐induced force and myosin light chain phosphorylation in guinea‐pig smooth muscle: role of Rho proteins ⬇️

scientific article published on January 1, 1998

Clostridium difficile toxin CDT hijacks microtubule organization and reroutes vesicle traffic to increase pathogen adherence

scientific article

Clostridium difficile toxin CDT induces formation of microtubule-based protrusions and increases adherence of bacteria

scientific article (publication date: October 2009)

Conformational changes and reaction of clostridial glycosylating toxins

scientific article

Cryo-EM structure of the fully-loaded asymmetric anthrax lethal toxin in its heptameric pre-pore state

scientific article published on 18 August 2020

Crystal structure of the C3bot-RalA complex reveals a novel type of action of a bacterial exoenzyme

scientific article

Crystal structure of the Clostridium limosum C3 exoenzyme

scientific article

Cyclophilin-facilitated membrane translocation as pharmacological target to prevent intoxication of mammalian cells by binary clostridial actin ADP-ribosylated toxins

scientific article

Cytotoxic Necrotizing Factors: Rho-Activating Toxins from Escherichia coli

scientific article published on December 2004

Cytotoxic glucosyltransferases of Legionella pneumophila

scientific article published on January 2013

Differential involvement of the actin cytoskeleton in differentiation and mitogenesis of thyroid cells: inactivation of Rho proteins contributes to cyclic adenosine monophosphate-dependent gene expression but prevents mitogenesis

scientific article published on 25 August 2005

Disturbing Gtp-Binding Protein Function Through Microinjection Into The Visual Cell Of Limulus ⬇️

scientific article published on 01 November 1992

Diverse effects of RacV12 on cell transformation by Raf: partial inhibition of morphological transformation versus deregulation of cell cycle control

scientific article

Domain organization of Legionella effector SetA.

scientific article published on 21 February 2012

EGA Protects Mammalian Cells from Clostridium difficile CDT, Clostridium perfringens Iota Toxin and Clostridium botulinum C2 Toxin

scientific article published on April 2016

Effector glycosyltransferases in legionella

scientific article published on 12 April 2011

Effects of large clostridial cytotoxins on activation of RBL 2H3-hm1 mast cells indicate common and different roles of Rac in FcepsilonRI and M1-receptor signaling

scientific article published in March 2003

EhRho1, a RhoA-like GTPase of Entamoeba histolytica, is modified by clostridial glucosylating cytotoxins

scientific article

Elongation factor 1A is the target of growth inhibition in yeast caused by Legionella pneumophila glucosyltransferase Lgt1.

scientific article published on 8 June 2012

Endoproteolytic processing of RhoA by Rce1 is required for the cleavage of RhoA by Yersinia enterocolitica outer protein T.

scientific article published on March 2006

Entrapment of Rho ADP-ribosylated by Clostridium botulinum C3 exoenzyme in the Rho-guanine nucleotide dissociation inhibitor-1 complex

scientific article published on 15 May 2003

Epinephrine inhibits adenylate cyclase and stimulates a GTPase in human platelet membranes vis α-adrenoceptors ⬇️

scientific article published on 01 August 1981

Exchange of glutamine-217 to glutamate of Clostridium limosum exoenzyme C3 turns the asparagine-specific ADP-ribosyltransferase into an arginine-modifying enzyme

scientific article published on January 2006

Fast neurotransmitter release regulated by the endocytic scaffold intersectin ⬇️

scientific article published on 30 April 2013

Formation of Nanotube-Like Protrusions, Regulation of Septin Organization and Re-guidance of Vesicle Traffic by Depolymerization of the Actin Cytoskeleton Induced by Binary Bacterial Protein Toxins

scientific article

From cosubstrate similarity to inhibitor diversity--inhibitors of ADP-ribosyltransferases from kinase inhibitor screening

scientific article

Functional characterization of an extended binding component of the actin-ADP-ribosylating C2 toxin detected in Clostridium botulinum strain (C) 2300.

scientific article

G13-dependent activation of MAPK by thyrotropin

scientific article

GTP-dependent inhibition of cardiac adenylate cyclase by muscarinic cholinergic agonists ⬇️

scientific article published on 01 December 1979

Gene expression of the small GTP-binding proteins RhoA, RhoB, Rac1, and Cdc42 in adult rat brain ⬇️

scientific article published on December 15, 1997

Glucosylation of Ras by Clostridium sordellii lethal toxin: consequences for effector loop conformations observed by NMR spectroscopy

scientific article published in October 2003

Hijacking of Rho GTPases during bacterial infection ⬇️

scientific article published on 03 May 2013

His1205 and His1223 are essential for the activity of the mitogenic Pasteurella multocida toxin

scientific article

Hsp70 facilitates trans-membrane transport of bacterial ADP-ribosylating toxins into the cytosol of mammalian cells

scientific article

Human alpha-defensins inhibit Clostridium difficile toxin B.

scientific article published on 10 March 2008

Identification of the cellular receptor of Clostridium spiroforme toxin

scientific article published on 17 January 2012

In vivo and in vitro desensitization of nicotinic acid-induced adipocyte adenylate cyclase inhibition ⬇️

scientific article published on February 1, 1982

Inactivation of the elongation factor Tu by mosquitocidal toxin-catalyzed mono-ADP-ribosylation

scientific article

Inactivation of the guanine nucleotide regulatory site mediating inhibition of the adenylate cyclase in hamster adipocytes ⬇️

scientific article published on 01 December 1982

Influence of Clostridium botulinum C2 toxin on FcɛRI-mediated secretion and tyrosine phosphorylation in RBL cells ⬇️

scientific article published on 01 March 1998

Inhibition of Rac GTPase triggers a c-Jun- and Bim-dependent mitochondrial apoptotic cascade in cerebellar granule neurons

scientific article

Inhibition of hamster fat cell adenylate cyclase by prostaglandin E1and epinephrine: Requirement for GTP and sodium ions ⬇️

scientific article published on November 1, 1979

Inhibition of the glucosyltransferase activity of clostridial Rho/Ras-glucosylating toxins by castanospermine

scientific article

Inhibitory Coupling of Hormone and Neurotransmitter Receptors to Adenylate Cyclase ⬇️

scientific article published on January 1, 1983

Inositol hexakisphosphate-dependent processing of Clostridium sordellii lethal toxin and Clostridium novyi alpha-toxin

scientific article published on 8 March 2011

Insecticidal Toxin Complexes from Photorhabdus luminescens

scientific article published on 24 February 2017

Insecticidal toxin complex proteins from Xenorhabdus nematophilus: structure and pore formation

scientific article published on 28 April 2011

Integrins and adhesion molecules: Tumour necrosis factor-α-mediated dyscohesion of epithelial cells is associated with disordered expression of cadherin/β-catenin and disassembly of actin filaments ⬇️

scientific article published on 01 April 1995

Interaction of the Clostridium difficile Binary Toxin CDT and Its Host Cell Receptor, Lipolysis-stimulated Lipoprotein Receptor (LSR).

scientific article

Interaction of the Rho-ADP-ribosylating C3 exoenzyme with RalA.

scientific article published on 14 February 2002

Intracellular plasma membrane guidance of Photorhabdus asymbiotica toxin is crucial for cell toxicity

scientific article published on 17 March 2015

Inverse control of Rab proteins by Yersinia ADP-ribosyltransferase and glycosyltransferase related to clostridial glucosylating toxins

scientific article published on 11 March 2020

Involvement of Osteocytes in the Action of Toxin

scientific article published on 13 August 2018

Islet-activating protein impairs ? 2-adrenoceptor-mediated inhibitory regulation of human platelet adenylate cyclase ⬇️

scientific article published on November 1, 1983

Islet-activating protein prevents nicotinic acid-induced GTPase stimulation and GTP but not GTPγS-induced adenylate cyclase inhibition in rat adipocytes ⬇️

scientific article published on May 30, 1983

Islet‐activating protein discriminates the antilipolytic mechanism of insulin from that of other antilipolytic compounds ⬇️

scientific article published on 01 September 1983

Isotype-specific degradation of Rac activated by the cytotoxic necrotizing factor 1.

scientific article

LRP1 is a receptor for Clostridium perfringens TpeL toxin indicating a two-receptor model of clostridial glycosylating toxins

scientific article

Large clostridial cytotoxins: cellular biology of Rho/Ras-glucosylating toxins

scientific article published in July 2004

Legionella pneumophila glucosyltransferase inhibits host elongation factor 1A.

scholarly article

Lgt: a family of cytotoxic glucosyltransferases produced by Legionella pneumophila

scientific article published on 15 February 2008

Lipolysis-stimulated lipoprotein receptor (LSR) is the host receptor for the binary toxin Clostridium difficile transferase (CDT)

scientific article

Localization of the C3-Like ADP-ribosyltransferase from Staphylococcus aureus during bacterial invasion of mammalian cells

scientific article published on June 2006

Loss of LSR affects epithelial barrier integrity and tumor xenograft growth of CaCo-2 cells

scientific article published on 6 July 2016

Lu/BCAM adhesion glycoprotein is a receptor for Escherichia coli Cytotoxic Necrotizing Factor 1 (CNF1)

scientific article

Mechanism of C2-toxin inhibition by fluphenazine and related compounds: investigation of their binding kinetics to the C2II-channel using the current noise analysis

scientific article published on October 2003

Mechanism of Tc toxin action revealed in molecular detail

scientific article

Mechanism of pertussis toxin action on the adenylate cyclase system. Inhibition of the turn-on reaction of the inhibitory regulatory site ⬇️

scientific article published on 01 April 1984

Mechanisms of the cytopathic action of actin-ADP-ribosylating toxins

scientific article published on October 1, 1992

Membrane translocation of binary actin-ADP-ribosylating toxins from Clostridium difficile and Clostridium perfringens is facilitated by cyclophilin A and Hsp90.

scientific article published on 18 July 2011

Modification of plant Rac/Rop GTPase signalling using bacterial toxin transgenes

scientific article

Modulation of host cell gene expression through activation of STAT transcription factors by Pasteurella multocida toxin

scientific article published on 6 December 2006

Molecular biology of Pasteurella multocida toxin

scientific article published on January 2012

Molecular characteristics of Clostridium perfringens TpeL toxin and consequences of mono-O-GlcNAcylation of Ras in living cells

scientific article published on 4 June 2012

Na+ amplifies adenosine receptor-mediated inhibition of adipocyte adenylate cyclase ⬇️

scientific article published on April 24, 1981

Neuronal apoptosis induced by selective inhibition of Rac GTPase versus global suppression of Rho family GTPases is mediated by alterations in distinct mitogen-activated protein kinase signaling cascades

scientific article

New insights into the mode of action of the actin ADP-ribosylating virulence factors Salmonella enterica SpvB and Clostridium botulinum C2 toxin

scientific article published on 17 January 2011

Noncanonical G-protein-dependent modulation of osteoclast differentiation and bone resorption mediated by Pasteurella multocida toxin

scientific article

Novel bacterial ADP-ribosylating toxins: structure and function

scientific article published on 14 July 2014

Novel receptors for bacterial protein toxins

scientific article

Pasteurella multocida toxin activates Gbetagamma dimers of heterotrimeric G proteins

scientific article

Pasteurella multocida toxin activates various heterotrimeric G proteins by deamidation

scientific article published on 28 January 2010

Pasteurella multocida toxin activation of heterotrimeric G proteins by deamidation

scholarly article

Pasteurella multocida toxin as a transporter of non-cell-permeating proteins

scientific article published on 29 April 2013

Pasteurella multocida toxin is a potent activator of anti-apoptotic signalling pathways

scientific article published on 12 March 2010

Pasteurella multocida toxin prevents osteoblast differentiation by transactivation of the MAP-kinase cascade via the Gα(q/11)--p63RhoGEF--RhoA axis

scientific article

Pasteurella multocida toxin-induced activation of RhoA is mediated via two families of G{alpha} proteins, G{alpha}q and G{alpha}12/13.

scientific article published in September 2005

Phenylalanine-427 of anthrax protective antigen functions in both pore formation and protein translocation

scholarly article

Photorhabdus luminescens Tc toxin is inhibited by the protease inhibitor MG132 and activated by protease cleavage resulting in increased binding to target cells

scientific article published on 02 December 2018

Photorhabdus luminescens toxins ADP-ribosylate actin and RhoA to force actin clustering

scientific article

Photorhabdus luminescens toxins TccC3 and TccC5: insecticidal ADP-ribosyltransferases that modify threonine and glutamine

scientific article

Pleiotropic role of Rac in mast cell activation revealed by a cell permeable Bordetella dermonecrotic fusion toxin

scientific article

Processing of Clostridium difficile toxins

scientific article published on June 2008

Proteasomal degradation of cytotoxic necrotizing factor 1-activated rac.

scientific article published on August 2002

Protein glutaminylation is a yeast-specific posttranslational modification of elongation factor 1A.

scientific article published on 11 August 2017

Purification and activity of the Rho ADP-ribosylating binary C2/C3 toxin

scientific article published in January 2006

Rac and Cdc42 play distinct roles in regulating PI(3,4,5)P3 and polarity during neutrophil chemotaxis

scientific article

Rac1 and Cdc42 but not RhoA or Rho kinase activities are required for neurite outgrowth induced by the Netrin-1 receptor DCC (deleted in colorectal cancer) in N1E-115 neuroblastoma cells

scientific article

Receptor-Binding and Uptake of Binary Actin-ADP-Ribosylating Toxins

scientific article published on 6 November 2016

RecombinantYersiniaYopT Leads to Uncoupling of RhoA-Effector Interaction ⬇️

scientific article published on December 1, 2001

Region of elongation factor 1A1 involved in substrate recognition by Legionella pneumophila glucosyltransferase Lgt1: identification of Lgt1 as a retaining glucosyltransferase

scientific article published on 28 May 2009

Rho GTPases and phosphoinositide 3-kinase organize formation of branched dendrites

scientific article published on 24 October 2003

Rho inhibits cAMP-induced translocation of aquaporin-2 into the apical membrane of renal cells ⬇️

scientific article published on December 1, 2001

Rho proteins: Targets for bacterial toxins ⬇️

scientific article published on July 1, 1997

Rho-glucosylating Clostridium difficile toxins A and B: new insights into structure and function

scientific article

Rho-modifying bacterial protein toxins

scientific article published on 09 October 2015

Rho-modifying bacterial protein toxins from Photorhabdus species

scientific article published on 28 May 2015

Rho-specific Bacillus cereus ADP-ribosyltransferase C3cer cloning and characterization

scientific article published in August 2003

RhoA exerts a permissive effect on volume-regulated anion channels in vascular endothelial cells

scientific article

RhoA is dispensable for skin development, but crucial for contraction and directed migration of keratinocytes

scientific article

Role of CypA and Hsp90 in membrane translocation mediated by anthrax protective antigen

scientific article

Roles of Asp179 and Glu270 in ADP-Ribosylation of Actin by Clostridium perfringens Iota Toxin

scientific article published on 29 December 2015

Salmonella Typhimurium effector SseI inhibits chemotaxis and increases host cell survival by deamidation of heterotrimeric Gi proteins

scientific article published on 13 August 2018

Salmonella enterica SpvB ADP-ribosylates actin at position arginine-177-characterization of the catalytic domain within the SpvB protein and a comparison to binary clostridial actin-ADP-ribosylating toxins

scientific article published in January 2006

Selection of nanobodies that block the enzymatic and cytotoxic activities of the binary Clostridium difficile toxin CDT

scientific article published on 19 January 2015

Semaphorins or Frizzled -it is the receptor that direct the action of clostridial glucosylating toxins

scientific article published on 19 September 2020

Septins guide microtubule protrusions induced by actin-depolymerizing toxins like Clostridium difficile transferase (CDT).

scientific article published on 23 June 2016

Signal transducer and activator of transcription-5 mediates neuronal apoptosis induced by inhibition of Rac GTPase activity

scientific article

Signal transformation mediated by membrane receptors for hormones and neurotransmitters ⬇️

scientific article published on October 1, 1982

Strain-alleviation model of ADP-ribosylation

scientific article published on March 2013

Structural basis for the function of Clostridium difficile toxin B.

scientific article

Structural basis of the action of glucosyltransferase Lgt1 from Legionella pneumophila

scientific article

Structural determinants for membrane insertion, pore formation and translocation of Clostridium difficile toxin B

scientific article published in 2012

Structural determinants for membrane insertion, pore formation and translocation of Clostridium difficile toxin B.

scientific article published on 28 January 2011

Structure and mode of action of a mosquitocidal holotoxin

scientific article

Structure and mode of action of clostridial glucosylating toxins: the ABCD model

scientific article

Structure of the mosquitocidal toxin from Bacillus sphaericus

scientific article published on 27 January 2006

Structure-function analysis of the Rho-ADP-ribosylating exoenzyme C3stau2 from Staphylococcus aureus

scientific article published in February 2002

Substrate specificity of Pasteurella multocida toxin for α subunits of heterotrimeric G proteins

scientific article published on 12 November 2012

Tailored cyclodextrin pore blocker protects mammalian cells from clostridium difficile binary toxin CDT.

scientific article published on 15 July 2014

Targeting of the actin cytoskeleton by insecticidal toxins from Photorhabdus luminescens

scientific article published on 12 November 2010

TcdA1 of Photorhabdus luminescens: electrophysiological analysis of pore formation and effector binding

scientific article published on July 2013

The ADP-ribosylating mosquitocidal toxin from Bacillus sphaericus: proteolytic activation, enzyme activity, and cytotoxic effects

scientific article published on 25 January 2002

The C terminus of YopT is crucial for activity and the N terminus is crucial for substrate binding

scientific article

The C terminus of component C2II of Clostridium botulinum C2 toxin is essential for receptor binding

scientific article

The Escherichia coli effector EspJ blocks Src kinase activity via amidation and ADP ribosylation

scientific article published on 19 December 2014

The Hsp90 machinery facilitates the transport of diphtheria toxin into human cells

scientific article

The Legionella effector LtpM is a new type of phosphoinositide-activated glucosyltransferase

scientific article published on 20 December 2018

The N-Terminal Part of the Enzyme Component (C2I) of the Binary Clostridium botulinum C2 Toxin Interacts with the Binding Component C2II and Functions as a Carrier System for a Rho ADP-Ribosylating C3-Like Fusion Toxin ⬇️

scientific article published on April 1, 1998

The Yersinia pseudotuberculosis cytotoxic necrotizing factor (CNFY) selectively activates RhoA.

scientific article published on 3 February 2004

The binary Clostridium botulinum C2 toxin as a protein delivery system: identification of the minimal protein region necessary for interaction of toxin components

scientific article published on 6 December 2001

The binary toxin CDT enhances Clostridium difficile virulence by suppressing protective colonic eosinophilia

scientific article

The chaperone Hsp90 and PPIases of the cyclophilin and FKBP families facilitate membrane translocation of Photorhabdus luminescens ADP-ribosyltransferases

scientific article published on 5 November 2013

The chaperonin TRiC/CCT is essential for the action of bacterial glycosylating protein toxins like Clostridium difficile toxins A and B

scientific article published on 04 September 2018

The cytotoxic necrotizing factors from Yersinia pseudotuberculosis and from Escherichia coli bind to different cellular receptors but take the same route to the cytosol

scientific article published on 16 April 2007

The haematopoietic GTPase RhoH modulates IL3 signalling through regulation of STAT activity and IL3 receptor expression

scientific article published on 25 August 2010

The hamster adipocyte adenylate cyclase system II. Regulation of enzyme stimulation and inhibition by monovalent cations ⬇️

scientific article published on 01 August 1981

The host cell chaperone Hsp90 is essential for translocation of the binary Clostridium botulinum C2 toxin into the cytosol

scientific article published on 12 June 2003

The host cell chaperone Hsp90 is necessary for cytotoxic action of the binary iota-like toxins

scientific article

The priority program Signal Pathways to the Cytoskeleton and Bacterial Pathogenesis (SPP1150) ⬇️

scientific article published on July 29, 2011

The uptake machinery of clostridial actin ADP-ribosylating toxins--a cell delivery system for fusion proteins and polypeptide drugs

scientific article

Thiol-modifying phenylarsine oxide inhibits guanine nucleotide binding of Rho but not of Rac GTPases

scientific article

Toxin-induced RhoA activity mediates CCL1-triggered signal transducers and activators of transcription protein signaling

scientific article published on 6 February 2012

Two-site autoinhibition of the ADP-ribosylating mosquitocidal toxin (MTX) from Bacillus sphaericus by its 70-kDa ricin-like binding domain

scientific article published in September 2004

Tyrosine glycosylation of Rho by Yersinia toxin impairs blastomere cell behaviour in zebrafish embryos

scientific article

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