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List of works by Gordon M. Keller

A Quantitative Proteomic Analysis of Hemogenic Endothelium Reveals Differential Regulation of Hematopoiesis by SOX17.

scientific article published on August 2015

A common precursor for primitive erythropoiesis and definitive haematopoiesis

scientific article (publication date: 3 April 1997)

A temporal chromatin signature in human embryonic stem cells identifies regulators of cardiac development

scientific article published on 11 September 2012

A view of human haematopoietic development from the Petri dish

scientific article published on 23 November 2016

Acceleration of mesoderm development and expansion of hematopoietic progenitors in differentiating ES cells by the mouse Mix-like homeodomain transcription factor

scientific journal article

Alternative induced pluripotent stem cell characterization criteria for in vitro applications

scientific article published on 01 March 2009

An endothelial cell niche induces hepatic specification through dual repression of Wnt and Notch signaling

scientific article

Ankrd11 is a chromatin regulator involved in autism that is essential for neural development

scientific article published on 31 December 2014

Ankrd11 is a chromatin regulator involved in autism that is essential for neural development

scientific article published on 12 June 2015

Apoptosis in human glioblastoma cells produced using embryonic stem cell-derived astrocytes expressing tumor necrosis factor-related apoptosis-inducing ligand

scientific article

Autonomous beating rate adaptation in human stem cell-derived cardiomyocytes

scientific article

BMP-4 is required for hepatic specification of mouse embryonic stem cell-derived definitive endoderm

scientific article published on 5 November 2006

Biodegradable scaffold with built-in vasculature for organ-on-a-chip engineering and direct surgical anastomosis

scientific article published on 07 March 2016

Biophysical properties of slow potassium channels in human embryonic stem cell derived cardiomyocytes implicate subunit stoichiometry

scientific article

Biowire: a platform for maturation of human pluripotent stem cell-derived cardiomyocytes

scientific article published on 23 June 2013

Clonal generation of multipotent and unipotent hemopoietic blast cell colonies in vitro

scientific article published on 01 July 1984

Committing embryonic stem cells to differentiate into thyrocyte-like cells in vitro

scientific article published in June 2003

Committing embryonic stem cells to early endocrine pancreas in vitro

scientific article published in January 2004

Comparison of Human Embryonic Stem Cell-Derived Cardiomyocytes, Cardiovascular Progenitors, and Bone Marrow Mononuclear Cells for Cardiac Repair

scientific article

Defined Engineered Human Myocardium With Advanced Maturation for Applications in Heart Failure Modeling and Repair.

scientific article published on 6 February 2017

Defining the path to hematopoietic stem cells

scientific article published on 01 May 2013

Design and formulation of functional pluripotent stem cell-derived cardiac microtissues

scientific article

Development and function of myeloid-derived suppressor cells generated from mouse embryonic and hematopoietic stem cells

scientific article

Development of definitive endoderm from embryonic stem cells in culture

scientific article published on 3 March 2004

Development of the hemangioblast defines the onset of hematopoiesis in human ES cell differentiation cultures

scientific article published on April 2007

Development of the hematopoietic system in the mouse.

scientific article

Developmental regulation of yolk sac hematopoiesis by Kruppel-like factor 6

scientific article published on 18 October 2005

Differential long-term and multilineage engraftment potential from subfractions of human CD34+ cord blood cells transplanted into NOD/SCID mice

scientific article

Differentiation of embryonic stem cells to clinically relevant populations: lessons from embryonic development

scientific article (publication date: 22 February 2008)

Directed differentiation of cholangiocytes from human pluripotent stem cells

scientific article published on 13 July 2015

Directed differentiation of hematopoietic precursors and functional osteoclasts from human ES and iPS cells

scientific article

Directed differentiation of mouse embryonic stem cells into thyroid follicular cells.

scientific article

Directed differentiation of pluripotent stem cells: from developmental biology to therapeutic applications.

scientific article published on January 2008

Distinct roles of microRNA-1 and -499 in ventricular specification and functional maturation of human embryonic stem cell-derived cardiomyocytes

scientific article (publication date: 2011)

Ductal pancreatic cancer modeling and drug screening using human pluripotent stem cell- and patient-derived tumor organoids

scientific article

Dynamic and coordinated epigenetic regulation of developmental transitions in the cardiac lineage

scientific article published on 12 September 2012

Efficient generation of NKX6-1+ pancreatic progenitors from multiple human pluripotent stem cell lines

scientific article

Embryonic stem cell differentiation: emergence of a new era in biology and medicine

scientific article

Embryonic stem cell-derived astrocytes expressing drug-inducible transgenes: differentiation and transplantion into the mouse brain

scientific article

Enhanced proapoptotic effects of tumor necrosis factor-related apoptosis-inducing ligand on temozolomide-resistant glioma cells

scientific article

Enzymatically degradable poly(ethylene glycol) hydrogels for the 3D culture and release of human embryonic stem cell derived pancreatic precursor cell aggregates

scientific article published on 22 April 2015

Evolutionarily conserved intercalated disc protein Tmem65 regulates cardiac conduction and connexin 43 function

scientific article

Expression of Fc gamma RIII defines distinct subpopulations of fetal liver B cell and myeloid precursors

scientific article published on 01 August 1995

Expression of a foreign gene in myeloid and lymphoid cells derived from multipotent haematopoietic precursors.

scientific article published in November 1985

Expression of a gene encoding a unique protein-tyrosine kinase within specific fetal- and adult-derived hematopoietic lineages.

scientific article

Expression of v-src induces a myeloproliferative disease in bone-marrow-reconstituted mice

scientific article published on 01 June 1989

FOXO1 is an essential regulator of pluripotency in human embryonic stem cells

scientific article

FZD4 Marks Lateral Plate Mesoderm and Signals with NORRIN to Increase Cardiomyocyte Induction from Pluripotent Stem Cell-Derived Cardiac Progenitors

scientific article published on 13 December 2017

Fetal reprogramming and senescence in hypoplastic left heart syndrome and in human pluripotent stem cells during cardiac differentiation

scientific article published on 17 July 2013

Gene delivery by embryonic stem cells for malignant glioma therapy: hype or hope?

scientific article published on 11 September 2008

Generation of anterior foregut endoderm from human embryonic and induced pluripotent stem cells.

scientific article published on 27 February 2011

Generation of articular chondrocytes from human pluripotent stem cells

scientific article published on 11 May 2015

Generation of beta cells from human pluripotent stem cells: Potential for regenerative medicine ⬇️

scientific article published on June 26, 2012

Generation of monoclonal antibodies specific for cell surface molecules expressed on early mouse endoderm

scientific article

Generation of purified stromal cell cultures that support lymphoid and myeloid precursors

scientific article published on 01 May 1986

Generation of the epicardial lineage from human pluripotent stem cells

scientific article

Germ layer induction from embryonic stem cells.

scientific article

Haemangioblast commitment is initiated in the primitive streak of the mouse embryo

scientific article (publication date: 2 December 2004)

Haematopoietic stem and progenitor cells from human pluripotent stem cells.

scientific article published on 17 May 2017

Haploinsufficiency of Runx1 results in the acceleration of mesodermal development and hemangioblast specification upon in vitro differentiation of ES cells

scientific article published on 2 October 2003

Hedgehog inhibits β-catenin activity in synovial joint development and osteoarthritis

scientific article published on 28 March 2016

Hematopoietic commitment during embryonic stem cell differentiation in culture

scientific article published on January 1993

Hematopoietic commitment of ES cells in culture

scientific article published in January 2003

Hematopoietic stem cells

scientific article published on 01 April 1992

Hemopoiesis in spleen and bone marrow cultures

scientific article published on 01 July 1983

Hemopoietic colonies on the chorioallantoic membrane of the chick embryo: induction by embryonic, adherent, non-hemopoietic spleen cells

scientific article published on 01 March 1980

Human Pluripotent Stem Cell-Derived Atrial and Ventricular Cardiomyocytes Develop from Distinct Mesoderm Populations

scientific article published in August 2017

Human Stem Cell-Derived Cardiac Model of Chronic Drug Exposure

Human definitive haemogenic endothelium and arterial vascular endothelium represent distinct lineages

scientific article

Human embryonic stem cells: the future is now

scientific article published on 01 February 1999

Hypoxia affects mesoderm and enhances hemangioblast specification during early development

scientific article published on 01 September 2004

INS(GFP/w) human embryonic stem cells facilitate isolation of in vitro derived insulin-producing cells

scientific article

Identification and targeting of the ROSA26 locus in human embryonic stem cells.

scientific article

Identification of a fetal hematopoietic precursor with B cell, T cell, and macrophage potential

scientific article published on 01 December 1998

In vitro differentiation of embryonic stem cells.

scientific article published on December 1995

In vivo detection of embryonic stem cell-derived cardiovascular progenitor cells using Cy3-labeled Gadofluorine M in murine myocardium

scientific article

In vivo gene delivery by embryonic-stem-cell-derived astrocytes for malignant gliomas

scientific article

Induced pluripotent stem cells used to reveal drug actions in a long QT syndrome family with complex genetics

scientific article published on January 2013

Interrogating functional integration between injected pluripotent stem cell-derived cells and surrogate cardiac tissue

scientific article

Introduction of a selectable gene into murine T-lymphoblasts by a retroviral vector.

scientific article published in May 1986

Life span of multipotential hematopoietic stem cells in vivo

scientific article published on May 1990

Looking inwards: opening a window onto human development

scientific article published in January 2015

Mechanical Stress Promotes Maturation of Human Myocardium From Pluripotent Stem Cell-Derived Progenitors

scientific article

Mechanism-based facilitated maturation of human pluripotent stem cell-derived cardiomyocytes

scientific article published on 7 February 2013

Metformin activates an atypical PKC-CBP pathway to promote neurogenesis and enhance spatial memory formation

scientific article

Micro-arrayed human embryonic stem cells-derived cardiomyocytes for in vitro functional assay

scientific article

Microfabricated perfusable cardiac biowire: a platform that mimics native cardiac bundle

scientific article published on March 2014

Modeling Atrial Fibrillation using Human Embryonic Stem Cell-Derived Atrial Tissue

scientific article published on 13 July 2017

Modeling altered T-cell development with induced pluripotent stem cells from patients with RAG1-dependent immune deficiencies.

scientific article published on 14 June 2016

Mouse Mix gene is activated early during differentiation of ES and F9 stem cells and induces endoderm in frog embryos

scientific journal article

Mouse embryonic stem cell-derived embryoid bodies generate progenitors that integrate long term into renal proximal tubules in vivo

scientific article published on 2 May 2007

Multipotent flk-1+ cardiovascular progenitor cells give rise to the cardiomyocyte, endothelial, and vascular smooth muscle lineages

scientific article

New markers for tracking endoderm induction and hepatocyte differentiation from human pluripotent stem cells

scientific article

Notch signaling respecifies the hemangioblast to a cardiac fate

scientific article

Novel insights into erythroid development revealed through in vitro differentiation of GATA-1 embryonic stem cells

scientific journal article

Numb mediates the interaction between Wnt and Notch to modulate primitive erythropoietic specification from the hemangioblast

scientific article

Parthenogenetic stem cells for tissue-engineered heart repair

scientific article

Pdx1 and Ngn3 overexpression enhances pancreatic differentiation of mouse ES cell-derived endoderm population

scientific article (publication date: 2011)

Primitive erythropoiesis is regulated by miR-126 via nonhematopoietic Vcam-1+ cells

scientific article

Production of de novo cardiomyocytes: human pluripotent stem cell differentiation and direct reprogramming

scientific article

Rational bioprocess design for human pluripotent stem cell expansion and endoderm differentiation based on cellular dynamics.

scientific article

Regulated expression and role of c-Myb in the cardiovascular-directed differentiation of mouse embryonic stem cells

scientific article published on 23 November 2011

Rescue of erythroid development in gene targeted GATA-1- mouse embryonic stem cells

scientific journal article

Retinoic acid signaling is essential for embryonic hematopoietic stem cell development

scientific article published in September 2013

Retrovirus transfer of a bacterial gene into mouse haematopoietic progenitor cells.

scientific article published in October 1983

Runx1 is essential for hematopoietic commitment at the hemangioblast stage of development in vitro

scientific article published in July 2002

SCL interacts with VEGF to suppress apoptosis at the onset of hematopoiesis

scientific journal article

SCL/Tal-1 is essential for hematopoietic commitment of the hemangioblast but not for its development

scientific journal article

SIRPA is a specific cell-surface marker for isolating cardiomyocytes derived from human pluripotent stem cells. ⬇️

scientific article published on 23 October 2011

Sequential development of hematopoietic and cardiac mesoderm during embryonic stem cell differentiation

scientific article

Serial in vivo positive contrast MRI of iron oxide-labeled embryonic stem cell-derived cardiac precursor cells in a mouse model of myocardial infarction

scientific article

Serum-free differentiation of functional human coronary-like vascular smooth muscle cells from embryonic stem cells

scientific article published on 4 December 2012

Silent IL2RG Gene Editing in Human Pluripotent Stem Cells.

scientific article

Simple and high yielding method for preparing tissue specific extracellular matrix coatings for cell culture

scientific article

Single cell RNA sequencing of human liver reveals distinct intrahepatic macrophage populations

scientific article published in Nature Communications

Sinoatrial node cardiomyocytes derived from human pluripotent cells function as a biological pacemaker.

scientific article published on 12 December 2016

Site-specific integration of adeno-associated virus involves partial duplication of the target locus.

scientific article

Smad1 expands the hemangioblast population within a limited developmental window

scientific article published on 21 September 2006

Specification of chondrocytes and cartilage tissues from embryonic stem cells

scientific article published in June 2013

Specification of multipotential cardiovascular progenitor cells during embryonic stem cell differentiation and embryonic development

scientific article published on October 2007

Stage-Specific Optimization of Activin/Nodal and BMP Signaling Promotes Cardiac Differentiation of Mouse and Human Pluripotent Stem Cell Lines ⬇️

scientific article (publication date: 4 February 2011)

Stage-specific signaling through TGFβ family members and WNT regulates patterning and pancreatic specification of human pluripotent stem cells.

scientific article published on 26 January 2011

Stem cells and regeneration: a special issue

scientific article

Substrate and mechanotransduction influence SERCA2a localization in human pluripotent stem cell-derived cardiomyocytes affecting functional performance.

scientific article published on 16 October 2017

T lymphocyte potential marks the emergence of definitive hematopoietic progenitors in human pluripotent stem cell differentiation cultures.

scientific article

Targeted disruption of p70s6kdefines its role in protein synthesis and rapamycin sensitivity ⬇️

scientific article published on April 28, 1998

Temporal specification of blood progenitors from mouse embryonic stem cells and induced pluripotent stem cells

scientific article

The cardiomyocyte lineage is critical for optimization of stem cell therapy in a mouse model of myocardial infarction

scientific article

The effect of cyclic stretch on maturation and 3D tissue formation of human embryonic stem cell-derived cardiomyocytes

scientific article published on 11 January 2014

The expression of Sox17 identifies and regulates haemogenic endothelium

scientific article

The functional and molecular characterisation of human embryonic stem cell-derived insulin-positive cells compared with adult pancreatic beta cells

scientific article published on 11 November 2011

The heart LIM protein gene (Hlp), expressed in the developing and adult heart, defines a new tissue-specific LIM-only protein family

scientific article

The homeobox gene HEX regulates proliferation and differentiation of hemangioblasts and endothelial cells during ES cell differentiation

scientific journal article

The homeobox gene Hex regulates hepatocyte differentiation from embryonic stem cell-derived endoderm

scientific article

The in vitro differentiation of mouse embryonic stem cells into neutrophils

scientific article published on January 2003

The in vitro production and characterization of neutrophils from embryonic stem cells

scientific article published on 2 October 2003

Three-dimensional culture and cAMP signaling promote the maturation of human pluripotent stem cell-derived hepatocytes.

scientific article published on August 2013

Tracking mesoderm formation and specification to the hemangioblast in vitro

scientific article

Tracking mesoderm induction and its specification to the hemangioblast during embryonic stem cell differentiation

scientific article

Transforming the promise of pluripotent stem cell-derived cardiomyocytes to a therapy: challenges and solutions for clinical trials

scientific article

Unsuspected role of the brain morphogenetic gene Otx1 in hematopoiesis

scientific article

Wnt and TGF-beta signaling are required for the induction of an in vitro model of primitive streak formation using embryonic stem cells

scholarly article

Wnt signaling controls the specification of definitive and primitive hematopoiesis from human pluripotent stem cells

scientific article

Wnt, activin, and BMP signaling regulate distinct stages in the developmental pathway from embryonic stem cells to blood.

scientific article

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