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List of works by Peter Keightley

A comparison of models to infer the distribution of fitness effects of new mutations

scientific article

A method for inferring the rate of occurrence and fitness effects of advantageous mutations

scientific article published on 27 September 2011

A resolution of the mutation load paradox in humans

scientific article

Analysis and implications of mutational variation.

scientific article published on 29 July 2008

Analysis of the genome sequences of three Drosophila melanogaster spontaneous mutation accumulation lines

scientific article published on 13 May 2009

Assessing Recent Selection and Functionality at Long Noncoding RNA Loci in the Mouse Genome

scientific article

Behavioural genetics: finding genes that cause complex trait variation.

scientific article published in January 2005

Bottleneck Effect on Genetic Variance: A Theoretical Investigation of the Role of Dominance ⬇️

scientific article published on September 1, 1998

Characterization of a QTL affecting skeletal size in mice

scientific article published on 01 March 2003

Comparing analysis methods for mutation-accumulation data

scientific article published on May 2004

Contributions of protein-coding and regulatory change to adaptive molecular evolution in murid rodents

scientific article

Current hypotheses for the evolution of sex and recombination ⬇️

scientific article published on June 1, 2012

DNA sequence error rates in Genbank records estimated using the mouse genome as a reference

scientific article

De Novo Mutation Rate Variation and Its Determinants in Chlamydomonas

scientific article published on 01 August 2021

Detecting positive selection in the genome

scientific article published on 30 October 2017

Direct Estimate of the Spontaneous Mutation Rate Uncovers the Effects of Drift and Recombination in the Chlamydomonas reinhardtii Plastid Genome

scientific article published on 28 November 2015

Direct estimation of per nucleotide and genomic deleterious mutation rates in Drosophila

scientific article

Direct estimation of the mitochondrial DNA mutation rate in Drosophila melanogaster

scientific article

Distributions of selectively constrained sites and deleterious mutation rates in the hominid and murid genomes.

scientific article published in January 2010

Effect of divergence time and recombination rate on molecular evolution of Drosophila INE-1 transposable elements and other candidates for neutrally evolving sites.

scientific article published on 25 September 2007

Effect of the assignment of ancestral CpG state on the estimation of nucleotide substitution rates in mammals

scientific article

Enhanced CpG mutability and tumorigenesis in MBD4-deficient mice.

scientific article

Estimate of the spontaneous mutation rate in Chlamydomonas reinhardtii

scientific article published on 10 October 2012

Estimating numbers of EMS-induced mutations affecting life history traits in Caenorhabditis elegans in crosses between inbred sublines

scientific article published on 01 December 2003

Estimating the rate of adaptive molecular evolution in the presence of slightly deleterious mutations and population size change

scientific article published on 17 June 2009

Estimating the rate of adaptive molecular evolution when the evolutionary divergence between species is small

scientific article

Estimation of the spontaneous mutation rate in Heliconius melpomene

scientific article

Estimation of the spontaneous mutation rate per nucleotide site in a Drosophila melanogaster full-sib family.

scientific article

Evidence for pervasive adaptive protein evolution in wild mice

scientific article

Evidence for widespread degradation of gene control regions in hominid genomes

scientific article

Evolution of genes and genomes on the Drosophila phylogeny

scientific article

Evolutionary constraints in conserved nongenic sequences of mammals.

scientific article published on October 2005

Extensive de novo mutation rate variation between individuals and across the genome of Chlamydomonas reinhardtii

scientific article

Faster-X adaptive protein evolution in house mice.

scientific article published on 20 December 2013

Fine mapping of a murine growth locus to a 1.4-cM region and resolution of linked QTL

scientific article published on 01 June 2004

Fitness change in relation to mutation number in spontaneous mutation accumulation lines of Chlamydomonas reinhardtii

scientific article published on 8 September 2017

Fitness decline in spontaneous mutation accumulation lines of Caenorhabditis elegans with varying effective population sizes

scientific article published on 09 December 2014

Fitness decline under osmotic stress in Caenorhabditis elegans populations subjected to spontaneous mutation accumulation at varying population sizes

scientific article published on 7 March 2018

Functional constraints and frequency of deleterious mutations in noncoding DNA of rodents

scientific article

Genetic architecture: dissecting the genetic basis of phenotypic variation

scientific article published on 01 June 2002

Genetic complexity of an obesity QTL ( Fob3) revealed by detailed genetic mapping

scientific article published on 01 June 2004

Genetic instability of C. elegans comes naturally

scientific article

Genomic selective constraints in murid noncoding DNA

scientific article

Global population divergence and admixture of the brown rat (Rattus norvegicus)

preprint

Global population divergence and admixture of the brown rat (Rattus norvegicus).

scientific article published in the Proceedings of the Royal Society B in October 2016

How many lethal alleles?

scientific article

Inbred lab mice are not isogenic: genetic variation within inbred strains used to infer the mutation rate per nucleotide site

scientific article published on 31 August 2020

Inference of Mutation Parameters and Selective Constraint in Mammalian Coding Sequences by Approximate Bayesian Computation ⬇️

scientific article published on February 1, 2011

Inference of Site Frequency Spectra From High-Throughput Sequence Data: Quantification of Selection on Nonsynonymous and Synonymous Sites in Humans ⬇️

scientific article published on May 19, 2011

Inferring the Frequency Spectrum of Derived Variants to Quantify Adaptive Molecular Evolution in Protein-Coding Genes of Drosophila melanogaster

scientific article published on 20 April 2016

Inferring the Probability of the Derived vs. the Ancestral Allelic State at a Polymorphic Site.

scientific article published on 16 May 2018

Inferring the distribution of fitness effects of spontaneous mutations in Chlamydomonas reinhardtii

scientific article published on 26 June 2019

Interference among deleterious mutations favours sex and recombination in finite populations

scientific article

Introduction: population genetics, quantitative genetics and animal improvement: papers in honour of William (Bill) Hill.

scientific article published on 7 July 2005

Intron size and exon evolution in Drosophila

scientific article

Joint inference of the distribution of fitness effects of deleterious mutations and population demography based on nucleotide polymorphism frequencies

scientific article published on December 2007

Life's formula

scientific article published in Nature

MCALIGN2: faster, accurate global pairwise alignment of non-coding DNA sequences based on explicit models of indel evolution

scientific article published on 8 June 2006

MCALIGN: stochastic alignment of noncoding DNA sequences based on an evolutionary model of sequence evolution

scientific article published on March 2004

MULTIFACTORIAL GENETICSUNDERSTANDING QUANTITATIVE GENETIC VARIATION

scientific article

Microarray gene expression analysis of the Fob3b obesity QTL identifies positional candidate gene Sqle and perturbed cholesterol and glycolysis pathways

scientific article published on 14 December 2004

Mitochondrial Mutation Rate, Spectrum and Heteroplasmy in Caenorhabditis elegans Spontaneous Mutation Accumulation Lines of Differing Population Size

scientific article published on 12 January 2017

Nuclear Gene Variation in Wild Brown Rats ⬇️

scientific article published on December 1, 2012

PAPPA2, an enzyme that cleaves an insulin-like growth-factor-binding protein, is a candidate gene for a quantitative trait locus affecting body size in mice

scientific article

Patterns of DNA-sequence divergence between Drosophila miranda and D. pseudoobscura

scientific article

Patterns of evolutionary constraints in intronic and intergenic DNA of Drosophila.

scientific article

Patterns of population structure and complex haplotype sharing among field isolates of the green alga Chlamydomonas reinhardtii

scientific article published on 11 September 2019

Patterns of selective constraints in noncoding DNA of rice

scientific article

Positive and negative selection in murine ultraconserved noncoding elements

scientific article published on 08 April 2011

Positive and negative selection on noncoding DNA close to protein-coding genes in wild house mice.

scientific article published on 8 November 2010

Quantifying the Slightly Deleterious Mutation Model of Molecular Evolution

article

Rates and Fitness Consequences of New Mutations in Humans ⬇️

scientific article published on February 1, 2012

Rates of molecular evolution in nuclear genes of east Mediterranean scorpions

scientific article published on 01 November 2004

Recent Evolution in Rattus norvegicus Is Shaped by Declining Effective Population Size

scientific article

Regulatory variation at glypican-3 underlies a major growth QTL in mice

scientific article

Spontaneous Mutation Accumulation Studies in Evolutionary Genetics

scientific article published in 2009

Spontaneous mutation accumulation in multiple strains of the green alga, Chlamydomonas reinhardtii

scientific article published on 9 July 2014

Spontaneous mutational variation for body size in Caenorhabditis elegans

scientific article

Studies of quantitative genetic variation

doctoral thesis

THE MAINTENANCE OF OBLIGATE SEX IN FINITE, STRUCTURED POPULATIONS SUBJECT TO RECURRENT BENEFICIAL AND DELETERIOUS MUTATION

scientific article published on 25 July 2012

TOWARD A REALISTIC MODEL OF MUTATIONS AFFECTING FITNESS

article

The Nature of Genetic Variation for Complex Traits Revealed by GWAS and Regional Heritability Mapping Analyses

scientific article published on 19 October 2015

The Recombination Landscape in Wild House Mice Inferred Using Population Genomic Data

scientific article

The distribution of fitness effects of new mutations

scientific article

The effect of variation in the effective population size on the rate of adaptive molecular evolution in eukaryotes.

scientific article

The role of advantageous mutations in enhancing the evolution of a recombination modifier

scientific article published on 5 February 2010

The scale of mutational variation in the murid genome

scientific article published on 15 July 2005

Toward a realistic model of mutations affecting fitness ⬇️

scientific article published on March 1, 2003

Ubiquitous selective constraints in the Drosophila genome revealed by a genome-wide interspecies comparison

scientific article

Understanding the degradation of hominid gene control

scientific article published in March 2006

Understanding the factors that shape patterns of nucleotide diversity in the house mouse genome

article

Unexpected conserved non-coding DNA blocks in mammals.

scientific article published in August 2004

What can we learn about the distribution of fitness effects of new mutations from DNA sequence data?

scientific article

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