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List of works by Florian Greten

A Wnt-induced phenotypic switch in cancer-associated fibroblasts inhibits EMT in colorectal cancer

scientific article published on 14 October 2020

A framework for advancing our understanding of cancer-associated fibroblasts

scientific article published on 24 January 2020

A murine tumor progression model for pancreatic cancer recapitulating the genetic alterations of the human disease

scientific article

AKT-dependent NOTCH3 activation drives tumor progression in a model of mesenchymal colorectal cancer

scientific article published on 01 October 2020

Aberrant epithelial GREM1 expression initiates colonic tumorigenesis from cells outside the stem cell niche

scientific article published on December 2014

Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway

scientific article (publication date: 24 August 2001)

Bcl-2 is a critical mediator of intestinal transformation

scientific article published on 9 March 2016

Canonical NF-κB signaling in myeloid cells promotes lung metastasis in a mouse breast cancer model

scientific article published on 30 March 2018

Card9-dependent IL-1β regulates IL-22 production from group 3 innate lymphoid cells and promotes colitis-associated cancer

scientific article published on 6 June 2017

Cell Autonomous and Non-Autonomous Functions of IKKβ and NF-κB during the Pathogenesis of Gastrointestinal Tumors

scientific article published on 28 April 2011

Cell plasticity in epithelial homeostasis and tumorigenesis.

scientific article

Chronic intestinal inflammation in mice expressing viral Flip in epithelial cells

scientific article published on 13 August 2018

Circulating hypoxia marker carbonic anhydrase IX (CA9) in patients with hepatocellular carcinoma and patients with cirrhosis

Concurrent video-rate color and near-infrared fluorescence laparoscopy

scientific article published on 01 October 2013

Corrigendum. IL-6R/STAT3/miR-34a feedback loop promotes EMT-mediated colorectal cancer invasion and metastasis

scientific article published on 2 March 2015

Cyclosporine inhibits growth through the activating transcription factor/cAMP-responsive element-binding protein binding site in the cyclin D1 promoter

scientific article

EGFR in Tumor-Associated Myeloid Cells Promotes Development of Colorectal Cancer in Mice and Associates With Outcomes of Patients

scientific article published on 8 April 2017

Epithelial-cell-intrinsic IKK-β expression regulates intestinal immune homeostasis

scientific article published in Nature

Fructose stimulated de novo lipogenesis is promoted by inflammation

scientific article published on 24 August 2020

Fungi Enter the Stage of Colon Carcinogenesis

scientific article published on 01 September 2018

Genetically induced pancreatic adenocarcinoma is highly immunogenic and causes spontaneous tumor-specific immune responses

scientific article published on January 2006

Glutathione peroxidase 4 prevents necroptosis in mouse erythroid precursors

scientific article published on 13 October 2015

High levels of the soluble programmed death-ligand (sPD-L1) identify hepatocellular carcinoma patients with a poor prognosis

scientific article

High-fat-diet-mediated dysbiosis promotes intestinal carcinogenesis independently of obesity

scientific article

Hypoxia-inducible factors 1 and 2 are important transcriptional effectors in primary macrophages experiencing hypoxia

scientific article

IKK- and NF-κB-mediated functions in carcinogenesis

scientific article published on January 2011

IKK/NF-kappaB and STAT3 pathways: central signalling hubs in inflammation-mediated tumour promotion and metastasis

scientific article

IKKalpha controls p52/RelB at the skp2 gene promoter to regulate G1- to S-phase progression.

scientific article published on 10 August 2006

IKKalpha provides an essential link between RANK signaling and cyclin D1 expression during mammary gland development

scientific journal article

IKKα controls ATG16L1 degradation to prevent ER stress during inflammation

scientific article published on 12 January 2017

IKKα promotes intestinal tumorigenesis by limiting recruitment of M1-like polarized myeloid cells

scientific article published on 29 May 2014

IKKβ acts as a tumor suppressor in cancer-associated fibroblasts during intestinal tumorigenesis

scientific article

IL-6R/STAT3/miR-34a feedback loop promotes EMT-mediated colorectal cancer invasion and metastasis

scientific article published on 18 March 2014

IkappaB-kinasebeta-dependent NF-kappaB activation provides radioprotection to the intestinal epithelium

scholarly article

IkappaBbeta is an essential co-activator for LPS-induced IL-1beta transcription in vivo.

scientific article published on 25 October 2010

Immunity, Inflammation, and Cancer

scientific article (publication date: 19 March 2010)

In vivo evaluation of 5-[(18)F]fluoro-2'-deoxyuridine as tracer for positron emission tomography in a murine pancreatic cancer model

scientific article published in May 2001

Inflammation and Cancer: Triggers, Mechanisms, and Consequences

scientific article published on 01 July 2019

Inflammation and cancer: tissue regeneration gone awry

scientific article published on 10 August 2016

Inflammation and mitochondrial fatty acid beta-oxidation link obesity to early tumor promotion

scientific article

Inhibiting signal transducer and activator of transcription 3: rationality and rationale design of inhibitors

scientific article

Ink4a/Arf and oncogene-induced senescence prevent tumor progression during alternative colorectal tumorigenesis

scientific article published in August 2010

Interleukin-11 is the dominant IL-6 family cytokine during gastrointestinal tumorigenesis and can be targeted therapeutically

scientific article published on August 2013

Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like properties

scientific article

Lifting the Mist on Gastric Stem Cells

scientific article published on 01 January 2016

Linear ubiquitination of cytosolic Salmonella Typhimurium activates NF-κB and restricts bacterial proliferation

scientific article

Loss of Stat6 affects chromatin condensation in intestinal epithelial cells causing diverse outcome in murine models of inflammation-associated and sporadic colon carcinogenesis

article

Loss of p53 in enterocytes generates an inflammatory microenvironment enabling invasion and lymph node metastasis of carcinogen-induced colorectal tumors

scientific article published on 27 December 2012

Macrophage apoptosis by anthrax lethal factor through p38 MAP kinase inhibition

scientific article published on 29 August 2002

Mesenchymal Cells in Colon Cancer

scientific article published on 19 January 2017

Mitophagy in Intestinal Epithelial Cells Triggers Adaptive Immunity during Tumorigenesis

scientific article published on 14 June 2018

Modulating inflammation for cancer therapy

scientific article published on 25 April 2019

Murine pancreatic tumor cell line TD2 bears the characteristic pattern of genetic changes with two independently amplified gene loci

scientific article

Myeloid Cell-Derived Reactive Oxygen Species Induce Epithelial Mutagenesis

scientific article published in December 2017

NF-kappaB is a negative regulator of IL-1beta secretion as revealed by genetic and pharmacological inhibition of IKKbeta

scientific article

NF-kappaB: linking inflammation and immunity to cancer development and progression

scientific article (publication date: October 2005)

Nonconventional initiation complex assembly by STAT and NF-kappaB transcription factors regulates nitric oxide synthase expression

scientific article published on July 2010

NoxO1 Controls Proliferation of Colon Epithelial Cells.

scientific article

Oocyte DNA damage quality control requires consecutive interplay of CHK2 and CK1 to activate p63.

scientific article published on 26 February 2018

Opioid receptors from a lower vertebrate (Catostomus commersoni): sequence, pharmacology, coupling to a G-protein-gated inward-rectifying potassium channel (GIRK1), and evolution.

scientific article

Opposing functions of IKKbeta during acute and chronic intestinal inflammation

scholarly article

Pattern of secondary genomic changes in pancreatic tumors of Tgf alpha/Trp53+/- transgenic mice

scientific article

Peering into the aftermath: JAKi rips STAT3 in cancer.

scientific article

Polyol pathway links glucose metabolism to the aggressiveness of cancer cells

scientific article published on 17 January 2018

Pseudo-HE images derived from CARS/TPEF/SHG multimodal imaging in combination with Raman-spectroscopy as a pathological screening tool

scientific article

ROS production and NF-κB activation triggered by RAC1 facilitate WNT-driven intestinal stem cell proliferation and colorectal cancer initiation

scientific article published on 09 May 2013

Regulation of cyclin D1 expression by autocrine IGF-I in human BON neuroendocrine tumour cells

scientific article

S1PR4 ablation reduces tumor growth and improves chemotherapy via CD8+ T cell expansion

scientific article published on 14 July 2020

STAT3 activation through IL-6/IL-11 in cancer-associated fibroblasts promotes colorectal tumour development and correlates with poor prognosis

scientific article published on 04 November 2019

Selective in vivo imaging of syngeneic, spontaneous, and xenograft tumors using a novel tumor cell-specific hsp70 peptide-based probe

scientific article published on 9 October 2014

Signaling pathways and genes that inhibit pathogen-induced macrophage apoptosis--CREB and NF-kappaB as key regulators

scientific article

Stat3 and NF-kappaB activation prevents apoptosis in pancreatic carcinogenesis

scientific article published on December 2002

Subthreshold IKK activation modulates the effector functions of primary mast cells and allows specific targeting of transformed mast cells.

scientific article published on March 2015

Systematic evaluation of the biological variance within the Raman based colorectal tissue diagnostics

scientific article published on 20 December 2015

TAK1 and IKK2, novel mediators of SCF-induced signaling and potential targets for c-Kit-driven diseases.

scientific article published on September 2015

TAK1: Another mesh in the NF-κB - JNK controlled network causing hepatocellular carcinoma

scientific article published on 10 May 2011

TGF alpha transgenic mice. A model of pancreatic cancer development.

scientific article

TGFβ pathway limits dedifferentiation following WNT and MAPK pathway activation to suppress intestinal tumourigenesis

scientific article published on 16 June 2017

TNF-alpha-dependent loss of IKKbeta-deficient myeloid progenitors triggers a cytokine loop culminating in granulocytosis

scientific article

Targeting c-MYC through Interference with NAMPT and SIRT1 and Their Association to Oncogenic Drivers in Murine Serrated Intestinal Tumorigenesis

scientific article published on 20 August 2019

The IKK/NF-kappaB activation pathway-a target for prevention and treatment of cancer

scientific article published on April 2004

The Iron y of Tumor-Induced Inflammation

scientific article published on 01 September 2016

The Prosurvival IKK-Related Kinase IKKε Integrates LPS and IL17A Signaling Cascades to Promote Wnt-Dependent Tumor Development in the Intestine

scientific article published on 15 March 2016

The architect who never sleeps: tumor-induced plasticity

scientific article

The gastrointestinal tumor microenvironment

scientific article

The two faces of IKK and NF-κB inhibition: prevention of systemic inflammation but increased local injury following intestinal ischemia-reperfusion

scientific article published on 07 April 2003

Therapeutic Ablation of Gain-of-Function Mutant p53 in Colorectal Cancer Inhibits Stat3-Mediated Tumor Growth and Invasion

scientific article published on 01 August 2018

Tolerizing CTL by Sustained Hepatic PD-L1 Expression Provides a New Therapy Approach in Mouse Sepsis

scientific article published on 16 March 2019

Transgenic overexpression of amphiregulin induces a mitogenic response selectively in pancreatic duct cells

scientific article published on 01 June 2002

Trp53 deficiency protects against acute intestinal inflammation

scientific article published on 14 June 2013

Tumor fibroblast-derived epiregulin promotes growth of colitis-associated neoplasms through ERK

scientific article published on 15 March 2013

Tumour stem-cell surprises

scientific article published in Nature

Up and downregulation of p16(Ink4a) expression in BRAF-mutated polyps/adenomas indicates a senescence barrier in the serrated route to colon cancer

scientific article published on 18 March 2011

YAP1 takes over when oncogenic K-Ras slumbers

scientific article published in July 2014

gp130-mediated Stat3 activation in enterocytes regulates cell survival and cell-cycle progression during colitis-associated tumorigenesis

scientific article published in February 2009

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