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List of works by Kōichi Yoshinari

A novel and sensitive assay for heme oxygenase activity

scientific article published on 29 July 2015

Acceleration of murine hepatocyte proliferation by imazalil through the activation of nuclear receptor PXR

scientific article published on 01 January 2018

Activated Sterol Regulatory Element-Binding Protein-2 Suppresses Hepatocyte Nuclear Factor-4-Mediated Cyp3a11 Expression in Mouse Liver ⬇️

scientific article published on 06 October 2010

Activation of PXR, CAR and PPARα by pyrethroid pesticides and the effect of metabolism by rat liver microsomes

scientific article published on 12 September 2019

Activation of nuclear receptor CAR by an environmental pollutant perfluorooctanoic acid.

scientific article published on 10 November 2016

Activation of p38 Mitogen-Activated Protein Kinase by Clotrimazole Induces Multidrug Resistance-Associated Protein 3 Activation through a Novel Transcriptional Element.

scientific article

Characterization of CYP2C Induction in Cryopreserved Human Hepatocytes and Its Application in the Prediction of the Clinical Consequences of the Induction

scientific article published on 23 May 2018

Chimeric Mice With Humanized Livers Demonstrate Human-Specific Hepatotoxicity Caused by a Therapeutic Antibody Against TRAIL-Receptor 2/Death Receptor 5

scientific article published on 01 January 2019

Clioquinol is sulfated by human jejunum cytosol and SULT1A3, a human-specific dopamine sulfotransferase ⬇️

scientific article published on July 27, 2011

Comparative study of the effect of 17 parabens on PXR-, CAR- and PPARα-mediated transcriptional activation

scientific article published on 28 August 2019

Constitutive androstane receptor transactivates the hepatic expression of mouse Dhcr24 and human DHCR24 encoding a cholesterogenic enzyme 24-dehydrocholesterol reductase ⬇️

scientific article published on November 11, 2011

Construction of the Database of Rat Repeated-dose Toxicity Tests of Pesticides for the Toxicological Characterization of Hepatocyte Hypertrophy.

scientific article published in January 2017

Coordinated Roles of Pregnane X Receptor and Constitutive Androstane Receptor in Autoinduction of Voriconazole Metabolism in Mice ⬇️

scientific article published on December 28, 2012

Discriminating between adaptive and carcinogenic liver hypertrophy in rat studies using logistic ridge regression analysis of toxicogenomic data: The mode of action and predictive models.

scientific article

Establishment of In Silico Prediction Models for CYP3A4 and CYP2B6 Induction in Human Hepatocytes by Multiple Regression Analysis Using Azole Compounds

scientific article

Fibroblast Growth Factor 19 Treatment Ameliorates Disruption of Hepatic Lipid Metabolism in Farnesoid X Receptor (Fxr)-Null Mice ⬇️

scientific article published on January 1, 2011

Liver X receptor α bidirectionally transactivates human CYP1A1 and CYP1A2 through two cis-elements common to both genes ⬇️

scientific article published on October 4, 2012

Metabolism of methiocarb and carbaryl by rat and human livers and plasma, and effect on their PXR, CAR and PPARα activities.

scientific article published in January 2016

Molecular Cloning and Expression of an Amine Sulfotransferase cDNA: A New Gene Family of Cytosolic Sulfotransferases in Mammals ⬇️

scientific article published on March 1, 1998

Molecular Cloning, Expression, and Enzymatic Characterization of Rabbit Hydroxysteroid Sulfotransferase AST-RB2 (ST2A8) ⬇️

scientific article published on April 1, 1998

Molecular characterization of ST1C1-related human sulfotransferase ⬇️

scientific article published on May 1, 1998

Novel Cell-based Reporter Assay System Using Epitope-tagged Protein for the Identification of Agonistic Ligands of Constitutive Androstane Receptor (CAR) ⬇️

scientific article published on December 25, 2012

PXR Functionally Interacts with NF-κB and AP-1 to Downregulate the Inflammation-Induced Expression of Chemokine CXCL2 in Mice

scientific article published on 15 October 2020

PXR stimulates growth factor-mediated hepatocyte proliferation by cross-talk with the FOXO transcription factor

scientific article published on 16 November 2015

Possible involvement of the competition for the transcriptional coactivator glucocorticoid receptor-interacting protein 1 in the inflammatory signal-dependent suppression of PXR-mediated CYP3A induction in vitro

scientific article published on 19 April 2019

Prediction of regioselectivity and preferred order of metabolisms on CYP1A2-mediated reactions part 3: Difference in substrate specificity of human and rodent CYP1A2 and the refinement of predicting system

scientific article published on 16 February 2019

Prediction of regioselectivity and preferred order of metabolisms on CYP1A2-mediated reactions. Part 1. Focusing on polycyclic arenes and the related chemicals.

scientific article published on 10 August 2016

Prediction of regioselectivity and preferred order of metabolisms on CYP1A2-mediated reactions. Part 2: Solving substrate interactions of CYP1A2 with non-PAH substrates on the template system

scientific article published on 29 May 2017

Pregnenolone 16α-carbonitrile ameliorates concanavalin A-induced liver injury in mice independent of the nuclear receptor PXR activation

scientific article published on 22 February 2017

Profiling of bisphenol A and eight its analogues on transcriptional activity via human nuclear receptors

scientific article published on 21 December 2018

Role of Nuclear Receptors PXR and CAR in Xenobiotic-Induced Hepatocyte Proliferation and Chemical Carcinogenesis

scientific article published on 01 January 2019

Role of YAP Activation in Nuclear Receptor CAR-Mediated Proliferation of Mouse Hepatocytes

scientific article published on 01 October 2018

SREBP-2 negatively regulates FXR-dependent transcription of FGF19 in human intestinal cells

scientific article published on 7 December 2013

Sensitive and Comprehensive LC-MS/MS Analyses of Chiral Pharmaceuticals and Their Hepatic Metabolites Using Ovomucoid Column

scientific article published on 20 July 2018

Transactivation of ABCG2 through a novel cis-element in the distal promoter by constitutive androstane receptor but not pregnane X receptor in human hepatocytes ⬇️

scientific article published on November 10, 2011

Tumor Necrosis Factor-Alpha-Nuclear Factor-Kappa B-Signaling Enhances St2b2 Expression during 12-O-Tetradecanoylphorbol-13-acetate-Induced Epidermal Hyperplasia ⬇️

scientific article published on 01 January 2011

[In silico prediction models of the induction of drug-metabolizing enzymes for drug discovery]

scientific article published on 01 January 2019

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