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List of works by Manfred Schubert-Zsilavecz

2‐(4‐(Biphenyl‐4‐ylamino)‐6‐chloropyrimidin‐2‐ylthio)octanoic acid (HZ52) – a novel type of 5‐lipoxygenase inhibitor with favourable molecular pharmacology and efficacy in vivo ⬇️

scientific article published on September 1, 2011

9-Hydroxyscilliphaeoside, a New Bufadienolide fromUrginea maritima1

scholarly article by Liselotte Krenn et al published January 1996 in Journal of Natural Products

A pirinixic acid derivative (LP105) inhibits murine 5-lipoxygenase activity and attenuates vascular remodelling in a murine model of aortic aneurysm

scientific article

A single-dose, randomized, cross-over, two-way, open-label study for comparing the absorption of boswellic acids and its lecithin formulation

scientific article published on 27 July 2016

A triterpene saponin from Herniaria glabra

scientific article published on 01 December 1993

Acidic elements in histamine H(3) receptor antagonists

scientific article published on 21 January 2010

Advances in personalized medicine - medicinal chemistry and pharmacology of vemurafenib and ivacaftor

scientific article published on July 2013

Allosteric modulation of the farnesoid X receptor by a small molecule

scientific article published in Scientific Reports

Alpha-alkyl substituted pirinixic acid derivatives as potent dual agonists of the peroxisome proliferator activated receptor alpha and gamma

scientific article

Aminothiazole-featured pirinixic acid derivatives as dual 5-lipoxygenase and microsomal prostaglandin E2 synthase-1 inhibitors with improved potency and efficiency in vivo

scientific article published on 15 November 2013

An innovative method to study target protein-drug interactions by mass spectrometry

scientific article

Analysis of drugs of abuse in Cerumen - correlation of postmortem analysis results with those for blood, urine and hair

scientific article

Anthranilic acid derivatives as novel ligands for farnesoid X receptor (FXR)

scientific article published in 2014

Anthranilic acid derivatives as nuclear receptor modulators--development of novel PPAR selective and dual PPAR/FXR ligands.

scientific article

Anti-oedematous activities of the main triterpendiol esters of marigold (Calendula officinalis L.).

scientific article published on 01 July 1997

Antidiabetic sulfonylureas modulate farnesoid X receptor activation and target gene transcription

scientific article

Antitussives and expectorants

scientific article published in January 2008

Bemerkung zum DPhG-Statement: Wissenschaftliche Pharmazie und Homöopathie

scientific article published on 01 January 2006

Biorelevant dissolution testing of St John's wort products

scientific article published in December 2002

Boswellia serrata: an overall assessment of in vitro, preclinical, pharmacokinetic and clinical data

scientific article (publication date: June 2011)

Brain permeability of bilobalide as probed by microdialysis before and after middle cerebral artery occlusion in mice ⬇️

scientific article published on January 1, 2010

Carnosic acid and carnosol potently inhibit human 5-lipoxygenase and suppress pro-inflammatory responses of stimulated human polymorphonuclear leukocytes

scientific article published in May 2008

Characterization of the molecular mechanism of 5-lipoxygenase inhibition by 2-aminothiazoles

scientific article published on 23 September 2016

Characterizing ligands for farnesoid X receptor--available in vitro test systems for farnesoid X receptor modulator development

scientific article

Charge conformity and biopharmaceutic characterization. St. John's Wort extract preparations in comparison

scientific article

Chronic administration of statins alters multiple gene expression patterns in mouse cerebral cortex

scientific article

Comparison of German St. John's wort products according to hyperforin and total hypericin content.

scientific article published in July 2001

Complementary Screening Techniques Yielded Fragments that Inhibit the Phosphatase Activity of Soluble Epoxide Hydrolase

Coupling of boswellic acid-induced Ca2+ mobilisation and MAPK activation to lipid metabolism and peroxide formation in human leucocytes

scientific article published on 22 December 2003

Cutaneous administration rather than swallowing

scientific article published in January 2005

Degradation of ginsenosides in humans after oral administration

scientific article (publication date: August 2003)

Design and synthesis of fused soluble epoxide hydrolase/peroxisome proliferator-activated receptor modulators

Design, synthesis, and biological evaluation of a novel class of gamma-secretase modulators with PPARgamma activity

scientific article published in June 2010

Detection of oxidative hair treatment using fluorescence microscopy.

scientific article

Detection of pyrrolizidine alkaloids in German licensed herbal medicinal teas

scientific article published on 29 April 2015

Determination of 11-keto-boswellic acid in human plasma

scientific article

Determination of St. John's wort flavonoid-metabolites in rat brain through high performance liquid chromatography coupled with fluorescence detection

scientific article published on 24 January 2006

Determination of boswellic acids in brain and plasma by high-performance liquid chromatography/tandem mass spectrometry

scientific article

Determination of hyperforin in mouse brain by high-performance liquid chromatography/tandem mass spectrometry

scientific article published in November 2003

Determination of hypericin and pseudohypericin from Hypericum perforatum in rat brain after oral administration

Determination of major boswellic acids in plasma by high-pressure liquid chromatography/mass spectrometry ⬇️

scientific article published on July 29, 2011

Development of a high-performance liquid chromatographic method for the determination of 11-keto-beta-boswellic acid in human plasma

scientific article published on 01 September 2001

Development, structures, and new trends. H1-antihistamines

scientific article published in January 2004

Differential antiviral and anti-inflammatory mechanisms of the flavonoids biochanin A and baicalein in H5N1 influenza A virus-infected cells

scientific article published on 23 October 2012

Dimethylcelecoxib inhibits mPGES-1 promoter activity by influencing EGR1 and NF-κB ⬇️

scientific article published on August 3, 2010

Discovery of a novel class of 2-mercaptohexanoic acid derivatives as highly active PPARalpha agonists.

scientific article published on 18 May 2009

Dose accuracy and injection force of different insulin glargine pens

scientific article published on September 2013

Dosing Accuracy of Two Disposable Insulin Pens According to New ISO 11608-1: 2012 Requirements

scientific article published on 17 July 2015

Dosing accuracy of commonly used disposable insulin pens.

scientific article published in April 2010

Effect of Phospholipid-Based Formulations of Boswellia serrata Extract on the Solubility, Permeability, and Absorption of the Individual Boswellic Acid Constituents Present ⬇️

scientific article published on September 26, 2012

Enantiomer separation and indirect chromatographic absolute configuration prediction of chiral pirinixic acid derivatives: Limitations of polysaccharide-type chiral stationary phases in comparison to chiral anion-exchangers

scientific article published on 21 October 2009

Enhanced absorption of boswellic acids by a lecithin delivery form (Phytosome(®)) of Boswellia extract

scientific article published on 23 October 2012

Extending the structure-activity relationship of anthranilic acid derivatives as farnesoid X receptor modulators: development of a highly potent partial farnesoid X receptor agonist

article

From machine learning to natural product derivatives that selectively activate transcription factor PPARgamma

scientific article published in February 2010

Functionalization of Fatty Acid Mimetics for Solid‐Phase Coupling and Subsequent Target Identification ⬇️

scientific article published on November 1, 2010

Ginkgo biloba extracts: a review of the pharmacokinetics of the active ingredients

scientific article published on September 2013

Hemmstoffe von Beta-Adrenozeptoren: Gemeinsamkeiten und Unterschiede

scholarly article by Perry Paige Griffin et al published November 2004 in Pharmazie in unserer Zeit

High-throughput screening for inhibitors of bacterial transglycosylase

scientific article published in January 2008

Hyperforin modifies neuronal membrane properties in vivo

scientific article

Hypericum perforatum: a 'modern' herbal antidepressant: pharmacokinetics of active ingredients

scientific article

Identification and characterisation of a prototype for a new class of competitive PPARγ antagonists

scientific article

Identification of 2-mercaptohexanoic acids as dual inhibitors of 5-lipoxygenase and microsomal prostaglandin E₂ synthase-1.

scientific article published on 22 April 2011

Identification of legal highs – Ergot alkaloid patterns in two Argyreia nervosa products

In vitro metabolism, permeation, and brain availability of six major boswellic acids from Boswellia serrata gum resins ⬇️

scientific article published on October 24, 2012

Innovations in the Treatment of Cystic Fibrosis: Outriders for the Treatment of Diseases with Other Genetic Defects? ⬇️

scientific article published on December 1, 2011

Interference of alpha-alkyl-substituted pirinixic acid derivatives with neutrophil functions and signalling pathways

scientific article published on 15 August 2009

Investigation of imatinib and other approved drugs as starting points for antidiabetic drug discovery with FXR modulating activity

scientific article

Isoquercitrin provides better bioavailability than quercetin: comparison of quercetin metabolites in body tissue and brain sections after six days administration of isoquercitrin and quercetin

scientific article

Isoscoparin-2″-O-glucoside from Passiflora incarnata

Kernel learning for ligand-based virtual screening: discovery of a new PPARγ agonist.

scientific article published on 4 May 2010

Lack of correlation between surface and interfacial activities of saponins and their hemolytic properties

scientific article published in October 1999

Lipophilic prodrugs of amino acids and vitamin E as osmolytes for the compensation of hyperosmotic stress in human keratinocytes

scientific article

MH84 improves mitochondrial dysfunction in a mouse model of early Alzheimer's disease

scientific article published on 13 February 2018

MH84: A Novel γ-Secretase Modulator/PPARγ Agonist--Improves Mitochondrial Dysfunction in a Cellular Model of Alzheimer's Disease

scientific article published on 31 December 2015

Medicinal Chemistry of Incretin Mimetics and DPP-4 Inhibitors

scientific article published on February 2010

Medicinal chemistry of farnesoid X receptor ligands: from agonists and antagonists to modulators

scientific article published on May 2012

Modulation of Pgp function by boswellic acids

scientific article published on May 2006

Molecular pharmacological profile of a novel thiazolinone-based direct and selective 5-lipoxygenase inhibitor

scientific article published on April 2012

Myrtucommulone from Myrtus communis: metabolism, permeability, and systemic exposure in rats

scientific article

N-Benzylbenzamides: A Novel Merged Scaffold for Orally Available Dual Soluble Epoxide Hydrolase/Peroxisome Proliferator-Activated Receptor γ Modulators

scientific article published on 23 November 2015

NSAIDs Ibuprofen, Indometacin, and Diclofenac do not interact with Farnesoid X Receptor

scientific article

Natural compound renews hope for diabetes and obesity therapeutic target

scientific article published in June 2015

New Hope Or Drawbacks: Will Chronic Kidney Disease Be Treatable with Small Molecules In The Near Future? ⬇️

scientific article published on March 1, 2012

New classes of drugs in the pipeline. New in the treatment of diabetes mellitus

scientific article published in March 2010

New drugs for GERD treatment

scientific article published in January 2005

Non-agonist inhibitors of Cdk5-dependent phosphorylation of PPAR as insulin sensitizers in the future?

scientific article published on May 1, 2012

Nonacidic inhibitors of human microsomal prostaglandin synthase 1 (mPGES 1) identified by a multistep virtual screening protocol

scientific article

Nonsteroidal anti-inflammatory drugs: a critical review on current concepts applied to reduce gastrointestinal toxicity

scientific article published on January 2009

Novel and potent inhibitors of 5-lipoxygenase product synthesis based on the structure of pirinixic acid

scientific article published on 19 August 2008

Novel prostaglandin receptor modulators--part II: EP receptor modulators; a patent review (2002 - 2012).

scientific article published on 04 January 2013

Novel prostaglandin receptor modulators: a patent review (2002 - 2012) - part I: non-EP receptor modulators

scientific article

Novel strategies to control lipid metabolism: can the antisense drug mipomersen fulfill the unmet need?

scientific article published in September 2012

Nuclear Receptors As Pharmaceutical Targets: Rise Of FXR And Rebirth Of PPAR? ⬇️

scientific article published on April 1, 2012

PTCA (1H-pyrrole-2,3,5-tricarboxylic acid) as a marker for oxidative hair treatment

scientific article

Permeation of Boswellia extract in the Caco-2 model and possible interactions of its constituents KBA and AKBA with OATP1B3 and MRP2.

scientific article

Pharmacokinetic properties of MH84, a γ-secretase modulator with PPARγ agonistic activity

scientific article published on 13 October 2014

Phospholipid bound to the flavohemoprotein from Alcaligenes eutrophus

scientific article (publication date: June 1999)

Pirinixic acid derivatives as novel dual inhibitors of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase

scientific article

Pirinixic acids: flexible fatty acid mimetics with various biological activities

scientific article published on 27 August 2015

Plant derived omega-3-fatty acids protect mitochondrial function in the brain

scientific article published on 15 January 2010

Plasma levels and distribution of flavonoids in rat brain after single and repeated doses of standardized Ginkgo biloba extract EGb 761®.

scientific article published on 19 May 2010

Polarographic assay of chimaphilin in Chimaphila umbellata primary tincture

scholarly article

Prunella vulgaris L. active components and their hypoglycemic and antinociceptive effects in alloxan-induced diabetic mice.

scientific article published on 18 October 2016

Quantification of active ingredients in semi-solid pharmaceutical formulations by near infrared spectroscopy

scientific article published on 06 May 2017

Rational design of a pirinixic acid derivative that acts as subtype-selective PPARgamma modulator

scientific article published on 4 March 2010

Rationales Design von Hemmern: Vom Teprotid zum Captopril

scholarly article by Karin Nemec & Manfred Schubert-Zsilavecz published January 2003 in Pharmazie in unserer Zeit

Regioselective enzymatic glycosylation of natural polyhydroxylated compounds: galactosylation and glucosylation of protopanaxatriol ginsenosides

scientific article

Repairing mutated proteins--development of small molecules targeting defects in the cystic fibrosis transmembrane conductance regulator

scientific article published on 11 April 2013

Resumption-inhibition in presynaptic action: the medicinal

scientific article

Revealing the macromolecular targets of complex natural products

scientific article published on 2 November 2014

SAR studies of acidic dual γ-secretase/PPARγ modulators ⬇️

scientific article published on August 6, 2011

SAR-studies of γ-secretase modulators with PPARγ-agonistic and 5-lipoxygenase-inhibitory activity for Alzheimer's disease

scientific article published on 30 December 2014

SQUIRRELnovo: de novo design of a PPARα agonist by bioisosteric replacement

Schilddrüsentherapeutika

scholarly article by Daniel Merk & Manfred Schubert-Zsilavecz published September 2012 in Pharmazie in unserer Zeit

Screening of herbal extracts for activation of the human peroxisome proliferator-activated receptor.

scientific article published on November 2006

Simultaneous determination of niacin, niacinamide and nicotinuric acid in human plasma

scientific article published in January 2005

Small molecules with anti-inflammatory properties in clinical development

scientific article

St. John's wort flavonoids and their metabolites show antidepressant activity and accumulate in brain after multiple oral doses.

scientific article published in April 2008

Structural properties of so-called NSAID–phospholipid-complexes

Structure-activity relationship and in vitro pharmacological evaluation of imidazo[1,2-a]pyridine-based inhibitors of 5-LO.

scientific article published on May 2013

Structure-activity relationship of nonacidic quinazolinone inhibitors of human microsomal prostaglandin synthase 1 (mPGES 1).

scientific article

Study of microbial contamination and dosing accuracy of oral dispensers ⬇️

scientific article published on June 1, 2010

Study on the Dosing Accuracy of Commonly Used Disposable Insulin Pens ⬇️

scientific article published on June 13, 2012

Substrate-specific effects of pirinixic acid derivatives on ABCB1-mediated drug transport

scientific article published on 12 February 2016

Survey on the Quality of the Top-Selling European and American Botanical Dietary Supplements Containing Boswellic Acids

scientific article published on 7 April 2016

Synthesis and pharmacological characterization of benzenesulfonamides as dual species inhibitors of human and murine mPGES-1.

scientific article

Synthesis of imidazo[1,2-a]pyridines in a sequential one-pot Groebke-Blackburn modification using 2-aminopyridines, aldehydes and amines.

scientific article published on August 2015

The medicinal chemistry of tricyclic antidepressives. Targets and stereochemistry

scientific article published in January 2008

The molecular pharmacology and in vivo activity of 2-(4-chloro-6-(2,3-dimethylphenylamino)pyrimidin-2-ylthio)octanoic acid (YS121), a dual inhibitor of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase

scientific article

The treatment of dyslipidemia--what's left in the pipeline?

scientific article published on February 2008

Therapeutic modulators of peroxisome proliferator-activated receptors (PPAR): a patent review (2008-present).

scientific article published on 15 June 2012

Transepithelial Transport of Curcumin in Caco-2 Cells Is significantly Enhanced by Micellar Solubilisation

scientific article published on 29 November 2016

Truxillic acid derivatives act as peroxisome proliferator-activated receptor gamma activators

scientific article published on 7 March 2010

Vanillin-derived antiproliferative compounds influence Plk1 activity

scientific article published on 16 September 2014

Virtual screening for PPAR modulators using a probabilistic neural network

scientific article published in December 2006

Zafirlukast Is a Dual Modulator of Human Soluble Epoxide Hydrolase and Peroxisome Proliferator-Activated Receptor γ

[Clinically relevant interaction between clopidogrel and proton pump inhibitors].

scientific article published in January 2009

[Regarding public health there is no doubt that in Germany and Europe that it is driven by economic considerations].

scientific article published in January 2003

[Various therapy options. Medical Chemistry of platelet aggregation inhibitors].

scientific article published in January 2009

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