List of works by Jürgen Knoblich

02-P011 Identification of new cell growth regulators in Drosophila melanogaster by genome wide RNAi screening

A human tissue screen identifies a regulator of ER secretion as a brain size determinant

scientific article published on 29 October 2020

A protein complex containing Inscuteable and the Galpha-binding protein Pins orients asymmetric cell divisions in Drosophila

scientific article published on April 2000

A regulatory transcriptional loop controls proliferation and differentiation in Drosophila neural stem cells

scientific article

A single allele of Hdac2 but not Hdac1 is sufficient for normal mouse brain development in the absence of its paralog.

scientific article published on February 2014

Analysis and modeling of mitotic spindle orientations in three dimensions

scientific article published on 31 December 2013

Asymmetric Rab 11 endosomes regulate delta recycling and specify cell fate in the Drosophila nervous system

scientific article published in September 2005

Asymmetric cell division: recent developments and their implications for tumour biology ⬇️

scientific article published on December 1, 2010

Asymmetric segregation of Numb and Prospero during cell division

scientific article published in October 1995

Asymmetric segregation of the tumor suppressor brat regulates self-renewal in Drosophila neural stem cells.

scientific article published in March 2006

Author Correction: Genetically engineered cerebral organoids model brain tumor formation

scientific article published in September 2018

BIOSAFETY. Safeguarding gene drive experiments in the laboratory

scientific article

Bazooka and PAR-6 are required with PAR-1 for the maintenance of oocyte fate in Drosophila

scientific article published in June 2001

Brain organoids: an ensemble of bioassays to investigate human neurodevelopment and disease

scientific article published on 01 June 2020

Broad applicability of a streamlined ethyl cinnamate-based clearing procedure

scientific article published on 01 February 2019

Cell biology. Sara splits the signal.

scientific article published in November 2006

Cell biology: Notch recycling is numbed

scientific article published in April 2013

Cell division, growth and death.

scientific article published on 21 November 2008

Cell multiplication

Cerebral Organoids Recapitulate Epigenomic Signatures of the Human Fetal Brain.

scientific article published on December 2016

Cerebral organoids model human brain development and microcephaly

scientific article

Coordinated Control of mRNA and rRNA Processing Controls Embryonic Stem Cell Pluripotency and Differentiation.

scientific article published in April 2018

Cyclin E controls S phase progression and its down-regulation during Drosophila embryogenesis is required for the arrest of cell proliferation.

scientific article published in April 1994

Dachsous-dependent asymmetric localization of spiny-legs determines planar cell polarity orientation in Drosophila

scientific article published on 3 July 2014

Dcas is required for importin-alpha3 nuclear export and mechano-sensory organ cell fate specification in Drosophila

scientific article published in April 2002

Deletion analysis of the Drosophila Inscuteable protein reveals domains for cortical localization and asymmetric localization

scientific article published on February 1999

Detailed Cerebral Organoid Fusion Method

Directional Delta and Notch trafficking in Sara endosomes during asymmetric cell division

scientific article published on 18 March 2009

Distinct modes of cyclin E/cdc2c kinase regulation and S-phase control in mitotic and endoreduplication cycles of Drosophila embryogenesis.

scientific article published in June 1995

Dividing cellular asymmetry: asymmetric cell division and its implications for stem cells and cancer

scientific article published on December 2009

Drosophila Aurora-A is required for centrosome maturation and actin-dependent asymmetric protein localization during mitosis

scientific article published in April 2002

Drosophila Cyclin B3 is required for female fertility and is dispensable for mitosis like Cyclin B.

scientific article

Drosophila Ric-8 is essential for plasma-membrane localization of heterotrimeric G proteins

scientific article published on November 2005

Drosophila neuroblasts: a model for stem cell biology

scientific article

Dynamics of activating and repressive histone modifications in Drosophila neural stem cell lineages and brain tumors

scientific article published on 02 December 2019

Ecdysone and mediator change energy metabolism to terminate proliferation in Drosophila neural stem cells

scientific article published in August 2014

Endosome dynamics during development

scientific article published on 27 June 2006

Epithelial polarity: the ins and outs of the fly epidermis.

scientific article

FACS purification and transcriptome analysis of drosophila neural stem cells reveals a role for Klumpfuss in self-renewal

scientific article published on 09 August 2012

FACS purification of Drosophila larval neuroblasts for next-generation sequencing

scientific article

Fly stem cell research gets infectious.

scientific article published in June 2009

Fragile X protein functions with lgl and the par complex in flies and mice

scientific article

Fused cerebral organoids model interactions between brain regions.

scientific article published on 10 May 2017

Generation of cerebral organoids from human pluripotent stem cells

scientific article (publication date: October 2014)

Genetically engineered cerebral organoids model brain tumor formation

scientific article published on 23 July 2018

Genome-wide analysis of Notch signalling in Drosophila by transgenic RNAi

scientific article

Genome-wide analysis of self-renewal in Drosophila neural stem cells by transgenic RNAi.

scientific article published on May 2011

Guided self-organization and cortical plate formation in human brain organoids.

scientific article published on 31 May 2017

Heterotrimeric G proteins direct two modes of asymmetric cell division in the Drosophila nervous system

scientific article

Heterotrimeric G proteins: new tricks for an old dog.

scientific article

Human blood vessel organoids as a model of diabetic vasculopathy

scientific article published on 16 January 2019

Human cerebral organoids recapitulate gene expression programs of fetal neocortex development

scientific article (publication date: 22 December 2015)

Human organoids: model systems for human biology and medicine

scientific article published on 07 July 2020

Human tissues in a dish: The research and ethical implications of organoid technology

scientific article published on January 2017

Identification of transcription factor binding sites from ChIP-seq data at high resolution

scientific article

Induction of Expansion and Folding in Human Cerebral Organoids

scientific article (publication date: December 2016)

Interaction of activator of G-protein signaling 3 (AGS3) with LKB1, a serine/threonine kinase involved in cell polarity and cell cycle progression: phosphorylation of the G-protein regulatory (GPR) motif as a regulatory mechanism for the interaction

scientific article

LIS1 and spindle orientation in neuroepithelial cells

scientific article published on March 2008

Lab-Built Brains

scientific article published on 01 December 2016

Lethal giant larvae take on a life of their own.

scientific article

LifeTime and improving European healthcare through cell-based interceptive medicine

scientific article published on 07 September 2020

Linking cell cycle to asymmetric division: Aurora-A phosphorylates the Par complex to regulate Numb localization

scientific article

Localization-dependent and -independent roles of numb contribute to cell-fate specification in Drosophila

scientific article published in September 2005

Long-term live cell imaging and automated 4D analysis of drosophila neuroblast lineages

scientific article

Mammalian inscuteable regulates spindle orientation and cell fate in the developing retina

scientific article published on November 2005

Mammary Stem Cell Self-Renewal Is Regulated by Slit2/Robo1 Signaling through SNAI1 and mINSC.

scientific article published on 29 September 2015

Mechanisms of asymmetric cell division during animal development

scientific article published on December 1997

Mechanisms of asymmetric stem cell division

scientific article published on February 2008

Mei-P26 regulates microRNAs and cell growth in the Drosophila ovarian stem cell lineage

scientific article

MicroRNA-34/449 controls mitotic spindle orientation during mammalian cortex development

scientific article

Mitotic activation of the kinase Aurora-A requires its binding partner Bora

scientific article published on August 2006

Mouse inscuteable induces apical-basal spindle orientation to facilitate intermediate progenitor generation in the developing neocortex

scientific article published on October 2011

Neurobiology: getting axons going.

scientific article published in August 2005

Numb and alpha-Adaptin regulate Sanpodo endocytosis to specify cell fate in Drosophila external sensory organs

scientific article published in September 2005

On the backroads to cellular asymmetry

Organogenesis in a dish: modeling development and disease using organoid technologies

scientific article

Oxidative Metabolism Drives Immortalization of Neural Stem Cells during Tumorigenesis

scientific article published on 30 August 2020

Par3-mInsc and Gαi3 cooperate to promote oriented epidermal cell divisions through LGN.

scientific article

Phosphorylation-induced autoinhibition regulates the cytoskeletal protein Lethal (2) giant larvae.

scientific article published on February 2005

Pins for spines

scientific article published in December 2005

Proliferation control in neural stem and progenitor cells

scientific article

Prospero Phase-Separating the Way to Neuronal Differentiation

scientific article published on 01 February 2020

Publisher Correction: Guided self-organization and cortical plate formation in human brain organoids

scientific article published on 01 October 2018

Publisher Correction: LifeTime and improving European healthcare through cell-based interceptive medicine

scientific article published on 17 March 2021

Quantitative analysis of protein dynamics during asymmetric cell division

scientific article published in October 2005

Reflections on the past two decades of neuroscience

scientific article published on 02 September 2020

Role of inscuteable in orienting asymmetric cell divisions in Drosophila

scientific article

SWI/SNF complex prevents lineage reversion and induces temporal patterning in neural stem cells

scientific article published in March 2014

Sec15, a component of the exocyst, promotes notch signaling during the asymmetric division of Drosophila sensory organ precursors.

scientific article

Self-organized developmental patterning and differentiation in cerebral organoids

scientific article published on 10 March 2017

Sequential roles of Cdc42, Par-6, aPKC, and Lgl in the establishment of epithelial polarity during Drosophila embryogenesis.

scientific article published in June 2004

Shortstop recruits EB1/APC1 and promotes microtubule assembly at the muscle-tendon junction

scientific article published on July 2003

Spindle orientation and asymmetric cell fate.

scientific article

Spindle orientation in mammalian cerebral cortical development

scientific article

The Drosophila NuMA Homolog Mud regulates spindle orientation in asymmetric cell division

scientific article

The E3-ubiquitin ligase TRIM2 regulates neuronal polarization

scientific article published on 28 September 2010

The N terminus of the Drosophila Numb protein directs membrane association and actin-dependent asymmetric localization

scientific article published on November 1997

The Organoid Cell Atlas

scientific article

The Organoid Cell Atlas: A Rosetta Stone for Biomedical Discovery and Regenerative Therapy ⬇️

journal article published in 2020

The PDZ protein Canoe regulates the asymmetric division of Drosophila neuroblasts and muscle progenitors.

scientific article published on 22 May 2008

The Par complex and integrins direct asymmetric cell division in adult intestinal stem cells

scientific article

The Par complex directs asymmetric cell division by phosphorylating the cytoskeletal protein Lgl.

scientific article published on 9 March 2003

The TRIM-NHL protein Brat promotes axon maintenance by repressing src64B expression

scientific article published in October 2014

The TRIM-NHL protein TRIM32 activates microRNAs and prevents self-renewal in mouse neural progenitors

scientific article

The adaptor protein X11Lalpha/Dmint1 interacts with the PDZ-binding domain of the cell recognition protein Rst in Drosophila.

scientific article published on 27 December 2005

The asymmetrically segregating lncRNA cherub is required for transforming stem cells into malignant cells.

scientific article

The chromodomain helicase Chd4 is required for Polycomb-mediated inhibition of astroglial differentiation

scientific journal article

The conserved c2 domain protein lethal (2) giant discs regulates protein trafficking in Drosophila

scientific article published in November 2006

The conserved discs-large binding partner Banderuola regulates asymmetric cell division in Drosophila

scientific article published on 31 July 2014

The endocytic protein alpha-Adaptin is required for numb-mediated asymmetric cell division in Drosophila

scientific article

The hope and the hype of organoid research.

scientific article published on March 2017

The orientation of asymmetric cell divisions directs lineage decisions in the mouse neocortex

article published in 2012

The phosphatase PP4c controls spindle orientation to maintain proliferative symmetric divisions in the developing neocortex

scientific article published on 03 July 2013

The splicing co-factor Barricade/Tat-SF1 is required for cell cycle and lineage progression in Drosophila neural stem cells

scientific article

The transcription factor odd-paired regulates temporal identity in transit-amplifying neural progenitors via an incoherent feed-forward loop

scientific article published on 22 July 2019

The tumor suppressor Brat controls neuronal stem cell lineages by inhibiting Deadpan and Zelda

scientific article published on 30 November 2017

The tumor suppressors Brat and Numb regulate transit-amplifying neuroblast lineages in Drosophila

scientific article published on 13 March 2008

The tumour suppressor L(3)mbt inhibits neuroepithelial proliferation and acts on insulator elements

scientific article published on 21 August 2011

Time-resolved transcriptomics in neural stem cells identifies a v-ATPase/Notch regulatory loop

scientific article published on 29 June 2018

Tracing Stem Cell Division in Adult Neurogenesis

scientific article published in February 2018

Transcriptome and proteome quantification of a tumor model provides novel insights into post-transcriptional gene regulation

scientific article

Wicked views on stem cell news

scientific article

You Are What You Eat: Linking Metabolic Asymmetry and Cell Fate Choice

scientific article published on 01 May 2016

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