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List of works by Robert Margolskee

33P is preferable to 35S for labeling probes used in in situ hybridization

scientific article published on 01 September 1993

A conditioned aversion study of sucrose and SC45647 taste in TRPM5 knockout mice

scientific article

A cyclic−nucleotide−suppressible conductance activated by transducin in taste cells

scientific article published in Nature

A highly efficient directional cDNA cloning method utilizing an asymmetrically tailed linker-primer plasmid ⬇️

scientific article published on December 1, 1991

A transient receptor potential channel expressed in taste receptor cells

scientific article

Action potential-enhanced ATP release from taste cells through hemichannels

scientific article published on 2 June 2010

Activation of intestinal tuft cell-expressed Sucnr1 triggers type 2 immunity in the mouse small intestine

article published in the Proceedings of the National Academy of Sciences of the United States of America

Afferent neurotransmission mediated by hemichannels in mammalian taste cells

scientific article published on 18 January 2007

Alignment of the restriction map of mouse adenovirus FL with that of human adenovirus 2

scientific article published on September 1, 1979

Amiloride-Insensitive Salt Taste Is Mediated by Two Populations of Type III Taste Cells with Distinct Transduction Mechanisms.

scientific article published on February 2016

An In vitro assay useful to determine the potency of several bitter compounds

scientific article published on 01 August 2000

An mRNA encoding a putative GABA-gated chloride channel is expressed in the human cardiac conduction system

scientific article

Angiotensin II modulates salty and sweet taste sensitivities.

scientific article published in April 2013

Assaying G protein-phosphodiesterase interactions in sensory systems.

scientific article published in January 2002

Bacterial d-amino acids suppress sinonasal innate immunity through sweet taste receptors in solitary chemosensory cells.

scientific article

Behavioral evidence for a role of alpha-gustducin in glutamate taste

scientific article published in September 2003

Biochemical analysis of the transducin-phosphodiesterase interaction

scientific article published on 01 November 1994

Biochemical and transgenic analysis of gustducin's role in bitter and sweet transduction

scientific article published on 01 January 1996

Bitter Taste Responses of Gustducin-positive Taste Cells in Mouse Fungiform and Circumvallate Papillae.

scientific article published on 4 November 2017

Bitter and sweet taste receptors regulate human upper respiratory innate immunity ⬇️

scientific article

Blocking taste receptor activation of gustducin inhibits gustatory responses to bitter compounds

scientific article

Characterization and solubilization of bitter-responsive receptors that couple to gustducin ⬇️

scientific article published on July 21, 1998

Characterization of the Binding Site of Aspartame in the Human Sweet Taste Receptor

scientific article

Cloning Nitrogen Fixing Genes from Klebsiella Pneumoniae In Vitro and the Isolation of NIF Promoter Mutants Affecting Glutamine Synthetase Regulation ⬇️

scientific article published on January 1, 1977

Cloning muscle isoforms of neural cell adhesion molecule using an episomal shuttle vector

scientific article published on March 1, 1992

Contribution of alpha-gustducin to taste-guided licking responses of mice.

scientific article published on 30 March 2005

Contribution of the T1r3 taste receptor to the response properties of central gustatory neurons

scientific article published on 11 March 2009

Coupling of bitter receptor to phosphodiesterase through transducin in taste receptor cells ⬇️

scientific article published on July 6, 1995

Detection of sweet and umami taste in the absence of taste receptor T1r3.

scientific article published on 17 July 2003

Differential contribution of TRPM4 and TRPM5 nonselective cation channels to the slow afterdepolarization in mouse prefrontal cortex neurons.

scientific article

Discrimination of taste qualities among mouse fungiform taste bud cells.

scientific article published on 21 July 2009

Dominant loss of responsiveness to sweet and bitter compounds caused by a single mutation in alpha -gustducin

scientific article published on 10 July 2001

Effects of Roux-en-Y gastric bypass on energy and glucose homeostasis are preserved in two mouse models of functional glucagon-like peptide-1 deficiency

scientific article

Electrophysiological characterization of voltage-gated currents in defined taste cell types of mice.

scientific article published in April 2003

Endocannabinoids selectively enhance sweet taste

scientific article

Endocrine taste cells.

scientific article

Epstein-Barr Virus Based Expression Vectors ⬇️

scientific article published on January 1, 1992

Erratum: Transduction of bitter and sweet taste by gustducin

scientific article published in Nature

Expression and nuclear translocation of glucocorticoid receptors in type 2 taste receptor cells.

scientific article

Expression of the voltage-gated potassium channel KCNQ1 in mammalian taste bud cells and the effect of its null-mutation on taste preferences

scientific article published on January 2009

Extracellular K+ activates a K+‐ and H+‐permeable conductance in frog taste receptor cells ⬇️

scientific article published on March 1, 1998

Fat and carbohydrate preferences in mice: the contribution of alpha-gustducin and Trpm5 taste-signaling proteins

scientific article published on 25 July 2007

Functional Analyses of Bitter Taste Receptors in Domestic Cats (Felis catus)

scientific article published on 21 October 2015

Functional expression of the taste specific G-protein, alpha-gustducin

scientific article

G protein subunit G gamma 13 is coexpressed with G alpha o, G beta 3, and G beta 4 in retinal ON bipolar cells

scientific article (publication date: 2003)

Genetic loss or pharmacological blockade of testes-expressed taste genes causes male sterility

scientific article

Ggamma13 colocalizes with gustducin in taste receptor cells and mediates IP3 responses to bitter denatonium

scientific article

Ggamma13 interacts with PDZ domain-containing proteins

scientific article

Gingival solitary chemosensory cells are immune sentinels for periodontitis

scientific article published on 03 October 2019

Gli3 is a negative regulator of Tas1r3-expressing taste cells.

scientific article published on 7 February 2018

Glucagon-like peptide-1 is specifically involved in sweet taste transmission.

scientific article

Glucose transporters and ATP-gated K+ (KATP) metabolic sensors are present in type 1 taste receptor 3 (T1r3)-expressing taste cells

scientific article

Glutamine synthetase mutations which affect expression of nitrogen fixation genes in Klebsiella pneumoniae ⬇️

scientific article published on November 1, 1979

Gustation genetics: sweet gustducin!

scientific article

Gustducin couples fatty acid receptors to GLP-1 release in colon

scientific article published on 22 January 2013

Gut T1R3 sweet taste receptors do not mediate sucrose-conditioned flavor preferences in mice

scientific article

Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1

scientific article

HLA class I-restricted human cytotoxic T cells recognize endogenously synthesized hepatitis B virus nucleocapsid antigen ⬇️

scientific article published on December 1, 1991

Heat activation of TRPM5 underlies thermal sensitivity of sweet taste

scientific article published on December 2005

Hepatitis B virus (HBV)-specific cytotoxic T-cell (CTL) response in humans: characterization of HLA class II-restricted CTLs that recognize endogenously synthesized HBV envelope antigens ⬇️

scientific article published on February 1, 1992

Hepatitis B virus (HBV)-specific cytotoxic T-cell response in humans: production of target cells by stable expression of HBV-encoded proteins in immortalized human B-cell lines ⬇️

scientific article published on May 1, 1992

Identification of the cyclamate interaction site within the transmembrane domain of the human sweet taste receptor subunit T1R3.

scientific article published on 2 August 2005

Immuno-localization of vesicular acetylcholine transporter in mouse taste cells and adjacent nerve fibers: indication of acetylcholine release.

scientific article published on 18 August 2007

Immunocytochemical evidence for co-expression of Type III IP3 receptor with signaling components of bitter taste transduction

scientific article

Impact of T1r3 and Trpm5 on carbohydrate preference and acceptance in C57BL/6 mice.

scientific article published on April 2013

Intestinal glucose sensing and regulation of intestinal glucose absorption.

scientific article

Involvement of T1R3 in calcium-magnesium taste

scientific article published on July 2008

Isolation of a clone which induces expression of the gene encoding the human tumor necrosis factor receptor

scientific article published on February 15, 1992

Lactisole interacts with the transmembrane domains of human T1R3 to inhibit sweet taste.

scientific article

Leptin Suppresses Mouse Taste Cell Responses to Sweet Compounds.

scientific article published on 26 June 2015

Lgr5-EGFP marks taste bud stem/progenitor cells in posterior tongue

scientific article published on May 2013

Loss of high-frequency glucose-induced Ca2+ oscillations in pancreatic islets correlates with impaired glucose tolerance in Trpm5-/- mice

scientific article

Major taste loss in carnivorous mammals. ⬇️

scientific article published on 12 March 2012

Making sense with TRP channels: store-operated calcium entry and the ion channel Trpm5 in taste receptor cells

scientific article published in May 2003

Molecular Mechanisms of Bitter and Sweet Taste Transduction ⬇️

scientific article (publication date: 4 January 2002)

Molecular cloning of G proteins and phosphodiesterases from rat taste cells

scientific journal article

Molecular mechanisms of sweet receptor function.

scientific article published on January 2005

Mouse nasal epithelial innate immune responses to Pseudomonas aeruginosa quorum-sensing molecules require taste signaling components.

scientific article published on 17 September 2013

Mouse taste cells with G protein-coupled taste receptors lack voltage-gated calcium channels and SNAP-25.

scientific article published on 30 March 2006

Multiple sweet receptors and transduction pathways revealed in knockout mice by temperature dependence and gurmarin sensitivity

scientific article

Mutational analysis of the simian virus 40 replicon: pseudorevertants of mutants with a defective replication origin ⬇️

scientific article published on December 1, 1979

Olfactory neurons expressing transient receptor potential channel M5 (TRPM5) are involved in sensing semiochemicals

scientific article

Partial rescue of taste responses of alpha-gustducin null mice by transgenic expression of alpha-transducin

scientific journal article

Perception of sweet taste is important for voluntary alcohol consumption in mice.

scientific article published on 21 March 2007

Phenoxy herbicides and fibrates potently inhibit the human chemosensory receptor subunit T1R3

scientific article

Pineal opsin: a nonvisual opsin expressed in chick pineal

scientific article published on 01 March 1995

REEP2 enhances sweet receptor function by recruitment to lipid rafts

scientific journal article

Release of endogenous opioids from duodenal enteroendocrine cells requires Trpm5

scientific article

Reply to Zhao and Zhang: Loss of taste receptor function in mammals is directly related to feeding specializations

scientific article published on 4 May 2012

Role of olfaction in the conditioned sucrose preference of sweet-ageusic T1R3 knockout mice.

scientific article published on 07 September 2009

Role of the G-protein subunit alpha-gustducin in taste cell responses to bitter stimuli.

scientific article published in October 2003

Signal transduction of umami taste: insights from knockout mice.

scientific article published in January 2005

Single Lgr5- or Lgr6-expressing taste stem/progenitor cells generate taste bud cells ex vivo

scientific article

Sugar-induced cephalic-phase insulin release is mediated by a T1r2+T1r3-independent taste transduction pathway in mice

scientific article

Suppression of a VP1 mutant of simian virus 40 by missense mutations in serine codons of the viral agnogene ⬇️

scientific article published on November 1, 1983

T1R3 and gustducin in gut sense sugars to regulate expression of Na+-glucose cotransporter 1

scientific article

T1R3 taste receptor is critical for sucrose but not Polycose taste.

scientific article published on 17 December 2008

T1r3 and alpha-gustducin in gut regulate secretion of glucagon-like peptide-1.

scientific article published in July 2009

TRPM5-expressing solitary chemosensory cells respond to odorous irritants.

scientific article published on 26 December 2007

Targeted taste cell-specific overexpression of brain-derived neurotrophic factor in adult taste buds elevates phosphorylated TrkB protein levels in taste cells, increases taste bud size, and promotes gustatory innervation

scientific article

Taste cell-expressed α-glucosidase enzymes contribute to gustatory responses to disaccharides

scientific article published on 09 May 2016

Taste cells of the gut and gastrointestinal chemosensation

scientific article published on April 2008

Taste receptor cell responses to the bitter stimulus denatonium involve Ca2+ influx via store-operated channels.

scientific article published in June 2002

Taste responses to sweet stimuli in alpha-gustducin knockout and wild-type mice

scientific article published on 01 June 2006

Taste signaling elements expressed in gut enteroendocrine cells regulate nutrient-responsive secretion of gut hormones

scientific article published on July 2009

Teaching resources. Sensory systems: taste perception.

scientific article published on 28 June 2005

The bamboo-eating giant panda (Ailuropoda melanoleuca) has a sweet tooth: behavioral and molecular responses to compounds that taste sweet to humans

scientific article

The biochemistry and molecular biology of taste transduction ⬇️

scientific article published on August 1, 1993

The cysteine-rich region of T1R3 determines responses to intensely sweet proteins

scientific article

The heterodimeric sweet taste receptor has multiple potential ligand binding sites.

scientific article published on January 2006

The molecular biology of taste transduction.

scientific article published on October 1993

The role of T1r3 and Trpm5 in carbohydrate-induced obesity in mice

scientific article

The taste transduction channel TRPM5 is a locus for bitter-sweet taste interactions

scientific article published on 10 December 2007

The transduction channel TRPM5 is gated by intracellular calcium in taste cells.

scientific article published on May 2007

Tonic activity of Galpha-gustducin regulates taste cell responsivity.

scientific article published on 16 October 2008

Transcriptome analyses of taste organoids reveal multiple pathways involved in taste cell generation

scientific article

Transsynaptic transport of wheat germ agglutinin expressed in a subset of type II taste cells of transgenic mice

scientific article

Trpm5 null mice respond to bitter, sweet, and umami compounds.

scientific article published on 25 January 2006

Tuft cells, taste-chemosensory cells, orchestrate parasite type 2 immunity in the gut.

scientific article

Ultrastructural localization of gustducin immunoreactivity in microvilli of type II taste cells in the rat

scientific article published on 01 September 2000

Umami responses in mouse taste cells indicate more than one receptor

scientific article published on February 2006

Umami taste in mice uses multiple receptors and transduction pathways

scientific article published on 19 December 2011

Umami taste responses are mediated by alpha-transducin and alpha-gustducin

scientific journal article

Whole transcriptome profiling of taste bud cells

scientific article published on 08 August 2017

Wnt signaling interacts with Shh to regulate taste papilla development

scientific journal article

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