List of works by Rudolph E. Tanzi

3D culture models of Alzheimer's disease: a road map to a "cure-in-a-dish"

scientific article

A 3D human neural cell culture system for modeling Alzheimer's disease

scientific article published on 11 June 2015

A 3D human triculture system modeling neurodegeneration and neuroinflammation in Alzheimer's disease

scientific article published on 27 June 2018

A Circadian Clock Gene, Cry, Affects Heart Morphogenesis and Function in Drosophila as Revealed by Optical Coherence Microscopy

scientific article (publication date: 2015)

A Curcumin Analog Reduces Levels of the Alzheimer's Disease-Associated Amyloid-β Protein by Modulating AβPP Processing and Autophagy

scientific article published on 01 January 2019

A Multidisciplinary Approach to Mind and Consciousness

scientific article (publication date: 30 October 2013)

A brief history of Alzheimer's disease gene discovery

scientific article published on January 2013

A current view of Alzheimer's disease ⬇️

scientific article published on 08 July 2009

A three-dimensional human neural cell culture model of Alzheimer's disease

scientific article published on 12 October 2014

A γ-secretase inhibitor, but not a γ-secretase modulator, induced defects in BDNF axonal trafficking and signaling: evidence for a role for APP

scientific article

ADAM10 missense mutations potentiate β-amyloid accumulation by impairing prodomain chaperone function

scientific article

APP substitutions V715F and L720P alter PS1 conformation and differentially affect Abeta and AICD generation

scientific article

Adjusting heterogeneous ascertainment bias for genetic association analysis with extended families

scientific article published on 19 August 2015

Age-dependent effect of apolipoprotein E4 on functional outcome after controlled cortical impact in mice

scientific article

Age-dependent postoperative cognitive impairment and Alzheimer-related neuropathology in mice

scientific article

Age-dependent, non-cell-autonomous deposition of amyloid from synthesis of β-amyloid by cells other than excitatory neurons

scientific article published on March 2014

Altered hippocampal gene expression 2 days after general anesthesia in rats

scientific article published on 26 August 2006

Alternatives to amyloid for Alzheimer's disease therapies-a symposium report

scientific article published on 29 May 2020

Alzheimer disease risk genes: 29 and counting

scientific article published on 01 April 2019

Alzheimer disease: New light on an old CLU.

scientific article published on January 2010

Alzheimer's Disease-Associated β-Amyloid Is Rapidly Seeded by Herpesviridae to Protect against Brain Infection

Alzheimer's Disease-Associated β-Amyloid Is Rapidly Seeded by Herpesviridae to Protect against Brain Infection

scientific article published on 01 December 2018

Alzheimer's disease amyloid-beta links lens and brain pathology in Down syndrome

scientific article

Alzheimer's disease and post-operative cognitive dysfunction

scientific article

Alzheimer's disease drug discovery targeted to the APP mRNA 5'untranslated region.

scientific article

Alzheimer's disease risk gene CD33 inhibits microglial uptake of amyloid beta

scientific article published on 25 April 2013

Alzheimer's disease-associated TREM2 variants exhibit either decreased or increased ligand-dependent activation.

scientific article published on 9 August 2016

Alzheimer's disease-associated ubiquilin-1 regulates presenilin-1 accumulation and aggresome formation

scientific article

Alzheimer's disease: The latest suspect.

scientific article published in August 2008

Alzheimer's disease: one disorder, too many genes?

scientific article published on 5 February 2004

Alzheimer's disease: the cholesterol connection

scientific article (publication date: April 2003)

Alzheimer's disease: the potential therapeutic role of the natural antibiotic amyloid-β peptide

scientific article published on 7 September 2016

Alzheimer's in 3D culture: challenges and perspectives

scientific article

Amyloid-β Production Via Cleavage of Amyloid-β Protein Precursor is Modulated by Cell Density ⬇️

scientific article published on January 1, 2010

Amyloid-β peptide protects against microbial infection in mouse and worm models of Alzheimer's disease

scientific article

Amyloid-β42/40 ratio drives tau pathology in 3D human neural cell culture models of Alzheimer's disease

scientific article published on 13 March 2020

An AICD-based functional screen to identify APP metabolism regulators.

scientific article published on 24 August 2007

An iron-responsive element type II in the 5'-untranslated region of the Alzheimer's amyloid precursor protein transcript

scientific article published on 26 August 2002

Anesthetic propofol attenuates the isoflurane-induced caspase-3 activation and Aβ oligomerization

scientific article

Anesthetics isoflurane and desflurane differently affect mitochondrial function, learning, and memory

scientific article

Antibiotic-induced perturbations in gut microbial diversity influences neuro-inflammation and amyloidosis in a murine model of Alzheimer's disease

scientific article published on 21 July 2016

Antibiotic-induced perturbations in microbial diversity during post-natal development alters amyloid pathology in an aged APPSWE/PS1ΔE9 murine model of Alzheimer's disease

scientific article

Artefactual effects of lipid-based cell transfection reagents on AbetaPP processing and Abeta production

scientific article published on June 2006

Assessment of Alzheimer's disease case-control associations using family-based methods

scientific article

Association between microdeletion and microduplication at 16p11.2 and autism

scientific article

Association of GSK3B with Alzheimer disease and frontotemporal dementia

scientific article

Association of UBQLN1 mutation with Brown-Vialetto-Van Laere syndrome but not typical ALS.

scientific article

Author Correction: Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

scientific article published on 01 September 2019

Autoantibodies to redox-modified oligomeric Abeta are attenuated in the plasma of Alzheimer's disease patients

scientific article published on 21 February 2005

Aβ-accelerated neurodegeneration caused by Alzheimer's-associated ACE variant R1279Q is rescued by angiotensin system inhibition in mice

scientific article published on 01 September 2020

BACE is degraded via the lysosomal pathway

scientific article published on 20 July 2005

Brown adipose tissue-derived MaR2 contributes to cold-induced resolution of inflammation

scientific article published in June 2022

CALHM1 P86L polymorphism does not alter amyloid-beta or tau in cerebrospinal fluid

scientific article

Caspase activation increases beta-amyloid generation independently of caspase cleavage of the beta-amyloid precursor protein (APP).

scientific article published on 5 September 2003

Cathepsin L Mediates the Degradation of Novel APP C-Terminal Fragments.

scientific article published on 28 April 2015

Cerebrospinal fluid aβ to tau ratio and postoperative cognitive change

scientific article published on August 2013

Change in Sense of Nondual Awareness and Spiritual Awakening in Response to a Multidimensional Well-Being Program.

scientific article published on 7 December 2017

Characterization of the precursor protein of the non-A beta component of senile plaques (NACP) in the human central nervous system

scientific article published in August 1996

Characterizing Gene and Protein Crosstalks in Subjects at Risk of Developing Alzheimer’s Disease: A New Computational Approach

article

Chronic traumatic encephalopathy in blast-exposed military veterans and a blast neurotrauma mouse model.

scientific article

Combined adult neurogenesis and BDNF mimic exercise effects on cognition in an Alzheimer's mouse model

scientific article published on 01 September 2018

Comment on "ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models".

scientific article

Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease

scientific article

Comprehensive research synopsis and systematic meta-analyses in Parkinson's disease genetics: The PDGene database

scientific article

Copper, beta-amyloid, and Alzheimer's disease: tapping a sensitive connection

scientific article

Correction to Cathepsin L Mediates the Degradation of Novel APP C-Terminal Fragments.

scientific article

Correction: The Zinc Dyshomeostasis Hypothesis of Alzheimer's Disease

scientific article published on 6 May 2013

Correction: The Zinc Dyshomeostasis Hypothesis of Alzheimer's Disease.

scientific article published on 3 April 2012

Correction: The Zinc Dyshomeostasis Hypothesis of Alzheimer'sDisease

scientific article published on 15 June 2012

Correspondence to Sand et al. “Critical Reappraisal of a Catechol-O-Methyltransferase Transversion Variant in Schizophrenia”

article by Christina M. Lill et al published April 2010 in Biological Psychiatry

Corrigendum: Identification of Altered Metabolomic Profiles Following a Panchakarma-based Ayurvedic Intervention in Healthy Subjects: The Self-Directed Biological Transformation Initiative (SBTI)

scientific article published on 10 October 2016

Cromolyn Reduces Levels of the Alzheimer's Disease-Associated Amyloid β-Protein by Promoting Microglial Phagocytosis

scientific article

Cromolyn sodium delays disease onset and is neuroprotective in the SOD1G93A Mouse Model of amyotrophic lateral sclerosis

scientific article published on 27 November 2019

Curcumin decreases amyloid-beta peptide levels by attenuating the maturation of amyloid-beta precursor protein.

scientific article published on 9 July 2010

Cysteine 27 variant of the delta-opioid receptor affects amyloid precursor protein processing through altered endocytic trafficking

scientific article

Cytokine-mediated inflammation mediates painful neuropathy from metabolic syndrome

scientific article

Cytosolic beta-amyloid deposition and supranuclear cataracts in lenses from people with Alzheimer's disease

scientific article

Decreased catalytic activity of the insulin-degrading enzyme in chromosome 10-linked Alzheimer disease families

scientific article

Depletion of GGA3 stabilizes BACE and enhances beta-secretase activity

scientific article

Design and synthesis of aminothiazole modulators of the gamma-secretase enzyme

scientific article published on 6 July 2016

Design and synthesis of novel methoxypyridine-derived gamma-secretase modulators

scientific article published on 01 September 2020

Diabetes-associated SorCS1 regulates Alzheimer's amyloid-beta metabolism: evidence for involvement of SorL1 and the retromer complex

scientific article published on September 2010

Drosophila Preparation and Longitudinal Imaging of Heart Function In Vivo Using Optical Coherence Microscopy (OCM)

scientific article published on 12 December 2016

Effect of potent γ-secretase modulator in human neurons derived from multiple presenilin 1-induced pluripotent stem cell mutant carriers

scientific article

Effects of RNA interference-mediated silencing of gamma-secretase complex components on cell sensitivity to caspase-3 activation

scientific article published on 7 June 2004

Effects of RNAi-mediated silencing of PEN-2, APH-1a, and nicastrin on wild-type vs FAD mutant forms of presenilin 1.

scientific article

Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study

scientific article

Effects of ubiquilin 1 on the unfolded protein response

scientific article published on 25 October 2008

Elucidation of the BACE1 regulating factor GGA3 in Alzheimer's disease

scientific article

Emerging role of Alzheimer's disease-associated ubiquilin-1 in protein aggregation

scientific article published on February 2010

Endotype reversal as a novel strategy for screening drugs targeting familial Alzheimer's disease

scientific article published on 27 January 2022

Evaluation of the potential excess of statistically significant findings in published genetic association studies: application to Alzheimer's disease

scientific article

Evidence of altered posteromedial cortical FMRI activity in subjects at risk for Alzheimer disease

scientific article

Exploring candidate gene associations with neuropsychological performance

scientific article published on 01 December 2007

Familial Alzheimer's disease mutations in presenilin 1 do not alter levels of the secreted amyloid-beta protein precursor generated by beta-secretase cleavage

scientific article

Family-based association between Alzheimer's disease and variants in UBQLN1

scientific article (publication date: 3 March 2005)

FlyNet 2.0: drosophila heart 3D (2D + time) segmentation in optical coherence microscopy images using a convolutional long short-term memory neural network

scientific article published on 21 February 2020

Follow-up mapping supports the evidence for linkage in the candidate region at 9q22 in the NIMH Alzheimer's disease Genetics Initiative cohort.

scientific article published in March 2007

Functional links between Aβ toxicity, endocytic trafficking, and Alzheimer's disease risk factors in yeast

scientific article published on 27 October 2011

GAB2 as an Alzheimer disease susceptibility gene: follow-up of genomewide association results

scientific article

GENETICS. The Human Variome Project

scientific article

Gain-of-function mutations in protein kinase Cα (PKCα) may promote synaptic defects in Alzheimer's disease

scientific article published on 10 May 2016

Gene therapy for Alzheimer's Disease targeting CD33 reduces amyloid beta accumulation and neuroinflammation

scientific article published on 17 August 2020

Generation of the β-Amyloid Peptide and the Amyloid Precursor Protein C-terminal Fragment γ Are Potentiated by FE65L1 ⬇️

scientific article (publication date: 19 December 2003)

Genetic association of Alzheimer's disease with multiple polymorphisms in alpha-2-macroglobulin.

scientific article published on 9 September 2003

Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

scientific article published on 28 February 2019

Genome-wide association analysis reveals putative Alzheimer's disease susceptibility loci in addition to APOE.

scientific article published on 30 October 2008

Genome-wide association study of Alzheimer's disease CSF biomarkers in the EMIF-AD Multimodal Biomarker Discovery dataset

scientific article published on 22 November 2020

Genome-wide linkage analysis of 723 affected relative pairs with late-onset Alzheimer's disease

article

Gga3 deletion and a GGA3 rare variant associated with late onset Alzheimer's disease trigger BACE1 accumulation in axonal swellings

scientific article published on 01 November 2020

HtrA2 regulates beta-amyloid precursor protein (APP) metabolism through endoplasmic reticulum-associated degradation.

scientific article published on 6 August 2007

Human Neurospheroid Arrays for In Vitro Studies of Alzheimer's Disease

scientific article

Human amyloid-derived aßcontains tyrosine cross-linked oligomers

article published in 2000

Hypocapnia induces caspase-3 activation and increases Abeta production

scientific article published on January 2004

Hypoxic ischemia and proteasome dysfunction alter tau isoform ratio by inhibiting exon 10 splicing

scientific article published on 03 April 2010

Identification of Altered Metabolomic Profiles Following a Panchakarma-based Ayurvedic Intervention in Healthy Subjects: The Self-Directed Biological Transformation Initiative (SBTI).

scientific article published on 09 September 2016

Identification of NEEP21 as a β-Amyloid Precursor Protein-Interacting ProteinIn VivoThat Modulates Amyloidogenic ProcessingIn Vitro ⬇️

scientific article published on November 17, 2010

Identification of Novel Alzheimer's Disease Loci Using Sex-Specific Family-Based Association Analysis of Whole-Genome Sequence Data

scientific article published on 19 March 2020

Identification of clusters of rapid and slow decliners among subjects at risk for Alzheimer's disease

scientific article

In Vivo Quasi-Elastic Light Scattering Eye Scanner Detects Molecular Aging in Humans

scientific article published on 09 June 2020

Inhibition of death-associated protein kinase 1 attenuates the phosphorylation and amyloidogenic processing of amyloid precursor protein.

scientific article

Insulin-degrading enzyme is genetically associated with Alzheimer's disease in the Finnish population

scientific article published on 11 May 2007

Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo

scientific article

Interaction between presenilin 1 and ubiquilin 1 as detected by fluorescence lifetime imaging microscopy and a high-throughput fluorescent plate reader

scientific article published on 30 June 2006

Involvement of ubiquilin-1 transcript variants in protein degradation and accumulation

scientific article published on July 2011

Iron-export ferroxidase activity of β-amyloid precursor protein is inhibited by zinc in Alzheimer's disease

scientific article

Is Alzheimer's Disease a Neurogenesis Disorder?

scientific article published on 01 July 2019

Is alpha-T catenin (VR22) an Alzheimer's disease risk gene?

scientific article published in January 2007

Isoflurane decreases self-renewal capacity of rat cultured neural stem cells

scientific article

Isoflurane-induced apoptosis: a potential pathogenic link between delirium and dementia

scientific article published in December 2006

Isoflurane-induced caspase-3 activation is dependent on cytosolic calcium and can be attenuated by memantine

scientific article published on April 2008

Isolation and characterization of the Drosophila ubiquilin ortholog dUbqln: in vivo interaction with early-onset Alzheimer disease genes

scientific article published on 18 August 2007

LRP-mediated clearance of Abeta is inhibited by KPI-containing isoforms of APP.

scientific article published in April 2005

Lack of hepatic apoE does not influence early Aβ deposition: observations from a new APOE knock-in model

scientific article published on 17 October 2019

Longitudinal change in cognitive performance among individuals with mild cognitive impairment.

scientific article published in March 2007

Loss of Ataxin-1 Potentiates Alzheimer's Pathogenesis by Elevating Cerebral BACE1 Transcription

scientific article published on 01 August 2019

Loss of function of ATXN1 increases amyloid beta-protein levels by potentiating beta-secretase processing of beta-amyloid precursor protein.

scientific article

Low Evolutionary Selection Pressure in Senescence Does Not Explain the Persistence of Aβ in the Vertebrate Genome

Low-density lipoprotein receptor-related protein levels and endocytic function are reduced by overexpression of the FE65 adaptor protein, FE65L1.

scientific article published in August 2002

Magnetic resonance imaging white matter hyperintensities and brain volume in the prediction of mild cognitive impairment and dementia.

scientific article published in January 2008

Mapping autism risk loci using genetic linkage and chromosomal rearrangements

scientific article

Massachusetts Alzheimer's Disease Research Center: progress and challenges

scientific article

Maximizing the Power of Genome-Wide Association Studies: A Novel Class of Powerful Family-Based Association Tests

scientific article

Mechanisms that synergistically regulate η-secretase processing of APP and Aη-α protein levels: relevance to pathogenesis and treatment of Alzheimer's disease

scientific article published in February 2017

Meditation and Yoga Practices as Potential Adjunctive Treatment of SARS-CoV-2 Infection and COVID-19: A Brief Overview of Key Subjects

scientific article published on 22 June 2020

Metal exposure and Alzheimer's pathogenesis.

scientific article

Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial

scientific article

Metalloenzyme-like activity of Alzheimer's disease beta-amyloid. Cu-dependent catalytic conversion of dopamine, cholesterol, and biological reducing agents to neurotoxic H(2)O(2).

scientific article published on 20 August 2002

Modulation of gamma-secretase reduces beta-amyloid deposition in a transgenic mouse model of Alzheimer's disease

scientific article

Molecular imaging of Alzheimer's disease-related gamma-secretase in mice and nonhuman primates

scientific article published on 01 December 2020

Nanoplasmonic fiber tip probe detects significant reduction of intracellular Alzheimer's disease-related oligomers by curcumin

scientific article

Near-infrared fluorescence molecular imaging of amyloid beta species and monitoring therapy in animal models of Alzheimer's disease

scientific article

Negative evidence for a role of APH1B T27I variant in Alzheimer's disease

scientific article published on 29 January 2020

Neuroinflammatory Environments Promote Amyloid-β Deposition and Posttranslational Modification

Neuroinflammatory Responses in the Alzheimer's Disease Brain Promote the Oxidative Post-translational Modification of Amyloid Deposits

article

Neuropsychological measures in normal individuals that predict subsequent cognitive decline.

scientific article published in June 2007

No association between CALHM1 and Alzheimer's disease risk

scientific article published on December 2008

Non-invasive red-light optogenetic control of Drosophila cardiac function

scientific article published on 29 June 2020

Novel late-onset Alzheimer disease loci variants associate with brain gene expression

scientific article

On the association analysis of genome-sequencing data: A spatial clustering approach for partitioning the entire genome into nonoverlapping windows.

scientific article

On the meta-analysis of genome-wide association studies: a robust and efficient approach to combine population and family-based studies

scientific article published on 18 January 2012

Optical Coherence Tomography for Brain Imaging and Developmental Biology

scientific article published on 30 December 2015

Optogenetic pacing in Drosophila melanogaster

scientific article

P1-131 (Aβ) in human lens & aqueous humor: further characterization of a novel AD biomarker

PBT2 rapidly improves cognition in Alzheimer's Disease: additional phase II analyses

scientific article published in January 2010

PLD3 gene variants and Alzheimer's disease.

scientific article

Palmitoylated APP Forms Dimers, Cleaved by BACE1.

scientific article

Partial loss-of-function mutations in insulin-degrading enzyme that induce diabetes also impair degradation of amyloid beta-protein

scientific article

Peripheral surgical wounding and age-dependent neuroinflammation in mice

scientific article (publication date: 2014)

Peroxidase activity of cyclooxygenase-2 (COX-2) cross-links beta-amyloid (Abeta) and generates Abeta-COX-2 hetero-oligomers that are increased in Alzheimer's disease

scientific article

Pharmacological and Toxicological Properties of the Potent Oral γ-Secretase Modulator BPN-15606.

scientific article

Potential late-onset Alzheimer's disease-associated mutations in the ADAM10 gene attenuate {alpha}-secretase activity

scientific article published on 15 July 2009

Potential therapeutic targets for Alzheimer’s disease

Potential use of γ-secretase modulators in the treatment of Alzheimer disease

scientific article

Preliminary studies of a novel bifunctional metal chelator targeting Alzheimer's amyloidogenesis

scientific article

Protein aggregates and novel presenilin gene variants in idiopathic dilated cardiomyopathy

scientific article

RNA interference silencing of the adaptor molecules ShcC and Fe65 differentially affect amyloid precursor protein processing and Abeta generation

scientific article published on 14 December 2006

RNA interference-mediated silencing of X11alpha and X11beta attenuates amyloid beta-protein levels via differential effects on beta-amyloid precursor protein processing.

scientific article published on 7 February 2005

RNAi-mediated knock-down of Dab and Numb attenuate Aβ levels via γ-secretase mediated APP processing

scientific article

Rapid restoration of cognition in Alzheimer's transgenic mice with 8-hydroxy quinoline analogs is associated with decreased interstitial Abeta

scientific article

Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

scientific article

Rarity of the Alzheimer disease-protective APP A673T variant in the United States

scientific article

Recapitulating amyloid β and tau pathology in human neural cell culture models: clinical implications

scientific article published on January 2015

Recovering unused information in genome-wide association studies: the benefit of analyzing SNPs out of Hardy-Weinberg equilibrium

scientific article published on 03 June 2009

Redox-active metals, oxidative stress, and Alzheimer's disease pathology

scientific article published on March 2004

Reduced amyloidogenic processing of the amyloid beta-protein precursor by the small-molecule Differentiation Inducing Factor-1

scientific article published on 25 December 2008

Region-based analysis of rare genomic variants in whole-genome sequencing datasets reveal two novel Alzheimer's disease-associated genes: DTNB and DLG2

scientific article published on 04 March 2022

Regulation of key proteins in Alzheimer’s disease molecular pathogenesis by ubiquilin-1

Relationship between ubiquilin-1 and BACE1 in human Alzheimer's disease and APdE9 transgenic mouse brain and cell-based models

scientific article published on 9 November 2015

Relationships among classifications of ayurvedic medicine diagnostics for imbalances (vikruti) and western measures of psychological states: An exploratory study

scientific article published on 29 October 2018

Relevance of the COPI complex for Alzheimer's disease progression in vivo

scientific article published on 25 April 2016

Response to Mancuso et al.: Curcumin and Alzheimer Disease: This Marriage Is Not to Be Performed

scientific article published in January 2011

Results of a high-resolution genome screen of 437 Alzheimer's disease families

scientific article published on January 2003

SARS-CoV-2 reservoir in post-acute sequelae of COVID-19 (PASC)

scientific article published in 2023

SUMO1 modulates Aβ generation via BACE1 accumulation.

scientific article published on 11 September 2012

Science Signaling Podcast for 10 May 2016: PKCα in Alzheimer's disease

scientific article published on 10 May 2016

Segmentation of Drosophila heart in optical coherence microscopy images using convolutional neural networks

scientific article published on 06 August 2018

Sex Differences in Cognitive Decline in Subjects with High Likelihood of Mild Cognitive Impairment due to Alzheimer's disease.

scientific article

Significant Upregulation of Alzheimer's β-Amyloid Levels in a Living System Induced by Extracellular Elastin Polypeptides

scientific article published on 04 November 2019

Silencing of the Drosophila ortholog of SOX5 in heart leads to cardiac dysfunction as detected by optical coherence tomography

scientific article published on 21 May 2013

Silencing of the Drosophila ortholog of SOX5 leads to abnormal neuronal development and behavioral impairment

scientific article published on 10 February 2017

Single-nucleotide polymorphism rs498055 on chromosome 10q24 is not associated with Alzheimer disease in two independent family samples

scientific article published on July 2006

Soluble Gamma-secretase Modulators Attenuate Alzheimer's β-amyloid Pathology and Induce Conformational Changes in Presenilin 1.

scientific article

Soluble γ-secretase modulators selectively inhibit the production of the 42-amino acid amyloid β peptide variant and augment the production of multiple carboxy-truncated amyloid β species

scientific article published on 22 January 2014

Spatial memory is intact in aged rats after propofol anesthesia

scientific article published in October 2008

Synaptotagmins interact with APP and promote Aβ generation

scientific article published on 23 July 2015

Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database

scientific article

Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database

scientific article

TREM2 Acts Downstream of CD33 in Modulating Microglial Pathology in Alzheimer's Disease

scientific article published on 10 July 2019

TREM2 and Risk of Alzheimer's Disease--Friend or Foe?

scientific article

Tangles and neurodegenerative disease--a surprising twist

scientific article published in October 2005

Targeting ubiquilin-1 in Alzheimer's disease

scientific article published on 21 April 2013

Tau molecular diversity contributes to clinical heterogeneity in Alzheimer's disease

scientific article published on 22 June 2020

The Alzheimer's disease-associated amyloid beta-protein is an antimicrobial peptide

scientific article published in 2010

The Amazon rain forest plant Uncaria tomentosa (cat's claw) and its specific proanthocyanidin constituents are potent inhibitors and reducers of both brain plaques and tangles

scientific article published in Scientific Reports

The CALHM1 P86L polymorphism is a genetic modifier of age at onset in Alzheimer's disease: a meta-analysis study

scientific article

The LDLR locus in Alzheimer's disease: a family-based study and meta-analysis of case-control data

scientific article

The Self-Directed Biological Transformation Initiative and Well-Being

scientific article published on 28 June 2016

The antimicrobial protection hypothesis of Alzheimer's disease

article

The common inhalation anesthetic isoflurane induces apoptosis and increases amyloid beta protein levels

scientific article published on May 2006

The common inhalation anesthetic isoflurane induces caspase activation and increases amyloid beta-protein level in vivo

scientific article published on December 2008

The common inhalational anesthetic sevoflurane induces apoptosis and increases beta-amyloid protein levels

scientific article published on May 2009

The current status of Alzheimer's disease genetics: what do we tell the patients?

scientific article published in October 2004

The effects of isoflurane and desflurane on cognitive function in humans

scientific article

The galvanization of beta-amyloid in Alzheimer's disease

scientific article

The genetic epidemiology of neurodegenerative disease

scientific article

The genetics of Alzheimer disease: back to the future

scientific article published on October 2010

The genetics of Alzheimer's disease

scientific article published on 01 January 2012

The inhalation anesthetic desflurane induces caspase activation and increases amyloid beta-protein levels under hypoxic conditions

scientific article published on 6 March 2008

The inhalation anesthetic isoflurane increases levels of proinflammatory TNF-α, IL-6, and IL-1β.

scientific article

The rare TREM2 R47H variant exerts only a modest effect on Alzheimer disease risk.

scientific article

The role of clusterin, complement receptor 1, and phosphatidylinositol binding clathrin assembly protein in Alzheimer disease risk and cerebrospinal fluid biomarker levels.

scientific article published in February 2011

The role of the low-density lipoprotein receptor-related protein (LRP1) in Alzheimer's A beta generation: development of a cell-based model system.

scientific article published in August 2002

The synaptic Abeta hypothesis of Alzheimer disease

scientific article published in August 2005

The zinc dyshomeostasis hypothesis of Alzheimer's disease

scientific article (publication date: 2012)

Therapeutics for Alzheimer's disease based on the metal hypothesis

scientific article published on July 2008

Thirty years of Alzheimer's disease genetics: the implications of systematic meta-analyses

scientific article

Trace metal contamination initiates the apparent auto-aggregation, amyloidosis, and oligomerization of Alzheimer's Abeta peptides.

scientific article published on 3 November 2004

Ubiquilin 1 modulates amyloid precursor protein trafficking and Abeta secretion

scientific article published on 31 August 2006

Ubiquilin-1 modulates γ-secretase-mediated ε-site cleavage in neuronal cells

scientific article published on 21 May 2013

Upregulation of Alzheimer's Disease Amyloid-β Protein Precursor in Astrocytes Both in vitro and in vivo

scientific article published on 24 June 2020

Welcome to the complex disease world. Alpha2-macroglobulin and Alzheimer's disease.

scientific article published in November 2003

Whole-genome sequencing reveals new Alzheimer's disease-associated rare variants in loci related to synaptic function and neuronal development

scientific article published on 04 November 2020

Whole-genome sequencing reveals new Alzheimer's disease-associated rare variants in loci related to synaptic function and neuronal development

scientific article published on 02 April 2021

iPSC-derived familial Alzheimer's PSEN2 N141I cholinergic neurons exhibit mutation-dependent molecular pathology corrected by insulin signaling.

scientific article

iPSCs to the rescue in Alzheimer's research

scientific article published on 01 March 2012

γ-Secretase modulators reduce endogenous amyloid β42 levels in human neural progenitor cells without altering neuronal differentiation

scientific article published on 22 April 2015

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