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List of works by Patrick Schöffski

A first in man, dose-finding study of the mTORC1/mTORC2 inhibitor OSI-027 in patients with advanced solid malignancies

scientific article published on 22 March 2016

A phase I study of two dosing schedules of oral BI 847325 in patients with advanced solid tumors.

scientific article

A phase I, dose-escalation study of the novel Polo-like kinase inhibitor volasertib (BI 6727) in patients with advanced solid tumours ⬇️

scientific article published on November 24, 2011

A phase II study of gefitinib for patients with advanced HER-1 expressing synovial sarcoma refractory to doxorubicin-containing regimens

scientific article published in April 2008

A phase II study of the efficacy and safety of AMG 102 in patients with metastatic renal cell carcinoma ⬇️

scientific article published on December 13, 2010

A phase Ib study of pictilisib (GDC-0941) in combination with paclitaxel, with and without bevacizumab or trastuzumab, and with letrozole in advanced breast cancer

A possible role for microRNA-141 down-regulation in sunitinib resistant metastatic clear cell renal cell carcinoma through induction of epithelial-to-mesenchymal transition and hypoxia resistance

scientific article published on 30 November 2012

A potent combination of the novel PI3K Inhibitor, GDC-0941, with imatinib in gastrointestinal stromal tumor xenografts: long-lasting responses after treatment withdrawal

scientific article

A retrospective analysis of antitumour activity with trabectedin in translocation-related sarcomas

scientific article

Absence of progression as assessed by response evaluation criteria in solid tumors predicts survival in advanced GI stromal tumors treated with imatinib mesylate: the intergroup EORTC-ISG-AGITG phase III trial

scientific article

Abstract LB-295: Detection of oncogenic kinase mutations in circulating plasma DNA and correlation with clinical benefit in the phase III GRID study of regorafenibvsplacebo in TKI-refractory metastatic GIST

article

Acral necrosis after inadequate excessive administration of bleomycin in a testicular cancer patient

scientific article

Adaptation and performance of an immuno-PCR assay for the quantification of Aviscumine in patient plasma samples

scientific article published on 27 June 2005

An economic evaluation of cetuximab combined with radiotherapy for patients with locally advanced head and neck cancer in Belgium, France, Italy, Switzerland, and the United Kingdom

scientific article published on 11 January 2008

Autophagy inhibition and antimalarials promote cell death in gastrointestinal stromal tumor (GIST).

scientific article

Avelumab in metastatic urothelial carcinoma after platinum failure (JAVELIN Solid Tumor): pooled results from two expansion cohorts of an open-label, phase 1 trial

scientific article published on 4 December 2017

Biological ageing and frailty markers in breast cancer patients

scientific article published on May 2015

Biology and management of clear cell sarcoma: state of the art and future perspectives

scientific article

Bisphosphonates in patients with renal cell carcinoma and bone metastases: a sunitinib global expanded-access trial subanalysis

scientific article

Cabozantinib Is Active against Human Gastrointestinal Stromal Tumor Xenografts Carrying Different KIT Mutations

scientific article published on 24 October 2016

Cabozantinib for metastatic breast carcinoma: results of a phase II placebo-controlled randomized discontinuation study

scientific article published on 06 October 2016

Cabozantinib in Patients With Advanced Prostate Cancer: Results of a Phase II Randomized Discontinuation Trial ⬇️

scientific article published on November 19, 2012

Cabozantinib in progressive medullary thyroid cancer

scientific article

Capecitabine/oxaliplatin, a safe and active first-line regimen for older patients with metastatic colorectal cancer: post hoc analysis of a large phase II study

scientific article published in July 2005

Cellular uptake of the tyrosine kinase inhibitors imatinib and AMN107 in gastrointestinal stromal tumor cell lines

scientific article published on 8 March 2006

Characterization and assessment of the sensitivity and resistance of a newly established human gastrointestinal stromal tumour xenograft model to treatment with tyrosine kinase inhibitors

scientific article

Chromosome instability accounts for reverse metastatic outcomes of pediatric and adult synovial sarcomas

scientific article published on 14 January 2013

Circulating MicroRNAs as easy-to-measure aging biomarkers in older breast cancer patients: correlation with chronological age but not with fitness/frailty status

scientific article

Circulating levels of soluble KIT serve as a biomarker for clinical outcome in gastrointestinal stromal tumor patients receiving sunitinib following imatinib failure

scientific article

Clinical presentation, pathological features and natural course of metastatic uveal melanoma, an orphan and commonly fatal disease

scientific article published on 23 April 2014

Coactivated platelet-derived growth factor receptor {alpha} and epidermal growth factor receptor are potential therapeutic targets in intimal sarcoma

scientific article published on 4 August 2010

Complete longitudinal analyses of the randomized, placebo-controlled, phase III trial of sunitinib in patients with gastrointestinal stromal tumor following imatinib failure

scientific article

Correlation of KIT and PDGFRA mutational status with clinical benefit in patients with gastrointestinal stromal tumor treated with sunitinib in a worldwide treatment-use trial

scientific article published on 15 January 2016

Correlative analyses of RET and RAS mutations in a phase 3 trial of cabozantinib in patients with progressive, metastatic medullary thyroid cancer

scientific article

Corrigendum to “Does a patient’s self-reported health-related quality of life predict survival beyond key biomedical data in advanced colorectal cancer?” [Eur. J. Cancer 42 (2006) 42–49]

article

Crizotinib achieves long-lasting disease control in advanced papillary renal-cell carcinoma type 1 patients with MET mutations or amplification. EORTC 90101 CREATE trial

scientific article published on 14 November 2017

Crizotinib in patients with advanced, inoperable inflammatory myofibroblastic tumours with and without anaplastic lymphoma kinase gene alterations (European Organisation for Research and Treatment of Cancer 90101 CREATE): a multicentre, single-drug,

scientific article published on 12 April 2018

Determination of 9-nitrocamptothecin and its metabolite 9-aminocamptothecin in human plasma using high-performance liquid chromatography with ultraviolet and fluorescence detection

scientific article

Development of an optimal pharmacokinetic sampling schedule for rubitecan administered orally in a daily times five schedule

scientific article

Documentation of thyroid function in clinical studies with sunitinib: why does it matter?

scientific article published on 29 September 2008

Does a patient's self-reported health-related quality of life predict survival beyond key biomedical data in advanced colorectal cancer?

scientific article published on 18 November 2005

Dose escalation results from a first-in-human, phase 1 study of glucocorticoid-induced TNF receptor-related protein agonist AMG 228 in patients with advanced solid tumors

scholarly article by Ben Tran et al published 25 September 2018 in Journal for Immunotherapy of Cancer

Doxorubicin plus evofosfamide versus doxorubicin alone in locally advanced, unresectable or metastatic soft-tissue sarcoma (TH CR-406/SARC021): an international, multicentre, open-label, randomised phase 3 trial

scientific article

Early phase II trial of oral vorinostat in relapsed or refractory breast, colorectal, or non-small cell lung cancer

scientific article

Efficacy and safety of motesanib, an oral inhibitor of VEGF, PDGF, and Kit receptors, in patients with imatinib-resistant gastrointestinal stromal tumors

scientific article

Efficacy and safety of regorafenib for advanced gastrointestinal stromal tumours after failure of imatinib and sunitinib (GRID): an international, multicentre, randomised, placebo-controlled, phase 3 trial

scientific article

Efficacy of the kinase inhibitor SU11248 against gastrointestinal stromal tumor mutants refractory to imatinib mesylate

scientific article

Efflux pump ABCB1 single nucleotide polymorphisms and dose reductions in patients with metastatic renal cell carcinoma treated with sunitinib

scientific article

Establishment of a mouse gastrointestinal stromal tumour model and evaluation of response to imatinib by small animal positron emission tomography

scientific article published on March 2006

First-in-man phase I study assessing the safety and pharmacokinetics of a 1-hour intravenous infusion of the doxorubicin prodrug DTS-201 every 3 weeks in patients with advanced or metastatic solid tumours

scientific article published on 19 October 2017

Flare-up: an often unreported phenomenon nevertheless familiar to oncologists prescribing tyrosine kinase inhibitors

scientific article

Frequent mono-allelic loss associated with deficient PTEN expression in imatinib-resistant gastrointestinal stromal tumors

scientific article published on 18 April 2014

Gastrointestinal stromal tumors I: pathology, pathobiology, primary therapy, and surgical issues

scientific article published on August 2009

Gastrointestinal stromal tumors II: medical oncology and tumor response assessment

scientific article published on August 2009

Ghrelin in chronic liver disease

scientific article published in April 2003

High efficacy of panobinostat towards human gastrointestinal stromal tumors in a xenograft mouse model

scientific article

Identification of microRNA biomarkers for response of advanced soft tissue sarcomas to eribulin: Translational results of the EORTC 62052 trial

scientific article published on 16 February 2017

Impact of tumor chronology and tumor biology on lymph node metastasis in breast cancer

scientific article published on 23 September 2013

Implications of mutational analysis for the management of patients with gastrointestinal stromal tumors and the application of targeted therapies

scientific article published on October 2010

In Vivo Antitumoral Efficacy of PhAc-ALGP-Doxorubicin, an Enzyme-Activated Doxorubicin Prodrug, in Patient-Derived Soft Tissue Sarcoma Xenograft Models

scientific article

Inter-telomeric recombination is present in telomerase-positive human cells

scientific article published on 6 June 2013

International expert opinion on patient-tailored management of soft tissue sarcomas

scientific article

Intestinal neurofibromatosis is a subtype of familial GIST and results from a dominant activating mutation in PDGFRA.

scientific article published on December 2006

Intrinsic cell memory reinforces myogenic commitment of pericyte-derived iPSCs

scientific article published on 21 February 2011

Key Issues in the Clinical Management of Gastrointestinal Stromal Tumors: An Expert Discussion

scientific article published on 12 June 2015

Lapatinib versus hormone therapy in patients with advanced renal cell carcinoma: a randomized phase III clinical trial

scientific article published in May 2008

MYC high level gene amplification is a distinctive feature of angiosarcomas after irradiation or chronic lymphedema

scientific article

Metastatic HER-2-positive salivary gland carcinoma treated with trastuzumab and a taxane: a series of six patients

scientific article published on 30 May 2016

Metastatic potential is determined early in synovial sarcoma development and reflected by tumor molecular features

scientific article published on 16 May 2014

Mitotic checkpoints and chromosome instability are strong predictors of clinical outcome in gastrointestinal stromal tumors

scientific article published on 13 December 2011

Molecular characterization by array comparative genomic hybridization and DNA sequencing of 194 desmoid tumors.

scientific article published in June 2010

Multicentric parallel phase II trial of the polo-like kinase 1 inhibitor BI 2536 in patients with advanced head and neck cancer, breast cancer, ovarian cancer, soft tissue sarcoma and melanoma. The first protocol of the European Organization for Res

scientific article

Neoadjuvant imatinib in locally advanced gastrointestinal stromal tumors (GIST): the EORTC STBSG experience

scientific article published on 13 June 2013

New targets and therapies for gastrointestinal stromal tumors

scientific article published on 7 November 2017

Outcome of patients with platelet-derived growth factor receptor alpha-mutated gastrointestinal stromal tumors in the tyrosine kinase inhibitor era.

scientific article

Overcoming Cost Implications of Mutational Analysis in Patients with Gastrointestinal Stromal Tumors: A Pragmatic Approach

scientific article published on 18 November 2016

Patient preference for oral chemotherapy

scientific article published in January 2002

Patient selection for oncology phase I trials: a multi-institutional study of prognostic factors

scientific article published on 21 February 2012

Patterns of care, prognosis, and survival in patients with metastatic gastrointestinal stromal tumors (GIST) refractory to first-line imatinib and second-line sunitinib

scientific article published on 8 November 2011

Pazopanib for metastatic soft-tissue sarcoma (PALETTE): a randomised, double-blind, placebo-controlled phase 3 trial

scientific article

Pazopanib in the treatment of soft tissue sarcoma ⬇️

scientific article published on June 1, 2012

Pazopanib, a Receptor Tyrosine Kinase Inhibitor, Suppresses Tumor Growth through Angiogenesis in Dedifferentiated Liposarcoma Xenograft Models

scientific article

Pazopanib, a multikinase angiogenesis inhibitor, in patients with relapsed or refractory advanced soft tissue sarcoma: a phase II study from the European organisation for research and treatment of cancer-soft tissue and bone sarcoma group (EORTC stu

scientific article

Phase I safety and pharmacokinetic dose-escalation study of pilaralisib polymorph E, a phosphoinositide 3-kinase inhibitor in tablet formulation, in patients with solid tumors or lymphoma

scientific article

Phase I study of OSI-7904L, a novel liposomal thymidylate synthase inhibitor in patients with refractory solid tumors

scientific article published in August 2005

Phase I trial of volasertib, a Polo-like kinase inhibitor, plus platinum agents in solid tumors: safety, pharmacokinetics and activity

scientific article

Phase I, open-label, multicentre, dose-escalation, pharmacokinetic and pharmacodynamic trial of the oral aurora kinase inhibitor PF-03814735 in advanced solid tumours ⬇️

scientific article published on August 16, 2011

Phase II randomised discontinuation trial of cabozantinib in patients with advanced solid tumours

scientific article published on 20 October 2017

Phase II randomized study of Plitidepsin (Aplidin), alone or in association with L-carnitine, in patients with unresectable advanced renal cell carcinoma

scientific article published on 05 March 2009

Phase II study of biweekly plitidepsin as second-line therapy for advanced or metastatic transitional cell carcinoma of the urothelium

scientific article published on 16 September 2009

Phosphoinositide 3-kinase inhibitors combined with imatinib in patient-derived xenograft models of gastrointestinal stromal tumors: rationale and efficacy

scientific article published on 14 October 2014

Plasma P-selectin levels are elevated in patients with chronic liver disease

scientific article published in June 2003

Polo-like kinase (PLK) inhibitors in preclinical and early clinical development in oncology

scientific article published on 27 May 2009

Pro-angiogenic gene expression is associated with better outcome on sunitinib in metastatic clear-cell renal cell carcinoma

scientific article published on 2 November 2017

Prognostic factors in adolescents and young adults (AYA) with high risk soft tissue sarcoma (STS) treated by adjuvant chemotherapy: A study based on pooled European Organisation for Research and Treatment of Cancer (EORTC) clinical trials 62771 and 6

Promoting role of cholecystokinin 2 receptor (CCK2R) in gastrointestinal stromal tumour pathogenesis.

scientific article

Proteolytic Processing of ErbB4 in Breast Cancer

scientific article

Recurrent low- to intermediate-grade chondrosarcoma of the thumb with lung metastases: an objective response to trofosfamide

scientific article published on 23 March 2007

Retrospective Analysis of Outcome of Patients with Metastatic Leiomyosarcoma in a Tertiary Referral Center

scientific article published on 23 March 2018

Retrospective quality control review of FDG scans in the imaging sub-study of PALETTE EORTC 62072/VEG110727: a randomized, double-blind, placebo-controlled phase III trial

scientific article

Safety and efficacy of sunitinib for metastatic renal-cell carcinoma: an expanded-access trial

scientific article

Sarcomatoid dedifferentiation in metastatic clear cell renal cell carcinoma and outcome on treatment with anti-vascular endothelial growth factor receptor tyrosine kinase inhibitors: a retrospective analysis.

scientific article

Shrinkage of thyroid volume in sunitinib-treated patients with renal-cell carcinoma: a potential marker of irreversible thyroid dysfunction?

scientific article published in March 2010

Single-Center Experience with Intimal Sarcoma, an Ultra-Orphan, Commonly Fatal Mesenchymal Malignancy

scientific article published on 12 May 2017

Soft tissue sarcoma: an update on systemic treatment options for patients with advanced disease

scientific article

Sphincter sparing resection of a large obstructive distal rectal gastrointestinal stromal tumour after neoadjuvant therapy with imatinib (Glivec).

scientific article published on 8 January 2015

Targeted therapies in the treatment of GIST: Adverse events and maximising the benefits of sunitinib through proactive therapy management

scientific article published on January 2010

The HSP90 inhibitor, AT13387, is effective against imatinib-sensitive and -resistant gastrointestinal stromal tumor models

scientific article published on 19 June 2012

The Novel HSP90 inhibitor, IPI-493, is highly effective in human gastrostrointestinal stromal tumor xenografts carrying heterogeneous KIT mutations

scientific article published on 7 July 2011

The effect of baseline morphology and its change during treatment on the accuracy of Response Evaluation Criteria in Solid Tumours in assessment of liver metastases

scientific article published on 27 January 2014

The footprint of the ageing stroma in older patients with breast cancer

scientific article

The heat shock protein 90 inhibitor IPI-504 induces KIT degradation, tumor shrinkage, and cell proliferation arrest in xenograft models of gastrointestinal stromal tumors

scientific article

The impact of adjuvant chemotherapy in older breast cancer patients on clinical and biological aging parameters

scientific article published on 18 April 2016

The modulated oral fluoropyrimidine prodrug S-1, and its use in gastrointestinal cancer and other solid tumors

scientific article

The more you look, the more you find: challenging results on FDG-PET CT in a patient with neurofibromatosis type I.

scientific article

The preclinical and clinical activity of aviscumine: A potential anticancer drug ⬇️

scientific article published on April 12, 2011

The tyrosine kinase inhibitor crizotinib does not have clinically meaningful activity in heavily pre-treated patients with advanced alveolar rhabdomyosarcoma with FOXO rearrangement: European Organisation for Research and Treatment of Cancer phase 2

scientific article

Therapeutic Efficacy Assessment of CK6, a Monoclonal KIT Antibody, in a Panel of Gastrointestinal Stromal Tumor Xenograft Models

scientific article published on April 2015

Thrombopoietin serum levels are elevated in patients with hepatitis B/C infection compared to other causes of chronic liver disease

scientific article

Trabectedin (ET-743): evaluation of its use in advanced soft-tissue sarcoma

scientific article published on August 2007

Tumor cell-based vaccination in renal cell carcinoma: rationale. approaches, and recent clinical development

scientific article

Tumor genotype is an independent prognostic factor in primary gastrointestinal stromal tumors of gastric origin: a european multicenter analysis based on ConticaGIST.

scientific article published on 7 October 2014

Tumor volume as an alternative response measurement for imatinib treated GIST patients

scientific article

Unbiased compound screening identifies unexpected drug sensitivities and novel treatment options for gastrointestinal stromal tumors

scientific article

Using pharmacokinetic and pharmacodynamic data in early decision making regarding drug development: a phase I clinical trial evaluating tyrosine kinase inhibitor, AEE788.

scientific article

VEGFR1 single nucleotide polymorphisms associated with outcome in patients with metastatic renal cell carcinoma treated with sunitinib - a multicentric retrospective analysis.

scientific article published on 20 February 2013

Validation of VEGFR1 rs9582036 as predictive biomarker in metastatic clear-cell renal cell carcinoma patients treated with sunitinib

scientific article published on 15 July 2016

XELOX (capecitabine plus oxaliplatin): active first-line therapy for patients with metastatic colorectal cancer

scientific article

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