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List of works by Kevan M. Shokat

A Bounty of New Challenging Targets in Oncology for Chemical Discovery

scientific article published on 25 July 2019

A Patient-derived Xenograft Model of Pancreatic Neuroendocrine Tumors Identifies Sapanisertib as a Possible New Treatment for Everolimus-resistant Tumors

scientific article published on 25 September 2018

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

scientific article published on 30 April 2020

A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing ⬇️

journal article from 'bioRxiv' published in 2020

Bifunctional Small-Molecule Ligands of K-Ras Induce Its Association with Immunophilin Proteins

scientific article published on 26 September 2019

Chemical Genetic Identification of NDR1/2 Kinase Substrates AAK1 and Rabin8 Uncovers Their Roles in Dendrite Arborization and Spine Development ⬇️

scientific article published on March 21, 2012

Chronic TGF-β exposure drives stabilized EMT, tumor stemness, and cancer drug resistance with vulnerability to bitopic mTOR inhibition

scientific article published on 26 February 2019

Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms

scientific article published on 15 October 2020

Cooperative Blockade of PKCα and JAK2 Drives Apoptosis in Glioblastoma

scientific article published on 05 December 2019

Dissecting the biology of mTORC1 beyond rapamycin

scientific article published on 21 September 2021

Drugging the “Undruggable” MYCN Oncogenic Transcription Factor: Overcoming Previous Obstacles to Impact Childhood Cancers

scientific article published in 2021

Expanding the Scope of Electrophiles Capable of Targeting K-Ras Oncogenes.

scientific article published on 16 June 2017

Farnesyltransferase-Mediated Delivery of a Covalent Inhibitor Overcomes Alternative Prenylation to Mislocalize K-Ras.

scientific article published on 22 May 2017

GABAA receptor trafficking is regulated by protein kinase C(epsilon) and the N-ethylmaleimide-sensitive factor

scientific article

Inducible protein knockout reveals temporal requirement of CaMKII reactivation for memory consolidation in the brain

scholarly article

Inhibition of Calcium Dependent Protein Kinase 1 (CDPK1) by Pyrazolopyrimidine Analogs Decreases Establishment and Reoccurrence of Central Nervous System Disease by Toxoplasma gondii.

scientific article published on 21 September 2017

KRASG12C inhibition produces a driver-limited state revealing collateral dependencies

scientific article published on 28 May 2019

Novel K-Ras G12C Switch-II covalent binders destabilize Ras and accelerate nucleotide exchange

scientific article published on 10 January 2018

Optimizing small molecule inhibitors of calcium-dependent protein kinase 1 to prevent infection by Toxoplasma gondii

scientific article

PI4KIIIβ is a therapeutic target in chromosome 1q-amplified lung adenocarcinoma

scientific article published on 01 January 2020

Protein kinase C epsilon regulates gamma-aminobutyrate type A receptor sensitivity to ethanol and benzodiazepines through phosphorylation of gamma2 subunits

scientific journal article

Targeting a splicing-mediated drug resistance mechanism in prostate cancer by inhibiting transcriptional regulation by PKCβ1

scientific article published on 27 January 2022

Type II Kinase Inhibitors Targeting Cys-Gatekeeper Kinases Display Orthogonality with Wild Type and Ala/Gly-Gatekeeper Kinases ⬇️

scientific article published on 09 October 2018

p27 allosterically activates cyclin-dependent kinase 4 and antagonizes palbociclib inhibition

scientific article

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