List of works - Katja Becker

1,2,4-Triazole-3-thione Compounds as Inhibitors of Dizinc Metallo-β-lactamases

scientific article

1H, 13C, and 15N sequence-specific resonance assignment and secondary structure of Plasmodium falciparum thioredoxin

scientific article published on 01 August 2005

4-Amino-1,2,4-triazole-3-thione-derived Schiff bases as metallo-β-lactamase inhibitors

scientific article published on 20 August 2020

A Putative Glutathione Peroxidase of Drosophila Encodes a Thioredoxin Peroxidase That Provides Resistance against Oxidative Stress But Fails to Complement a Lack of Catalase Activity ⬇️

scientific article published on March 1, 2003

A high susceptibility to redox imbalance of the transmissible stages of Plasmodium falciparum revealed with a luciferase-based mature gametocyte assay

scientific article (publication date: April 2017)

Adenylate kinase and GTP:AMP phosphotransferase of the malarial parasite Plasmodium falciparum. Central players in cellular energy metabolism

scientific article (publication date: August 2004)

Allosteric coupling of two different functional active sites in monomeric Plasmodium falciparum glyoxalase I.

scientific article

Alternative Protein Secretion in the Malaria Parasite Plasmodium falciparum

scientific article (publication date: 2015)

Antiglioma activity of 2,2':6',2"-terpyridineplatinum(II) complexes in a rat model--effects on cellular redox metabolism

scientific article published on 19 October 2005

Antimalarial NADPH-Consuming Redox-Cyclers As Superior Glucose-6-Phosphate Dehydrogenase Deficiency Copycats

scientific article published on 14 April 2015

Antimalarial dual drugs based on potent inhibitors of glutathione reductase from Plasmodium falciparum

scientific article published on 9 February 2008

Antiparasitic Peptides ⬇️

scientific article published on January 1, 2013

Arylmethylamino steroids as antiparasitic agents

scientific article published on 17 February 2017

Atomic resolution crystal structure of glutaredoxin 1 from Plasmodium falciparum and comparison with other glutaredoxins

scientific article

Benzo[b]quinolizinium Derivatives Have a Strong Antimalarial Activity and Inhibit Indoleamine Dioxygenase

scientific article published on 12 October 2015

Biochemical and structural characterization of Plasmodium falciparum glutamate dehydrogenase 2 ⬇️

scientific article published on February 9, 2012

Biochemical characterization of Toxoplasma gondii 1-Cys peroxiredoxin 2 with mechanistic similarities to typical 2-Cys Prx.

scientific article published in March 2005

Characterization and redox regulation of Plasmodium falciparum methionine adenosyltransferase

scientific article (publication date: December 2016)

Characterization of Plasmodium falciparum 6-Phosphogluconate Dehydrogenase as an Antimalarial Drug Target

Characterization of the 26S proteasome network in Plasmodium falciparum

scientific article (publication date: 7 December 2015)

Characterization of the glyoxalases of the malarial parasite Plasmodium falciparum and comparison with their human counterparts

scientific article (publication date: 2005)

Characterization of tryptophan aminotransferase 1 of Malassezia furfur, the key enzyme in the production of indolic compounds by M. furfur.

scientific article

Comparative structural analysis of oxidized and reduced thioredoxin from Drosophila melanogaster

scientific article published on 16 December 2004

Comparison of methods probing the intracellular redox milieu in Plasmodium falciparum

scientific article published on 16 November 2015

Compartmentation of Redox Metabolism in Malaria Parasites ⬇️

scientific article (publication date: 23 December 2010)

Compounds structurally related to ellagic acid show improved antiplasmodial activity

scientific article published on 17 November 2008

Conformational stability and energetics of Plasmodium falciparum glutaredoxin

scientific article published on 17 December 2009

Crystal Structure of the Antioxidant Enzyme Glutathione Reductase Inactivated by Peroxynitrite ⬇️

scientific article published on November 8, 2001

Crystal structure of a novel Plasmodium falciparum 1-Cys peroxiredoxin

scientific article published on 8 January 2005

Crystal structure of the Plasmodium falciparum thioredoxin reductase-thioredoxin complex

scientific article

Crystal structure of the human thioredoxin reductase–thioredoxin complex ⬇️

scientific article published on July 12, 2011

Cynaropicrin targets the trypanothione redox system in Trypanosoma brucei

scientific article published on 5 September 2013

Depletion of Plasmodium berghei plasmoredoxin reveals a non-essential role for life cycle progression of the malaria parasite

scientific article

Detection of thiol-based redox switch processes in parasites - facts and future

scientific article

Determination of glutathione redox potential and pH value in subcellular compartments of malaria parasites

scientific article published on 3 January 2017

Differential genomic and proteomic profiling of glioblastoma cells exposed to terpyridineplatinum(II) complexes

scientific article

Diversity of chemical mechanisms in thioredoxin catalysis revealed by single-molecule force spectroscopy.

scientific article published on 13 July 2009

Energy, Macronutrient Intake, and Anthropometrics of Vegetarian, Vegan, and Omnivorous Children (1⁻3 Years) in Germany (VeChi Diet Study).

scientific article published on 12 April 2019

Erratum: Diversity of chemical mechanisms in thioredoxin catalysis revealed by single-molecule force spectroscopy

scholarly article published in Nature Structural & Molecular Biology

Ethaselen: a potent mammalian thioredoxin reductase 1 inhibitor and novel organoselenium anticancer agent ⬇️

scientific article published on December 21, 2011

Exploring synthetic avenues for the effective synthesis of selenium- and tellurium-containing multifunctional redox agents.

scientific article published on 11 September 2009

Expression and regulation of thioredoxin reductases and other selenoproteins in bone

scientific article published in January 2002

Fiber array based hyperspectral Raman imaging for chemical selective analysis of malaria-infected red blood cells

scientific article published on 29 August 2015

Flavins and flavoproteins: applications in medicine

scientific article published on January 2014

Glucose 6-phosphate dehydrogenase 6-phosphogluconolactonase: characterization of the Plasmodium vivax enzyme and inhibitor studies

scientific article published on 25 January 2019

Glucose-6-phosphate dehydrogenase–6-phosphogluconolactonase: a unique bifunctional enzyme from Plasmodium falciparum ⬇️

scientific article (publication date: 15 June 2011)

Glucose-6-phosphate metabolism in Plasmodium falciparum

scientific article published on 28 May 2012

Glutathione S-transferase from malarial parasites: structural and functional aspects

scientific article

Glutathione S-transferase of the malarial parasite Plasmodium falciparum: characterization of a potential drug target

scientific article (publication date: May 2002)

Glutathione mediated regulation of oligomeric structure and functional activity of Plasmodium falciparum glutathione S-transferase

scientific article

Glutathione – Functions and Metabolism in the Malarial Parasite Plasmodium falciparum ⬇️

scientific article published on April 1, 2003

Glutathione- and thioredoxin-related enzymes are modulated by sulfur-containing chemopreventive agents

scientific article

Glyoxalase I of the malarial parasite Plasmodium falciparum: evidence for subunit fusion ⬇️

scientific article (publication date: 20 November 2003)

H2O2 dynamics in the malaria parasite Plasmodium falciparum

scientific article

HIPK2 kinase activity depends on cis-autophosphorylation of its activation loop

scientific article

High-throughput screening for small-molecule inhibitors of plasmodium falciparum glucose-6-phosphate dehydrogenase 6-phosphogluconolactonase

scientific article

Highlight: dynamics of thiol-based redox switches

scientific article published on 01 May 2015

Human placenta thioredoxin reductase: preparation and inhibitor studies

scientific article published in January 2002

Identification and characterization of heme-interacting proteins in the malaria parasite, Plasmodium falciparum

scientific article

Identification and characterization of novel human glucose-6-phosphate dehydrogenase inhibitors

scientific article

Identification of M. tuberculosis Thioredoxin Reductase Inhibitors Based on High-Throughput Docking Using Constraints ⬇️

scientific article published on June 13, 2013

Identification of acid-base catalytic residues of high-Mr thioredoxin reductase from Plasmodium falciparum

scientific article published in September 2006

Identification of proteins targeted by the thioredoxin superfamily in Plasmodium falciparum

scientific article

In situ localization and structural analysis of the malaria pigment hemozoin

scientific article published on 25 August 2007

In vitro assessment of methylene blue on chloroquine-sensitive and -resistant Plasmodium falciparum strains reveals synergistic action with artemisinins

scientific article published on November 2005

Infectious diseases - a global challenge

scientific article

Inherited glutathione reductase deficiency and Plasmodium falciparum malaria--a case study

scientific article

Insight into the Selenoproteome of the Malaria Parasite Plasmodium falciparum ⬇️

scientific article (publication date: 15 August 2012)

Interactions of methylene blue with human disulfide reductases and their orthologues from Plasmodium falciparum

scientific article

Intracellular positioning of isoforms explains an unusually large adenylate kinase gene family in the parasite Trypanosoma brucei

scientific article published on 18 January 2005

Kinetic characterization of wild-type and mutant human thioredoxin glutathione reductase defines its reaction and regulatory mechanisms

scientific article published on 8 December 2017

Large-scale differential proteome analysis in Plasmodium falciparum under drug treatment

scientific article

Large-scale differential proteome analysis in Plasmodium falciparum under drug treatment

scientific article published in January 2015

Lipase Processing of Complex Lipid Antigens

scientific article published in September 2016

Lipoprotein Glycosylation by Protein-O-Mannosyltransferase (MAB_1122c) Contributes to Low Cell Envelope Permeability and Antibiotic Resistance of Mycobacterium abscessus.

scientific article

Mechanism-based inactivation of thioredoxin reductase from Plasmodium falciparum by Mannich bases. Implication for cytotoxicity

scientific article published on November 2003

Mechanistic studies on a novel, highly potent gold-phosphole inhibitor of human glutathione reductase

scientific article (publication date: 27 May 2005)

Methylene blue as an antimalarial agent

scientific article

Microinjected glutathione reductase crystals as indicators of the redox status in living cells

scholarly article by Michael A. Keese published in March 1999

Mitochondrial and cytoplasmic thioredoxin reductase variants encoded by a single Drosophila gene are both essential for viability

scientific article published on 16 January 2002

Molecular basis of glutathione reductase deficiency in human blood cells

scientific article

Molecular evolution of a novel hyperactive Sleeping Beauty transposase enables robust stable gene transfer in vertebrates

scientific article (publication date: June 2009)

Molecular genetics evidence for the in vivo roles of the two major NADPH-dependent disulfide reductases in the malaria parasite

scientific article published on 19 September 2010

Molecular principles of parasitism. Preface

scientific article published on 01 September 2012

Morphology-sensitive Raman modes of the malaria pigment hemozoin

scientific article published on 9 April 2009

Myristoylated adenylate kinase-2 of Plasmodium falciparum forms a heterodimer with myristoyltransferase

scientific article (publication date: February 2009)

NMR assignments of oxidised thioredoxin from Plasmodium falciparum

scientific article published on 8 May 2009

Of malaria, metabolism and membrane transport

scientific article

Optimization of a whole-cell biocatalyst by employing genetically encoded product sensors inside nanolitre reactors.

scientific article published on 13 July 2015

Oxidative stress in malaria parasite-infected erythrocytes: host-parasite interactions

scientific article published on February 2004

Peroxiredoxin systems of protozoal parasites.

scientific article published on January 2007

Phospholipid Topography of Whole-Body Sections of the Anopheles stephensi Mosquito, Characterized by High-Resolution Atmospheric-Pressure Scanning Microprobe Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging

scientific article

Plasmodium Apicoplast Gln-tRNAGln Biosynthesis Utilizes a Unique GatAB Amidotransferase Essential for Erythrocytic Stage Parasites

scientific article (publication date: 4 December 2015)

Plasmodium falciparum 2-Cys peroxiredoxin reacts with plasmoredoxin and peroxynitrite

scientific article published on 01 November 2005

Plasmodium falciparum glucose-6-phosphate dehydrogenase 6-phosphogluconolactonase is a potential drug target

scientific article (publication date: October 2015)

Plasmodium falciparum glutaredoxin-like proteins

scientific article

Plasmodium falciparum glutathione S-transferase--structural and mechanistic studies on ligand binding and enzyme inhibition

scientific article published on 29 December 2005

Plasmodium falciparum thioredoxins and glutaredoxins as central players in redox metabolism

scientific article published on January 2003

Plasmodium falciparum--do killers commit suicide?

scientific article published on April 2004

Plasmoredoxin, a novel redox-active protein unique for malarial parasites

scientific article (publication date: March 2003)

Protein S-Glutathionylation in Malaria Parasites ⬇️

scientific article published on 07 July 2011

Protein S-nitrosylation in Plasmodium falciparum

scientific article

Real-time imaging of the intracellular glutathione redox potential in the malaria parasite Plasmodium falciparum

scientific article (publication date: 2013)

Redox Regulation of Plasmodium falciparum Ornithine δ-Aminotransferase ⬇️

scientific article published on July 29, 2010

Redox status of patients before cardiac surgery.

scientific article published on 19 December 2017

Resveratrol modulates mRNA transcripts of genes related to redox metabolism and cell proliferation in non-small-cell lung carcinoma cells

scientific article published on February 2007

SELDI-TOF-MS analysis of chloroquine resistant and sensitive Plasmodium falciparum strains

scientific article

Selenenyl iodide: a new substrate for mammalian thioredoxin reductase

scientific article published in August 2003

Stable integration and comparison of hGrx1-roGFP2 and sfroGFP2 redox probes in the malaria parasite Plasmodium falciparum

scientific article published on 06 September 2018

Structural and Functional Characterization of Plasmodium falciparum Nicotinic Acid Mononucleotide Adenylyltransferase

scientific article (publication date: 4 December 2016)

Structural and stability characteristics of a monothiol glutaredoxin: glutaredoxin-like protein 1 from Plasmodium falciparum

scientific article

Structural insights into the neuroprotective-acting carbonyl reductase Sniffer of Drosophila melanogaster

scientific article published in October 2004

Structural, functional and unfolding characteristics of glutathione S-transferase of Plasmodium vivax.

scientific article published on 23 May 2009

Subcellular localization of adenylate kinases in Plasmodium falciparum

scientific article (publication date: 21 September 2012)

Synthesis and biological evaluation of 1,4-naphthoquinones and quinoline-5,8-diones as antimalarial and schistosomicidal agents

scientific article

Synthesis and evaluation of 1,4-naphthoquinone ether derivatives as SmTGR inhibitors and new anti-schistosomal drugs

scientific article published on 25 June 2015

Synthesis of 5-nitro-2-furancarbohydrazides and their cis-diamminedichloroplatinum complexes as bitopic and irreversible human thioredoxin reductase inhibitors

scientific article published on November 2005

Targeting the intersubunit cavity of Plasmodium falciparum glutathione reductase by a novel natural inhibitor: computational and experimental evidence

scientific article published on 4 February 2015

The Drosophila carbonyl reductase sniffer prevents oxidative stress-induced neurodegeneration.

scientific article published in May 2004

The Plasmodium selenoproteome

scientific article

The aza-analogues of 1,4-naphthoquinones are potent substrates and inhibitors of plasmodial thioredoxin and glutathione reductases and of human erythrocyte glutathione reductase

scientific article published on 30 May 2008

The bacterial redox signaller pyocyanin as an antiplasmodial agent: comparisons with its thioanalog methylene blue ⬇️

scientific article published on January 1, 2011

The endophytic fungus Piriformospora indica reprograms barley to salt-stress tolerance, disease resistance, and higher yield

scientific article

The malarial parasite Plasmodium falciparum imports the human protein peroxiredoxin 2 for peroxide detoxification

scientific article

The structure of human thioredoxin reductase 1 provides insights into C-terminal rearrangements during catalysis

scientific article

The thioredoxin specificity of Drosophila GPx: a paradigm for a peroxiredoxin-like mechanism of many glutathione peroxidases.

scientific article published on 13 October 2006

The thioredoxin system—From science to clinic ⬇️

scientific article published on January 1, 2004

Thiol-Based Posttranslational Modifications in Parasites ⬇️

scientific article published on January 16, 2012

Thioredoxin and glutathione systems in Plasmodium falciparum ⬇️

scientific article published on August 29, 2012

Thioredoxin networks in the malarial parasite Plasmodium falciparum

scientific article (publication date: 2006)

Thioredoxin, thioredoxin reductase, and thioredoxin peroxidase of malaria parasite Plasmodium falciparum

scientific article published in January 2002

Truncated mutants of human thioredoxin reductase 1 do not exhibit glutathione reductase activity

scientific journal article

Undressing of phosphine gold(I) complexes as irreversible inhibitors of human disulfide reductases

scientific article published on March 2006

X-ray structure of glutathione S -transferase from the malarial parasite Plasmodium falciparum ⬇️

scientific article published on November 17, 2003

List of works by Katja Becker

1,2,4-Triazole-3-thione Compounds as Inhibitors of Dizinc Metallo-β-lactamases

1H, 13C, and 15N sequence-specific resonance assignment and secondary structure of Plasmodium falciparum thioredoxin

4-Amino-1,2,4-triazole-3-thione-derived Schiff bases as metallo-β-lactamase inhibitors

A Putative Glutathione Peroxidase of Drosophila Encodes a Thioredoxin Peroxidase That Provides Resistance against Oxidative Stress But Fails to Complement a Lack of Catalase Activity ⬇️

A high susceptibility to redox imbalance of the transmissible stages of Plasmodium falciparum revealed with a luciferase-based mature gametocyte assay

Adenylate kinase and GTP:AMP phosphotransferase of the malarial parasite Plasmodium falciparum. Central players in cellular energy metabolism

Allosteric coupling of two different functional active sites in monomeric Plasmodium falciparum glyoxalase I.

Alternative Protein Secretion in the Malaria Parasite Plasmodium falciparum

Antiglioma activity of 2,2':6',2"-terpyridineplatinum(II) complexes in a rat model--effects on cellular redox metabolism

Antimalarial NADPH-Consuming Redox-Cyclers As Superior Glucose-6-Phosphate Dehydrogenase Deficiency Copycats

Antimalarial dual drugs based on potent inhibitors of glutathione reductase from Plasmodium falciparum

Antiparasitic Peptides ⬇️

Arylmethylamino steroids as antiparasitic agents

Atomic resolution crystal structure of glutaredoxin 1 from Plasmodium falciparum and comparison with other glutaredoxins

Benzo[b]quinolizinium Derivatives Have a Strong Antimalarial Activity and Inhibit Indoleamine Dioxygenase

Biochemical and structural characterization of Plasmodium falciparum glutamate dehydrogenase 2 ⬇️

Biochemical characterization of Toxoplasma gondii 1-Cys peroxiredoxin 2 with mechanistic similarities to typical 2-Cys Prx.

Characterization and redox regulation of Plasmodium falciparum methionine adenosyltransferase

Characterization of Plasmodium falciparum 6-Phosphogluconate Dehydrogenase as an Antimalarial Drug Target

Characterization of the 26S proteasome network in Plasmodium falciparum

Characterization of the glyoxalases of the malarial parasite Plasmodium falciparum and comparison with their human counterparts

Characterization of tryptophan aminotransferase 1 of Malassezia furfur, the key enzyme in the production of indolic compounds by M. furfur.

Comparative structural analysis of oxidized and reduced thioredoxin from Drosophila melanogaster

Comparison of methods probing the intracellular redox milieu in Plasmodium falciparum

Compartmentation of Redox Metabolism in Malaria Parasites ⬇️

Compounds structurally related to ellagic acid show improved antiplasmodial activity

Conformational stability and energetics of Plasmodium falciparum glutaredoxin

Crystal Structure of the Antioxidant Enzyme Glutathione Reductase Inactivated by Peroxynitrite ⬇️

Crystal structure of a novel Plasmodium falciparum 1-Cys peroxiredoxin

Crystal structure of the Plasmodium falciparum thioredoxin reductase-thioredoxin complex

Crystal structure of the human thioredoxin reductase–thioredoxin complex ⬇️

Cynaropicrin targets the trypanothione redox system in Trypanosoma brucei

Depletion of Plasmodium berghei plasmoredoxin reveals a non-essential role for life cycle progression of the malaria parasite

Detection of thiol-based redox switch processes in parasites - facts and future

Determination of glutathione redox potential and pH value in subcellular compartments of malaria parasites

Differential genomic and proteomic profiling of glioblastoma cells exposed to terpyridineplatinum(II) complexes

Diversity of chemical mechanisms in thioredoxin catalysis revealed by single-molecule force spectroscopy.

Energy, Macronutrient Intake, and Anthropometrics of Vegetarian, Vegan, and Omnivorous Children (1⁻3 Years) in Germany (VeChi Diet Study).

Erratum: Diversity of chemical mechanisms in thioredoxin catalysis revealed by single-molecule force spectroscopy

Ethaselen: a potent mammalian thioredoxin reductase 1 inhibitor and novel organoselenium anticancer agent ⬇️

Exploring synthetic avenues for the effective synthesis of selenium- and tellurium-containing multifunctional redox agents.

Expression and regulation of thioredoxin reductases and other selenoproteins in bone

Fiber array based hyperspectral Raman imaging for chemical selective analysis of malaria-infected red blood cells

Flavins and flavoproteins: applications in medicine

Glucose 6-phosphate dehydrogenase 6-phosphogluconolactonase: characterization of the Plasmodium vivax enzyme and inhibitor studies

Glucose-6-phosphate dehydrogenase–6-phosphogluconolactonase: a unique bifunctional enzyme from Plasmodium falciparum ⬇️

Glucose-6-phosphate metabolism in Plasmodium falciparum

Glutathione S-transferase from malarial parasites: structural and functional aspects

Glutathione S-transferase of the malarial parasite Plasmodium falciparum: characterization of a potential drug target

Glutathione mediated regulation of oligomeric structure and functional activity of Plasmodium falciparum glutathione S-transferase

Glutathione – Functions and Metabolism in the Malarial Parasite Plasmodium falciparum ⬇️

Glutathione- and thioredoxin-related enzymes are modulated by sulfur-containing chemopreventive agents

Glyoxalase I of the malarial parasite Plasmodium falciparum: evidence for subunit fusion ⬇️

H2O2 dynamics in the malaria parasite Plasmodium falciparum

HIPK2 kinase activity depends on cis-autophosphorylation of its activation loop

High-throughput screening for small-molecule inhibitors of plasmodium falciparum glucose-6-phosphate dehydrogenase 6-phosphogluconolactonase

Highlight: dynamics of thiol-based redox switches

Human placenta thioredoxin reductase: preparation and inhibitor studies

Identification and characterization of heme-interacting proteins in the malaria parasite, Plasmodium falciparum

Identification and characterization of novel human glucose-6-phosphate dehydrogenase inhibitors

Identification of M. tuberculosis Thioredoxin Reductase Inhibitors Based on High-Throughput Docking Using Constraints ⬇️

Identification of acid-base catalytic residues of high-Mr thioredoxin reductase from Plasmodium falciparum

Identification of proteins targeted by the thioredoxin superfamily in Plasmodium falciparum

In situ localization and structural analysis of the malaria pigment hemozoin

In vitro assessment of methylene blue on chloroquine-sensitive and -resistant Plasmodium falciparum strains reveals synergistic action with artemisinins

Infectious diseases - a global challenge

Inherited glutathione reductase deficiency and Plasmodium falciparum malaria--a case study

Insight into the Selenoproteome of the Malaria Parasite Plasmodium falciparum ⬇️

Interactions of methylene blue with human disulfide reductases and their orthologues from Plasmodium falciparum

Intracellular positioning of isoforms explains an unusually large adenylate kinase gene family in the parasite Trypanosoma brucei

Kinetic characterization of wild-type and mutant human thioredoxin glutathione reductase defines its reaction and regulatory mechanisms

Large-scale differential proteome analysis in Plasmodium falciparum under drug treatment

Large-scale differential proteome analysis in Plasmodium falciparum under drug treatment

Lipase Processing of Complex Lipid Antigens

Lipoprotein Glycosylation by Protein-O-Mannosyltransferase (MAB_1122c) Contributes to Low Cell Envelope Permeability and Antibiotic Resistance of Mycobacterium abscessus.

Mechanism-based inactivation of thioredoxin reductase from Plasmodium falciparum by Mannich bases. Implication for cytotoxicity

Mechanistic studies on a novel, highly potent gold-phosphole inhibitor of human glutathione reductase

Methylene blue as an antimalarial agent

Microinjected glutathione reductase crystals as indicators of the redox status in living cells