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List of works by Hans Einar Krokan

22 DNA repair and cancer

A Combined Nuclear and Nucleolar Localization Motif in Activation-Induced Cytidine Deaminase (AID) Controls Immunoglobulin Class Switching

scientific article published on 23 November 2012

A Genome-wide Association Study of Lung Cancer Identifies a Region of Chromosome 5p15 Associated with Risk for Adenocarcinoma

scientific article published on 10 June 2011

A filter binding assay for characterization of antibodies towards damaged DNA

scientific article published on 01 February 1987

A gel electrophoresis method for detection of mitochondrial DNA mutation (3243 tRNA(Leu (UUR))) applied to a Norwegian family with diabetes mellitus and hearing loss

scientific article published in April 2004

A genome-wide association study of lung cancer identifies a region of chromosome 5p15 associated with risk for adenocarcinoma

scientific article

A new high resolution screening method for study of phenotype stress responses of Saccharomyces cerevisae mutants

scientific article

A novel method for the efficient and selective identification of 5-hydroxymethylcytosine in genomic DNA.

scientific article published on 7 February 2011

A nucleotide-flipping mechanism from the structure of human uracil-DNA glycosylase bound to DNA

scientific article

A robust, sensitive assay for genomic uracil determination by LC/MS/MS reveals lower levels than previously reported

scientific article published on 3 June 2013

A sequence in the N-terminal region of human uracil-DNA glycosylase with homology to XPA interacts with the C-terminal part of the 34-kDa subunit of replication protein A

scientific article

A simplified assay for O6-methylguanine-DNA methyltransferase activity and its application to human neoplastic and non-neoplastic tissues

scientific article published in August 1984

A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25

scientific article (publication date: 3 April 2008)

AID expression in B-cell lymphomas causes accumulation of genomic uracil and a distinct AID mutational signature.

scientific article

ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility

scientific article

ALKBH8-mediated formation of a novel diastereomeric pair of wobble nucleosides in mammalian tRNA

scientific article

Acrolein cytotoxicity and glutathione depletion in n-3 fatty acid sensitive- and resistant human tumor cells

scientific article published on January 1999

Activation-induced cytidine deaminase (AID) is localized to subnuclear domains enriched in splicing factors

scientific article published on 13 January 2014

AlkB demethylases flip out in different ways

scientific article published on 06 September 2008

Alkylation damage in DNA and RNA--repair mechanisms and medical significance

scientific article published in November 2004

Analysis of uracil DNA glycosylase in human colorectal cancer.

scientific article

Analysis of uracil-DNA glycosylases from the murine Ung gene reveals differential expression in tissues and in embryonic development and a subcellular sorting pattern that differs from the human homologues

scientific journal article

Association between a 15q25 gene variant, nicotine-related habits, lung cancer and COPD among 56,307 individuals from the HUNT study in Norway

scientific article published on 27 February 2013

Autobiographical sketch: A life in DNA repair—and beyond

scientific article published in March 2012

B cells from hyper-IgM patients carrying UNG mutations lack ability to remove uracil from ssDNA and have elevated genomic uracil

scientific article

Base Excision Repair ⬇️

scientific article published on April 1, 2013

Base excision repair efficiency and mechanism in nuclear extracts are influenced by the ratio between volume of nuclear extraction buffer and nuclei-implications for comparative studies

scientific article published on 28 June 2011

Base excision repair in a network of defence and tolerance

scientific article

Base excision repair initiation revealed by crystal structures and binding kinetics of human uracil-DNA glycosylase with DNA.

scientific article

Base excision repair of DNA in mammalian cells

scientific article

Bg/ll polymorphism in the UNG gene in 4 populations

article

Cell cycle regulation and in vitro hybrid arrest analysis of the major human uracil-DNA glycosylase

scientific article

Cell cycle regulation and subcellular localization of the major human uracil-DNA glycosylase

scientific article

Cell cycle regulation of human DNA repair and chromatin remodeling genes

scientific article

Cell cycle-specific UNG2 phosphorylations regulate protein turnover, activity and association with RPA.

scientific article

Cell specific effects of polyunsaturated fatty acids on 5-aminolevulinic acid based photosensitization

scientific article

Cell-specific enhancement of doxorubicin toxicity in human tumour cells by docosahexaenoic acid

scientific article published in January 2001

Characterization of antibodies specific for UV-damaged DNA by ELISA

scientific article published on 01 April 1987

Chromosomal assignment of human uracil-DNA glycosylase to chromosome 12.

scientific article published in May 1990

Closely related colon cancer cell lines display different sensitivity to polyunsaturated fatty acids, accumulate different lipid classes and downregulate sterol regulatory element-binding protein 1.

scientific article published on June 2006

Consensus sequences for good and poor removal of uracil from double stranded DNA by uracil-DNA glycosylase

scientific article published on May 1993

Crystal structure and mutational analysis of human uracil-DNA glycosylase: structural basis for specificity and catalysis

scientific article

Crystal structure of human uracil-DNA glycosylase in complex with a protein inhibitor: protein mimicry of DNA

scientific article

Cytotoxicity and mutagenicity of endogenous DNA base lesions as potential cause of human aging

scientific article published on 12 February 2008

DHA alters expression of target proteins of cancer therapy in chemotherapy resistant SW620 colon cancer cells

scientific article published on January 2010

DHA induces ER stress and growth arrest in human colon cancer cells: associations with cholesterol and calcium homeostasis

scientific article

DNA base modifications in honey bee and fruit fly genomes suggest an active demethylation machinery with species- and tissue-specific turnover rates

scientific article published on 22 February 2016

DNA glycosylases in the base excision repair of DNA

scientific article published on July 1997

DNA repair in mammalian tissues and cells

scientific article published on January 1990

DNA replication in short-time organ cultures of human epidermis. Inhibition by aphidicolin, and detection of DNA polymerases alpha, beta, and gamma

scientific article published on 01 January 1982

DNA-uracil and human pathology

scientific article published on 18 May 2007

Damage Specific Mammalian Endonucleases ⬇️

scientific article published on January 1, 1990

Different organization of base excision repair of uracil in DNA in nuclei and mitochondria and selective upregulation of mitochondrial uracil-DNA glycosylase after oxidative stress

scientific article published on 13 November 2006

Differential capacities for DNA repair in Clara cells, alveolar type II cells and macrophages of rabbit lung

scientific article published on 01 April 1985

Direct interaction between XRCC1 and UNG2 facilitates rapid repair of uracil in DNA by XRCC1 complexes

scientific article

Divergent ß-hairpins determine double-strand versus single-strand substrate recognition of human AlkB-homologues 2 and 3

scientific article

Docosahexaenoic acid activates some SREBP-2 targets independent of cholesterol and ER stress in SW620 colon cancer cells

scientific article

Effects of n-3 fatty acids during neoplastic progression and comparison of in vitro and in vivo sensitivity of two human tumour cell lines

scientific article

Enzymatic repair of premutagenic DNA lesions in human epidermis. Quantitation of O6-methylguanine-DNA methyltransferase and uracil-DNA glycosylase activities

scientific article published on 01 March 1984

Erratum: Corrigendum: Rare variants of large effect in BRCA2 and CHEK2 affect risk of lung cancer

scholarly article published in Nature Genetics

Erratum: Sequence variations in the UDP-glucuronosyltransferase 2B7 (UGT2B7) gene: identification of 10 novel single nucleotide polymorphisms (SNPs) and analysis of their relevance to morphine glucuronidation in cancer patients

article

Error-free versus mutagenic processing of genomic uracil--relevance to cancer

scientific article

Evidence that changes in Se-glutathione peroxidase levels affect the sensitivity of human tumour cell lines to n-3 fatty acids

scientific article published on October 1997

Excerpts from the 1st international NTNU symposium on current and future clinical biomarkers of cancer: innovation and implementation, June 16th and 17th 2016, Trondheim, Norway

scientific article published on 19 October 2016

Excision of cytosine and thymine from DNA by mutants of human uracil-DNA glycosylase

scientific article

Excision of uracil from double-stranded DNA by uracil-DNA glycosylase is sequence specific

scientific article published on 01 July 1994

Expression and recruitment of uracil-DNA glycosylase are regulated by E2A during antibody diversification

scientific article published on 18 April 2014

Expression of O6-methylguanine-DNA methyltransferase and uracil-DNA glycosylase in human placentae from smokers and non-smokers

scientific article published on 01 October 1992

Extracts of proliferating and non-proliferating human cells display different base excision pathways and repair fidelity

scientific article

Fading correction for fluorescence quantitation in confocal microscopy

scientific article published on March 1996

Gene-targeted mice lacking the Ung uracil-DNA glycosylase develop B-cell lymphomas

scientific article published in August 2003

Genetic analysis of the murine mu opioid receptor: increased complexity of Oprm gene splicing

scientific article

Genomic uracil and human disease

scientific article

Hexyl aminolevulinate and light induces posttranslational modifications of proteins in different cell pathways

High pressure liquid chromatographic separation of furocoumarins in Heracleum laciniatum

scientific article published on 01 April 1984

Human ABH3 structure and key residues for oxidative demethylation to reverse DNA/RNA damage

scientific article

Human AlkB homolog 1 is a mitochondrial protein that demethylates 3-methylcytosine in DNA and RNA

scientific article

Human Uracil-DNA Glycosylase

Human and bacterial oxidative demethylases repair alkylation damage in both RNA and DNA

scientific article (publication date: 20 February 2003)

Human mitochondrial uracil-DNA glycosylase preform (UNG1) is processed to two forms one of which is resistant to inhibition by AP sites

scientific article published on November 1998

Human uracil-DNA glycosylase complements E. coli ung mutants

scientific article published on August 1991

Human uracil-DNA glycosylase deficiency associated with profoundly impaired immunoglobulin class-switch recombination

scientific article published on 7 September 2003

Human uracil-DNA glycosylase gene: sequence organization, methylation pattern, and mapping to chromosome 12q23-q24.1

scientific article

Identification of a novel, widespread, and functionally important PCNA-binding motif

scientific article

Identification of lung cancer histology-specific variants applying Bayesian framework variant prioritization approaches within the TRICL and ILCCO consortia

scientific article

In vivoandin vitrophototoxicity of different parts ofHeracleum Laciniatum ⬇️

scientific article published on 01 July 1983

Incorporation of dUMP into DNA is a major source of spontaneous DNA damage, while excision of uracil is not required for cytotoxicity of fluoropyrimidines in mouse embryonic fibroblasts

scientific article

Influence of common genetic variation on lung cancer risk: meta-analysis of 14 900 cases and 29 485 controls

scientific article

Interindividual variation in the activity of O6-methyl guanine-DNA methyltransferase and uracil-DNA glycosylase in human organs

scientific article

Investigation of the fine structure of European populations with applications to disease association studies

scientific article published in December 2008

LEUCINE-272-ALANINE URACIL-DNA GLYCOSYLASE BOUND TO ABASIC SITE-CONTAINING DNA

scholarly article published 6 May 1999

Lack of effect of hyperoxia on photodynamic therapy and lipid peroxidation in three different cancer cell lines

scientific article published on 26 September 2005

Low Incorporation of dUMP by Some Thermostable DNA Polymerases May Limit Their Use in PCR Amplifications

scientific article published in 1993

Low copy number DNA template can render polymerase chain reaction error prone in a sequence-dependent manner

scientific article published on February 2005

Lung cancer and DNA repair genes: multilevel association analysis from the International Lung Cancer Consortium

scientific article published in March 2012

Lung cancer susceptibility locus at 5p15.33

scientific article

Mammalian ALKBH8 possesses tRNA methyltransferase activity required for the biogenesis of multiple wobble uridine modifications implicated in translational decoding

scientific article

Metabolism of dITP in HeLa cell extracts, incorporation into DNA by isolated nuclei and release of hypoxanthine from DNA by a hypoxanthine-DNA glycosylase activity.

scientific article published on June 1982

Methylation damage to RNA induced in vivo in Escherichia coli is repaired by endogenous AlkB as part of the adaptive response

scientific article published on 29 December 2012

Mitochondrial base excision repair of uracil and AP sites takes place by single-nucleotide insertion and long-patch DNA synthesis

scientific article

Molecular cloning of human uracil-DNA glycosylase, a highly conserved DNA repair enzyme

scientific article

Monitoring of hexyl 5-aminolevulinate-induced photodynamic therapy in rat bladder cancer by optical spectroscopy

scientific article

Monoclonal B-cell hyperplasia and leukocyte imbalance precede development of B-cell malignancies in uracil-DNA glycosylase deficient mice

scientific article published on 19 September 2005

Morphine glucuronide-to-morphine plasma ratios are unaffected by the UGT2B7 H268Y and UGT1A1*28 polymorphisms in cancer patients on chronic morphine therapy

scientific article published on 13 July 2002

Multiple microRNAs may regulate the DNA repair enzyme uracil-DNA glycosylase

scientific article published on 08 December 2012

Novel activities of human uracil DNA N-glycosylase for cytosine-derived products of oxidative DNA damage

scientific journal article

Novel aspects of macromolecular repair and relationship to human disease

scientific article published on 24 February 2004

Nuclear and mitochondrial forms of human uracil-DNA glycosylase are encoded by the same gene

scientific article

Nuclear and mitochondrial splice forms of human uracil-DNA glycosylase contain a complex nuclear localisation signal and a strong classical mitochondrial localisation signal, respectively

scientific article published on October 1998

Nuclear and mitochondrial uracil-DNA glycosylases are generated by alternative splicing and transcription from different positions in the UNG gene

scientific article

Omega-3 fatty acids suppress growth of SW620 human colon cancer xenografts in nude mice.

scientific article published in November 2008

Overexpression of transcription factor AP-2 stimulates the PA promoter of the human uracil-DNA glycosylase (UNG) gene through a mechanism involving derepression

scientific article published on 2 May 2009

Paracetamol increases sensitivity to ultraviolet (UV) irradiation, delays repair of the UNG-gene and recovery of RNA synthesis in HaCaT cells

article

Photochemical reactions of Heracleum laciniatum. Influence of dimethyl sulphoxide and corticosteroids

scientific article published on 01 July 1983

Photodynamic therapy with hexyl aminolevulinate induces carbonylation, posttranslational modifications and changed expression of proteins in cell survival and cell death pathways

scientific article published on 30 March 2011

Photodynamic treatment with hexyl-aminolevulinate mediates reversible thiol oxidation in core oxidative stress signaling proteins

scientific article published on 8 January 2016

Phototoxic and contact toxic reactions of the exocarp of sweet oranges: a common cause of cheilitis?

scientific article published on 01 May 1983

Post-replicative base excision repair in replication foci

scientific article

Preface

Properties and functions of human uracil-DNA glycosylase from the UNG gene

scientific article

Properties of a Recombinant Human Uracil-DNA Glycosylase from the UNG Gene and Evidence that UNG Encodes the Major Uracil-DNA Glycosylase

article

Protozoan ALKBH8 oxygenases display both DNA repair and tRNA modification activities

scientific article

Pseudogenes for the human uracil-DNA glycosylase on chromosomes 14 and 16.

scientific article published on July 1996

Purification and determination of the NH2-terminal amino acid sequence of uracil-DNA glycosylase from human placenta

scientific article published on 01 January 1989

RNA base damage and repair

scientific article published on December 2007

Rare variants of large effect in BRCA2 and CHEK2 affect risk of lung cancer

scientific journal article

Red versus blue light illumination in hexyl 5-aminolevulinate photodynamic therapy: the influence of light color and irradiance on the treatment outcome in vitro

scientific article

Regulation of expression of nuclear and mitochondrial forms of human uracil-DNA glycosylase

scientific article

Repair deficient mice reveal mABH2 as the primary oxidative demethylase for repairing 1meA and 3meC lesions in DNA

scientific article

Repair of O6-methyl-guanine residues in DNA takes place by a similar mechanism in extracts from HeLa cells, human liver, and rat liver

scientific article published on January 1982

Repair of U/G and U/A in DNA by UNG2-associated repair complexes takes place predominantly by short-patch repair both in proliferating and growth-arrested cells

scientific article published on 12 October 2004

Repair of chromosomal abasic sites in vivo involves at least three different repair pathways

scientific article

Repair of cyclobutane pyrimidine dimers in the O6-methylguanine-DNA methyltransferase (MGMT) gene of MGMT proficient and deficient human cell lines and comparison with the repair of other genes and a repressed X-chromosomal locus

scientific article published on June 1998

Repair of premutagenic DNA lesions in human fetal tissues: evidence for low levels of O6-methylguanine-DNA methyltransferase and uracil-DNA glycosylase activity in some tissues

scientific article published in December 1983

Roles of Trm9- and ALKBH8-like proteins in the formation of modified wobble uridines in Arabidopsis tRNA.

scientific article

Sequence specificity for removal of uracil from U.A pairs and U.G mismatches by uracil-DNA glycosylase from Escherichia coli, and correlation with mutational hotspots

scientific article published on 01 April 1995

Sequence variation in the human uracil-DNA glycosylase (UNG) gene

scientific article published in January 2001

Sequence variations in the UDP-glucuronosyltransferase 2B7 (UGT2B7) gene: identification of 10 novel single nucleotide polymorphisms (SNPs) and analysis of their relevance to morphine glucuronidation in cancer patients

article by Holthe M et al published 1 January 2003 in The Pharmacogenomics Journal

Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation

scientific article

Strikingly different properties of uracil-DNA glycosylases UNG2 and SMUG1 may explain divergent roles in processing of genomic uracil

scientific article

Structural basis for the removal and exclusion of uracil from DNA

article published in 1996

Structure of the gene for human uracil-DNA glycosylase and analysis of the promoter function

scientific article (publication date: 17 October 1994)

The 118 A > G polymorphism in the human mu-opioid receptor gene may increase morphine requirements in patients with pain caused by malignant disease

scientific article published in November 2004

The DNA dioxygenase ALKBH2 protects Arabidopsis thaliana against methylation damage

scientific article

The UNG2 Arg88Cys variant abrogates RPA-mediated recruitment of UNG2 to single-stranded DNA.

scientific article

The Val158Met polymorphism of the human catechol-O-methyltransferase (COMT) gene may influence morphine requirements in cancer pain patients

scientific article published in July 2005

The antiproliferative effect of EPA in HL60 cells is mediated by alterations in calcium homeostasis

scientific article

The causal role of smoking in anxiety and depression: a Mendelian randomization analysis of the HUNT study

scientific article published on 12 June 2012

The inhibitory effect of conjugated dienoic derivatives (CLA) of linoleic acid on the growth of human tumor cell lines is in part due to increased lipid peroxidation

scientific article published on July 1, 1995

The interacting pathways for prevention and repair of oxidative DNA damage

scientific article published on October 2003

The methylation status of the gene for O6-methylguanine-DNA methyltransferase in human Mer+ and Mer- cells

scientific article published on August 1995

The rate of base excision repair of uracil is controlled by the initiating glycosylase

scientific article

Tissue responses to hexyl 5-aminolevulinate-induced photodynamic treatment in syngeneic orthotopic rat bladder cancer model: possible pathways of action

scientific article published on February 2011

Transcription profiling during the cell cycle shows that a subset of Polycomb-targeted genes is upregulated during DNA replication

scientific article published on 15 January 2013

Trypanosoma cruzi contains a single detectable uracil-DNA glycosylase and repairs uracil exclusively via short patch base excision repair.

scientific article published in September 2004

U.v.-induced DNA damage and its repair in human skin in vivo studied by sensitive immunohistochemical methods

scientific article published on 01 January 1983

UNG-initiated base excision repair is the major repair route for 5-fluorouracil in DNA, but 5-fluorouracil cytotoxicity depends mainly on RNA incorporation

scientific article

UV-Irradiated SV40 minichromosomes as substrates for DNA repair endonucleases ⬇️

scientific article published on May 31, 1983

Uracil Accumulation and Mutagenesis Dominated by Cytosine Deamination in CpG Dinucleotides in Mice Lacking UNG and SMUG1.

scientific article

Uracil in DNA and its processing by different DNA glycosylases

scientific article

Uracil in DNA--general mutagen, but normal intermediate in acquired immunity

scientific article

Uracil in DNA--occurrence, consequences and repair

scientific article

Uracil-DNA Glycosylase UNG Promotes Tet-mediated DNA Demethylation

scientific article

Uracil-DNA glycosylase (UNG)-deficient mice reveal a primary role of the enzyme during DNA replication

scientific article

Uracil-DNA glycosylase in base excision repair and adaptive immunity: species differences between man and mouse.

scientific article

Uracil-DNA glycosylase-DNA substrate and product structures: conformational strain promotes catalytic efficiency by coupled stereoelectronic effects

scientific article

Uracil-DNA glycosylases SMUG1 and UNG2 coordinate the initial steps of base excision repair by distinct mechanisms

scientific article

Uracil–DNA glycosylase UNG1 isoform variant supports class switch recombination and repairs nuclear genomic uracil

scientific article published on 01 May 2019

XRCC1 coordinates disparate responses and multiprotein repair complexes depending on the nature and context of the DNA damage

scientific article

[DNA repair enzymes and their genes]

scientific article published on 01 May 1998

hUNG2 is the major repair enzyme for removal of uracil from U:A matches, U:G mismatches, and U in single-stranded DNA, with hSMUG1 as a broad specificity backup

scientific article

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