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List of works by Johanne Martel-Pelletier

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Role of proinflammatory cytokines in the pathophysiology of osteoarthritis

scientific article published on November 30, 2010
The role of cytokines in osteoarthritis pathophysiology

scientific article
Meniscal tear and extrusion are strongly associated with progression of symptomatic knee osteoarthritis as assessed by quantitative magnetic resonance imaging

scientific article published on 16 September 2004
Cartilage in normal and osteoarthritis conditions

scientific article published on April 2008
Safety and efficacy of long-term intraarticular steroid injections in osteoarthritis of the knee: a randomized, double-blind, placebo-controlled trial

scientific article published on February 2003
Regulation of the IGFBP-5 and MMP-13 genes by the microRNAs miR-140 and miR-27a in human osteoarthritic chondrocytes

scientific article
An algorithm recommendation for the management of knee osteoarthritis in Europe and internationally: a report from a task force of the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO).

scientific article
Cyclooxygenase-2 and prostaglandins in articular tissues

scientific article published on December 2003
Long term evaluation of disease progression through the quantitative magnetic resonance imaging of symptomatic knee osteoarthritis patients: correlation with clinical symptoms and radiographic changes

scientific article
Cartilage-specific deletion of mTOR upregulates autophagy and protects mice from osteoarthritis

scientific article published on March 20, 2014
Osteoarthritis

article by Johanne Martel-Pelletier et al published 13 October 2016 in Nature Reviews Disease Primers
Risk factors associated with the loss of cartilage volume on weight-bearing areas in knee osteoarthritis patients assessed by quantitative magnetic resonance imaging: a longitudinal study

scientific article
In vivo transfer of interleukin-1 receptor antagonist gene in osteoarthritic rabbit knee joints: prevention of osteoarthritis progression

scientific article published on April 1999
Bone marrow lesions in people with knee osteoarthritis predict progression of disease and joint replacement: a longitudinal study

scientific article published on 7 September 2010
Quantitative magnetic resonance imaging evaluation of knee osteoarthritis progression over two years and correlation with clinical symptoms and radiologic changes

scientific article published on 01 February 2004
Protective effects of licofelone, a 5-lipoxygenase and cyclo-oxygenase inhibitor, versus naproxen on cartilage loss in knee osteoarthritis: a first multicentre clinical trial using quantitative MRI.

scientific article
Chondroitin sulphate reduces both cartilage volume loss and bone marrow lesions in knee osteoarthritis patients starting as early as 6 months after initiation of therapy: a randomised, double-blind, placebo-controlled pilot study using MRI

scientific article
Can altered production of interleukin-1beta, interleukin-6, transforming growth factor-beta and prostaglandin E(2) by isolated human subchondral osteoblasts identify two subgroups of osteoarthritic patients

scientific article
Targeting subchondral bone for treating osteoarthritis: what is the evidence?

scientific article published on February 2010
The inhibition of subchondral bone resorption in the early phase of experimental dog osteoarthritis by licofelone is associated with a reduction in the synthesis of MMP-13 and cathepsin K.

scientific article published in March 2004
Altered mineralization of human osteoarthritic osteoblasts is attributable to abnormal type I collagen production

scientific article published on May 2009
Meniscal tear as an osteoarthritis risk factor in a largely non-osteoarthritic cohort: a cross-sectional study.

scientific article published on 15 March 2007
A consensus statement on the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) algorithm for the management of knee osteoarthritis-From evidence-based medicine to the real-life setting

scientific article
PPARγ deficiency results in severe, accelerated osteoarthritis associated with aberrant mTOR signalling in the articular cartilage

scientific article published on 8 January 2015
Reliability of a quantification imaging system using magnetic resonance images to measure cartilage thickness and volume in human normal and osteoarthritic knees

scientific article published in May 2003
High mobility group box 1 potentiates the pro-inflammatory effects of interleukin-1β in osteoarthritic synoviocytes

scientific article
Histone deacetylase inhibitors suppress interleukin-1beta-induced nitric oxide and prostaglandin E2 production in human chondrocytes

scientific article published on 15 April 2008
Combined chondroitin sulfate and glucosamine for painful knee osteoarthritis: a multicentre, randomised, double-blind, non-inferiority trial versus celecoxib

scientific article
What is the predictive value of MRI for the occurrence of knee replacement surgery in knee osteoarthritis?

scientific article published on 25 July 2013
Bone marrow lesions predict site-specific cartilage defect development and volume loss: a prospective study in older adults

scientific article
In vivo selective inhibition of mitogen-activated protein kinase kinase 1/2 in rabbit experimental osteoarthritis is associated with a reduction in the development of structural changes

scientific article published on 01 June 2003
Strontium ranelate inhibits key factors affecting bone remodeling in human osteoarthritic subchondral bone osteoblasts

scientific article published on 12 June 2011
Differential gene expression and regulation of the bone morphogenetic protein antagonists follistatin and gremlin in normal and osteoarthritic human chondrocytes and synovial fibroblasts

scientific article
Disease-modifying effect of strontium ranelate in a subset of patients from the Phase III knee osteoarthritis study SEKOIA using quantitative MRI: reduction in bone marrow lesions protects against cartilage loss

scientific article published on December 2, 2013
Activation of peroxisome proliferator-activated receptor gamma inhibits interleukin-1beta-induced membrane-associated prostaglandin E2 synthase-1 expression in human synovial fibroblasts by interfering with Egr-1.

scientific article published on 15 March 2004
Characterization of osteoarthritis in cats and meloxicam efficacy using objective chronic pain evaluation tools

scientific article published on 14 February 2013
The association between subchondral bone cysts and tibial cartilage volume and risk of joint replacement in people with knee osteoarthritis: a longitudinal study

scientific article
New perspective in osteoarthritis: the OPG and RANKL system as a potential therapeutic target?

scientific article published on March 2009
Degradation of small leucine-rich repeat proteoglycans by matrix metalloprotease-13: identification of a new biglycan cleavage site

scientific article
Future therapeutics for osteoarthritis

scientific article published on 17 October 2011
Pioglitazone, a peroxisome proliferator-activated receptor gamma agonist, reduces the progression of experimental osteoarthritis in guinea pigs

scientific article published in February 2005
Tiludronate treatment improves structural changes and symptoms of osteoarthritis in the canine anterior cruciate ligament model

scientific article published on 21 June 2011
Inhibition of tumor necrosis factor alpha-induced prostaglandin E2 production by the antiinflammatory cytokines interleukin-4, interleukin-10, and interleukin-13 in osteoarthritic synovial fibroblasts: distinct targeting in the signaling pathways

scientific article published on April 1999
Strontium ranelate reduces the progression of experimental dog osteoarthritis by inhibiting the expression of key proteases in cartilage and of IL-1β in the synovium

scientific article published on 13 October 2012
The differential expression of osteoprotegerin (OPG) and receptor activator of nuclear factor kappaB ligand (RANKL) in human osteoarthritic subchondral bone osteoblasts is an indicator of the metabolic state of these disease cells

scientific article
Modulation of OPG, RANK and RANKL by human chondrocytes and their implication during osteoarthritis

scientific article published on 17 September 2009
The association between objectively measured physical activity and knee structural change using MRI.

scientific article
Knee meniscal extrusion in a largely non-osteoarthritic cohort: association with greater loss of cartilage volume

scientific article published in January 2007
Decrease in serum level of matrix metalloproteinases is predictive of the disease-modifying effect of osteoarthritis drugs assessed by quantitative MRI in patients with knee osteoarthritis

scientific article published on 22 June 2010
Interleukin 17 (IL-17) induces collagenase-3 production in human osteoarthritic chondrocytes via AP-1 dependent activation: differential activation of AP-1 members by IL-17 and IL-1beta

scientific article

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