List of works by Óscar Fernández-Capetillo

53BP1 mediates productive and mutagenic DNA repair through distinct phosphoprotein interactions.

scientific article

A Chemical Screen Identifies Compounds Capable of Selecting for Haploidy in Mammalian Cells

scientific article published on 01 July 2019

A Chemical Screen Identifies Compounds Limiting the Toxicity of C9ORF72 Dipeptide Repeats

scientific article published on 06 December 2018

A Genome-wide CRISPR Screen Identifies CDC25A as a Determinant of Sensitivity to ATR Inhibitors

scientific article published on 05 April 2016

A SUMO and ubiquitin code coordinates protein traffic at replication factories.

scientific article published on 26 September 2016

A Single Conserved Residue Mediates Binding of the Ribonucleotide Reductase Catalytic Subunit RRM1 to RRM2 and Is Essential for Mouse Development.

scientific article published on 15 June 2015

A cell-based screen identifies ATR inhibitors with synthetic lethal properties for cancer-associated mutations.

scientific article published on 8 May 2011

A mouse model of ATR-Seckel shows embryonic replicative stress and accelerated aging

scientific article

A p53-dependent response limits the viability of mammalian haploid cells.

scientific article published on 14 August 2017

A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity

scientific article (publication date: 27 August 2009)

A synthetic lethal interaction between APC/C and topoisomerase poisons uncovered by proteomic screens.

scientific article published on 6 February 2014

ATM breaks into heterochromatin.

scientific article

ATR is required to complete meiotic recombination in mice.

scientific article published on 5 July 2018

ATR suppresses telomere fragility and recombination but is dispensable for elongation of short telomeres by telomerase

scientific article

Aging counts on chromosomes

scientific article published on 01 July 2004

CGK733 does not inhibit ATM or ATR kinase activity in H460 human lung cancer cells.

scientific article

Cdk2 suppresses cellular senescence induced by the c-myc oncogene.

scientific article

Changes in chromatin structure and mobility in living cells at sites of DNA double-strand breaks

scientific article

Class switching and meiotic defects in mice lacking the E3 ubiquitin ligase RNF8

scientific article

Cyclin-dependent kinase inhibitor p21 controls adult neural stem cell expansion by regulating Sox2 gene expression

scientific article published on 20 December 2012

DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1

scientific article (publication date: December 2002)

ERF deletion rescues RAS deficiency in mouse embryonic stem cells.

scientific article published on 12 April 2018

Efficacy of ATR inhibitors as single agents in Ewing sarcoma.

scientific article published on 26 August 2016

Emergence and evolutionary analysis of the human DDR network: implications in comparative genomics and downstream analyses

scientific article published on 16 January 2014

Erratum: Replication fork stability confers chemoresistance in BRCA-deficient cells.

scientific article

Exploiting oncogene-induced replicative stress for the selective killing of Myc-driven tumors

scientific article published on 27 November 2011

Fos-dependent induction of Chk1 protects osteoblasts from replication stress

scientific article

Genomic instability in iPS: time for a break

scientific article

Genomic instability in mice lacking histone H2AX

scientific journal article

Genomic instability: on the birth and death of cancer.

scientific article published on April 2007

Global chromatin compaction limits the strength of the DNA damage response

scientific article

H2AX regulates meiotic telomere clustering ⬇️

scientific article published on October 6, 2003

Histone H2A C-terminus regulates chromatin dynamics, remodeling, and histone H1 binding

scientific article

Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks

scientific article (publication date: July 2003)

INK4a/ARF limits the expansion of cells suffering from replication stress

scientific article published on 15 May 2013

Increased Rrm2 gene dosage reduces fragile site breakage and prolongs survival of ATR mutant mice

scientific article

Increased telomere fragility and fusions resulting from TRF1 deficiency lead to degenerative pathologies and increased cancer in mice

scientific article

Lac operator repeats generate a traceable fragile site in mammalian cells

scientific article

Late-replicating CNVs as a source of new genes.

scientific article published on 15 March 2014

Limited role of murine ATM in oncogene-induced senescence and p53-dependent tumor suppression.

scientific article

Limiting replication stress during somatic cell reprogramming reduces genomic instability in induced pluripotent stem cells

scientific article

Modeling the study of DNA damage responses in mice

scientific article

Mutation of E2F2 in Mice Causes Enhanced T Lymphocyte Proliferation, Leading to the Development of Autoimmunity

article

NSMCE2 suppresses cancer and aging in mice independently of its SUMO ligase activity

scientific article

Naked replication forks break apRPArt

scientific article

Neuropilin-1 regulates attachment in human endothelial cells independently of vascular endothelial growth factor receptor-2

scientific article published on 02 November 2004

Oncogenic stress sensitizes murine cancers to hypomorphic suppression of ATR

scientific article published on December 2011

PARP-2 sustains erythropoiesis in mice by limiting replicative stress in erythroid progenitors.

scientific article

POLD3 Is Haploinsufficient for DNA Replication in Mice.

scientific article published on 11 August 2016

Phosphorylation of histone H2B at DNA double-strand breaks.

scientific article

Polycomb protein SCML2 regulates the cell cycle by binding and modulating CDK/CYCLIN/p21 complexes.

scientific article

Prolonged estrogen deprivation triggers a broad immunosuppressive phenotype in breast cancer cells

scientific article published on 29 August 2021

RAD51C deficiency in mice results in early prophase I arrest in males and sister chromatid separation at metaphase II in females

scientific journal article

Reducing genomic instability in iPSCs

scientific article published on October 2015

Replication fork stability confers chemoresistance in BRCA-deficient cells

scientific article

Replication stress and cancer: it takes two to tango.

scientific article published on 26 September 2014

Replication stress caused by low MCM expression limits fetal erythropoiesis and hematopoietic stem cell functionality

scientific article

Silencing of unsynapsed meiotic chromosomes in the mouse

scientific article published on 5 December 2004

Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer.

scientific article published on 12 April 2010

TIAR marks nuclear G2/M transition granules and restricts CDK1 activity under replication stress

scientific article published on 11 December 2018

Targeting ATR and Chk1 kinases for cancer treatment: a new model for new (and old) drugs

scientific article

Targeting ATR in cancer

scientific article published on 01 September 2018

Targeting the kinase activities of ATR and ATM exhibits antitumoral activity in mouse models of MLL-rearranged AML.

scientific article

The (elusive) role of the SMC5/6 complex

scientific article published on 08 January 2016

The ATR barrier to replication-born DNA damage.

scientific article published on 30 October 2010

The RNA Polymerase II Factor RPAP1 Is Critical for Mediator-Driven Transcription and Cell Identity

scientific article published in January 2018

The maternal side of Fanconi Anemia

scientific article published on 01 September 2014

The solute carrier SLC35F2 enables YM155-mediated DNA damage toxicity

scientific article published on 27 July 2014

TrapSeq: An RNA Sequencing-Based Pipeline for the Identification of Gene-Trap Insertions in Mammalian Cells.

scientific article published on 4 August 2017

USP7 is a SUMO deubiquitinase essential for DNA replication

scientific article (publication date: April 2016)

USP7 limits CDK1 activity throughout the cell cycle

scientific article published on 15 April 2021

When the going gets tough: scientists' personal challenges

scientific article published on 01 October 2014

Why cells respond differently to DNA damage: a chromatin perspective

scientific article published on 18 January 2008

p21 suppresses inflammation and tumorigenesis on pRB-deficient stratified epithelia

scientific article published on 14 October 2013

p27Kip1 stabilization is essential for the maintenance of cell cycle arrest in response to DNA damage.

scientific article published on 20 October 2009

p38 Mitogen-activated protein kinase- and HuR-dependent stabilization of p21(Cip1) mRNA mediates the G(1)/S checkpoint

scientific article published on 15 June 2009

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