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List of works by Luca Scorrano

(De)constructing mitochondria: what for?

scientific article published on August 2006

A BID on mitochondria with MTCH2

scientific article published on 13 July 2010

A Distinct Pathway Remodels Mitochondrial Cristae and Mobilizes Cytochrome c during Apoptosis ⬇️

scientific article published on January 1, 2002

A cut short to death: Parl and Opa1 in the regulation of mitochondrial morphology and apoptosis

scientific article

A novel deletion in the GTPase domain of OPA1 causes defects in mitochondrial morphology and distribution, but not in function

scientific article

A novel mitochondriotoxic small molecule that selectively inhibits tumor cell growth.

scientific article

A reversible component of mitochondrial respiratory dysfunction in apoptosis can be rescued by exogenous cytochrome c.

scientific article

Age-Associated Loss of OPA1 in Muscle Impacts Muscle Mass, Metabolic Homeostasis, Systemic Inflammation, and Epithelial Senescence.

scientific article

Akt protects the heart against ischaemia-reperfusion injury by modulating mitochondrial morphology

scientific article published on 25 September 2014

An intimate liaison: spatial organization of the endoplasmic reticulum-mitochondria relationship

scientific article

An ode to mitochondria biologists, new and old.

scientific article published in March 2018

Apaf1 plays a pro-survival role by regulating centrosome morphology and function

scientific article published on 07 October 2011

Arachidonic acid causes cell death through the mitochondrial permeability transition. Implications for tumor necrosis factor-alpha aopototic signaling

scientific article

Arachidonic acid released by phospholipase A(2) activation triggers Ca(2+)-dependent apoptosis through the mitochondrial pathway

scientific article published on 7 April 2004

At the right distance: ER-mitochondria juxtaposition in cell life and death

scientific article

BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis

scientific journal article

BAX and BAK regulation of endoplasmic reticulum Ca2+: a control point for apoptosis

scientific article (publication date: 4 April 2003)

Cardioprotection and lifespan extension by the natural polyamine spermidine.

scientific article

Caspase-8 goes cardiolipin: a new platform to provide mitochondria with microdomains of apoptotic signals?

scientific article published on 10 November 2008

Cell biology: The organelle replication connection.

scientific article

Cell death induced by granzyme C.

scientific article

Changing perspective on oncometabolites: from metabolic signature of cancer to tumorigenic and immunosuppressive agents

scientific article

Chloromethyltetramethylrosamine (Mitotracker Orange) induces the mitochondrial permeability transition and inhibits respiratory complex I. Implications for the mechanism of cytochrome c release.

scientific article published on August 1999

Cisplatin resistance can be curtailed by blunting Bnip3-mediated mitochondrial autophagy

scientific article published on 22 April 2022

Close encounter: mitochondria, endoplasmic reticulum and Alzheimer's disease ⬇️

scientific article published on October 9, 2012

Cofilin1-dependent actin dynamics control DRP1-mediated mitochondrial fission.

scientific article published on 5 October 2017

Coming together to define membrane contact sites

scientific article published on 20 March 2019

Commitment to apoptosis by GD3 ganglioside depends on opening of the mitochondrial permeability transition pore

scientific article published in August 1999

Critical reappraisal confirms that Mitofusin 2 is an endoplasmic reticulum-mitochondria tether

scientific article published on 19 September 2016

D. melanogaster, mitochondria and neurodegeneration: small model organism, big discoveries.

scientific article published on 24 August 2012

DRP1-mediated mitochondrial shape controls calcium homeostasis and muscle mass.

scientific article published on 12 June 2019

Defective Mitochondrial tRNA Taurine Modification Activates Global Proteostress and Leads to Mitochondrial Disease

scientific article published in January 2018

Divide et impera: Ca2+ signals, mitochondrial fission and sensitization to apoptosis

scientific article published on 01 December 2003

During autophagy mitochondria elongate, are spared from degradation and sustain cell viability.

scientific article

Early effects of the antineoplastic agent salinomycin on mitochondrial function.

scientific article published on 22 October 2015

Endosome-mitochondria juxtaposition during apoptosis induced by H. pylori VacA

scientific article

Essential amino acids and glutamine regulate induction of mitochondrial elongation during autophagy.

scientific article published on 15 August 2011

Extracellular regulated kinase phosphorylates mitofusin 1 to control mitochondrial morphology and apoptosis.

scientific article

Finding a new balance to cure Charcot-Marie-Tooth 2A

scientific article published on 18 March 2019

Flaming Mitochondria: The Anti-inflammatory Drug Leflunomide Boosts Mitofusins

scientific article published on 01 March 2018

Functional wiring of proteostatic and mitostatic modules ensures transient organismal survival during imbalanced mitochondrial dynamics

scientific article published on 17 May 2019

Granzyme B can cause mitochondrial depolarization and cell death in the absence of BID, BAX, and BAK ⬇️

scientific article published on December 18, 2001

Guidelines for the use and interpretation of assays for monitoring autophagy

scientific article

Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes.

scientific article published on 17 April 2009

High levels of Fis1, a pro-fission mitochondrial protein, trigger autophagy

scientific article

Hyperactivation of Nrf2 increases stress tolerance at the cost of aging acceleration due to metabolic deregulation

scientific article published on 10 December 2018

Impaired Mitochondrial ATP Production Downregulates Wnt Signaling via ER Stress Induction

scientific article published on 01 August 2019

In epilepsy, BAD is not really bad

scientific article published on 01 May 2012

Inhibition of autophagy curtails visual loss in a model of autosomal dominant optic atrophy

scientific article published on 12 August 2020

Inhibition of the deubiquitinase USP8 corrects a Drosophila PINK1 model of mitochondria dysfunction

scientific article published on 15 April 2019

Interplay between hepatic mitochondria-associated membranes, lipid metabolism and caveolin-1 in mice

scientific article published on 06 June 2016

Judging a tumor cell by its cover: a matter of mitochondrial contact sites

scientific article

Keeping mitochondria in shape: a matter of life and death ⬇️

scientific article published on August 1, 2013

Laying the foundations of programmed cell death

scientific article published in August 2006

Leducq Network: Modulating Autophagy to Treat Cardiovascular Disease

scientific article published on 01 July 2018

Less than perfect divorces: dysregulated mitochondrial fission and neurodegeneration.

scientific article published on 17 December 2011

Loss of prohibitin induces mitochondrial damages altering β-cell function and survival and is responsible for gradual diabetes development.

scientific article published on 17 July 2013

MCUB Hearts Mitochondria in Sickness, Less in Health

scientific article published on 18 November 2019

MITOSTATIN, a putative tumor suppressor on chromosome 12q24.1, is downregulated in human bladder and breast cancer

scientific article

Macroautophagy inhibition maintains fragmented mitochondria to foster T cell receptor-dependent apoptosis.

scientific article published on 7 July 2016

Mechanisms of cytochrome c release by proapoptotic BCL-2 family members ⬇️

scientific article published on May 9, 2003

Mice deficient in the respiratory chain gene Cox6a2 are protected against high-fat diet-induced obesity and insulin resistance

scientific article

Milder degenerative effects of Carfilzomib vs. Bortezomib in the Drosophila model: a link to clinical adverse events

scientific article published on 19 December 2017

Mito-Morphosis: Mitochondrial Fusion, Fission, and Cristae Remodeling as Key Mediators of Cellular Function

scientific article

Mitochondria Restrict Growth of the Intracellular Parasite Toxoplasma gondii by Limiting Its Uptake of Fatty Acids

scientific article

Mitochondria and cell death. Mechanistic aspects and methodological issues

scientific article

Mitochondria are direct targets of the lipoxygenase inhibitor MK886. A strategy for cell killing by combined treatment with MK886 and cyclooxygenase inhibitors

scientific article published on 21 June 2002

Mitochondria: from cell death executioners to regulators of cell differentiation

scientific article published on 02 September 2014

Mitochondrial Cristae: Where Beauty Meets Functionality.

scientific article published on 5 February 2016

Mitochondrial Dynamics in Cancer and Neurodegenerative and Neuroinflammatory Diseases ⬇️

scientific article published on June 27, 2012

Mitochondrial cristae shape determines respiratory chain supercomplexes assembly and respiratory efficiency

scientific article published on 19 September 2013

Mitochondrial dynamics and physiology.

scientific article published on 7 November 2012

Mitochondrial dynamics in cell life and death

Mitochondrial dynamics protein Drp1 is overexpressed in oncocytic thyroid tumors and regulates cancer cell migration

scientific article

Mitochondrial elongation during autophagy: a stereotypical response to survive in difficult times.

scientific article

Mitochondrial fission and cristae disruption increase the response of cell models of Huntington's disease to apoptotic stimuli

scientific article

Mitochondrial fission and fusion factors reciprocally orchestrate mitophagic culling in mouse hearts and cultured fibroblasts

scientific article

Mitochondrial fission and remodelling contributes to muscle atrophy.

scientific article published on 16 April 2010

Mitochondrial fusion directs cardiomyocyte differentiation via calcineurin and Notch signaling

scientific article published on 03 October 2013

Mitochondrial morphology in mitophagy and macroautophagy ⬇️

scientific article published on March 1, 2012

Mitochondrial rhomboid PARL regulates cytochrome c release during apoptosis via OPA1-dependent cristae remodeling

scientific journal article

Mitochondrial shape changes: orchestrating cell pathophysiology.

scientific article

Mitofusin 2 regulates STIM1 migration from the Ca2+ store to the plasma membrane in cells with depolarized mitochondria.

scientific article

Mitofusin 2 tethers endoplasmic reticulum to mitochondria

scientific article (publication date: 4 December 2008)

Mitofusin-2 regulates mitochondrial and endoplasmic reticulum morphology and tethering: the role of Ras.

scientific article published on 6 March 2009

Mitofusins, from Mitochondria to Metabolism

scientific article published on March 2016

Molecular definitions of autophagy and related processes.

scientific article published on 08 June 2017

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

scientific article

Mutational signatures reveal the role of RAD52 in p53-independent p21-driven genomic instability.

scientific article published on 16 March 2018

Neuronal Mitochondrial Dysfunction Activates the Integrated Stress Response to Induce Fibroblast Growth Factor 21

scientific article published on 01 August 2018

Neutrophil extracellular trap formation requires OPA1-dependent glycolytic ATP production

scientific article published in Nature Communications

Nitric oxide inhibition of Drp1-mediated mitochondrial fission is critical for myogenic differentiation

scientific article published on 14 May 2010

O ROM(e)O1, ROM(e)O1, wherefore art thou ROM(e)O1?

scientific article published on 28 January 2014

OPA1 controls apoptotic cristae remodeling independently from mitochondrial fusion

scientific article

OPA1 promotes pH flashes that spread between contiguous mitochondria without matrix protein exchange

scientific article

OPA1 requires mitofusin 1 to promote mitochondrial fusion

scientific article

On the voltage dependence of the mitochondrial permeability transition pore. A critical appraisal

scientific article

Opa1 overexpression ameliorates the phenotype of two mitochondrial disease mouse models.

scientific article published on June 2015

Opening the doors to cytochrome c: changes in mitochondrial shape and apoptosis.

scientific article published on 23 April 2009

Optic Atrophy 1 Is Epistatic to the Core MICOS Component MIC60 in Mitochondrial Cristae Shape Control

scientific article

Optic atrophy 1 mediates mitochondria remodeling and dopaminergic neurodegeneration linked to complex I deficiency.

scientific article

Optic atrophy 1-dependent mitochondrial remodeling controls steroidogenesis in trophoblasts.

scientific article

Orchestration of lymphocyte chemotaxis by mitochondrial dynamics

scientific article

Organelle isolation: functional mitochondria from mouse liver, muscle and cultured filroblasts

scientific article published on 01 January 2007

PARP Inhibitor PJ34 Protects Mitochondria and Induces DNA-Damage Mediated Apoptosis in Combination With Cisplatin or Temozolomide in B16F10 Melanoma Cells

scientific article published on 07 May 2019

Parkinson's disease mutations in PINK1 result in decreased Complex I activity and deficient synaptic function

scientific article

Perspectives on the mitochondrial permeability transition

Perspectives on: SGP symposium on mitochondrial physiology and medicine: the pathophysiology of LETM1.

scientific article published on June 2012

Phagocytosis: coupling of mitochondrial uncoupling and engulfment.

scientific article published on October 2011

Phosphorylation of BCL-2 regulates ER Ca2+ homeostasis and apoptosis.

scientific article

Poly(adenosine diphosphate-ribose) polymerase as therapeutic target: lessons learned from its inhibitors

scientific article

Proapoptotic BAX and BAK regulate the type 1 inositol trisphosphate receptor and calcium leak from the endoplasmic reticulum

scientific journal article

Proenkephalin Derived Peptides Are Involved in the Modulation of Mitochondrial Respiratory Control During Epileptogenesis

scientific article published on 25 September 2018

Prohibitin(g) cancer: aurilide and killing by Opa1-dependent cristae remodeling

scientific article published on 01 January 2011

Proteasome dysfunction induces excessive proteome instability and loss of mitostasis that can be mitigated by enhancing mitochondrial fusion or autophagy

scientific article published on 19 April 2019

Proteins that fuse and fragment mitochondria in apoptosis: con-fissing a deadly con-fusion?

scientific article

Rapidly purified ganglion cells from neonatal mouse retinas allow studies of mitochondrial morphology and autophagy

scientific article published on 02 August 2018

Reactive oxygen species are NOXious for neurons.

scientific article published in July 2009

Reduction of endoplasmic reticulum stress attenuates the defects caused by Drosophila mitofusin depletion.

scientific article published on 27 January 2014

Regulation of endoplasmic reticulum Ca2+ dynamics by proapoptotic BCL-2 family members.

scientific article published on October 2003

Reply to Filadi et al.: Does Mitofusin 2 tether or separate endoplasmic reticulum and mitochondria?

scientific article published on 13 March 2017

Resistance of Dynamin-related Protein 1 Oligomers to Disassembly Impairs Mitophagy, Resulting in Myocardial Inflammation and Heart Failure ⬇️

scientific article published on 14 September 2015

Respiratory dysfunction by AFG3L2 deficiency causes decreased mitochondrial calcium uptake via organellar network fragmentation

scientific article

RevAMPing Mitochondrial Shape to Live Longer.

scientific article published in December 2017

Role of endoplasmic reticulum depletion and multidomain proapoptotic BAX and BAK proteins in shaping cell death after hypericin-mediated photodynamic therapy

scientific article published on 2 February 2006

SPLICS: a split green fluorescent protein-based contact site sensor for narrow and wide heterotypic organelle juxtaposition.

scientific article published on 11 December 2017

Seminars in Cell & Developmental Biology. Editorial

scientific article published on 27 April 2010

Shaping the role of mitochondria in the pathogenesis of Huntington's disease

scientific article

Shipping Calpastatin to the Rescue: Prevention of Neuromuscular Degeneration through Mitofusin 2

scientific article published on 01 October 2018

Silencing of the Charcot-Marie-Tooth disease-associated gene GDAP1 induces abnormal mitochondrial distribution and affects Ca2+ homeostasis by reducing store-operated Ca2+ entry

scientific article published on 28 March 2013

Single cell analysis reveals the involvement of the long non-coding RNA Pvt1 in the modulation of muscle atrophy and mitochondrial network

scientific article published on 01 February 2019

Sirtuin 5 protects mitochondria from fragmentation and degradation during starvation.

scientific article published on 15 November 2016

Splice variants of mitofusin 2 shape the endoplasmic reticulum and tether it to mitochondria

scientific article published on 22 June 2023

Stanley J. Korsmeyer (1950-2005).

scientific article published in June 2005

Superoxide-mediated activation of uncoupling protein 2 causes pancreatic beta cell dysfunction.

scientific article published on December 2003

Synaptic dysfunction, memory deficits and hippocampal atrophy due to ablation of mitochondrial fission in adult forebrain neurons

scientific article published on 24 April 2015

Targeting cell death.

scientific article published on October 2007

The INs and OUTs of mitofusins

scientific article published on 18 January 2018

The OPA1-dependent mitochondrial cristae remodeling pathway controls atrophic, apoptotic, and ischemic tissue damage

scientific article

The SUMO arena goes mitochondrial with MAPL

scientific article published on 12 June 2009

The cell biology of mitochondrial membrane dynamics

scientific article published on 18 February 2020

The cristae modulator Optic atrophy 1 requires mitochondrial ATP synthase oligomers to safeguard mitochondrial function

scientific article published in Nature Communications

The endogenous caspase-8 inhibitor c-FLIPL regulates ER morphology and crosstalk with mitochondria.

scientific article

The energy disruptor metformin targets mitochondrial integrity via modification of calcium flux in cancer cells.

scientific article

The interplay between BCL-2 family proteins and mitochondrial morphology in the regulation of apoptosis.

scientific article published on January 2010

The many shapes of mitochondrial death

scientific article published on August 2006

The mitochondrial fission protein hFis1 requires the endoplasmic reticulum gateway to induce apoptosis

scientific article

The mitochondrial permeability transition, release of cytochrome c and cell death. Correlation with the duration of pore openings in situ

scientific article

The relationship between mitochondrial shape and function and the cytoskeleton.

scientific article

To fuse and to protect. A novel role for CED-9 in mitochondrial morphology reveals an ancient function

scientific article published on 14 July 2006

Tonight, the same old, deadly programme: BH3-only proteins, mitochondria and yeast ⬇️

scientific article published on July 20, 2011

Too close not to encyst: Polycystic kidney disease and interorganellar contact sites

scientific article published on 28 May 2019

Transcriptomic Analysis of Single Isolated Myofibers Identifies miR-27a-3p and miR-142-3p as Regulators of Metabolism in Skeletal Muscle

scientific article published on 01 March 2019

Transgene expression in mice of the Opa1 mitochondrial transmembrane protein through bicontinuous cubic lipoplexes containing gemini imidazolium surfactants

scientific article published on 18 December 2021

Traveling Bax and forth from mitochondria to control apoptosis.

scientific article published on April 2011

Trichoplein/mitostatin regulates endoplasmic reticulum-mitochondria juxtaposition

scientific article

Two modes of activation of the permeability transition pore: the role of mitochondrial cyclophilin

scientific article published on 01 September 1997

When numbers matters: mitochondrial DNA and gliomagenesis

scientific article published on December 2013

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