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List of works by Shigekazu Nagata

A Role of TMEM16E Carrying a Scrambling Domain in Sperm Motility.

scientific article published on 14 December 2015

A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD ⬇️

scientific article published on January 1, 1998

Aberrant transcription caused by the insertion of an early transposable element in an intron of the Fas antigen gene of lpr mice ⬇️

scientific article published on March 1, 1993

Abrogation of Fas-Induced Fulminant Hepatic Failure in Mice by Hepatocyte Growth Factor ⬇️

scientific article published on March 27, 1998

Activation of distinct caspase-like proteases by Fas and reaper in Drosophila cells ⬇️

scientific article published on October 28, 1997

Activation of the innate immunity in Drosophila by endogenous chromosomal DNA that escaped apoptotic degradation

scientific article published on October 2002

An Apoptotic 'Eat Me' Signal: Phosphatidylserine Exposure.

scientific article published on 14 September 2015

Apaf-1- and Caspase-8-independent apoptosis ⬇️

scientific article published on November 30, 2012

Apaf-1-independent programmed cell death in mouse development.

scientific article published on 4 December 2009

Apoptosis and Clearance of Apoptotic Cells.

scientific article published on 5 February 2018

Apoptosis and autoimmune diseases

scientific article

Apoptosis and autoimmune diseases

scientific article published on 01 October 2010

Apoptosis by death factor

scientific article

Apoptotic cells suppress mast cell inflammatory responses via the CD300a immunoreceptor

scientific article

Assignment of the human granulocyte colony-stimulating factor receptor gene (CSF3R) to chromosome 1 at region p35–p34.3 ⬇️

scientific article published on August 1, 1991

Autoimmune disease and impaired uptake of apoptotic cells in MFG-E8-deficient mice

scientific article

Autoimmune diseases caused by defects in clearing dead cells and nuclei expelled from erythroid precursors

scientific article published on December 2007

Autoimmunity and the clearance of dead cells

scientific article published on March 2010

Autoinflammation by endogenous DNA.

scientific article published on January 2011

Binding of NF-Y Transcription Factor to One of the Cis-elements in the Myeloperoxidase Gene Promoter That Responds to Granulocyte Colony-stimulating Factor ⬇️

scientific article published on September 12, 1997

Biogenesis and proteolytic processing of lysosomal DNase II

scientific article

Breakdown of chromosomal DNA.

scientific article

Calcium-dependent phospholipid scramblase activity of TMEM16 protein family members

scientific journal article

Calcium-dependent phospholipid scrambling by TMEM16F

scientific article

Cardiac myofibroblast engulfment of dead cells facilitates recovery after myocardial infarction

scientific article published on 05 December 2016

Caspase-mediated cleavage of phospholipid flippase for apoptotic phosphatidylserine exposure

scientific article

Cell biology: Killer enzymes tethered.

scientific article published on 18 May 2016

Characterization of the scrambling domain of the TMEM16 family.

scientific article published on 30 May 2017

Characterization of the threonine-phosphatase of mouse eyes absent 3

scientific article published on 02 August 2011

Chronic polyarthritis caused by mammalian DNA that escapes from degradation in macrophages

scientific article published in Nature

Clearance of Apoptotic Cells and Pyrenocytes.

scientific article published on 11 September 2015

Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis ⬇️

scientific article published on January 1, 1998

Constitutive Production of Granulocyte Colony-Stimulating Factor by Hybrids of a SV40-Transformed Mouse Macrophage and a Renal Adenocarcinoma Cell Line ⬇️

scientific article published on January 1, 1991

Constitutive and inducible factors bind to regulatory element 3 in the promoter of the gene encoding mouse granulocyte colony-stimulating factor

scientific article published on November 16, 1992

Constitutive exposure of phosphatidylserine on viable cells

scientific article published on 14 November 2011

Corrigendum: Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis.

scientific article published on 23 September 2015

Crystal structure of a human plasma membrane phospholipid flippase

scientific article published on 03 June 2020

Cytokine-dependent but acquired immunity-independent arthritis caused by DNA escaped from degradation

scientific article

DNA degradation and its defects.

scientific article published on 02 June 2014

DNA degradation in development and programmed cell death

scientific article

DNA-Mediated Cyclic GMP-AMP Synthase-Dependent and -Independent Regulation of Innate Immune Responses.

scientific article published on 8 April 2015

Degradation of nuclear DNA by DNase II-like acid DNase in cortical fiber cells of mouse eye lens

scientific article published on 17 May 2007

Differential localization of Src homology 2 domain-containing protein tyrosine phosphatase substrate-1 and CD47 and its molecular mechanisms in cultured hippocampal neurons.

scientific article

Distribution of the low molecular weight form of eukaryotic elongation factor 1 in various tissues ⬇️

scientific article published on July 1, 1976

Downregulation of Fas ligand by shedding ⬇️

scientific article published on January 1, 1998

Down‐modulation of CD4+ T helper type 2 and type 0 cells by T helper type 1 cells via Fas/Fasligand interaction ⬇️

scientific article published on 01 September 1995

Drosophila EYA regulates the immune response against DNA through an evolutionarily conserved threonine phosphatase motif

scientific article

ERM (Ezrin/Radixin/Moesin)-based Molecular Mechanism of Microvillar Breakdown at an Early Stage of Apoptosis ⬇️

scientific article published on November 3, 1997

Efferocytosis and autoimmune disease

scientific article published on 01 November 2018

Erratum: Chronic polyarthritis caused by mammalian DNA that escapes from degradation in macrophages

scientific article published in Nature

Erratum: Lethal effect of the anti-Fas antibody in mice

scientific article published in Nature

Erratum: correction: A caspase-activated DNase that degrades DNA during apoptosis and its inhibitor ICAD

scientific article published in Nature

Essential role of p400/mDomino chromatin-remodeling ATPase in bone marrow hematopoiesis and cell-cycle progression

scientific article

Exposure of phosphatidylserine by Xk-related protein family members during apoptosis

scientific article

Exposure of phosphatidylserine on the cell surface

scientific article

Expression of Granulocyte Colony-Stimulating Factor and its Receptor at the Fetomaternal Interface in Murine and Human Pregnancy ⬇️

scientific article published on 01 January 1994

Expression of developmental endothelial locus-1 in a subset of macrophages for engulfment of apoptotic cells

scientific article published on March 2004

Expression of milk fat globule epidermal growth factor 8 in immature dendritic cells for engulfment of apoptotic cells

scientific article

Fas-induced Apoptosis ⬇️

scientific article published on February 1, 1998

Fas/FasL Interaction Is Not Involved in Apoptosis of Activated CD4+ T Cells Upon HIV-1 Infection in Vitro ⬇️

scientific article published on August 1, 1998

Fas‐induced DNA fragmentation and proteolysis of nuclear proteins ⬇️

scientific article published on May 1, 1998

Flippases and scramblases in the plasma membrane

scientific article published in January 2014

Frequent Fas gene mutations in testicular germ cell tumors

scientific article

Functional Expression of the P2X7 ATP Receptor Requires Eros

scientific article published on 20 December 2019

Functional expression and tissue distribution of a novel receptor for vasoactive intestinal polypeptide

scientific article published on April 1, 1992

Functional swapping between transmembrane proteins TMEM16A and TMEM16F.

scientific article

Growth and differentiation signals mediated by different regions in the cytoplasmic domain of granulocyte colony-stimulating factor receptor ⬇️

scientific article published on September 24, 1993

High Fas ligand expression on lymphocytes in lesions of ulcerative colitis ⬇️

scientific article published on July 1, 1998

Human Type IV P-type ATPases That Work as Plasma Membrane Phospholipid Flippases and Their Regulation by Caspase and Calcium

scientific article

Human autoimmune lymphoproliferative syndrome, a defect in the apoptosis-inducing Fas receptor: A lesson from the mouse model ⬇️

scientific article published on January 1, 1998

Human leukocyte and fibroblast interferons are structurally related

scientific article published in Nature

Hyperproduction of human interferon gamma by rat cells maintained in low-serum medium using the fibronectin gene promoter ⬇️

scientific article published on November 1, 1992

Identification of Tim4 as a phosphatidylserine receptor

scientific article

Identification of a factor that links apoptotic cells to phagocytes

scientific article (publication date: 9 May 2002)

Imaging of Rab5 activity identifies essential regulators for phagosome maturation

scientific article

Immunosuppression via adenosine receptor activation by adenosine monophosphate released from apoptotic cells.

scientific article published on 25 March 2014

Impaired involution of mammary glands in the absence of milk fat globule EGF factor 8

scientific article

Increased Fas antigen expression in murine retrovirus‐induced immunodeficiency syndrome, MAIDS ⬇️

scientific article published on 01 October 1994

Inhibition of autophagy prevents hippocampal pyramidal neuron death after hypoxic-ischemic injury

scientific article published on 10 January 2008

Interaction of the low molecular weight form of elongation factor 1 with guanine nucleotides and aminoacyl-tRNA

scientific article published on January 1, 1976

Involvement of STAT3 in the Granulocyte Colony-stimulating Factor-induced Differentiation of Myeloid Cells ⬇️

scientific article published on October 3, 1997

Lactadherin and clearance of platelet-derived microvesicles

scientific article

Lethal anemia caused by interferon-beta produced in mouse embryos carrying undigested DNA

scientific journal article

Lethal effect of the anti-Fas antibody in mice ⬇️

scientific article published on August 26, 1993

Levels of soluble Fas ligand in myocarditis ⬇️

scientific article published on July 15, 1998

Lupus-like autoimmune disease caused by a lack of Xkr8, a caspase-dependent phospholipid scramblase.

scientific article published on 12 February 2018

Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis

scientific article published on March 26, 1992

MERTK tyrosine kinase receptor together with TIM4 phosphatidylserine receptor mediates distinct signal transduction pathways for efferocytosis and cell proliferation

scientific article published on 07 March 2019

MFG-E8-dependent clearance of apoptotic cells, and autoimmunity caused by its failure

scientific article

Masking of phosphatidylserine inhibits apoptotic cell engulfment and induces autoantibody production in mice

scientific article

Membrane Fas Ligand Kills Human Peripheral Blood T Lymphocytes, and Soluble Fas Ligand Blocks the Killing ⬇️

scientific article published on December 15, 1997

MerTK-mediated engulfment of pyrenocytes by central macrophages in erythroblastic islands

scientific article published on 21 March 2014

Milk fat globule EGF factor 8 in the serum of human patients of systemic lupus erythematosus

scientific article

Milk fat globule-EGF factor 8 mediates the enhancement of apoptotic cell clearance by glucocorticoids.

scientific article published on 5 July 2013

Mnk2 and Mnk1 are essential for constitutive and inducible phosphorylation of eukaryotic initiation factor 4E but not for cell growth or development

scientific article published on August 2004

Molecular analysis of the human interferon-α gene family ⬇️

scientific article published on 01 December 1981

Molecular cloning and characterization of human caspase-activated DNase ⬇️

scientific article published on August 4, 1998

Molecular cloning and sequence determination of the nuclear gene coding for mitochondrial elongation factor Tu of Saccharomyces cerevisiae ⬇️

scientific article published on October 1, 1983

Molecular cloning of cDNA and a chromosomal gene encoding GPE1-BP, a nuclear protein which binds to granulocyte colony-stimulating factor promoter element 1 ⬇️

scientific article published on April 22, 1991

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

scientific article

Mouse macrophages show different requirements for phosphatidylserine receptor Tim4 in efferocytosis.

scientific article published on 2 August 2017

Myeloid-specific transcriptional activation by murine myeloid zinc-finger protein 2 ⬇️

scientific article published on March 31, 1998

No requirement of reactive oxygen intermediates in Fas‐mediated apoptosis ⬇️

scientific article published on September 12, 1994

Nuclear removal during terminal lens fiber cell differentiation requires CDK1 activity: appropriating mitosis-related nuclear disassembly

scientific article

Opposite effects of rho family GTPases on engulfment of apoptotic cells by macrophages

scientific article published on 26 January 2006

Osteopontin in Spontaneous Germinal Centers Inhibits Apoptotic Cell Engulfment and Promotes Anti-Nuclear Antibody Production in Lupus-Prone Mice

scientific article

Partial Mapping of Ten Genes of the Human Interferon- α Family ⬇️

scientific article published on 01 February 1981

Phosphatidylserine-dependent engulfment by macrophages of nuclei from erythroid precursor cells

scientific article

Phospholipid flippase activities and substrate specificities of human type IV P-type ATPases localized to the plasma membrane

scientific article

Phospholipid flippase activities and substrate specificities of human type IV P-type ATPases localized to the plasma membrane.

scientific article published on October 2016

Phospholipid flippases enable precursor B cells to flee engulfment by macrophages

article published in the Proceedings of the National Academy of Sciences of the United States of America

Phospholipid scrambling on the plasma membrane.

scientific article

Phosphorylation-mediated activation of mouse Xkr8 scramblase for phosphatidylserine exposure

scientific article published on 04 February 2019

Platelet apoptosis and apoptotic platelet clearance by macrophages in secondary dengue virus infections

scientific article

Predominant localization of phosphatidylserine at the cytoplasmic leaflet of the ER, and its TMEM16K-dependent redistribution

scientific article published on 19 June 2019

Premature expression of the macrophage colony-stimulating factor receptor on a multipotential stem cell line does not alter differentiation lineages controlled by stromal cells used for coculture ⬇️

scientific article published on May 1, 1991

Production of human granulocyte colony stimulating factor by various kinds of stromal cells in vitro detected by enzyme immunoassay and in situ hybridization ⬇️

scientific article published on July 1, 1994

Programmed cell death and the immune system

scientific article published on 6 February 2017

Protective targeting of high mobility group box chromosomal protein 1 in a spontaneous arthritis model

scientific article published on 01 October 2010

Purification and Properties of Polypeptide Chain Elongation Factor-lα from Pig Liver ⬇️

scientific article published on 01 December 1977

Pyroptotic cells externalize eat-me and release find-me signals and are efficiently engulfed by macrophages.

scientific article published on 26 February 2013

Rational design of potent antagonists to the human growth hormone receptor

scientific article published on June 19, 1992

Regulation of the innate immune response by threonine-phosphatase of Eyes absent

scientific article

Regulatory elements responsible for inducible expression of the granulocyte colony-stimulating factor gene in macrophages ⬇️

scientific article published on May 1, 1990

Requirement for the CD95 Receptor-Ligand Pathway in c-Myc-Induced Apoptosis ⬇️

scientific article published on November 14, 1997

Requirement of Fas for the Development of Autoimmune Diabetes in Nonobese Diabetic Mice ⬇️

scientific article published on August 18, 1997

Rheumatoid polyarthritis caused by a defect in DNA degradation

scientific article published on 29 May 2008

Role of Ca(2+) in the Stability and Function of TMEM16F and 16K.

scientific article published on 26 May 2016

SEI family of nuclear factors regulates p53-dependent transcriptional activation

scientific article

Serum milk fat globule epidermal growth factor 8 elevation may subdivide systemic lupus erythematosus into two pathophysiologically distinct subsets

scientific article published on 19 February 2014

Signal transduction mediated by growth hormone receptor and its chimeric molecules with the granulocyte colony-stimulating factor receptor ⬇️

scientific article published on January 1, 1993

Single-molecule analysis of phospholipid scrambling by TMEM16F.

scientific article

Soluble Fas ligand in the joints of patients with rheumatoid arthritis and osteoarthritis ⬇️

scientific article published on 01 April 1998

Spatiotemporal activation of Rac1 for engulfment of apoptotic cells

scientific article

Structure of the gene encoding the mouse pituitary adenylate cyclase-activating polypeptide receptor

scientific article published on October 27, 1995

Synergistic effect of Tim4 and MFG-E8 null mutations on the development of autoimmunity ⬇️

scientific article published on June 20, 2012

TIM4 expression by dendritic cells mediates uptake of tumor-associated antigens and anti-tumor responses

scientific article published on 14 April 2021

TMEM16F is required for phosphatidylserine exposure and microparticle release in activated mouse platelets

scientific article published on 28 September 2015

Targeted mutation in the Fas gene causes hyperplasia in peripheral lymphoid organs and liver ⬇️

scientific article published on 01 November 1995

Tethering of apoptotic cells to phagocytes through binding of CD47 to Src homology 2 domain-bearing protein tyrosine phosphatase substrate-1

scientific journal article

The CDC50A extracellular domain is required for forming a functional complex with and chaperoning phospholipid flippases to the plasma membrane

scientific article published on 24 December 2017

The many roles of FAS receptor signaling in the immune system

scientific article

The structure of one of the eight or more distinct chromosomal genes for human interferon-α ⬇️

scientific article published on October 2, 1980

The tertiary structure of the human Xkr8-Basigin complex that scrambles phospholipids at plasma membranes

scientific article published on 08 October 2021

Three different mRNAs encoding human granulocyte colony-stimulating factor receptor ⬇️

scientific article published on November 1, 1990

Three individual regulatory elements of the promoter positively activate the transcription of the murine gene encoding granulocyte colony-stimulating factor ⬇️

scientific article published on November 15, 1991

Tim4- and MerTK-mediated engulfment of apoptotic cells by mouse resident peritoneal macrophages.

scientific article published on 10 February 2014

Toll-like receptor-independent gene induction program activated by mammalian DNA escaped from apoptotic DNA degradation

scientific article published on November 2005

Two-step engulfment of apoptotic cells

scientific article

Vasoactive Intestinal Polypeptide and Pituitary Adenylate Cyclase-Activating Polypeptide Receptor Chimeras Reveal Domains That Determine Specificity of Vasoactive Intestinal Polypeptide Binding and Activation ⬇️

scientific article published on 01 July 1997

Xk-related protein 8 and CED-8 promote phosphatidylserine exposure in apoptotic cells

scientific article

Xkr8 phospholipid scrambling complex in apoptotic phosphatidylserine exposure.

scientific article published on 08 August 2016

cDNA clones encoding leucine-zipper proteins which interact with G-CSF gene promoter element 1-binding protein

scientific article published on March 24, 1992

pEF-BOS, a powerful mammalian expression vector ⬇️

scientific article (publication date: 11 September 1990)

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