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List of works by Iwao Ojima

%VO2max as an indicator of prosthetic rehabilitation outcome after dysvascular amputation.

scientific article published in April 2002

109881 Aventis

scientific article

A New Paclitaxel Photoaffinity Analog with a 3-(4-Benzoylphenyl)propanoyl Probe for Characterization of Drug-Binding Sites on Tubulin and P-Glycoprotein

scientific article published on 01 September 1995

A common pharmacophore for cytotoxic natural products that stabilize microtubules

scientific article

A highly efficient route to taxotere by the β-Lactam Synthon Method

A highly epothilone B-resistant A549 cell line with mutations in tubulin that confer drug dependence

scientific article published on June 2005

A trisubstituted benzimidazole cell division inhibitor with efficacy against Mycobacterium tuberculosis

scientific article (publication date: 2014)

Acylhydrazones as Antifungal Agents Targeting the Synthesis of Fungal Sphingolipids.

scientific article published on 5 March 2018

Advances in the chemistry of β-lactam and its medicinal applications.

scientific article published on 7 August 2012

Anti-proliferative activity of a new class of taxanes (14β-hydroxy-10-deacetylbaccatin III derivatives) on multidrug-resistance-positive human cancer cells

scientific article published on 01 September 1997

Antithrombotic agents: from RGD to peptide mimetics.

scientific article published on April 1995

Antitumor efficacy of taxane liposomes on a human ovarian tumor xenograft in nude athymic mice.

scientific article published on December 1995

Antitumour activity of novel taxanes that act at the same time as cytotoxic agents and P-glycoprotein inhibitors

scientific article published on December 2000

BMS-184476 Bristol-Myers Squibb

scientific article

Benzimidazole-based antibacterial agents against Francisella tularensis

scientific article

Biodistribution and Pharmacokinetic Evaluations of a Novel Taxoid DHA-SBT-1214 in an Oil-in-Water Nanoemulsion Formulation in Naïve and Tumor-Bearing Mice

scientific article published on 08 March 2018

Broad-spectrum modulation of ATP-binding cassette transport proteins by the taxane derivatives ortataxel (IDN-5109, BAY 59-8862) and tRA96023.

scientific article published on 27 January 2004

Caspase-2 is involved in cell death induction by taxanes in breast cancer cells

scientific article published on 15 May 2013

Cell death induced by novel fluorinated taxanes in drug-sensitive and drug-resistant cancer cells.

scientific article

Cell division inhibitors with efficacy equivalent to isoniazid in the acute murine Mycobacterium tuberculosis infection model

scientific article

Characterization of the Taxol Binding Site on the Microtubule

scientific article published in Journal of Biological Chemistry

Characterizing septum inhibition in Mycobacterium tuberculosis for novel drug discovery

scientific article published on 13 May 2008

Chemistry and chemical biology of taxane anticancer agents.

scientific article

Comparison of cell death-inducing effect of novel taxane SB-T-1216 and paclitaxel in breast cancer cells

scientific article

Computational Design and Synthesis of Novel Fluoro-Analogs of Combretastatins A-4 and A-1.

scientific article published on 10 September 2017

Computer-aided identification, synthesis, and biological evaluation of novel inhibitors for botulinum neurotoxin serotype A.

scientific article published on 27 July 2015

Construction of Fused Tropone Systems Through Intramolecular Rh(I)-Catalyzed Carbonylative [2+2+2+1] Cycloadditon of Triynes

Contribution of diacylglycerol lipase β to pain after surgery.

scientific article published on 5 March 2018

Crystallographic study of FABP5 as an intracellular endocannabinoid transporter

scientific article

Cytotoxic effects toward human hematopoietic progenitor cells and tumor cell lines of paclitaxel, docetaxel, and newly developed analogues IDN5109, IDN5111, and IDN5127

Design and synthesis of de novo cytotoxic alkaloids by mimicking the bioactive conformation of paclitaxel

scientific article

Design and synthesis of de novo cytotoxic alkaloids through mimicking taxoid skeleton

scientific article published on 01 July 2004

Design and synthesis of tumor-targeting theranostic drug conjugates for SPECT and PET imaging studies.

scientific article published on 11 December 2017

Design, Synthesis and Application of Fluorine-Labeled Taxoids as (19)F NMR Probes for the Metabolic Stability Assessment of Tumor-Targeted Drug Delivery Systems

scientific article

Design, Synthesis, and Biological Evaluations of Asymmetric Bow-Tie PAMAM Dendrimer-Based Conjugates for Tumor-Targeted Drug Delivery.

scientific article

Design, synthesis and biological activity of novel C2-C3' N-Linked macrocyclic taxoids

scientific article published on February 2002

Design, synthesis and biological evaluation of a highly-potent and cancer cell selective folate-taxoid conjugate

scientific article

Design, synthesis and enzyme inhibitory activities of new trifluoromethyl-containing inhibitors for angiotensin converting enzyme

scientific article published on 01 February 1994

Design, synthesis and evaluation of novel 2,5,6-trisubstituted benzimidazoles targeting FtsZ as antitubercular agents.

scientific article

Design, synthesis and structure-activity relationships of novel taxane-based multidrug resistance reversal agents

scientific article

Design, synthesis, and biological evaluation of new-generation taxoids

scientific article published on 09 May 2008

Design, synthesis, and biological evaluation of novel C14-C3'BzN-linked macrocyclic taxoids

scientific article published on December 2008

Design, synthesis, and biological evaluation of theranostic vitamin-linker-taxoid conjugates

scientific article

Design, synthesis, and biological evaluations of tumor-targeting dual-warhead conjugates for a taxoid-camptothecin combination chemotherapy

scientific article

Desymmetrization of 4-Dimethylsiloxy-1,6-heptadiynes through Sequential Double Silylformylation

scientific article published on 01 May 2001

Differing Mechanisms of Death Induction by Fluorinated Taxane SB-T-12854 in Breast Cancer Cells

scientific article published in April 2017

Discovery of anti-TB agents that target the cell-division protein FtsZ.

scientific article

Drug discovery targeting cell division proteins, microtubules and FtsZ.

scientific article

Drug resistance mechanisms and novel drug targets for tuberculosis therapy

scientific article published on 11 October 2016

Effects of novel taxanes SB-T-1213 and IDN5109 on tubulin polymerization and mitosis

scientific article published in January 2002

Effects of orally active taxanes on P-glycoprotein modulation and colon and breast carcinoma drug resistance

scientific article

Efficient Asymmetric Syntheses of β-Lactams Bearing a Cyclopropane or an Epoxide Moiety and Their Application to the Syntheses of Novel Isoserines and Taxoids

Efficient Syntheses of Crispine A and Harmicine by Rh-Catalyzed Cyclohydrocarbonylation

scientific article published on 01 June 2009

Efficient and practical asymmetric synthesis of the taxol C-13 side chain, N-benzoyl-(2R,3S)-3-phenylisoserine, and its analogs via chiral 3-hydroxy-4-aryl-.beta.-lactams through chiral ester enolate-imine cyclocondensation

Electronic effects on the regio- and enantioselectivity of the asymmetric aminohydroxylation of O-substituted 4-hydroxy-2-butenoates.

scientific article published on February 2002

Erratum for Mor et al., "Identification of a New Class of Antifungals Targeting the Synthesis of Fungal Sphingolipids".

scientific article published on 13 March 2018

Establishment of highly tumorigenic human colorectal cancer cell line (CR4) with properties of putative cancer stem cells

scientific article

Exploration of fluorine chemistry at the multidisciplinary interface of chemistry and biology.

scientific article published on 06 May 2013

Fatty acid binding protein 5 controls microsomal prostaglandin E synthase 1 (mPGES-1) induction during inflammation

scientific article published on 13 February 2018

Fatty acid-binding proteins (FABPs) are intracellular carriers for Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD).

scientific article

Fatty-acid-binding protein inhibition produces analgesic effects through peripheral and central mechanisms

scientific article

Fluorine-Containing Taxoid Anticancer Agents and Their Tumor-Targeted Drug Delivery

scientific article published on August 2013

Formal Enantioselective Total Synthesis of Schulzeines A–C via Pd–Catalyzed Intramolecular Asymmetric Allylic Amination

scientific article published on 08 July 2011

FtsZ: a novel target for tuberculosis drug discovery

scientific article published on January 2007

Functionalized single-walled carbon nanotubes as rationally designed vehicles for tumor-targeted drug delivery.

scientific article

GPIIb/IIIa integrin antagonists with the new conformational restriction unit, trisubstituted beta-amino acid derivatives, and a substituted benzamidine structure.

scientific article published in June 1998

Great Challenges in Organic Chemistry.

scientific article published on 12 July 2017

Guided molecular missiles for tumor-targeting chemotherapy--case studies using the second-generation taxoids as warheads.

scientific article published on 31 July 2007

Hedgehog pathway overexpression in pancreatic cancer is abrogated by new-generation taxoid SB-T-1216.

scientific article published on 30 August 2016

Highly Enantioselective Copper-Catalyzed Conjugate Addition of Diethylzinc to Nitroalkenes

article

Hydrogel microstructure live-cell array for multiplexed analyses of cancer stem cells, tumor heterogeneity and differential drug response at single-element resolution.

scientific article published on 23 February 2016

Identification of a New Class of Antifungals Targeting the Synthesis of Fungal Sphingolipids

scientific article published on 23 June 2015

Identification of small molecule inhibitors of botulinum neurotoxin serotype E via footprint similarity

scientific article

Identification of the Domains of Photoincorporation of the 3‘- and 7-Benzophenone Analogues of Taxol in the Carboxyl-Terminal Half of Murine mdr1b P-glycoprotein ⬇️

scientific article published on August 11, 1998

In vitro-in vivo activity relationship of substituted benzimidazole cell division inhibitors with activity against Mycobacterium tuberculosis

scientific article

Incarvillateine produces antinociceptive and motor suppressive effects via adenosine receptor activation

scientific article published on 25 June 2019

Inexpensive chemical method for preparation of enantiomerically pure phenylalanine

scientific article published on 03 January 2014

Inhibition of fatty acid binding proteins elevates brain anandamide levels and produces analgesia.

scientific article

Mechanism and inhibition of saFabI, the enoyl reductase from Staphylococcus aureus

scientific journal article

Mechanism-based tumor-targeting drug delivery system. Validation of efficient vitamin receptor-mediated endocytosis and drug release.

scientific article

Medicinal chemistry and chemical biology of new generation taxane antitumor agents.

scientific article published in April 2002

Medicinal chemistry at a crossroads: challenges and new possibilities

scientific article published on 01 June 2009

Metabolism of new-generation taxanes in human, pig, minipig and rat liver microsomes

scientific article published on 01 September 2006

Modern Molecular Approaches to Drug Design and Discovery

scientific article published on 01 January 2008

Modern Natural Products Chemistry and Drug Discovery

scientific article published on 05 April 2008

Nanoemulsion formulation of a novel taxoid DHA-SBT-1214 inhibits prostate cancer stem cell-induced tumor growth.

scientific article published on 10 August 2017

New Insights into Drug Resistance in Cancer

scientific article published on 01 July 2003

New Monocyclic, Bicyclic, and Tricyclic Ethynylcyanodienones as Activators of the Keap1/Nrf2/ARE Pathway and Inhibitors of Inducible Nitric Oxide Synthase

scientific article published on 20 May 2015

New and Efficient Synthesis of Azabicyclo[4.4.0]alkane Amino Acids by Rh-Catalyzed Cyclohydrocarbonylation

scientific article published on 01 December 2002

New and efficient approaches to the semisynthesis of taxol and its C-13 side chain analogs by means of β-lactam synthon method

New and efficient routes to norstatine and its analogs with high enantiomeric purity by β-Lactam Synthon Method

New biphenol-based, fine-tunable monodentate phosphoramidite ligands for catalytic asymmetric transformations.

scholarly article

New photoaffinity analogs of paclitaxel

scientific article published on 01 April 1999

New taxanes as highly efficient reversal agents for multi-drug resistance in cancer cells

scientific article published on 01 January 1998

New-generation taxoid SB-T-1214 inhibits stem cell-related gene expression in 3D cancer spheroids induced by purified colon tumor-initiating cells

scientific article published on 14 July 2010

Novel C-seco-taxoids possessing high potency against paclitaxel-resistant cancer cell lines overexpressing class III beta-tubulin

scientific article published on 22 April 2009

Novel DMAP-Catalyzed Skeletal Rearrangement of 5-exo-(2-Hydroxy- ethylene)oxasilacyclopentanes

scientific article published on 01 July 2001

Novel Taxoid-Based Tumor-Targeting Drug Conjugates.

scientific article published on November 2009

Novel [2 + 2 + 2 + 1] Cycloaddition of Enediynes Catalyzed by Rhodium Complexes

scientific article published on 01 September 2004

Novel trisubstituted benzimidazoles, targeting Mtb FtsZ, as a new class of antitubercular agents

scientific article

One-step formation of fused tetracyclic skeletons from cyclohexene-diynes and carbon monoxide through Rh(i)-catalyzed [2 + 2 + 2 + 1] cycloaddition reaction

scientific article published on 29 June 2009

Overcoming multidrug resistance in taxane chemotherapy

scientific article

Pd-catalyzed asymmetric allylic etherification using chiral biphenol-based diphosphinite ligands and its application for the formal total synthesis of (-)-galanthamine

scientific article

Physical Fitness of Lower Limb Amputees

scientific article published on 01 May 2002

Poly(2-oxazoline) based micelles with high capacity for 3rd generation taxoids: preparation, in vitro and in vivo evaluation

scientific article published on 26 February 2015

Prostate cancer stem cell-targeted efficacy of a new-generation taxoid, SBT-1214 and novel polyenolic zinc-binding curcuminoid, CMC2.24

scientific article (publication date: 2013)

Quest for Efficacious Next-Generation Taxoid Anticancer Agents and Their Tumor-Targeted Delivery.

scientific article published on 22 February 2018

Recent advances in the discovery and development of antibacterial agents targeting the cell-division protein FtsZ.

scientific article published on 5 May 2016

Recent advances in the medicinal chemistry of taxoids with novel beta-amino acid side chains

scientific article

Recent advances in the new generation taxane anticancer agents.

scientific article published on March 2005

Recent advances in the study of the bioactive conformation of taxol

scientific article

Recent advances in tumor-targeting anticancer drug conjugates.

scientific article

Regioselective hydrosilylation of 1,3-dienes catalyzed by phosphine complexes of palladium and rhodium

scholarly article by Iwao Ojima & Miyoko Kumagai published September 1978 in Journal of Organometallic Chemistry

Rhodium-catalyzed cyclohydrocarbonylation approach to the syntheses of enantiopure homokainoids

scientific article published on 14 November 2007

Rhodium-catalyzed silylcarbocyclization (SiCaC) and carbonylative silylcarbocyclization (CO-SiCaC) reactions of enynes

scientific article published in August 2002

SAR Studies on Aromatic Acylhydrazone-Based Inhibitors of Fungal Sphingolipid Synthesis as Next-Generation Antifungal Agents

scientific article published on 16 August 2019

SAR studies on trisubstituted benzimidazoles as inhibitors of Mtb FtsZ for the development of novel antitubercular agents

scientific article

SAR studies on truxillic acid mono esters as a new class of antinociceptive agents targeting fatty acid binding proteins

SB-RA-2001 inhibits bacterial proliferation by targeting FtsZ assembly

scientific article

SB-T-121205, a next-generation taxane, enhances apoptosis and inhibits migration/invasion in MCF-7/PTX cells

scientific article published on 10 February 2017

Second generation taxanes: from the natural framework to the challenge of drug resistance

scientific article

Second-generation taxanes effectively suppress subcutaneous rat lymphoma: role of disposition, transport, metabolism, in vitro potency and expression of angiogenesis genes

scientific journal article

Silicon-initiated carbonylative carbotricyclization and [2+2+2+1] cycloaddition of enediynes catalyzed by rhodium complexes

scientific article published on December 2005

Strategic Incorporation of Fluorine into Taxoid Anticancer Agents for Medicinal Chemistry and Chemical Biology Studies

scientific article

Strategic incorporation of fluorine in the drug discovery of new-generation antitubercular agents targeting bacterial cell division protein FtsZ.

scientific article

Structural Significance of the Benzoyl Group at the C-3′-N Position of Paclitaxel for Nitric Oxide and Tumor Necrosis Factor Production by Murine Macrophages

article

Structural significance of the acyl group at the C-10 position and the A ring of the taxane core of paclitaxel for inducing nitric oxide and tumor necrosis factor production by murine macrophages

scientific article published on August 2000

Structure-activity analysis of taxane-based broad-spectrum multidrug resistance modulators.

scientific article published on March 2004

Structure-activity relationship study of taxoids for their ability to activate murine macrophages as well as inhibit the growth of macrophage-like cells

scientific article

Structure-activity relationships of new taxoids derived from 14 beta-hydroxy-10-deacetylbaccatin III.

scientific article

Substituents at the C3' and C3'N positions are critical for taxanes to overcome acquired resistance of cancer cells to paclitaxel

scientific article published on 3 April 2018

Syntheses and Structure-Activity Relationships of Novel 3'-Difluoromethyl and 3'-Trifluoromethyl-Taxoids

scientific article published on January 2008

Syntheses and Structure−Activity Relationships of Novel Nor-seco Taxoids

Syntheses and biological activity of C-3'-difluoromethyl-taxoids.

scientific article published on July 2000

Syntheses and evaluation of novel fatty acid-second-generation taxoid conjugates as promising anticancer agents

scientific article published on 18 November 2005

Syntheses and structure-activity relationships of taxoids derived from 14 beta-hydroxy-10-deacetylbaccatin III.

scientific article published on January 1997

Syntheses and structure-activity relationships of the second-generation antitumor taxoids: exceptional activity against drug-resistant cancer cells

scientific article published on September 1996

Syntheses of Norstatine, Its Analogs, and Dipeptide Isosteres by Means of β-Lactam Synthon Method.

scientific article

Synthesis and Biological Evaluation of Novel 3'-Difluorovinyl Taxoids

scientific article

Synthesis and Structure-Activity Relationships of Novel Nor-Seco Analogs of Taxol and Taxotere

article published in 1994

Synthesis and Structure−Activity Relationships of Nonaromatic Taxoids: Effects of Alkyl and Alkenyl Ester Groups on Cytotoxicity

scientific article published on 01 January 1997

Synthesis and biological activity of novel 3′-trifluoromethyl taxoids

scientific article published in 1997

Synthesis and biological evaluation of biotin conjugates of (±)-(4bS,8aR,10aS)-10a-ethynyl-4b,8,8-trimethyl-3,7-dioxo-3,4b,7,8,8a,9,10,10a-octahydro-phenanthrene-2,6-dicarbonitrile, an activator of the Keap1/Nrf2/ARE pathway, for the isolation of it

scientific article published on 21 August 2013

Synthesis and evaluation of 6-[18F]fluoro-3-(2(S)-azetidinylmethoxy)pyridine as a PET tracer for nicotinic acetylcholine receptors

scientific article published on 01 May 2000

Synthesis and stereochemical assignments of diastereomeric Ni(II) complexes of glycine Schiff base with (R)-2-(N-{2-[N-alkyl-N-(1-phenylethyl)amino]acetyl}amino)benzophenone; a case of configurationally stable stereogenic nitrogen

scientific article published on 19 February 2014

Synthesis and structure-activity relationships of new antitumor taxoids. Effects of cyclohexyl substitution at the C-3' and/or C-2 of taxotere (docetaxel).

scientific article published on August 1994

Synthesis and structure-activity relationships of new second-generation taxoids

scientific article published on 01 December 1999

Synthesis of (13) C2 (15) N2 -labeled anti-inflammatory and cytoprotective tricyclic bis(cyanoenone) ([(13) C2 (15) N2 ]-TBE-31) as an internal standard for quantification by stable isotope dilution LC-MS method.

scientific article published on August 2014

Synthesis of Chiral Biphenol-Based Diphosphonite Ligands and Their Application in Palladium-Catalyzed Intermolecular Asymmetric Allylic Amination Reactions

article

Synthesis of Colchicinoids and Allocolchicinoids through Rh(I)-Catalyzed [2+2+2+1] and [2+2+2] Cycloadditions of o-Phenylenetriynes with and without CO

Synthesis of Colchicinoids and Allocolchicinoids through Rh(I)-Catalyzed [2+2+2+1] and [2+2+2] Cycloadditions of o-Phenylenetriynes with and without CO

Synthesis of a Next-Generation Taxoid by Rapid Methylation Amenable for 11C-Labeling

scientific article published on 14 February 2018

Synthesis of new chiral monodentate phosphite ligands and their use in catalytic asymmetric hydrogenation.

scientific article

Synthesis of novel 3'-trifluoromethyl taxoids through effective kinetic resolution of racemic 4-CF3-beta-lactams with baccatins

scientific article published on 01 January 1997

Synthesis of novel C2-C3'N-linked macrocyclic taxoids by means of highly regioselective Heck macrocyclization

scientific article published on October 2003

Synthesis of potent taxoids for tumor-specific delivery using monoclonal antibodies

scientific article published on August 2004

Synthesis, chemical reactivity as Michael acceptors, and biological potency of monocyclic cyanoenones, novel and highly potent anti-inflammatory and cytoprotective agents

scientific article published on 7 May 2012

Targeted and armed oncolytic adenovirus via chemoselective modification.

scientific article published on 20 May 2011

Targeting FtsZ for antituberculosis drug discovery: noncytotoxic taxanes as novel antituberculosis agents

scientific article published on January 2006

Targeting fatty acid binding protein (FABP) anandamide transporters - a novel strategy for development of anti-inflammatory and anti-nociceptive drugs

scientific article published in 2012

Targeting the Hemopexin-like Domain of Latent Matrix Metalloproteinase-9 (proMMP-9) with a Small Molecule Inhibitor Prevents the Formation of Focal Adhesion Junctions.

scientific article

Taxane anticancer agents: a patent perspective

scientific article published on 10 December 2015

Taxane-based reversal agents modulate drug resistance mediated by P-glycoprotein, multidrug resistance protein, and breast cancer resistance protein.

scientific article

Taxanes with high potency inducing tubulin assembly overcome tumoural cell resistances.

scientific article

Taxol Analogues Exhibit Differential Effects on Photoaffinity Labeling of β-Tubulin and the Multidrug Resistance Associated P-Glycoprotein.

scientific article published on 8 March 2018

The Antinociceptive Agent SBFI-26 Binds to Anandamide Transporters FABP5 and FABP7 at Two Different Sites

scientific article

The efficacy of the one-leg cycling test for determining the anaerobic threshold (AT) of lower limb amputees ⬇️

scientific article published on 01 August 1997

The role of individual caspases in cell death induction by taxanes in breast cancer cells.

scientific article

The use of a novel taxane-based P-glycoprotein inhibitor to identify mutations that alter the interaction of the protein with paclitaxel.

scientific article published in July 2001

Therapeutic potential of FtsZ inhibition: a patent perspective

scientific article published on 18 March 2011

Transition Metal-Catalyzed Carbocyclizations in Organic Synthesis

article

Transport and cytotoxicity of paclitaxel, docetaxel, and novel taxanes in human breast cancer cells

scientific article

Transport, metabolism, cytotoxicity and effects of novel taxanes on the cell cycle in MDA-MB-435 and NCI/ADR-RES cells

scientific article

Trunk deformity evaluation based on 3D measurements of front body surface landmarks in people with severe physical disabilities.

scientific article published on 12 August 2016

Tubulins in the primate retina: evidence that xanthophylls may be endogenous ligands for the paclitaxel-binding site

scientific article (publication date: August 2001)

Tubulins in the primate retina: evidence that xanthophylls may be endogenous ligands for the paclitaxel-binding site††This work was presented in part at the Association for Research in Vision and Ophthalmology annual meetings May 1999 and May 200

article

Tumor-Specific Novel Taxoid−Monoclonal Antibody Conjugates

scientific article published on 01 December 2002

Tumor-targeting drug delivery of new-generation taxoids

scientific article published on January 2012

Use of the tubulin bound paclitaxel conformation for structure-based rational drug design

scientific article

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