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List of works by Josef Penninger

"Catching heart disease": antigenic mimicry and bacterial infections

scientific article published in August 2000

491 Loss of Apelin exacerbates post-myocardial infarction remodeling and myocardial ischemia-reperfusion injury

52 Genetic Loci Influencing Myocardial Mass

scientific article

A Genome-Wide siRNA Screen Implicates Spire1/2 in SipA-Driven Salmonella Typhimurium Host Cell Invasion

scientific article

A RANKL G278R mutation causing osteopetrosis identifies a functional amino acid essential for trimer assembly in RANKL and TNF

scientific article published on 07 November 2011

A Specific Role of Phosphatidylinositol 3–Kinase γ

A crucial role for Jagunal homolog 1 in humoral immunity and antibody glycosylation in mice and humans

scientific article published on 01 January 2021

A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury

scientific article

A cryoinjury model in neonatal mice for cardiac translational and regeneration research

scientific article

A diabetic milieu increases ACE2 expression and cellular susceptibility to SARS-CoV-2 infections in human kidney organoids and patient cells

scientific article published on 12 May 2022

A dual role for autophagy in a murine model of lung cancer

scientific article published in Nature Communications

A genome-wide Drosophila epithelial tumorigenesis screen identifies Tetraspanin 29Fb as an evolutionarily conserved suppressor of Ras-driven cancer

article

A genome-wide Drosophila screen for heat nociception identifies α2δ3 as an evolutionarily conserved pain gene

scientific article

A global in vivo Drosophila RNAi screen identifies NOT3 as a conserved regulator of heart function.

scientific article

A mouse model to identify cooperating signaling pathways in cancer

article

A reproducible protocol for neonatal ischemic injury and cardiac regeneration in neonatal mice

scientific article

A reversible haploid mouse embryonic stem cell biobank resource for functional genomics.

scientific article published on 27 September 2017

A role for Fkbp6 and the chaperone machinery in piRNA amplification and transposon silencing

scientific journal article

A specific role of phosphatidylinositol 3-kinase gamma. A regulation of autonomic Ca(2)+ oscillations in cardiac cells

scientific journal article

A story of two ACEs

scientific article

A synthetic peptide library for benchmarking crosslinking-mass spectrometry search engines for proteins and protein complexes

scientific article published on 06 February 2020

A vital sugar code for ricin toxicity

scientific article published on 19 September 2017

ACE2 - from the renin-angiotensin system to gut microbiota and malnutrition

scientific article published on 17 August 2013

ACE2 Deficiency Worsens Epicardial Adipose Tissue Inflammation and Cardiac Dysfunction in Response to Diet-Induced Obesity

scientific article

ACE2 deficiency enhances angiotensin II-mediated aortic profilin-1 expression, inflammation and peroxynitrite production

scientific article

ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation

scientific journal article

ADAP-ting TCR signaling to integrins

scientific article

AIF and cyclophilin A cooperate in apoptosis-associated chromatinolysis

scientific article published on February 2004

AIF deficiency compromises oxidative phosphorylation

scientific article

AIF-regulated oxidative phosphorylation supports lung cancer development

scientific article published on 27 May 2019

AIF: not just an apoptosis-inducing factor

scientific article

ANGIOTENSIN II-MEDIATED MYOCARDIAL EXPRESSION OF MMP2, MMP9 AND MT1-MMP WERE ENHANCED IN ACE2-NULL MICE

Aberrant regulation of RANKL/OPG in women at high risk of developing breast cancer

scientific article published on 18 December 2016

Abstract 1209: Comparison of lung adenocarcinoma development in genetically engineered mouse and in humans - similarities and differences

article

Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand

scientific article (publication date: 18 November 1999)

Activation of dendritic cells through the interleukin 1 receptor 1 is critical for the induction of autoimmune myocarditis

scientific article

Activation of stress-activated protein kinases/c-Jun N-terminal protein kinases (SAPKs/JNKs) by a novel mitogen-activated protein kinase kinase

scientific article published in December 1997

Adhesion mediated by LFA-1 is required for efficient IL-12-induced NK and NKT cell cytotoxicity

scientific article published on 01 December 2000

Adoptive transfer of siRNA Cblb-silenced CD8+ T lymphocytes augments tumor vaccine efficacy in a B16 melanoma model

scientific article

Afatinib restrains K-RAS–driven lung tumorigenesis

scientific article published on 01 June 2018

Age-dependent motor dysfunction due to neuron-specific disruption of stress-activated protein kinase MKK7.

scientific article published on 4 August 2017

Alloreactive gamma delta thymocytes utilize distinct costimulatory signals from peripheral T cells.

scientific article

Alterations in the level of CD45 surface expression affect the outcome of thymic selection

scientific article published on 01 April 1997

An immunosurveillance mechanism controls cancer cell ploidy

scientific article

Analysis of PNGase F-Resistant N-Glycopeptides Using SugarQb for Proteome Discoverer 2.1 Reveals Cryptic Substrate Specificities

scientific article published on 10 June 2018

Angiotensin II plasma levels are linked to disease severity and predict fatal outcomes in H7N9-infected patients

scientific article published on 6 May 2014

Angiotensin II-mediated oxidative stress and inflammation mediate the age-dependent cardiomyopathy in ACE2 null mice

scientific article published on 21 April 2007

Angiotensin converting enzyme 2 abrogates bleomycin-induced lung injury

scientific article published on 14 January 2012

Angiotensin converting enzyme-2 confers endothelial protection and attenuates atherosclerosis.

scientific article

Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: molecular mechanisms and potential therapeutic target ⬇️

scientific article published on 03 March 2020

Angiotensin-converting enzyme 2 (ACE2) in disease pathogenesis

scientific article published on 04 February 2010

Angiotensin-converting enzyme 2 (ACE2) mediates influenza H7N9 virus-induced acute lung injury

scientific article

Angiotensin-converting enzyme 2 antagonizes angiotensin II-induced pressor response and NADPH oxidase activation in Wistar-Kyoto rats and spontaneously hypertensive rats

scientific article published on 29 June 2012

Angiotensin-converting enzyme 2 attenuates oxidative stress and VSMC proliferation via the JAK2/STAT3/SOCS3 and profilin-1/MAPK signaling pathways

scientific article published on 28 June 2013

Angiotensin-converting enzyme 2 in acute respiratory distress syndrome.

scientific article published on August 2007

Angiotensin-converting enzyme 2 in lung diseases

scientific article

Angiotensin-converting enzyme 2 is an essential regulator of heart function

scientific article (publication date: 20 June 2002)

Angiotensin-converting enzyme 2 protects from lethal avian influenza A H5N1 infections.

scientific article published on 6 May 2014

Angiotensin-converting enzyme 2 protects from severe acute lung failure

scientific article published in July 2005

Angiotensin-converting enzyme 2 suppresses pathological hypertrophy, myocardial fibrosis, and cardiac dysfunction

scientific article published on 2 August 2010

Angiotensin-converting enzyme II in the heart and the kidney

scientific article

Angiotensin-converting-enzyme 2 inhibits liver fibrosis in mice

scientific article published on September 2009

Antagonistic control of cell fates by JNK and p38-MAPK signaling.

scientific article published on 31 August 2007

Antigen receptor-induced activation and cytoskeletal rearrangement are impaired in Wiskott-Aldrich syndrome protein-deficient lymphocytes

scientific article

Apaf1 is required for mitochondrial pathways of apoptosis and brain development

scientific journal article

Apelin Is a Negative Regulator of Angiotensin II-Mediated Adverse Myocardial Remodeling and Dysfunction.

scientific article

Apelin inhibition prevents resistance and metastasis associated with anti-angiogenic therapy

scientific article published on 24 June 2019

Apelin is a positive regulator of ACE2 in failing hearts.

scientific article

Apelin protects against abdominal aortic aneurysm and the therapeutic role of neutral endopeptidase resistant apelin analogs

scientific article published on 12 June 2019

Apelin treatment increases complete Fatty Acid oxidation, mitochondrial oxidative capacity, and biogenesis in muscle of insulin-resistant mice.

scientific article

Apoptosis control in syncytia induced by the HIV type 1-envelope glycoprotein complex: role of mitochondria and caspases.

scientific article

Apoptosis inducing factor (AIF): a phylogenetically old, caspase-independent effector of cell death

scientific article

Apoptotic cell death in disease—Current understanding of the NCCD 2023

scientific article published in 2023

Autoimmune heart failure: new understandings of pathogenesis

scientific article published in January 2005

Autophagy in malignant transformation and cancer progression

scientific article

Autophagy in non-small cell lung carcinogenesis: A positive regulator of antitumor immunosurveillance

scientific article

Autophagy suppresses Ras-driven epithelial tumourigenesis by limiting the accumulation of reactive oxygen species

scientific article

Autophagy suppresses Ras-driven epithelial tumourigenesis by limiting the accumulation of reactive oxygen species.

scientific article published on 5 June 2017

B38-CAP is a bacteria-derived ACE2-like enzyme that suppresses hypertension and cardiac dysfunction

scientific article published on 26 February 2020

Behavioral phenotyping of calcium channel (CACN) subunit α2δ3 knockout mice: Consequences of sensory cross-modal activation

scientific article published on 2 January 2018

Biology of murine gamma delta T cells.

scientific article published on January 1991

Blockade of receptor activator of nuclear factor-κB (RANKL) signaling improves hepatic insulin resistance and prevents development of diabetes mellitus

scientific article published on 10 February 2013

Blockage by SP600125 of Fcepsilon receptor-induced degranulation and cytokine gene expression in mast cells is mediated through inhibition of phosphatidylinositol 3-kinase signalling pathway

scientific article

Bnip3 and AIF cooperate to induce apoptosis and cavitation during epithelial morphogenesis

scientific article

Bnip3 and AIF cooperate to induce apoptosis and cavitation during epithelial morphogenesis

scientific article published in April 2013

CBL-B is required for leukemogenesis mediated by BCR-ABL through negative regulation of bone marrow homing.

scientific article

CD28 costimulation is crucial for the development of spontaneous autoimmune encephalomyelitis

scientific article published on 01 April 1999

CD36/Sirtuin 1 Axis Impairment Contributes to Hepatic Steatosis in ACE2-Deficient Mice

scientific article published on 22 December 2016

CD4 expression is differentially required for deletion of MLS-1a-reactive T cells.

scientific article

CD4, CD8 and tyrosine kinases in thymic selection

scientific article

CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling

scientific article

CD45 regulated signaling pathways

scientific article

CD45: new jobs for an old acquaintance

scientific article

CD45RA and CD45RBhigh expression induced by thymic selection events

scientific article

CHMP5 controls bone turnover rates by dampening NF-κB activity in osteoclasts

scientific article published on 20 July 2015

CLP1 acts as the main RNA kinase in mice

scientific article published on 17 February 2020

CLP1 as a novel player in linking tRNA splicing to neurodegenerative disorders

scientific article

CLP1 links tRNA metabolism to progressive motor-neuron loss

scientific article published on 10 March 2013

CXCL10-CXCR3 enhances the development of neutrophil-mediated fulminant lung injury of viral and nonviral origin

scientific article

Calcium-regulated DNA binding and oligomerization of the neuronal calcium-sensing protein, calsenilin/DREAM/KChIP3

scientific article (publication date: 2 November 2001)

Caloric Restriction Mimetics Enhance Anticancer Immunosurveillance

scientific article published on July 2016

Can osteoclasts be excluded? (Reply)

scientific article published in Nature

Cardiac myosin-induced myocarditis: target recognition by autoreactive T cells requires prior activation of cardiac interstitial cells

scientific article published on 01 May 1996

Cardiac protective effects of irbesartan via the PPAR-gamma signaling pathway in angiotensin-converting enzyme 2-deficient mice

scientific article

Cardiac regeneration in a newborn: what does this mean for future cardiac repair research?

scientific article published on 7 February 2018

Cardiac regulation by phosphoinositide 3-kinases and PTEN

scientific article

Cardiac sarcoplasmic reticulum calcium release and load are enhanced by subcellular cAMP elevations in PI3Kgamma-deficient mice

scientific article published on 28 April 2005

Cationic nanoparticles directly bind angiotensin-converting enzyme 2 and induce acute lung injury in mice

scientific article

Cavitation of embryoid bodies requires optimal oxidative phosphorylation and AIF.

scientific article published on 29 September 2006

Cbl-3-deficient mice exhibit normal epithelial development

scientific article

Cbl-b deficiency provides protection against UVB-induced skin damage by modulating inflammatory gene signature

article

Cbl-b in T-cell activation

scientific article published on 21 February 2010

Cbl-b is a negative regulator of receptor clustering and raft aggregation in T cells

scientific journal article

Cbl-b regulates airway mucosal tolerance to aeroallergen

scientific article

Cell type-specific regulation of ITAM-mediated NF-kappaB activation by the adaptors, CARMA1 and CARD9.

scientific article published in July 2008

Cellular and molecular mechanisms of murine autoimmune myocarditis

scientific article published on January 1997

Cellular and molecular mechanisms of murine autoimmune myocarditis

Central RANK signalling in NPY neurons alters bone mass in male mice

scientific article published on 15 February 2018

Central control of fever and female body temperature by RANKL/RANK

scientific article

Central regulation of body temperature by RANKL/RANK pathway

scientific article published on August 1, 2011

Cerebral organoids model human brain development and microcephaly

scientific article

Chemosensitization by a non-apoptogenic heat shock protein 70-binding apoptosis-inducing factor mutant.

scientific article published in December 2003

Chicken thymic nurse cells: an overview.

scientific article published on July 1995

Chlamydia and antigenic mimicry.

scientific article

Chlamydia infections and heart disease linked through antigenic mimicry

scientific article published on February 1999

Colorectal carcinomas in mice lacking the catalytic subunit of PI(3)Kgamma

scientific article published in August 2000

Combining functional magnetic resonance imaging with mouse genomics: new options in pain research

scientific article published in January 2010

Communication between the TCR and integrins: role of the molecular adapter ADAP/Fyb/Slap

scientific article

Comparative glycoproteomics of stem cells identifies new players in ricin toxicity.

scientific article

Complete cardiac regeneration in a mouse model of myocardial infarction ⬇️

scientific article published on December 1, 2012

Compromising the 19S proteasome complex protects cells from reduced flux through the proteasome

scientific article

Construction of a global pain systems network highlights phospholipid signaling as a regulator of heat nociception

scientific article

Contact-dependent signaling triggers tumor-like proliferation of CCM3 knockout endothelial cells in co-culture with wild-type cells

scientific article published on 04 June 2022

Control of cell polarity and motility by the PtdIns(3,4,5)P3 phosphatase SHIP1

scientific article published on 17 December 2006

Converging evidence that sequence variations in the novel candidate gene MAP2K7 (MKK7) are functionally associated with schizophrenia

scientific article published on 16 August 2012

Cooperation between CD44 and LFA-1/CD11a adhesion receptors in lymphokine-activated killer cell cytotoxicity ⬇️

scientific article published on June 15, 1998

Coronin 1A is an essential regulator of the TGFβ receptor/SMAD3 signaling pathway in Th17 CD4(+) T cells.

scientific article

Correction: The Airn lncRNA does not require any DNA elements within its locus to silence distant imprinted genes

scientific article published on 21 October 2020

Correction: The hemopoietic Rho/Rac guanine nucleotide exchange factor Vav1 regulates N-formyl-methionyl-leucyl-phenylalanine-activated neutrophil functions

Coupling of bone resorption and formation by RANKL reverse signalling

scientific article published in Nature

Cutting edge: differential roles for phosphoinositide 3-kinases, p110gamma and p110delta, in lymphocyte chemotaxis and homing

scientific article

Cytoskeletal disorganization underlies PABPN1-mediated myogenic disability

scientific article published on 19 October 2020

DREAM ablation selectively alters THC place aversion and analgesia but leaves intact the motivational and analgesic effects of morphine

scientific article

DREAM is a critical transcriptional repressor for pain modulation

scientific article (publication date: 11 January 2002)

DREAMing about arthritic pain.

scientific article published in November 2004

Decreased glomerular and tubular expression of ACE2 in patients with type 2 diabetes and kidney disease

scientific article

Defective intestinal amino acid absorption in Ace2 null mice

scientific article published on 12 July 2012

Defective liver formation and liver cell apoptosis in mice lacking the stress signaling kinase SEK1/MKK4.

scientific article published in February 1999

Deficiency of Src homology 2 domain-containing inositol 5-phosphatase 1 affects platelet responses and thrombus growth

scientific article

Dendritic cell-induced autoimmune heart failure requires cooperation between adaptive and innate immunity

scientific article

Dendritic cells at the osteo-immune interface: implications for inflammation-induced bone loss.

scientific article published on June 2007

Depletion of angiotensin-converting enzyme 2 reduces brain serotonin and impairs the running-induced neurogenic response.

scientific article published on 20 April 2018

Derivation and maintenance of mouse haploid embryonic stem cells

scientific article published on 03 June 2019

Development and function of murine B cells lacking RANK.

scientific article published on 4 January 2012

Developmental expression of IL-2-receptor light chain (CD25) in the chicken embryo

scientific article published on January 1991

Developmentally regulated availability of RANKL and CD40 ligand reveals distinct mechanisms of fetal and adult cross-talk in the thymus medulla

scientific article published on 14 November 2012

Developmentally regulated expression of the regulator of G-protein signaling gene 2 (Rgs2) in the embryonic mouse pituitary

scientific article published in February 2005

Dexras1 potentiates photic and suppresses nonphotic responses of the circadian clock

scientific article published in September 2004

Different properties of SEK1 and MKK7 in dual phosphorylation of stress-induced activated protein kinase SAPK/JNK in embryonic stem cells.

scientific article published on 6 March 2003

Differential Control of CD28-Regulated In Vivo Immunity by the E3 Ligase Cbl-b

scientific article published on 01 February 2005

Differential expression of a novel ankyrin containing E3 ubiquitin-protein ligase, Hace1, in sporadic Wilms' tumor versus normal kidney

scientific article published on 14 July 2004

Differential requirement for caspase 9 in apoptotic pathways in vivo.

scientific article published on August 1998

Differential requirement for p56lck in fetal and adult thymopoiesis

scientific article published on 01 April 1998

Disruption of STAT3 signalling promotes KRAS-induced lung tumorigenesis

scientific article

Disruption of the growth hormone--signal transducer and activator of transcription 5--insulinlike growth factor 1 axis severely aggravates liver fibrosis in a mouse model of cholestasis.

scientific article

Dissociating the dual roles of apoptosis-inducing factor in maintaining mitochondrial structure and apoptosis

scientific article

Distinct functions of junD in cardiac hypertrophy and heart failure

scientific article

Distinct roles for angiotensin-converting enzyme 2 and carboxypeptidase A in the processing of angiotensins within the murine heart

scientific article published on 20 March 2008

Distribution of Angiotensin-(1-7) and ACE2 in Human Placentas of Normal and Pathological Pregnancies

article published in 2006

Dominant cell death induction by extramitochondrially targeted apoptosis-inducing factor

article by MARKUS LOEFFLER et al published March 2001 in FASEB Journal

Drosophila genome-wide obesity screen reveals hedgehog as a determinant of brown versus white adipose cell fate

scientific article

Dual deficiency of angiotensin-converting enzyme-2 and Mas receptor enhances angiotensin II-induced hypertension and hypertensive nephropathy

scientific article published on 24 September 2020

Dysregulation in Akt/mTOR/HIF-1 signaling identified by proteo-transcriptomics of SARS-CoV-2 infected cells

scientific article published on 21 July 2020

Dysregulation in mTOR/HIF-1 signaling identified by proteo-transcriptomics of SARS-CoV-2 infected cells

scientific article published on 02 May 2020

E3 ubiquitin ligase Cbl-b regulates Pten via Nedd4 in T cells independently of its ubiquitin ligase activity

scientific article

E3 ubiquitin ligase Cbl-b suppresses proallergic T cell development and allergic airway inflammation

scientific article published on 06 February 2014

E3 ubiquitin ligases in T-cell tolerance

scientific article published on September 2009

ELABELA-APJ axis protects from pressure overload heart failure and angiotensin II-induced cardiac damage.

scientific article published on 23 March 2017

ESCI award lecture: from a little mouse to rationale medicine for bone loss

scientific article published on October 2009

Electrical Activation of Wound-Healing Pathways ⬇️

scientific article published on January 1, 2010

Electrical signals control wound healing through phosphatidylinositol-3-OH kinase-gamma and PTEN.

scientific article

Enhanced ERK-1/2 activation in mice susceptible to coxsackievirus-induced myocarditis

scientific article

Enhanced ERK-1/2 activation in mice susceptible to coxsackievirus-induced myocarditis

Enhanced Renal Immunocytochemical Expression of ANG-(1-7) and ACE2 During Pregnancy

article

Enhanced susceptibility to biomechanical stress in ACE2 null mice is prevented by loss of the p47(phox) NADPH oxidase subunit

scientific article

Epidermal JunB represses G-CSF transcription and affects haematopoiesis and bone formation

scientific article published on 20 July 2008

Epidermal RANKL controls regulatory T-cell numbers via activation of dendritic cells

Erratum to: Severe Coronavirus Disease 2019 (COVID-19) is Associated With Elevated Serum Immunoglobulin (Ig) A and Antiphospholipid IgA Antibodies

erratum

Erratum: Corrigendum: Colorectal carcinomas in mice lacking the catalytic subunit of PI(3)Kγ

scientific article published in Nature

Erratum: Corrigendum: The lipid phosphatase SHIP2 controls insulin sensitivity

scientific article published in Nature

Essential Role of LFA-1 in Activating Th2-Like Responses by -Galactosylceramide-Activated NKT Cells

article

Essential role for collectrin in renal amino acid transport

scientific journal article

Essential role of E3 ubiquitin ligase activity in Cbl-b-regulated T cell functions

scientific article published on 19 January 2011

Essential role of Fkbp6 in male fertility and homologous chromosome pairing in meiosis

scientific article

Essential role of the E3 ubiquitin ligase Cbl-b in T cell anergy induction.

scientific article published in August 2004

Essential role of the adhesion receptor LFA-1 for T cell-dependent fulminant hepatitis

scientific article published on December 2002

Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death

scientific article (publication date: 29 March 2001)

Essential versus accessory aspects of cell death: recommendations of the NCCD 2015.

scientific article

Evidence for osteocyte regulation of bone homeostasis through RANKL expression

scientific article (publication date: 11 September 2011)

Evolution of the mammary gland from the innate immune system?

scientific article

Experimental allergic encephalomyelitis (EAE) in mice lacking CD4+ T cells

scholarly article by Dow-Rhoon Koh et al published September 1994 in European Journal of Immunology

Exploring the emerging complexity in transcriptional regulation of energy homeostasis

scientific article published on 13 October 2015

Fibroblasts as a source of self-antigens for central immune tolerance

scientific article published on 24 August 2020

Forward and reverse genetics through derivation of haploid mouse embryonic stem cells.

scientific article published on December 2011

Fos plays an essential role in the upregulation of RANK expression in osteoclast precursors within the bone microenvironment

article

From T-cell activation signals to signaling control of anti-cancer immunity

scientific article published on December 2007

Frontline Science: Coincidental null mutation of Csf2rα in a colony of PI3Kγ-/- mice causes alveolar macrophage deficiency and fatal respiratory viral infection

scientific article published on 28 July 2016

Function of PI3Kgamma in thymocyte development, T cell activation, and neutrophil migration

scientific article

Functional Recovery of a Human Neonatal Heart After Severe Myocardial Infarction.

scientific article

Functional human T-cell immunity and osteoprotegerin ligand control alveolar bone destruction in periodontal infection

scientific article

Functionally Conserved Noncoding Regulators of Cardiomyocyte Proliferation and Regeneration in Mouse and Human

scientific article published on 01 February 2018

G(-) anaerobes-reactive CD4+ T-cells trigger RANKL-mediated enhanced alveolar bone loss in diabetic NOD mice

scientific article published in May 2005

G0/G1 Switch Gene 2 Regulates Cardiac Lipolysis.

scientific article published on 8 September 2015

Gab2 promotes colony-stimulating factor 1-regulated macrophage expansion via alternate effectors at different stages of development.

scientific article published on 19 September 2011

Gab2 signaling in chronic myeloid leukemia cells confers resistance to multiple Bcr-Abl inhibitors.

scientific article

Generation of blood vessel organoids from human pluripotent stem cells

scientific article published on 25 September 2019

Generation of humanized mice susceptible to peptide-induced inflammatory heart disease

scientific article published on April 1999

Genetic Deletion of ACE2 Induces Vascular Dysfunction in C57BL/6 Mice: Role of Nitric Oxide Imbalance and Oxidative Stress

scientific article

Genetic analysis of the mammalian cell death machinery

scientific article

Genetic deletion of muscle RANK or selective inhibition of RANKL is not as effective as full-length OPG-fc in mitigating muscular dystrophy.

scientific article

Genetically corrected iPSCs as cell therapy for recessive dystrophic epidermolysis bullosa.

scientific article

Genetically modified animals and immunodeficiency

scientific article published on August 1993

Genome wide functional genetics in haploid cells

scientific article

Genome-wide RNAi screen identifies genes involved in intestinal pathogenic bacterial infection

scientific article

Glycogen Synthase Kinase-3 Modulates Cbl-b and Constrains T Cell Activation.

scientific article published on 6 November 2017

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

scientific article

Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes.

scientific article published on 17 April 2009

HACE1 deficiency leads to structural and functional neurodevelopmental defects

scientific article published on 29 April 2019

HACE1 prevents lung carcinogenesis via inhibition of RAC-family GTPases

scientific article published on 04 May 2020

HACE1 reduces oxidative stress and mutant Huntingtin toxicity by promoting the NRF2 response.

scientific article published on 10 February 2014

HACE1-dependent protein degradation provides cardiac protection in response to haemodynamic stress

scientific article

Hace1 controls ROS generation of vertebrate Rac1-dependent NADPH oxidase complexes

scientific article published on January 2013

Heat-shock protein 70 antagonizes apoptosis-inducing factor

scientific article (publication date: September 2001)

Hedgehog partial agonism drives Warburg-like metabolism in muscle and brown fat.

scientific article

Hepatocyte MKK7 Contributes to Restoration of the Liver Parenchyma Following Injury

scientific article published on 23 September 2020

Heterozygote loss of ACE2 is sufficient to increase the susceptibility to heart disease

scientific article published on 15 April 2014

High Precision Quantitative Proteomics Using iTRAQ on an LTQ Orbitrap: A New Mass Spectrometric Method Combining the Benefits of All

scientific article

Human CD4 and human major histocompatibility complex class II (DQ6) transgenic mice: supersensitivity to superantigen-induced septic shock

scientific article published in May 1996

Human CD4-major histocompatibility complex class II (DQw6) transgenic mice in an endogenous CD4/CD8-deficient background: reconstitution of phenotype and human-restricted function.

scientific article

Human CLP1 mutations alter tRNA biogenesis, affecting both peripheral and central nervous system function

scientific article

Human blood vessel organoids as a model of diabetic vasculopathy

scientific article published on 16 January 2019

Human recombinant ACE2 reduces the progression of diabetic nephropathy

scientific article published on 23 November 2009

Human recombinant soluble ACE2 in severe COVID-19

scientific article published on 24 September 2020

Human soluble ACE2 improves the effect of remdesivir in SARS-CoV-2 infection

scientific article published on 12 November 2020

Hypertension and prolonged vasoconstrictor signaling in RGS2-deficient mice

scientific article

Hypertension and prolonged vasoconstrictor signaling in RGS2-deficient mice

article

Hypertension with a grain of salt

scientific article published in November 2004

ICOS is essential for effective T-helper-cell responses

scientific journal article

IL-1 Receptor-Associated Kinase 4 Is Essential for IL-18-Mediated NK and Th1 Cell Responses

article

IL-10 Induces Regulatory T Cell Apoptosis by Up-Regulation of the Membrane Form of TNF-

scientific article published on 01 January 2004

IL-1R-Associated Kinase 4 Is Required for Lipopolysaccharide- Induced Activation of APC

scientific article published on 01 December 2003

Id2-, RORgammat-, and LTbetaR-independent initiation of lymphoid organogenesis in ocular immunity

scientific article published on 12 October 2009

Identification and functional analysis of endothelial tip cell-enriched genes

scientific article

Identification of ALK in Thinness

scientific article published on 13 May 2020

Identification of cardiac myosin peptides capable of inducing autoimmune myocarditis in BALB/c mice

scientific article

Identification of cell cycle-arrested quiescent osteoclast precursors in vivo

scientific article published on February 2009

Identification of embryonic precursor cells that differentiate into thymic epithelial cells expressing autoimmune regulator

scientific article published on 11 July 2016

Identification of lectin receptors for conserved SARS-CoV-2 glycosylation sites

scientific article

Identification of oxidative stress and Toll-like receptor 4 signaling as a key pathway of acute lung injury

scientific article published in April 2008

Identification of subepithelial mesenchymal cells that induce IgA and diversify gut microbiota.

scientific article published on 24 April 2017

Identifying the MAGUK protein Carma-1 as a central regulator of humoral immune responses and atopy by genome-wide mouse mutagenesis.

scientific article

Immune Interactions with CD4+ T Cells Promote the Development of Functional Osteoclasts from Murine CD11c+ Dendritic Cells

article

Immunity by ubiquitylation: a reversible process of modification

scientific article

Impact of ACE2 deficiency and oxidative stress on cerebrovascular function with aging

scientific article

Impaired CD28-mediated interleukin 2 production and proliferation in stress kinase SAPK/ERK1 kinase (SEK1)/mitogen-activated protein kinase kinase 4 (MKK4)-deficient T lymphocytes.

scientific article published in September 1997

Impaired Negative Selection of T Cells in Hodgkin's Disease Antigen CD30–Deficient Mice

article

Impaired T-cell development in the absence of Vav1 and Itk.

scientific article published in December 2008

Impaired TCR-mediated apoptosis and Bcl-XL expression in T cells lacking the stress kinase activator SEK1/MKK4 ⬇️

scientific article published on 01 October 1998

Impaired heart contractility in Apelin gene-deficient mice associated with aging and pressure overload

scientific article (publication date: 17 August 2007)

Impaired synergistic activation of stress-activated protein kinase SAPK/JNK in mouse embryonic stem cells lacking SEK1/MKK4: different contribution of SEK2/MKK7 isoforms to the synergistic activation

scientific article

Imprinted expression in cystic embryoid bodies shows an embryonic and not an extra-embryonic pattern

scientific article published on 24 April 2015

Improved Sensitivity in Low-Input Proteomics Using Micropillar Array-Based Chromatography

scientific article published on 31 October 2019

In situ analyses of in ovo graft-vs.-host reaction induced by thymic nurse cell lymphocytes

scientific article published in April 1993

Increased renal responsiveness to vasopressin and enhanced V2 receptor signaling in RGS2-/- mice

scientific article published on 2 May 2007

Induction of autoimmunity in the absence of CD28 costimulation

scientific article published on 01 August 1996

Inhibition of CBLB protects from lethal Candida albicans sepsis

scientific article published on 18 July 2016

Inhibition of RANK signaling in breast cancer induces an anti-tumor immune response orchestrated by CD8+ T cells

scientific article published on 10 December 2020

Inhibition of SARS-CoV-2 Infections in Engineered Human Tissues Using Clinical-Grade Soluble Human ACE2

scientific article published on 17 April 2020

Inhibition of the TNF Family Cytokine RANKL Prevents Autoimmune Inflammation in the Central Nervous System

scientific article published on 8 December 2015

Insulin-Like Growth Factor-1 and PTEN Deletion Enhance Cardiac L-Type Ca 2+ Currents via Increased PI3Kα/PKB Signaling

scientific article published on 20 April 2006

Intercellular Communication between Keratinocytes and Fibroblasts Induces Local Osteoclast Differentiation: a Mechanism Underlying Cholesteatoma-Induced Bone Destruction

scientific article published on 21 March 2016

Intra-thymic nurse cell lymphocytes can induce a graft-versus-host reaction with high efficiency

scientific article published on 01 January 1989

Intrathymic nurse cell lymphocytes can induce a specific graft-versus-host reaction

scientific article

Involvement of phosphoinositide 3-kinases and phosphoinositide phosphatases in immune responses, glucose metabolism and tumorigenesis

scientific article

Involvement of phosphoinositide 3-kinases in neutrophil activation and the development of acute lung injury

scientific article published in December 2001

Involvement of the IRF-1 transcription factor in antiviral responses to interferons

scientific article published in June 1994

JAGN1 deficiency causes aberrant myeloid cell homeostasis and congenital neutropenia

scientific article

JAK inhibition reduces SARS-CoV-2 liver infectivity and modulates inflammatory responses to reduce morbidity and mortality

scientific article published on 13 November 2020

JNK signalling mediates aspects of maternal immune activation: importance of maternal genotype in relation to schizophrenia risk

scientific article published on 28 January 2019

Jagunal homolog 1 is a critical regulator of neutrophil function in fungal host defense

scientific journal article

Jun and JunD-dependent functions in cell proliferation and stress response.

scientific article published on 19 March 2010

Just the beginning: novel functions for angiotensin-converting enzymes

scientific article

KCNJ15/Kir4.2 couples with polyamines to sense weak extracellular electric fields in galvanotaxis

scientific article (publication date: 2015)

Knockout mice: a paradigm shift in modern immunology

scientific article

LGR4 is a receptor for RANKL and negatively regulates osteoclast differentiation and bone resorption.

scientific article

LOX Fails to Substitute for RANKL in Osteoclastogenesis

scientific article published on 8 September 2016

Lack of DREAM Protein Enhances Learning and Memory and Slows Brain Aging

Lack of DREAM protein enhances learning and memory and slows brain aging

scientific article

Lessons from SARS: control of acute lung failure by the SARS receptor ACE2.

scientific article published on 19 September 2006

Leukocyte PI3K and PI3K have temporally distinct roles for leukocyte recruitment in vivo

scientific article published on 08 May 2007

Leukotriene B4 promotes neovascularization and macrophage recruitment in murine wet-type AMD models

scientific article published on 20 September 2018

Lineage-committed osteoclast precursors circulate in blood and settle down into bone

scientific article published in December 2011

Lineage-specific control of superantigen-induced cell death by the protein tyrosine kinase p56(lck)

scientific article published on 01 December 1996

Linking cytoarchitecture to metabolism: sarcolemma-associated plectin affects glucose uptake by destabilizing microtubule networks in mdx myofibers

scientific article published on 12 June 2013

Loss of Aif function causes cell death in the mouse embryo, but the temporal progression of patterning is normal

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Loss of Apelin exacerbates myocardial infarction adverse remodeling and ischemia-reperfusion injury: therapeutic potential of synthetic Apelin analogues.

scientific article published on July 2013

Loss of PI3Kγ enhances cAMP-dependent MMP remodeling of the myocardial N-cadherin adhesion complexes and extracellular matrix in response to early biomechanical stress

scientific journal article

Loss of PTEN attenuates the development of pathological hypertrophy and heart failure in response to biomechanical stress

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Loss of angiotensin-converting enzyme 2 accelerates maladaptive left ventricular remodeling in response to myocardial infarction

scientific article published on 15 June 2009

Loss of angiotensin-converting enzyme 2 enhances TGF-β/Smad-mediated renal fibrosis and NF-κB-driven renal inflammation in a mouse model of obstructive nephropathy

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Loss of angiotensin-converting enzyme-2 (Ace2) accelerates diabetic kidney injury

scientific article published on 28 June 2007

Loss of angiotensin-converting enzyme-2 leads to the late development of angiotensin II-dependent glomerulosclerosis

scientific article

Loss of dexras1 alters nonphotic circadian phase shifts and reveals a role for the intergeniculate leaflet (IGL) in gene-targeted mice

scientific article published on 11 August 2011

Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.

scientific article published on 24 April 2018

Low-molecular-weight tumor necrosis factor receptor p55 controls induction of autoimmune heart disease

scientific article published in February 1997

Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4

scientific article

Lymphotoxin signal promotes thymic organogenesis by eliciting RANK expression in the embryonic thymic stroma.

scientific article

MKK7 and ARF: new players in the DNA damage response scenery.

scientific article published on 26 March 2014

MKK7 couples stress signalling to G2/M cell-cycle progression and cellular senescence.

scientific article published on 22 February 2004

MKK7-deficiency in mature neurons impairs parental behavior in mice

scientific article published on 23 October 2020

Map2k7 Haploinsufficiency Induces Brain Imaging Endophenotypes and Behavioral Phenotypes Relevant to Schizophrenia

scientific article published on 01 January 2020

Mapping the mouse Allelome reveals tissue-specific regulation of allelic expression

scientific article published on 14 August 2017

Mast cells are not associated with systemic insulin resistance

scientific article published on 7 September 2016

Maternal transfer of infectious mouse mammary tumor retroviruses does not depend on clonal deletion of superantigen-reactive V beta 14+ T cells

scientific article published in May 1994

Mice haploinsufficient for Map2k7, a gene involved in neurodevelopment and risk for schizophrenia, show impaired attention, a vigilance decrement deficit and unstable cognitive processing in an attentional task: impact of minocycline.

scientific article published on 24 October 2016

Mild Impairment of Mitochondrial OXPHOS Promotes Fatty Acid Utilization in POMC Neurons and Improves Glucose Homeostasis in Obesity

scientific article published on 01 October 2018

Mitochondria, AIF and caspases--rivaling for cell death execution.

scientific article

Mitochondrio-nuclear translocation of AIF in apoptosis and necrosis

scientific article (publication date: April 2000)

Mitogen-activated protein kinases in apoptosis regulation

scientific article published on April 2004

Molecular and cellular mechanisms of T lymphocyte apoptosis

scientific article published on January 1998

Molecular characterization of mitochondrial apoptosis-inducing factor

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Molecular control of bone remodeling and osteoporosis

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Molecular controls of antigen receptor clustering and autoimmunity

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Molecular definitions of autophagy and related processes.

scientific article published on 08 June 2017

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

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Molecular motors involved in T cell receptor clusterings

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Molecular organization, ontogeny and expression of murine alpha beta and gamma delta T cell receptors

scientific article published on January 1991

Monoclonal antibody against CXCL-10/IP-10 ameliorates influenza A (H1N1) virus induced acute lung injury

scientific article published on 19 February 2013

Monoglyceride lipase deficiency in mice impairs lipolysis and attenuates diet-induced insulin resistance.

scientific article

Multiple functions of angiotensin-converting enzyme 2 and its relevance in cardiovascular diseases

scientific article published on 18 January 2013

Muscle RANK is a key regulator of Ca2+ storage, SERCA activity, and function of fast-twitch skeletal muscles

scientific article published on 28 January 2016

Muscle-specific loss of apoptosis-inducing factor leads to mitochondrial dysfunction, skeletal muscle atrophy, and dilated cardiomyopathy

scientific article

Mutant meiotic chromosome core components in mice can cause apparent sexual dimorphic endpoints at prophase or X-Y defective male-specific sterility

scientific article published on 28 June 2005

MyD88 signaling controls autoimmune myocarditis induction.

scientific article

Myeloid differentiation factor-88/interleukin-1 signaling controls cardiac fibrosis and heart failure progression in inflammatory dilated cardiomyopathy

scientific article published on 17 September 2009

NADH oxidase activity of mitochondrial apoptosis-inducing factor

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NF-kappaB and p53 are the dominant apoptosis-inducing transcription factors elicited by the HIV-1 envelope

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Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

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Negative regulation of T cell receptor signals

scientific article published in August 2004

Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b

scientific article published in Nature

Negative regulation of wnt11 expression by Jnk signaling during zebrafish gastrulation

scientific article published in July 2010

Neuregulin stimulation of cardiomyocyte regeneration in mice and human myocardium reveals a therapeutic window

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Neuroanatomy of pain-deficiency and cross-modal activation in calcium channel subunit (CACN) α2δ3 knockout mice.

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New gene functions in megakaryopoiesis and platelet formation

scientific article published on 30 November 2011

New insights into the transmembrane protein tyrosine phosphatase CD45.

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No death without life: vital functions of apoptotic effectors

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Normal B lymphocyte development but impaired T cell maturation in CD45-exon6 protein tyrosine phosphatase-deficient mice

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Normal thymic selection, normal viability and decreased lymphoproliferation in T cell receptor-transgenic CTLA-4-deficient mice

scholarly article by Paul Waterhouse et al published August 1997 in European Journal of Immunology

Novel functions of RANK(L) signaling in the immune system

scientific article published on January 2010

Novel insights into the mechanisms mediating the local antihypertrophic effects of cardiac atrial natriuretic peptide: role of cGMP-dependent protein kinase and RGS2.

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Nutrition and the biology of human ageing: Bone health & osteoporosis / sarcopenia / immune deficiency

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OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis

scientific journal article

Orphan transporter SLC6A18 is renal neutral amino acid transporter B0AT3

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Osteoblasts Provide a Suitable Microenvironment for the Action of Receptor Activator of Nuclear Factor-κB Ligand

scientific article published on 20 April 2006

Osteoclast differentiation factor RANKL controls development of progestin-driven mammary cancer

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Osteoclasts are dispensable for hematopoietic stem cell maintenance and mobilization

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Osteoclasts are dispensable for hematopoietic stem cell maintenance and mobilization

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Osteoprotegerin Reduces the Serum Level of Receptor Activator of NF- B Ligand Derived from Osteoblasts

scientific article published on 01 January 2007

Osteoprotegerin and Denosumab Stimulate Human Beta Cell Proliferation through Inhibition of the Receptor Activator of NF-κB Ligand Pathway

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Osteoprotegerin full length protein mitigates muscular dystrophy in fast-twitch skeletal muscles

scholarly article by S. Dufresne et al published October 2016 in Neuromuscular Disorders

Osteoprotegerin ligand induces beta-casein gene expression through the transcription factor CCAAT/enhancer-binding protein beta

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Osteoprotegerin ligand: a common link between osteoclastogenesis, lymph node formation and lymphocyte development.

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Osteoprotegerin ligand: a regulator of immune responses and bone physiology.

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Osteoprotegerin protects against muscular dystrophy

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Overexpression of apoptosis inducing factor aggravates hypoxic-ischemic brain injury in neonatal mice

scientific article published on 30 January 2020

Overexpression of the oncogenic signal transducer Gab2 occurs early in breast cancer development

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PDGFR blockade is a rational and effective therapy for NPM-ALK-driven lymphomas

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PI3K mediated electrotaxis of embryonic and adult neural progenitor cells in the presence of growth factors

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PI3Kgamma protects from myocardial ischemia and reperfusion injury through a kinase-independent pathway

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PI3Kgamma regulates cartilage damage in chronic inflammatory arthritis

scientific article published on 4 September 2009

PKC-theta modulates the strength of T cell responses by targeting Cbl-b for ubiquitination and degradation

scientific article published on 23 June 2009

PRDM12 Is Transcriptionally Active and Required for Nociceptor Function Throughout Life

scientific article published on 27 September 2021

Paul Ehrlich (1854-1915) and His Contributions to the Foundation and Birth of Translational Medicine.

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Pharmacokinetics and pharmacodynamics of recombinant human angiotensin-converting enzyme 2 in healthy human subjects

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Phenotypic drug screen uncovers the metabolic GCH1/BH4 pathway as key regulator of EGFR/KRAS-mediated neuropathic pain and lung cancer

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Phosphatidylinositide 3-kinase gamma regulates key pathologic responses to cholecystokinin in pancreatic acinar cells

scientific article published in February 2004

Phosphatidylinositol 3-kinase facilitates bile acid-induced Ca2+ responses in pancreatic acinar cells

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Phosphatidylinositol 3-kinase gamma is a critical mediator of myocardial ischemic and adenosine-mediated preconditioning

scientific article published on 7 August 2008

Phosphatidylinositol 3-kinase regulates Ca2+ signaling in pancreatic acinar cells through inhibition of sarco(endo)plasmic reticulum Ca2+-ATPase

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Phosphatidylinositol-3-kinase gamma plays a central role in blood-brain barrier dysfunction in acute experimental stroke

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Phosphatidylinositol-3-kinase-gamma is integral to homing functions of progenitor cells

scientific article published on 6 March 2008

Phosphoinositide 3-kinase gamma-deficient mice are protected from isoproterenol-induced heart failure.

scientific article published on 8 September 2003

Phosphoinositide 3-kinase-gamma expression is upregulated in brain microglia and contributes to ischemia-induced microglial activation in acute experimental stroke

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Phosphoinositide 3-kinases in immunity: lessons from knockout mice

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Phosphorylation and ubiquitination of the IkappaB kinase complex by two distinct signaling pathways

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Physiological roles of angiotensin-converting enzyme 2.

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Physiology and pathophysiology of the RANKL/RANK system

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Positive Regulation of T Cell Activation and Integrin Adhesion by the Adapter Fyb/Slap

scientific article published in Science

Predicting functional neuroanatomical maps from fusing brain networks with genetic information

Predicting functional neuroanatomical maps from fusing brain networks with genetic information.

scientific article published on 3 September 2017

Preferential signaling and induction of allergy-promoting lymphokines upon weak stimulation of the high affinity IgE receptor on mast cells.

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Prevention of angiotensin II-induced hypertension and cardiac remodeling by recombinant human angiotensin-converting enzyme 2 in mice

Prevention of angiotensin II-mediated renal oxidative stress, inflammation, and fibrosis by angiotensin-converting enzyme 2.

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Prkar1a is an osteosarcoma tumor suppressor that defines a molecular subclass in mice

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Progesterone drives mammary secretory differentiation via RankL-mediated induction of Elf5 in luminal progenitor cells.

scientific article published on 5 March 2013

Proto-oncoprotein Vav interacts with c-Cbl in activated thymocytes and peripheral T cells

scientific article (publication date: July 1997)

Publisher Correction: The metabolite BH4 controls T cell proliferation in autoimmunity and cancer

scientific article published on 01 August 2019

Pulmonary phagocyte-derived NPY controls the pathology of severe influenza virus infection

scholarly article by Seiki Fujiwara et al published 19 November 2018 in Nature Microbiology

RANK Signaling Amplifies WNT-Responsive Mammary Progenitors through R-SPONDIN1.

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RANK deletion in neuropeptide Y neurones attenuates oestrogen deficiency-related bone loss

scientific article published on 01 February 2019

RANK links thymic regulatory T cells to fetal loss and gestational diabetes in pregnancy

scientific article published on 23 December 2020

RANK rewires energy homeostasis in lung cancer cells and drives primary lung cancer.

scientific article published on 8 November 2017

RANK signals from CD4(+)3(-) inducer cells regulate development of Aire-expressing epithelial cells in the thymic medulla

scientific article published on 14 May 2007

RANK(L) as a key target for controlling bone loss

scientific article published on January 2009

RANK-L and RANK: T cells, bone loss, and mammalian evolution

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RANK/RANKL: regulators of immune responses and bone physiology

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RANKL and OPG and their influence on breast volume changes during pregnancy in healthy women

scientific article published on 20 March 2020

RANKL and RANK as novel therapeutic targets for arthritis

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RANKL and RANK in sex hormone-induced breast cancer and breast cancer metastasis

scientific article published on 04 April 2011

RANKL and RANK: From Mammalian Physiology to Cancer Treatment.

scientific article published on 11 December 2017

RANKL blockade prevents and treats aggressive osteosarcomas.

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RANKL-RANK signaling in osteoclastogenesis and bone disease

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RANKL/RANK - from bone physiology to breast cancer

scientific article published on 10 January 2014

RANKL/RANK as key factors for osteoclast development and bone loss in arthropathies.

scientific article published on January 2009

RANKL/RANK control Brca1 mutation-driven mammary tumors

scientific article published on 31 May 2016

RANKL/RANK-beyond bones

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RANKL/RANK: from bone loss to the prevention of breast cancer

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RGS14 is a mitotic spindle protein essential from the first division of the mammalian zygote

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Rank signaling links the development of invariant γδ T cell progenitors and Aire(+) medullary epithelium

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Receptor Activator of NF- B Ligand and Osteoprotegerin Regulate Proinflammatory Cytokine Production in Mice

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Receptor Activator of NF-κB Orchestrates Activation of Antiviral Memory CD8 T Cells in the Spleen Marginal Zone.

scientific article published in November 2017

Receptor activator of NF-kappa B ligand and osteoprotegerin regulate proinflammatory cytokine production in mice

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Receptor activator of NF-kappaB (RANK) stimulates the proliferation of epithelial cells of the epidermo-pilosebaceous unit

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Receptor activator of NF-kappaB ligand regulates the proliferation of mammary epithelial cells via Id2

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Receptor-specific allelic exclusion of TCRV alpha-chains during development

scientific article published in August 1998

Recombinant Human Angiotensin-Converting Enzyme 2 as a New Renin-Angiotensin System Peptidase for Heart Failure Therapy ⬇️

scientific article published on September 1, 2011

Recombinant angiotensin-converting enzyme 2 improves pulmonary blood flow and oxygenation in lipopolysaccharide-induced lung injury in piglets.

scientific article published on February 2010

Recombinant angiotensin-converting enzyme 2 suppresses pulmonary vasoconstriction in acute hypoxia

scientific article published on 01 March 2012

Reduced Prenatal Pulmonary Lymphatic Function Is Observed in Clp1 K/K Embryos With Impaired Motor Functions Including Fetal Breathing Movements in Preparation of the Developing Lung for Inflation at Birth

scientific article published on 06 March 2020

Reduction of Neuropathic and Inflammatory Pain through Inhibition of the Tetrahydrobiopterin Pathway

scientific article published on June 2015

Regulation of T cell activation, anxiety, and male aggression by RGS2.

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Regulation of anaphylactic responses by phosphatidylinositol phosphate kinase type I {alpha}.

scientific article published on 14 March 2005

Regulation of apoptosis in mature alphabeta+CD4-CD8- antigen-specific suppressor T cell clones.

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Regulation of cancer cell migration and bone metastasis by RANKL.

scientific article published on March 2006

Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways

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Regulation of peripheral T cell tolerance by the E3 ubiquitin ligase Cbl-b

scientific article published on 27 March 2007

Reinforcement of cancer immunotherapy by adoptive transfer of cblb-deficient CD8+ T cells combined with a DC vaccine

scientific article published on 8 March 2011

Requirement for tyrosine kinase p56lck for thymic development of transgenic gamma delta T cells

scientific article published in Science

Requirement of phosphatidylinositol 3-kinase activation and calcium influx for leukotriene B4-induced enzyme release

scientific journal article

Response to ‘Angiotensin-converting enzyme 2 (ACE2) gene and protein expression in diabetic patients without nephropathy’

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Review of microbial infections and the immune response to cardiac antigens

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Role of RANKL and RANK in bone loss and arthritis.

scientific article

Role of regulator of G protein signaling 2 (RGS2) in Ca(2+) oscillations and adaptation of Ca(2+) signaling to reduce excitability of RGS2-/- cells

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SARS-coronavirus modulation of myocardial ACE2 expression and inflammation in patients with SARS.

scientific article published on 6 May 2009

SEK1/MKK4-Mediated SAPK/JNK Signaling Participates in Embryonic Hepatoblast Proliferation via a Pathway Different from NF-κB-Induced Anti-Apoptosis

scholarly article by Tomomi Watanabe et al published October 2002 in Developmental Biology

SEK1/MKK4-Mediated SAPK/JNK Signaling Participates in Embryonic Hepatoblast Proliferation via a Pathway Different from NF-κB-Induced Anti-Apoptosis

scientific article published on 01 October 2002

SH2-containing inositol 5-phosphatases 1 and 2 in blood platelets: their interactions and roles in the control of phosphatidylinositol 3,4,5-trisphosphate levels

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SHIP is a negative regulator of growth factor receptor-mediated PKB/Akt activation and myeloid cell survival

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SHIP-1 inhibits CD95/APO-1/Fas-induced apoptosis in primary T lymphocytes and T leukemic cells by promoting CD95 glycosylation independently of its phosphatase activity

scientific article published on 11 February 2010

Salmonella-based platform for efficient delivery of functional binding proteins to the cytosol

scientific article published on 03 July 2020

Sclerostin expression in trabecular bone is downregulated by osteoclasts

scientific article published on 13 August 2020

Seventy-five genetic loci influencing the human red blood cell

scientific article published on 5 December 2012

Severe COVID-19 is associated with elevated serum IgA and antiphospholipid IgA-antibodies

scientific article published on 30 September 2020

Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4

scientific article (publication date: 18 April 2002)

Sigma-1 receptors control immune-driven peripheral opioid analgesia during inflammation in mice.

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Sigma-1 receptors control neuropathic pain and macrophage infiltration into the dorsal root ganglion after peripheral nerve injury

scientific article published on 10 March 2020

Signal transduction, mitotic catastrophes, and death in T-cell development

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Silencing Nociceptor Neurons Reduces Allergic Airway Inflammation.

scientific article published on 25 June 2015

Site-specific ubiquitination of the E3 ligase HOIP regulates apoptosis and immune signaling

scientific article published on 20 November 2020

Spatial (Tbata) expression in mature medullary thymic epithelial cells

scientific article published in February 2010

Spinophilin regulates Ca2+ signalling by binding the N-terminal domain of RGS2 and the third intracellular loop of G-protein-coupled receptors

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Spleen serves as a reservoir of osteoclast precursors through vitamin D-induced IL-34 expression in osteopetrotic op/op mice

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Spontaneous resistance to acute T-cell leukaemias in TCRV gamma 1.1J gamma 4C gamma 4 transgenic mice

scientific article published on May 1995

Spontaneous tumor rejection by cbl-b-deficient CD8+ T cells

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Stem cells. PTEN--coupling tumor suppression to stem cells?

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Stepwise cell fate decision pathways during osteoclastogenesis at single-cell resolution

scientific article published on 07 December 2020

Stimulation of bone formation in cortical bone of mice treated with a receptor activator of nuclear factor-κB ligand (RANKL)-binding peptide that possesses osteoclastogenesis inhibitory activity

scientific article published on 14 January 2013

Stress induces mitochondria-mediated apoptosis independent of SAPK/JNK activation in embryonic stem cells

scientific article published on 29 October 2003

Stress kinase MKK7: savior of cell cycle arrest and cellular senescence.

scientific article published on 29 May 2004

Stress-activated protein kinase MKK7 regulates axon elongation in the developing cerebral cortex.

scientific article published in November 2011

Stress-signalling kinase Sek1 protects thymocytes from apoptosis mediated by CD95 and CD3

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Sucralose Promotes Food Intake through NPY and a Neuronal Fasting Response.

scientific article published on July 2016

Susceptibility to myocarditis is dependent on the response of alphabeta T lymphocytes to coxsackieviral infection

scientific article published in September 1999

T Cell-Specific Loss of Pten Leads to Defects in Central and Peripheral Tolerance

scientific article published on 01 May 2001

T cell development in mice expressing splice variants of the protein tyrosine phosphatase CD45

scientific article published on 01 April 1997

T cell repertoire and clonal deletion of Mtv superantigen-reactive T cells in mice lacking CD4 and CD8 molecules

scientific article published on 01 July 1995

T lymphocyte development in p56lck deficient mice: allelic exclusion of the TcR β locus is incomplete but thymocyte development is not restored by TcR β or TcR αβ transgenes

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T-bet negatively regulates autoimmune myocarditis by suppressing local production of interleukin 17

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T-cell development and function in gene-knockout mice

scientific article published on April 1994

T-cell receptor-induced NF-kappaB activation is negatively regulated by E3 ubiquitin ligase Cbl-b

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TCR affinity and negative regulation limit autoimmunity

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TNF Conference 2009: Beyond Bones – RANKL/RANK in the Immune System

scientific article published on 01 January 2011

TNF-driven cell fate: till HACE do us part

scientific article published on 19 June 2016

TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling

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Targeted deletion of AIF decreases mitochondrial oxidative phosphorylation and protects from obesity and diabetes

scientific article published in November 2007

Targeting APLN/APLNR Improves Antiangiogenic Efficiency and Blunts Proinvasive Side Effects of VEGFA/VEGFR2 Blockade in Glioblastoma

scientific article published on 04 February 2019

Targeting the MKK7-JNK (Mitogen-Activated Protein Kinase Kinase 7-c-Jun N-Terminal Kinase) Pathway with Covalent Inhibitors.

scientific article published on 21 February 2019

Targeting the RANKL/RANK/OPG Axis for Cancer Therapy

scientific article published on 07 August 2020

Targeting the degradation of angiotensin II with recombinant angiotensin-converting enzyme 2: prevention of angiotensin II-dependent hypertension

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Telmisartan attenuates aortic hypertrophy in hypertensive rats by the modulation of ACE2 and profilin-1 expression.

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Temporally regulated and tissue-specific gene manipulations in the adult and embryonic heart using a tamoxifen-inducible Cre protein

scientific article published in July 2001

The Actin Cytoskeleton and Lymphocyte Activation

scientific article published on 01 January 1999

The Airn lncRNA does not require any DNA elements within its locus to silence distant imprinted genes

scientific article published on 22 July 2019

The C-terminal moiety of HIV-1 Vpr induces cell death via a caspase-independent mitochondrial pathway

scientific article (publication date: November 2002)

The CCR4-NOT deadenylase complex controls Atg7-dependent cell death and heart function

scientific article published on 6 February 2018

The E3 ligase Cbl-b and TAM receptors regulate cancer metastasis via natural killer cells.

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The E3 ligase HACE1 is a critical chromosome 6q21 tumor suppressor involved in multiple cancers

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The MAGUK family protein CARD11 is essential for lymphocyte activation

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The RANKL-RANK Story

scientific article published on 14 February 2015

The RNA helicase DDX3X is an essential mediator of innate antimicrobial immunity

scientific article published on 26 November 2018

The Role of Angiotensin Converting Enzyme 2 (ACE2) in Modulating Gut Microbiota, Intestinal Inflammation, and Coronavirus Infection

scientific article published on 29 October 2020

The Role of Iron Regulation in Immunometabolism and Immune-Related Disease

scientific article published on 22 November 2019

The Role of TAM Family Receptors in Immune Cell Function: Implications for Cancer Therapy

scientific article (publication date: 21 October 2016)

The Tumor Necrosis Factor Family Receptors RANK and CD40 Cooperatively Establish the Thymic Medullary Microenvironment and Self-Tolerance

The Tumor Suppressor Hace1 Is a Critical Regulator of TNFR1-Mediated Cell Fate

scientific article published on 04 May 2016

The Tumor Suppressor Hace1 Is a Critical Regulator of TNFR1-Mediated Cell Fate

scientific article published on September 2016

The adaptor protein CARD9 is essential for the activation of myeloid cells through ITAM-associated and Toll-like receptors

article by Hiromitsu Hara et al published 7 May 2007 in Nature Immunology

The alarmin cytokine, high mobility group box 1, is produced by viable cardiomyocytes and mediates the lipopolysaccharide-induced myocardial dysfunction via a TLR4/phosphatidylinositol 3-kinase gamma pathway.

scientific article published on 18 December 2009

The crystal structure of the mouse apoptosis-inducing factor AIF

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The cyclin-dependent kinase Cdk2 regulates thymocyte apoptosis

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The cytokine RANKL produced by positively selected thymocytes fosters medullary thymic epithelial cells that express autoimmune regulator.

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The discovery of angiotensin-converting enzyme 2 and its role in acute lung injury in mice

scientific article published on 10 April 2008

The enigmatic meiotic dense body and its newly discovered component, SCML1, are dispensable for fertility and gametogenesis in mice.

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The evolutionarily conserved transcription factor PRDM12 controls sensory neuron development and pain perception

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The guanine-nucleotide exchange factor Vav is a crucial regulator of B cell receptor activation and B cell responses to nonrepetitive antigens.

scientific article published in July 1999

The hemopoietic Rho/Rac guanine nucleotide exchange factor Vav1 regulates N-formyl-methionyl-leucyl-phenylalanine-activated neutrophil functions

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The histone chaperone CAF-1 safeguards somatic cell identity

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The induction of experimental autoimmune myocarditis in mice lacking CD4 or CD8 molecules [corrected].

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The inositol polyphosphate 5-phosphatase ship is a crucial negative regulator of B cell antigen receptor signaling

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The interferon regulatory transcription factor IRF-1 controls positive and negative selection of CD8+ thymocytes.

scientific article published on August 1997

The lipid mediator protectin D1 inhibits influenza virus replication and improves severe influenza

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The lipid phosphatase SHIP2 controls insulin sensitivity

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The many roles of RANKL-RANK signaling in bone, breast and cancer

The metabolite BH4 controls T cell proliferation in autoimmunity and cancer

scientific article published in Nature

The mevalonate pathway regulates primitive streak formation via protein farnesylation

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The molecular adapter Carma1 controls entry of IkappaB kinase into the central immune synapse

scientific article published on November 2004

The molecular archaeology of a mitochondrial death effector: AIF in Drosophila

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The molecular gatekeeper Dexras1 sculpts the photic responsiveness of the mammalian circadian clock.

scientific article published in December 2006

The molecular scaffold Gab2 is a crucial component of RANK signaling and osteoclastogenesis

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The novel lncRNA is pro-neurogenic and mutated in human neurodevelopmental disorders

scientific article published on 10 January 2019

The oncogene product Vav is a crucial regulator of primary cytotoxic T cell responses but has no apparent role in CD28-mediated co-stimulation

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The oncogene product Vav is a crucial regulator of primary cytotoxic T cell responses but has no apparent role in CD28-mediated co-stimulation

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The osteoclast differentiation factor osteoprotegerin-ligand is essential for mammary gland development

scientific article (publication date: 29 September 2000)

The paradox of overnutrition in aging and cognition

scientific article published on 17 May 2013

The phosphoinositide-3 kinase gamma-Akt pathway mediates renal tubular injury in cisplatin nephrotoxicity

scientific article published on 28 November 2007

The renin-angiotensin system in acute respiratory distress syndrome

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The role of ACE2 in cardiovascular physiology

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The role of ACE2 in pulmonary diseases--relevance for the nephrologist

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The role of LFA-1 in osteoclast development induced by co-cultures of mouse bone marrow cells and MC3T3-G2/PA6 cells

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The role of endothelial PI3Kgamma activity in neutrophil trafficking

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The role of p56lck and p59fyn tyrosine kinases and CD45 protein tyrosine phosphatase in T-cell development and clonal selection

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The role of phosphoinositide-3 kinase and PTEN in cardiovascular physiology and disease

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The role of the e3 ligase cbl-B in murine dendritic cells.

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The role of transgenic knockout models in defining the pathogenesis of viral heart disease

scientific article published on December 1995

The stress kinase MKK7 couples oncogenic stress to p53 stability and tumor suppression

scientific article published on 13 February 2011

The stress kinase mitogen-activated protein kinase kinase (MKK)7 is a negative regulator of antigen receptor and growth factor receptor-induced proliferation in hematopoietic cells.

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The transcription factor NF-ATc1 regulates lymphocyte proliferation and Th2 cytokine production

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The tumor necrosis factor family receptors RANK and CD40 cooperatively establish the thymic medullary microenvironment and self-tolerance

scientific article published in September 2008

The tyrosine kinase p56lck is essential in coxsackievirus B3-mediated heart disease

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The ubiquitin E3 ligase Cbl-b in T cells tolerance and tumor immunity

scientific article published on 26 July 2007

Thymic heterotypic cellular complexes in gene-targeted mice with defined blocks in T cell development and adhesion molecule expression

scientific article published in September 1998

Thymic nurse cell lymphocytes react against self major histocompatibility complex ⬇️

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Thymic nurse cells: a site for positive selection and differentiation of T cells

scientific article published on January 1991

Thymocyte selection in Vav and IRF-1 gene-deficient mice

scientific article published on October 1998

Tissue expression and immunolocalization of tumor necrosis factor-alpha in postinfarction dysfunctional myocardium

scientific article published on 01 March 1999

Tissue-specific amino acid transporter partners ACE2 and collectrin differentially interact with hartnup mutations.

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Tolerance and self-reactivity in V gamma 1.1C gamma 4 transgenic mice

scientific article published on January 1994

Transcriptional mechanisms underlying neuropathic pain: DREAM, transcription factors and future pain management?

scientific article published on September 2002

Trilogy of ACE2: a peptidase in the renin-angiotensin system, a SARS receptor, and a partner for amino acid transporters

scientific article published on 03 July 2010

Trim28 Haploinsufficiency Triggers Bi-stable Epigenetic Obesity.

scientific article published on January 2016

TrpA1 regulates thermal nociception in Drosophila

scientific article

Tumor necrosis factor induces matrix metalloproteinases in cardiomyocytes and cardiofibroblasts differentially via superoxide production in a PI3Kgamma-dependent manner

scientific article published on 9 December 2009

Two distinct pathways leading to nuclear apoptosis

scientific article

Tyrosine pre-transfer RNA fragments are linked to p53-dependent neuronal cell death via PKM2

scientific article published on 04 March 2020

Ultrastructural analysis of thymic nurse cell epithelium

article

Unbiased compound-protein interface mapping and prediction of chemoresistance loci through forward genetics in haploid stem cells

scientific article published on 23 January 2018

Up-regulation of endogenous RGS2 mediates cross-desensitization between Gs and Gq signaling in osteoblasts.

scientific article

Variants in STAT5B Associate with Serum TC and LDL-C Levels

article published in 2011

Vav is a regulator of cytoskeletal reorganization mediated by the T-cell receptor

scientific article published on 01 May 1998

Vav links antigen-receptor signaling to the actin cytoskeleton

scientific article published in August 1998

Vav regulates peptide-specific apoptosis in thymocytes

scientific article

Vav1 controls integrin clustering and MHC/peptide-specific cell adhesion to antigen-presenting cells

scientific article published in March 2002

Vav1 regulates MHCII expression in murine resting and activated B cells

scientific article

Vav1 regulates the migration and adhesion of dendritic cells.

scientific article published in July 2009

Viral myocarditis: balance between viral infection and immune response.

scientific article published on October 1996

Weak agonist self-peptides promote selection and tuning of virus-specific T cells

scientific article published in March 2003

When the DREAM is gone: from basic science to future prospectives in pain management and beyond

scientific article

X protein of hepatitis B virus inhibits Fas-mediated apoptosis and is associated with up-regulation of the SAPK/JNK pathway

scientific article

ZPK/DLK and MKK4 form the critical gateway to axotomy-induced motoneuron death in neonates

scientific article

[Lessons from SARS: a new potential therapy for acute respiratory distress syndrome (ARDS) with angiotensin converting enzyme 2 (ACE2)]

scientific article published on 01 March 2008

[Phenotypic and functional analysis of thymic nurse cell (TNC)-lymphocytes]

scientific article published on 01 January 1991

cbl-3: a new mammalian cbl family protein

scientific article

iNOS expression and nitrotyrosine formation in the myocardium in response to inflammation is controlled by the interferon regulatory transcription factor 1 ⬇️

scientific article published on July 15, 1997

p110γ and p110δ Phosphoinositide 3-Kinase Signaling Pathways Synergize to Control Development and Functions of Murine NK Cells

article

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