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List of works by Paul Talalay

A dicyanotriterpenoid induces cytoprotective enzymes and reduces multiplicity of skin tumors in UV-irradiated mice

scientific article published on 17 January 2008

A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure

scientific article

An exceptionally potent inducer of cytoprotective enzymes: elucidation of the structural features that determine inducer potency and reactivity with Keap1

scientific article

An unusual case of 'uncompetitive activation' by ascorbic acid: purification and kinetic properties of a myrosinase from Raphanus sativus seedlings

scientific article

Anticarcinogenic activities of sulforaphane and structurally related synthetic norbornyl isothiocyanates

scientific article published on 12 April 1994

Bioavailability of Sulforaphane from Two Broccoli Sprout Beverages: Results of a Short-term, Cross-over Clinical Trial in Qidong, China ⬇️

scientific article published on March 1, 2011

Biomarker-Guided Strategy for Treatment of Autism Spectrum Disorder (ASD).

scientific article published on 13 April 2016

Broccoli sprouts: an exceptionally rich source of inducers of enzymes that protect against chemical carcinogens

scientific article

Characterization of the three tyrosine residues of delta 5-3-ketosteroid isomerase by time-resolved fluorescence and circular dichroism

scientific article published on 01 June 1994

Chemical and molecular regulation of enzymes that detoxify carcinogens

scientific article

Chemical structures of inducers of nicotinamide quinone oxidoreductase 1 (NQO1).

scientific article published on January 2004

Chemoprotection against cancer by isothiocyanates and glucosinolates.

scientific article published on August 1996

Chlorophyll, chlorophyllin and related tetrapyrroles are significant inducers of mammalian phase 2 cytoprotective genes

scientific article

Combined effects of two mutations of catalytic residues on the ketosteroid isomerase reaction

scientific article published on 01 November 1990

Coordinate regulation of enzyme markers for inflammation and for protection against oxidants and electrophiles.

scholarly article

Correction: Lack of Effect of Oral Sulforaphane Administration on Nrf2 Expression in COPD: A Randomized, Double-Blind, Placebo Controlled Trial

scientific article published on 28 March 2017

Design and synthesis of bifunctional isothiocyanate analogs of sulforaphane: correlation between structure and potency as inducers of anticarcinogenic detoxication enzymes

scientific article

Dietary amelioration of Helicobacter pylori infection: design criteria for a clinical trial.

scientific article published in October 2004

Dietary glucoraphanin-rich broccoli sprout extracts protect against UV radiation-induced skin carcinogenesis in SKH-1 hairless mice.

scientific article published on April 2010

Direct and indirect antioxidant properties of inducers of cytoprotective proteins

scientific article published on June 2008

Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

scientific article (publication date: 3 September 2002)

Divergent responses of chondrocytes and endothelial cells to shear stress: cross-talk among COX-2, the phase 2 response, and apoptosis

scientific article

Electrophile and antioxidant regulation of enzymes that detoxify carcinogens

scientific article

Electrophile and oxidant damage of mitochondrial DNA leading to rapid evolution of homoplasmic mutations

scholarly article

Electrophilic tuning of the chemoprotective natural product sulforaphane.

scientific article

Environments and mechanistic roles of the tyrosine residues of delta 5-3-ketosteroid isomerase

scientific article published on 01 February 1993

Enzymatic and nonenzymatic polarizations of alpha,beta-unsaturated ketosteroids and phenolic steroids. Implications for the roles of hydrogen bonding in the catalytic mechanism of delta 5-3-ketosteroid isomerase

scientific article published on 01 January 1995

Erratum to “Quantitative determination of dithiocarbamates in human plasma, serum, erythrocytes and urine: pharmacokinetics of broccoli sprout isothiocyanates in humans” [Clin. Chim. Acta 316 (2002) 43–53]

scholarly article published in Clinica Chimica Acta

Extremely potent triterpenoid inducers of the phase 2 response: correlations of protection against oxidant and inflammatory stress

scientific article

Importance of phase 2 gene regulation in protection against electrophile and reactive oxygen toxicity and carcinogenesis

scientific article

Inactivation of Tautomerase Activity of Macrophage Migration Inhibitory Factor by Sulforaphane: a Potential Biomarker for Anti-inflammatory Intervention ⬇️

scientific article published on May 20, 2011

Induction of phase 2 genes by sulforaphane protects retinal pigment epithelial cells against photooxidative damage

scholarly article

Induction of the phase 2 response in mouse and human skin by sulforaphane-containing broccoli sprout extracts.

scientific article

Isothiocyanates as substrates for human glutathione transferases: structure-activity studies.

scientific article published on October 1995

Keap1-nrf2 signaling: a target for cancer prevention by sulforaphane

scientific article published on January 2013

Kinetic and ultraviolet spectroscopic studies of active-site mutants of delta 5-3-ketosteroid isomerase

scientific article published on 01 January 1989

Lack of Effect of Oral Sulforaphane Administration on Nrf2 Expression in COPD: A Randomized, Double-Blind, Placebo Controlled Trial

scientific article

Mercurials and Dimercaptans: Synergism in the Induction of Chemoprotective Enzymes

scientific article published on 01 January 1995

NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1), a multifunctional antioxidant enzyme and exceptionally versatile cytoprotector

scientific article

NMR evidence for the participation of a low-barrier hydrogen bond in the mechanism of delta 5-3-ketosteroid isomerase

scientific article published on August 1996

Neuroprotective effects of sulforaphane after contusive spinal cord injury.

scientific article

Novel semisynthetic analogues of betulinic acid with diverse cytoprotective, antiproliferative, and proapoptotic activities.

scientific article

Nrf2 Activation Protects against Solar-Simulated Ultraviolet Radiation in Mice and Humans

scientific article published on 24 March 2015

Potency ranking of triterpenoids as inducers of a cytoprotective enzyme and as inhibitors of a cellular inflammatory response via their electron affinity and their electrophilicity index

scientific article

Precise determination of the erythema response of human skin to ultraviolet radiation and quantification of effects of protectors

scientific article published on February 2009

Preclinical and clinical evaluation of sulforaphane for chemoprevention in the breast.

scientific article published on 7 March 2007

Protection against UV-light-induced skin carcinogenesis in SKH-1 high-risk mice by sulforaphane-containing broccoli sprout extracts

scientific article published on 3 November 2005

Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducers

scientific article (publication date: 17 February 2004)

Protection against electrophile and oxidative stress by induction of phase 2 genes: the quest for the elusive sensor that responds to inducers.

scientific article

Protection of Humans by Plant Glucosinolates: Efficiency of Conversion of Glucosinolates to Isothiocyanates by the Gastrointestinal Microflora ⬇️

scientific article published on February 7, 2012

Quantitative determination of dithiocarbamates in human plasma, serum, erythrocytes and urine: pharmacokinetics of broccoli sprout isothiocyanates in humans

scientific article published in February 2002

Rapid body weight gain increases the risk of UV radiation-induced skin carcinogenesis in SKH-1 hairless mice

scientific article published on August 2008

Redox ranking of inducers of a cancer-protective enzyme via the energy of their highest occupied molecular orbital

scientific article

Regulation of phase 2 enzyme induction by oltipraz and other dithiolethiones

scientific article published on 01 February 1994

Relevance of anti-inflammatory and antioxidant activities of exemestane and synergism with sulforaphane for disease prevention

scientific article

Reply to Scahill: Behavioral outcome measures in autism

scientific article published on 13 January 2015

Reprogramming of keratin biosynthesis by sulforaphane restores skin integrity in epidermolysis bullosa simplex

scientific article

Role of nicotinamide quinone oxidoreductase 1 (NQO1) in protection against toxicity of electrophiles and reactive oxygen intermediates

scientific article published on January 2004

Safety, Tolerance, and Metabolism of Broccoli Sprout Glucosinolates and Isothiocyanates: A Clinical Phase I Study

scientific article published on 01 January 2006

Spectroscopic quantitation of organic isothiocyanates by cyclocondensation with vicinal dithiols

scientific article published on 01 August 1992

Stabilized sulforaphane for clinical use: Phytochemical delivery efficiency

scientific article published on 9 December 2016

Stimulation of phagocytosis by sulforaphane.

scientific article

Studies of the catalytic mechanism of an active-site mutant (Y14F) of delta 5-3-ketosteroid isomerase by kinetic deuterium isotope effects

scientific article published on 01 November 1991

Studies of the mechanism of the delta 5-3-ketosteroid isomerase reaction by substrate, solvent, and combined kinetic deuterium isotope effects on wild-type and mutant enzymes

scientific article published on 01 August 1990

Sulforaphane Bioavailability from Glucoraphanin-Rich Broccoli: Control by Active Endogenous Myrosinase

scientific article published on 2 November 2015

Sulforaphane from Broccoli Reduces Symptoms of Autism: A Follow-up Case Series from a Randomized Double-blind Study.

scientific article

Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors

scientific article

Sulforaphane mobilizes cellular defenses that protect skin against damage by UV radiation

scholarly article

Sulforaphane treatment of autism spectrum disorder (ASD).

scientific article

The "Prochaska" microtiter plate bioassay for inducers of NQO1.

scientific article published on January 2004

The electrophile counterattack response: protection against neoplasia and toxicity.

scientific article

The potency of inducers of NAD(P)H:(quinone-acceptor) oxidoreductase parallels their efficiency as substrates for glutathione transferases. Structural and electronic correlations

scientific article published on February 1991

Transcription factors NRF2 and HSF1 have opposing functions in autophagy

scientific article published on 8 September 2017

Two-step mechanism of induction of the gene expression of a prototypic cancer-protective enzyme by diphenols.

scientific article

Ultraviolet resonance Raman spectroscopy of delta 5-3-ketosteroid isomerase revisited: substrate polarization by active-site residues

scientific article published on 01 April 1995

Unexpected genetic and structural relationships of a long-forgotten flavoenzyme to NAD(P)H:quinone reductase (DT-diaphorase)

scientific article

Urease from Helicobacter pylori is inactivated by sulforaphane and other isothiocyanates

scientific article

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